Article
Neurosciences
Qing Gao, Yingying Zhang, Xiaoying Wang, Rui Wang, Limei Zhang
Summary: The mechanism of pain symptoms in Parkinson's disease is unclear, and this study aims to investigate the effect of NE on the activation of brain cells and regulate the nociception threshold in a PD animal model. It was found that changes in NE content can affect the activation of glial cells and participate in the regulation of nociception in PD rats. Both adrenergic a2 receptor agonist and central presynaptic membrane a2 receptor blocker can improve hyperalgesia.
CNS NEUROSCIENCE & THERAPEUTICS
(2023)
Review
Biochemistry & Molecular Biology
Sabyasachi Maity, Raman Abbaspour, David Nahabedian, Steven A. Connor
Summary: The noradrenergic system plays a crucial role in memory formation and synaptic plasticity. Norepinephrine stimulates beta-ARs to regulate memory formation and affects neural circuit function through epigenetic modifications. Understanding these mechanisms is essential for studying brain disorders and developing neurotherapeutic applications.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Orthopedics
Tingmo Huang, Liyang Wan, Yang Chen, Yinghong Xiong, Feifei Yuan, Shansha Xie, Jianjun Huang, Hongbin Lu
Summary: This study aimed to explore the effect of local sympatholysis (LS) on bone-tendon interface (BTI) healing in a murine rotator cuff repair model. The results indicated that LS was beneficial for BTI healing outcomes. This study found that sympathetic innervation played a role in the healing process of injured BTI, and local sympathetic denervation using guanethidine could improve BTI healing.
JOURNAL OF ORTHOPAEDIC TRANSLATION
(2023)
Article
Endocrinology & Metabolism
Jiju Wang, Yunhui Tang, Songcun Wang, Liyuan Cui, Dajin Li, Meirong Du
Summary: This study found that excess norepinephrine inhibits endometrial decidualization by upregulating the alpha 1b-adrenergic receptor, affecting embryo and fetal development in a normal pregnancy model. The findings suggest a potential mechanism through which stress-related norepinephrine exposure could impact female reproductive health.
JOURNAL OF ENDOCRINOLOGY
(2021)
Article
Neurosciences
Dong-oh Seo, Eric T. Zhang, Sean C. Piantadosi, David J. Marcus, Laura E. Motard, Bryce K. Kan, Adrian M. Gomez, Tammy K. Nguyen, Li Xia, Michael R. Bruchas
Summary: The study found that the activation of noradrenergic neurons can lead to contextual generalization, which requires b-adrenergic-mediated modulation to promote aversive generalization. This suggests that disruption of noradrenergic tone may be an important avenue for treating stress-induced disorders.
Article
Pharmacology & Pharmacy
Christopher L. Moore, David S. Henry, Samantha J. McClenahan, Kelly K. Ball, Nancy J. Rusch, Sung W. Rhee
Summary: Research indicates that beta-blockers may impair cerebral blood flow under certain conditions by affecting vasodilator responses of cerebral arteries. Metoprolol, a commonly prescribed beta 1AR-selective antagonist, not only attenuates heart stimulation but also eliminates vasodilator responses to adrenergic stimuli in rat cerebral arteries, potentially predisposing to ischemic stroke.
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS
(2021)
Article
Cell Biology
Zizhen Wu, Gabor Toro, Guoying Xu, Danny Dang, Charmaine Prater, Qing Yang
Summary: Paclitaxel-induced peripheral neuropathy (PIPN), a common complication in cancer patients undergoing paclitaxel treatment, has no effective therapy currently available. The study found that acute hyperexcitability of primary sensory neurons in PIPN is caused by the inhibition of KCNQ2 potassium channels by paclitaxel. Further experiments demonstrated that administration of KCNQ channel blocker XE-991 induced PIPN-like alterations in rats, while genetic deletion of KCNQ2 in mice attenuated the development of PIPN. These findings provide insights into the pathogenesis of PIPN and may lead to the development of new therapeutic approaches targeting KCNQ channels.
Review
Biochemistry & Molecular Biology
Evgenia Sitnikova, Elizaveta Rutskova, Kirill Smirnov
Summary: Spike-wave discharges are caused by thalamocortical network disorder in idiopathic generalized epilepsy. Currently available anti-epileptic drugs have significant side effects due to low selectivity to molecular targets. Activation of alpha2B adrenergic receptors (ARs) in the thalamus shows potential as a specific molecular target for absence epilepsy. HCN and calcium channels are proposed as relevant cellular targets of alpha2 ARs in spike-wave activity generation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Anatomy & Morphology
Daisuke Kondoh, Yusuke K. Kawai, Kenichi Watanabe, Yuki Muranishi
Summary: This study found that artiodactyl livestock species have a uniform type of vomeronasal system, consisting only of the V1R pathway. This finding suggests caution when extrapolating knowledge of laboratory rodents with two vomeronasal pathways to livestock animals that have only one.
