The aromatic amino acid hydroxylases: Structures, catalysis, and regulation of phenylalanine hydroxylase, tyrosine hydroxylase, and tryptophan hydroxylase

Structural mechanism for tyrosine hydroxylase inhibition by dopamine and reactivation by Ser40 phosphorylation

(2022) María Teresa Bueno-Carrasco et al.   Nature Communications

Thermodynamics of iron, tetrahydrobiopterin, and phenylalanine binding to phenylalanine hydroxylase from Chromobacterium violaceum

(2022) Mingjie Li et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Direct coordination of pterin to FeII enables neurotransmitter biosynthesis in the pterin-dependent hydroxylases

(2021) Shyam R. Iyer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Manipulation of a cation-π sandwich reveals conformational flexibility in phenylalanine hydroxylase

(2020) Emilia C. Arturo et al.   BIOCHIMIE

The phenylketonuria-associated substitution R68S converts phenylalanine hydroxylase to a constitutively active enzyme but reduces its stability

(2019) Crystal A. Khan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structure of full-length human phenylalanine hydroxylase in complex with tetrahydrobiopterin

(2019) Marte Innselset Flydal et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Serine 19 phosphorylation and 14‐3‐3 binding regulate phosphorylation and dephosphorylation of tyrosine hydroxylase on serine 31 and serine 40

(2019) Sadaf Ghorbani et al.   JOURNAL OF NEUROCHEMISTRY

Phosphorylation of Phenylalanine Hydroxylase Increases the Rate Constant for Formation of the Activated Conformation of the Enzyme

(2018) Crystal A. Khan et al.   BIOCHEMISTRY

The regulatory domain of human tryptophan hydroxylase 1 forms a stable dimer

(2016) Shengnan Zhang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Kinetic Mechanism and Intrinsic Rate Constants for the Reaction of a Bacterial Phenylalanine Hydroxylase

(2016) Bishnu P. Subedi et al.   BIOCHEMISTRY

Genetics of Phenylketonuria: Then and Now

(2016) Nenad Blau   HUMAN MUTATION

Identification of the Allosteric Site for Phenylalanine in Rat Phenylalanine Hydroxylase

(2016) Shengnan Zhang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Domain Movements upon Activation of Phenylalanine Hydroxylase Characterized by Crystallography and Chromatography-Coupled Small-Angle X-ray Scattering

(2016) Steve P. Meisburger et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

First structure of full-length mammalian phenylalanine hydroxylase reveals the architecture of an autoinhibited tetramer

(2016) Emilia C. Arturo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural basis for ligand-dependent dimerization of phenylalanine hydroxylase regulatory domain

(2016) Dipali Patel et al.   Scientific Reports

Stabilization of tryptophan hydroxylase 2 byl-phenylalanine-induced dimerization

(2016) Kasper D. Tidemand et al.   FEBS Open Bio

HYSCORE Analysis of the Effects of Substrates on Coordination of Water to the Active Site Iron in Tyrosine Hydroxylase

(2015) John McCracken et al.   BIOCHEMISTRY

Structural insights into the regulation of aromatic amino acid hydroxylation

(2015) Paul F Fitzpatrick   CURRENT OPINION IN STRUCTURAL BIOLOGY

Characterization of Unstable Products of Flavin- and Pterin-Dependent Enzymes by Continuous-Flow Mass Spectrometry

(2014) Kenneth M. Roberts et al.   BIOCHEMISTRY

Phenylalanine Binding Is Linked to Dimerization of the Regulatory Domain of Phenylalanine Hydroxylase

(2014) Shengnan Zhang et al.   BIOCHEMISTRY

Activation of Phenylalanine Hydroxylase by Phenylalanine Does Not Require Binding in the Active Site

(2014) Kenneth M. Roberts et al.   BIOCHEMISTRY

Dissection of Binding between a Phosphorylated Tyrosine Hydroxylase Peptide and 14-3-3ζ: A Complex Story Elucidated by NMR

(2014) Jozef Hritz et al.   BIOPHYSICAL JOURNAL

Complex molecular regulation of tyrosine hydroxylase

(2014) Izel Tekin et al.   JOURNAL OF NEURAL TRANSMISSION

A new model for allosteric regulation of phenylalanine hydroxylase: Implications for disease and therapeutics

(2013) Eileen K. Jaffe et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Regulation of phenylalanine hydroxylase: Conformational changes upon phosphorylation detected by H/D exchange and mass spectrometry

