Article
Pharmacology & Pharmacy
Jamal Alyoussef Alkrad, Shereen M. Assaf, Samer H. Hussein-Al-Ali, Rabaa Alrousan
Summary: This research evaluated the oral and transdermal absorption of enoxaparin using nonionic microemulsions as liquid carriers. The results showed that the microemulsions had the desired particle size and viscosity, and the transdermal application of enoxaparin had higher bioavailability compared to oral administration.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2022)
Review
Pharmacology & Pharmacy
Tingting Zhang, Xuan Luo, Keming Xu, Wenying Zhong
Summary: This article provides an overview of the current developments in peptides and nanotechnology for transdermal drug delivery, as well as innovative strategies for enhancing skin penetration. It also discusses the therapeutic potential of peptide-containing nanoformulations in addressing various diseases and the challenges hindering clinical translation.
ADVANCED DRUG DELIVERY REVIEWS
(2023)
Review
Chemistry, Multidisciplinary
Qing Zhao, Siyu Zhang, Fengchang Wu, Dengyu Li, Xuejiao Zhang, Wei Chen, Baoshan Xing
Summary: This review examines recent advances in the rational design and structural modulation of nanogels to improve drug delivery efficiency by incorporating functional moieties or domains that allow them to regulate their structure and properties to overcome biological barriers. Future perspectives on the precise and efficient therapeutic use of nanogel formulations are also presented in this review.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Review
Pharmacology & Pharmacy
Ting Liu, Minglong Chen, Jintao Fu, Ying Sun, Chao Lu, Guilan Quan, Xin Pan, Chuanbin Wu
Summary: Microneedles play a crucial role in transdermal delivery of protein and peptide drugs, offering advantages over traditional injection methods and promising prospects in conventional therapies.
ACTA PHARMACEUTICA SINICA B
(2021)
Article
Biotechnology & Applied Microbiology
Qingling Song, Junfei Yang, Xiaocui Wu, Yao Li, Hongjuan Zhao, Qianhua Feng, Zhenzhong Zhang, Yun Zhang, Lei Wang
Summary: The biological barriers pose significant challenges to the efficacious responses of oral delivery system in diseases treatment. Utilizing a carrier with single construction is insufficient to overcome these obstacles due to the complex gastrointestinal tract environment. In this study, a biomimetic spore nanoplatform (SC@DS NPs) was developed to successfully overcome oral biological barriers and improve therapeutic effect.
JOURNAL OF NANOBIOTECHNOLOGY
(2023)
Article
Chemistry, Multidisciplinary
Ying Wang, Zhanzhan Zhang, Chunxiong Zheng, Xinzhi Zhao, Yadan Zheng, Qi Liu, Yang Liu, Linqi Shi
Summary: Multistage adaptive nanoparticles (MAN) with a core-shell structure made of responsive polymers can adapt to the biological microenvironment, achieve stability in blood circulation, accumulate in tumor tissues, release drugs effectively in cells, and suppress tumors with reduced systemic toxicity. MAN can load various hydrophobic drugs, providing a general strategy for targeted delivery of hydrophobic drugs to overcome multiple biological barriers and enhance chemotherapy efficacy.
Article
Pharmacology & Pharmacy
Zening Men, Xiaotong Lu, Ting He, Mengfang Wu, Tong Su, Teng Shen
Summary: The recombinant hirudin-loaded dissoluble microneedle patch demonstrated effective anticoagulant effects, prevented thrombotic diseases, and showed potential for preventing venous thrombosis.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2022)
Review
Chemistry, Multidisciplinary
Vivek Phatale, Klaudi K. Vaiphei, Shikha Jha, Dnyaneshwar Patil, Mukta Agrawal, Amit Alexander
Summary: Transdermal drug delivery system (TDDS) is a potential approach for effective drug delivery, with advantages such as easy administration, controlled release, and prolonged therapeutic effect. Poor skin permeability is a primary challenge, but can be overcome through fusion with other methods. This article summarizes the fundamental features, components, and design of TDDS, as well as methods for assessing skin permeability. It also explores the application of active methods and passive methods in transdermal drug delivery.