Review
Oncology
Maria-Bernadette Madel, Florent Elefteriou
Summary: Bone is a common site for breast cancer metastasis, impacting patient survival and quality of life, with the interaction between sympathetic nerves and bone cells influencing this process. Stimulation of beta-adrenergic receptors in stromal bone cells promotes the establishment of disseminated cancer cells in the skeleton.
Review
Biochemistry & Molecular Biology
Karen P. Briski, Mostafa M. H. Ibrahim, A. S. M. Hasan Mahmood, Ayed A. Alshamrani
Summary: This review explores the impact of NE on astrocyte glycogen metabolism within the VMN, as well as the interaction with estrogen signaling in shaping neuro-metabolic stability. Sex-dimorphic NE control may be due to differential regulation of AR and ER variants between males and females.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Physiology
Victor De la Rosa, Maria Luisa Guzman-Hernandez, Elisa Carrillo
Summary: KCNQ channels play a crucial role in the physiology of various cell types, particularly in neurons of the central nervous system. Activating these channels helps control neuronal activity and prevent excessive firing. In this study, it was found that triclosan, a widely used bactericide in personal care products, activates KCNQ3 channels, offering new possibilities for the treatment of epilepsy and other hyperexcitability conditions.
PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY
(2022)
Review
Physiology
Maddison Reed, Michael G. Jonz
Summary: This review aims to summarize the receptor types implicated in O-2 sensing in fish gills, including serotonergic, cholinergic, purinergic, and dopaminergic receptor subtypes. Recent transcriptomic analysis has shed light on specific receptor targets in the gills, but the lack of receptor characterization at the cellular level remains a major limitation in understanding the neurochemical control of hypoxia signalling.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Chemistry, Medicinal
Fernanda V. B. Mota, Felipe N. Coutinho, Vanessa M. F. de Caryalho, Julyanne C. de Assis Correia, Isla V. G. A. Bastos, Pedro P. M. Neto, Rafael M. Ximenes, Dalci J. Brondani, Antonio R. de Faria, Pascal Marchand, Teresinha G. Silva
Summary: This study assessed the mechanisms involved in the antinociceptive activity of the compounds R-99 and R-123 in chemical pain models. The results showed that these compounds exert antinociceptive effects by interacting with opioid receptors, adrenergic systems, and TRPV1 pathways.
CURRENT TOPICS IN MEDICINAL CHEMISTRY
(2022)
Article
Neurosciences
Debora Laker, Frederik Tolle, Michael Stegen, Marco Heerdegen, Rudiger Kohling, Timo Kirschstein, Jakob Wolfart
Summary: The slow afterhyperpolarizing potential (sAHP) determines the discharge behavior of neurons, particularly in dentate granule cells (DGCs) where burst-like firing is the default phenotype. sAHP is mediated by K(v)7 and K(ir)6 channels, and its inhibition affects burst firing and synaptic plasticity.
Article
Physiology
Luara A. Batista, Lais M. Cabral, Thiago S. Moreira, Ana C. Takakura
Summary: The study found that inhibition of anandamide hydrolysis does not reverse respiratory deficits in an animal model of Parkinson's disease, leading to increased variability in respiratory frequency and impaired response to hypercapnia.
EXPERIMENTAL PHYSIOLOGY
(2022)
Review
Neurosciences
Yasmin C. Aquino, Lais M. Cabral, Nicole C. Miranda, Monique C. Naccarato, Barbara Falquetto, Thiago S. Moreira, Ana C. Takakura
Summary: Parkinson's disease is a neurodegenerative disorder characterized by the loss of dopaminergic neurons. It mainly affects individuals over the age of 60 and leads to both classic and nonclassical symptoms. Respiratory changes associated with PD are the main cause of mortality in patients. However, there is limited research and knowledge about these respiratory disorders, making treatment challenging.