(2013) Jun Li et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Mutagenesis of a Specificity-Determining Residue in Tyrosine Hydroxylase Establishes That the Enzyme Is a Robust Phenylalanine Hydroxylase but a Fragile Tyrosine Hydroxylase

(2013) S. Colette Daubner et al.   BIOCHEMISTRY

Kinetic Mechanism of Phenylalanine Hydroxylase: Intrinsic Binding and Rate Constants from Single-Turnover Experiments

(2013) Kenneth M. Roberts et al.   BIOCHEMISTRY

Pulsed EPR Study of Amino Acid and Tetrahydropterin Binding in a Tyrosine Hydroxylase Nitric Oxide Complex: Evidence for Substrate Rearrangements in the Formation of the Oxygen-Reactive Complex

(2013) Matthew D. Krzyaniak et al.   BIOCHEMISTRY

Mechanisms of tryptophan and tyrosine hydroxylase

(2013) Kenneth M. Roberts et al.   IUBMB LIFE

Phenylalanine hydroxylase: Function, structure, and regulation

(2013) Marte I. Flydal et al.   IUBMB LIFE

The N-Terminal Sequence of Tyrosine Hydroxylase Is a Conformationally Versatile Motif That Binds 14-3-3 Proteins and Membranes

(2013) Åge Aleksander Skjevik et al.   JOURNAL OF MOLECULAR BIOLOGY

The Solution Structure of the Regulatory Domain of Tyrosine Hydroxylase

(2013) Shengnan Zhang et al.   JOURNAL OF MOLECULAR BIOLOGY

Allosteric regulation of phenylalanine hydroxylase

(2011) Paul F. Fitzpatrick   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Evidence for a High-Spin Fe(IV) Species in the Catalytic Cycle of a Bacterial Phenylalanine Hydroxylase

(2011) Aram Joel Panay et al.   BIOCHEMISTRY

Fluorescence Spectroscopy as a Probe of the Effect of Phosphorylation at Serine 40 of Tyrosine Hydroxylase on the Conformation of Its Regulatory Domain

(2011) Shanzhi Wang et al.   BIOCHEMISTRY

Identification of Phenylalanine 3-Hydroxylase formeta-Tyrosine Biosynthesis

(2011) Wenjun Zhang et al.   BIOCHEMISTRY

Direct evidence for a phenylalanine site in the regulatory domain of phenylalanine hydroxylase

(2010) Jun Li et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Tyrosine hydroxylase and regulation of dopamine synthesis

(2010) S. Colette Daubner et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Single Turnover Kinetics of Tryptophan Hydroxylase: Evidence for a New Intermediate in the Reaction of the Aromatic Amino Acid Hydroxylases

(2010) Jorge Alex Pavon et al.   BIOCHEMISTRY

Regulation of Phenylalanine Hydroxylase: Conformational Changes Upon Phenylalanine Binding Detected by Hydrogen/Deuterium Exchange and Mass Spectrometry

(2010) Jun Li et al.   BIOCHEMISTRY

Identification by Hydrogen/Deuterium Exchange of Structural Changes in Tyrosine Hydroxylase Associated with Regulation

(2009) Shanzhi Wang et al.   BIOCHEMISTRY

Measurement of Intrinsic Rate Constants in the Tyrosine Hydroxylase Reaction

(2009) Bekir E. Eser et al.   BIOCHEMISTRY

Spatio-temporal expression of tryptophan hydroxylase isoforms in murine and human brain: Convergent data from Tph2 knockout mice

(2009) Lise Gutknecht et al.   EUROPEAN NEUROPSYCHOPHARMACOLOGY

Spectroscopy and Kinetics of Wild-Type and Mutant Tyrosine Hydroxylase: Mechanistic Insight into O2Activation

(2009) Marina S. Chow et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Demonstration of a Peroxide Shunt in the Tetrahydropterin-Dependent Aromatic Amino Acid Monooxygenases

(2009) Jorge Alex Pavon et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Activation and stabilization of human tryptophan hydroxylase 2 by phosphorylation and 14-3-3 binding

(2008) Ingeborg Winge et al.   BIOCHEMICAL JOURNAL

The 14-3-3 Protein Affects the Conformation of the Regulatory Domain of Human Tyrosine Hydroxylase†

(2008) Veronika Obsilova et al.   BIOCHEMISTRY

A Regulatory Domain in the N Terminus of Tryptophan Hydroxylase 2 Controls Enzyme Expression

(2008) Karen L. Murphy et al.   JOURNAL OF BIOLOGICAL CHEMISTRY