Bullatine A stimulates spinal microglial dynorphin A expression to produce anti-hypersensitivity in a variety of rat pain models

Aconitum-Derived Bulleyaconitine A Exhibits Antihypersensitivity Through Direct Stimulating Dynorphin A Expression in Spinal Microglia

(2016) Teng-Fei Li et al.   JOURNAL OF PAIN

Methylglyoxal mediates streptozotocin-induced diabetic neuropathic pain via activation of the peripheral TRPA1 and Nav1.8 channels

(2016) Qian Huang et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Shanzhiside methylester, the principle effective iridoid glycoside from the analgesic herb Lamiophlomis rotata , reduces neuropathic pain by stimulating spinal microglial β-endorphin expression

(2016) Hui Fan et al.   NEUROPHARMACOLOGY

Development and validation of an LC-MS/MS method for the determination of bullatine A in rat plasma: application to a pharmacokinetic study

(2015) Shi-Yong Teng et al.   BIOMEDICAL CHROMATOGRAPHY

The non-peptide GLP-1 receptor agonist WB4-24 blocks inflammatory nociception by stimulating β-endorphin release from spinal microglia

(2014) Hui Fan et al.   BRITISH JOURNAL OF PHARMACOLOGY

Activated microglia in the spinal cord underlies diabetic neuropathic pain

(2014) Dongmei Wang et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Activation of Spinal Glucagon-Like Peptide-1 Receptors Specifically Suppresses Pain Hypersensitivity

(2014) N. Gong et al.   JOURNAL OF NEUROSCIENCE

Minocycline prevents dynorphin-induced neurotoxicity during neuropathic pain in rats

(2014) Ewelina Rojewska et al.   NEUROPHARMACOLOGY

Novel Molecular Targets of Dezocine and Their Clinical Implications

(2013) Renyu Liu et al.   ANESTHESIOLOGY

Bullatine A, a diterpenoid alkaloid of the genus Aconitum, could attenuate ATP-induced BV-2 microglia death/apoptosis via P2X receptor pathways

(2013) Jun Li et al.   BRAIN RESEARCH BULLETIN

Spinal astrocytes produce and secrete dynorphin neuropeptides

(2013) Andrew Wahlert et al.   NEUROPEPTIDES

Pain-Related Depression of the Mesolimbic Dopamine System in Rats: Expression, Blockade by Analgesics and Role of Endogenous κ-opioids

(2013) Michael D Leitl et al.   NEUROPSYCHOPHARMACOLOGY

Role of spinal opioid receptor on the antiallodynic effect of intrathecal nociceptin in neuropathic rat

(2013) Jin Ju et al.   NEUROSCIENCE LETTERS

Gelsemine, a principal alkaloid from Gelsemium sempervirens Ait., exhibits potent and specific antinociception in chronic pain by acting at spinal α3 glycine receptors

(2013) Jing-Yang Zhang et al.   PAIN

Occlusal Disharmony Transiently Impairs Learning and Memory in the Mouse by Increasing Dynorphin A Levels in the Amygdala

(2013) Kentaro Yamada et al.   TOHOKU JOURNAL OF EXPERIMENTAL MEDICINE

Microglia and Spinal Cord Synaptic Plasticity in Persistent Pain

(2013) Sarah Taves et al.   NEURAL PLASTICITY

Contributions of spinal d-amino acid oxidase to bone cancer pain

(2012) Jin-Lu Huang et al.   AMINO ACIDS

Minocycline Markedly Reduces Acute Visceral Nociception via Inhibiting Neuronal ERK Phosphorylation

(2012) Ik-Hyun Cho et al.   Molecular Pain

Extracellular signal-regulated kinase activation in spinal astrocytes and microglia contributes to cancer-induced bone pain in rats

(2012) X.-W. Wang et al.   NEUROSCIENCE

Minocycline blocks lipopolysaccharide induced hyperalgesia by suppression of microglia but not astrocytes

(2012) S.-Y. Yoon et al.   NEUROSCIENCE

Glia as a Link between Neuroinflammation and Neuropathic Pain

(2012) Mithilesh Kumar Jha et al.   Immune Network

The effect of intrathecal administration of glial activation inhibitors on dorsal horn BDNF overexpression and hind paw mechanical allodynia in spinal nerve ligated rats

(2011) Xin Zhang et al.   JOURNAL OF NEURAL TRANSMISSION

Post-injury administration of minocycline: An effective treatment for nerve-injury induced neuropathic pain

(2011) Xiao-Peng Mei et al.   NEUROSCIENCE RESEARCH

Neurokinin B and Dynorphin A in Kisspeptin Neurons of the Arcuate Nucleus Participate in Generation of Periodic Oscillation of Neural Activity Driving Pulsatile Gonadotropin-Releasing Hormone Secretion in the Goat

(2010) Y. Wakabayashi et al.   JOURNAL OF NEUROSCIENCE

Enkephalins, dynorphins, and β-endorphin in the rat dorsal horn: An immunofluorescence colocalization study

(2009) Juan Carlos G. Marvizón et al.   JOURNAL OF COMPARATIVE NEUROLOGY

Aconitum in Traditional Chinese Medicine—A valuable drug or an unpredictable risk?

(2009) Judith Singhuber et al.   JOURNAL OF ETHNOPHARMACOLOGY

Cathepsin L participates in dynorphin production in brain cortex, illustrated by protease gene knockout and expression

(2009) Ardalan Minokadeh et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Minocycline prevents the development of neuropathic pain, but not acute pain: Possible anti-inflammatory and antioxidant mechanisms

(2008) Satyanarayana S.V. Padi et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Cytokine Mechanisms of Central Sensitization: Distinct and Overlapping Role of Interleukin-1 , Interleukin-6, and Tumor Necrosis Factor-  in Regulating Synaptic and Neuronal Activity in the Superficial Spinal Cord

(2008) Y. Kawasaki et al.   JOURNAL OF NEUROSCIENCE