期刊
JOURNAL OF NEUROPHYSIOLOGY
卷 115, 期 2, 页码 992-1002出版社
AMER PHYSIOLOGICAL SOC
DOI: 10.1152/jn.00699.2015
关键词
spike sorting; grid cells; medial entorhinal cortex
资金
- Alberta Innovates Health Solutions
- National Sciences and Engineering Research Council of Canada
- Neuroelectronics Research Flanders
Neural recording technology is improving rapidly, allowing for the detection of spikes from hundreds of cells simultaneously. The limiting step in multielectrode electrophysiology continues to be single cell isolation. However, this step is crucial to the interpretation of data from putative single neurons. We present here, in simulation, an illustration of possibly erroneous conclusions that may be reached when poorly isolated single cell data are analyzed. Grid cells are neurons recorded in rodents, and bats, that spike in equally spaced locations in a hexagonal pattern. One theory states that grid firing patterns arise from a combination of band firing patterns. However, we show here that summing the grid firing patterns of two poorly resolved neurons can result in spurious band-like patterns. Thus, evidence of neurons spiking in band patterns must undergo extreme scrutiny before it is accepted. Toward this aim, we discuss single cell isolation methods and metrics.
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