JOURNAL OF NEUROPHYSIOLOGY
(2022)
Editorial Material
Physiology
Thiago S. Moreira, Ana C. Takakura, Eduardo Colombari
FRONTIERS IN PHYSIOLOGY
(2022)
Meeting Abstract
Biochemistry & Molecular Biology
Thiago S. Moreira, Yingtang Shi, Cleyton R. Sobrinho, Brenda M. Milla, Jaseph Sota-Perez, Daniel S. Stornetta, Ruth L. Stornetta, Ana C. Takakura, Daniel K. Mulkey, Douglas A. Bayliss
Item Withdrawal
Biochemistry & Molecular Biology
T. De Melo e Silva, C. B. Ferreira, P. E. Silva, F. C. Sousa, C. J. Czeisler, J. J. Otero, A. C. Takakura, T. S. Moreira
Meeting Abstract
Biochemistry & Molecular Biology
Lais Maria C. Cabral, Luiz M. Oliveira, Thiago dos Santos Moreira, Ana C. Takakura
Article
Neurosciences
Yingtang Shi, Cleyton R. Sobrinho, Jaseph Soto-Perez, Brenda M. Milla, Daniel S. Stornetta, Ruth L. Stornetta, Ana C. Takakura, Daniel K. Mulkey, Thiago S. Moreira, Douglas A. Bayliss
Summary: Research suggests that the role of 5-HT7 receptors in RTN neurons in response to CO2 stimulation is minimal, and these receptors are not essential for respiratory activity. 5-HT7 receptors are mainly expressed in a small subset of RTN neurons, and have no impact on CO2-stimulated breathing.
JOURNAL OF PHYSIOLOGY-LONDON
(2022)
Article
Medicine, General & Internal
Camilo Toledo, Esteban Diaz-Jara, Hugo S. Diaz, Karla G. Schwarz, Katherin Pereyra, Alexandra Las Heras, Angelica Rios-Gallardo, David C. Andrade, Thiago Moreira, Ana Takakura, Noah J. Marcus, Rodrigo Del Rio
Summary: This study found that RTN astrocytes play a pivotal role in the generation and maintenance of breathing disorders (BD) in chronic heart failure (CHF) patients through the mechanism of P2X7 receptor (P2X7r) signaling. The activity and ATP bioavailability of RTN astrocytes were reduced in CHF patients, and restoring normal astrocyte activity and ATP levels improved breathing regularity in CHF. Additionally, delivering human P2X7 receptor into astrocytes increased ATP bioavailability and abolished BD in CHF.
Article
Physiology
Camilo Toledo, David C. Andrade, Esteban Diaz-Jara, Domiziana Ortolani, Ignacio Bernal-Santander, Karla G. Schwarz, Fernando C. Ortiz, Noah J. Marcus, Luiz M. Oliveira, Ana C. Takakura, Thiago S. Moreira, Rodrigo Del Rio
Summary: Intermittent activation of RVLM-C1 neurons induces long-term autonomic and breathing dysfunction, suggesting that episodic stimulation of RVLM-C1 may serve as a pathological substrate for the development of cardiorespiratory disorders.
Editorial Material
Physiology
Ana C. Takakura
EXPERIMENTAL PHYSIOLOGY
(2022)
Article
Neurosciences
Andre L. F. Nascimento, Pamela O. S. Medeiros, Luiz F. A. T. Pedrao, Vitoria C. Queiroz, Luiz M. Oliveira, Leonardo S. Novaes, Ariadiny L. Caetano, Carolina D. Munhoz, Ana C. Takakura, Barbara Falquetto
Summary: Parkinson's Disease (PD) is a neurogenerative disorder characterized by the death of dopaminergic neurons in the Substantia Nigra pars compacta (SNpc), leading to motor, cognitive, learning, and respiratory dysfunctions. New evidence revealed that breathing impairment in PD mainly results from oxidative stress (OS) that initiates apoptotic signaling in respiratory neurons. In this study, the role of OS inhibition using apocynin in a 6-OHDA PD animal model was investigated. The results showed that OS contributes to respiratory neuron death and breathing dysfunction in the PD animal model. Preventing oxidative stress may provide a new perspective for preventing respiratory impairments in PD.
Article
Neurosciences
Talita M. Silva, Frederick Wasinski, Karine C. Flor, Edward O. List, John J. Kopchick, Ana C. Takakura, Jose Donato Jr, Thiago S. Moreira
Summary: Growth hormone-responsive neurons regulate various homeostatic behaviors, and this study suggests that central growth hormone receptor may modulate respiratory activity in conscious mice, leading to a reduction in the tachypneic response to hypoxia.
Article
Neurosciences
Nicole C. Miranda, Luiz M. Oliveira, Yasmin C. Aquino, Thiago S. Moreira, Ana C. Takakura
Summary: This study investigated the effects of degenerated Pedunculopontine Tegmental Nucleus (PPTg) neurons on respiratory activity in a Parkinson's disease (PD) model. The results showed that PPTg neurons in PD model were less activated by hypercapnia, suggesting the involvement of PPTg in the ventilatory response to high carbon dioxide.