JOURNAL OF CONTROLLED RELEASE
(2022)
Article
Biophysics
Xiaoli Guo, Tingting Zhu, Xixi Yu, Xin Yi, Longhao Li, Xiaoying Qu, Zhe Zhang, Yuanping Hao, Wanchun Wang
Summary: Oral inflammatory disease (OID), particularly oral ulcers, is a common oral lesion that affects quality of life and can lead to oral cancer. Traditional treatment methods for oral ulcers, such as localized hormone injections, can cause pain and fear. To address this, a soluble hyaluronic acid (HA) microneedle patch containing betamethasone 21-phosphate sodium (BSP) and betamethasone 17,21-dipropionate (BDP) was developed. The patch showed mechanical strength to penetrate the mucosa and released BSP and BDP into the ulcer base rapidly. It exhibited wound healing-promoting and anti-inflammatory effects, providing a new prospect for oral ulcer treatment.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2023)
Article
Chemistry, Multidisciplinary
Eva Ramsay, Tatu Lajunen, Madhushree Bhattacharya, Mika Reinisalo, Kirsi Rilla, Heidi Kidron, Tetsuya Terasaki, Arto Urtti
Summary: Retinal drug delivery is challenging due to anatomical and physiological barriers, resulting in limited bioavailability. Current methods like intravitreal injections have limitations for different types of drugs. Selective delivery technologies for retinal drug delivery are not well studied, but they hold promise for cell-specific drug delivery in the eyes.
JOURNAL OF CONTROLLED RELEASE
(2023)
Review
Pharmacology & Pharmacy
Adam J. Plaunt, Tam L. Nguyen, Michel R. Corboz, Vladimir S. Malinin, David C. Cipolla
Summary: While inhalation route has been used for pharmacologic effect, it posed challenges for treating lung disease until sophisticated device and formulation technologies emerged. Now, there are several inhalation device technologies that efficiently deliver therapeutics to the lung and avoid excessive deposition elsewhere. Formulation technologies and drug chemistry modifications have also emerged to overcome degradation and clearance mechanisms, improve tolerability, or facilitate intracellular uptake.
Review
Engineering, Biomedical
Li Zhao, Chunyang Zhang, Juhaina M. Abu-Ershaid, Mingshan Li, Yaocun Li, Yara Naser, Xianbing Dai, Marco T. A. Abbate, Ryan F. Donnelly
Summary: Traditional drug delivery routes have disadvantages, leading to exploration of alternative routes like transdermal drug delivery. Microarray patches (MAPs) are a promising technology for transdermal drug delivery, offering precise and safe drug release, as well as potential for biological monitoring.
ADVANCED HEALTHCARE MATERIALS
(2021)
Review
Biotechnology & Applied Microbiology
Jiangmei Xu, Hao Chen, Haisheng Qian, Fei Wang, Yunsheng Xu
Summary: The study focuses on ROS in psoriatic lesions contributing to immuno-metabolic disorders, highlighting the potential of ROS-regulating nanomedicines as a key approach for anti-psoriasis treatment. Additionally, the evolution of nanomaterials for transdermal drug delivery has shown promising advancements in recent years.
JOURNAL OF NANOBIOTECHNOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Zhiguo Li, Xuexun Fang, Dahai Yu
Summary: Transdermal drug delivery (TDD) has emerged as an effective alternative to traditional oral and injection administration, with potential for enhanced anti-obesity drug delivery. Obesity is a global epidemic with significant health threats, requiring more effective drug delivery strategies. Despite most studies being in the animal stage, the application of TDD in anti-obesity drugs could bring safe and effective therapies to obese patients in the future.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Pharmacology & Pharmacy
Thomas C. Chen, Clovis O. da Fonseca, Daniel Levin, Axel H. Schoenthal
Summary: Perillyl alcohol (POH) is a naturally occurring monoterpenoid with versatile applications, particularly in drug development and delivery, with its potential in cancer therapy highlighted through research.
