Article
Pharmacology & Pharmacy
Xiaoman Yuan, Bin Tang, Yilan Chen, Lijuan Zhou, Jingwen Deng, Lin Han, Yonggong Zhai, Yandong Zhou, Donald L. Gill, Chuanjian Lu, Youjun Wang
Summary: Celastrol, a natural compound, is identified as a novel SOCE inhibitor. It ameliorates skin lesions and reduces PASI scores in psoriasis-like mice by inhibiting Ca2+ entry through its actions on STIM1 and Orai1. These findings suggest that the SOCE pathway may serve as a new druggable target for treating psoriasis.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Cell Biology
Pan Cheng, Xiaoying Tian, Wanyi Tang, Juan Cheng, Jin Bao, Haipeng Wang, Sisi Zheng, Youjun Wang, Xunbin Wei, Tunan Chen, Hua Feng, Tian Xue, Keisuke Goda, Hao He
Summary: This study introduces a method called femtoSOC, which enables direct control of Ca2+ channels solely by ultrafast laser, without the need for optogenetic tools or any other exogenous reagents. By multiphoton excitation on the plasma membrane, Ca2+ influx was induced directly in cultured cells. The mechanistic study shows that photoexcited flavins can facilitate Orai1 polymerization to form calcium channels, enabling optical activation of Ca2+ influx and downstream signaling pathways.
Article
Chemistry, Medicinal
Yu-Shiuan Wang, Teng-Kuang Yeh, Wei-Chiao Chang, Jing-Ping Liou, Yi-Min Liu, Wan-Chen Huang
Summary: Ca2+ entry from store-operated Ca2+ channel (SOC) is involved in regulating colorectal cancer progression. In this study, compound 2,6-Difluoro-N-(5-(4-fluorophenyl)pyridine-2-yl)benzamide (MPT0M004, 8a) demonstrated prominent inhibitory ability on SOC and lower cytotoxicity compared to 2-APB. It has the potential to be developed into a drug for treating colorectal cancer.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2022)
Review
Cell Biology
Inbal Dagan, Raz Palty
Summary: Calcium signaling in cells plays a crucial role in regulating cell survival, proliferation, and death. Store-operated Ca2+ entry through CRAC channels is a major pathway for Ca2+ influx in non-excitable cells, regulated by a negative feedback mechanism called slow Ca2+ dependent inactivation (SCDI).
Review
Neurosciences
Pragnya Chakraborty, Gaiti Hasan
Summary: Key components of endoplasmic reticulum (ER) Ca2+ release and store-operated Ca2+ entry (SOCE) are expressed in all metazoan cells. This review presents evidence on how these two mechanisms impact neuronal physiology and their interaction with ion channels in neurons. The careful regulation of neural SOCE is essential due to the detrimental effects of Ca2+ imbalance on neurons. The study also discusses different mechanisms of SOCE regulation in Drosophila and mammalian neurons, and their significance in human neurodegenerative diseases.
JOURNAL OF PHYSIOLOGY-LONDON
(2023)
Article
Biochemistry & Molecular Biology
Yu Tao, Sarika Chaudhari, Parisa Yazdizadeh Shotorbani, Yanfeng Ding, Zhenglan Chen, Ramesh Kasetti, Gulab Zode, Rong Ma
Summary: In this study, it was found that hyperglycemia-induced podocyte injury in diabetic nephropathy is related to increased signaling via the Orai1/Store-operated Ca2+ Entry (SOCE)/Calpain pathway.
JOURNAL OF BIOLOGICAL CHEMISTRY
(2022)
Article
Cell Biology
Anthony J. Morgan, Antony Galione
Summary: Pharmacological manipulation that disrupts lysosome membrane integrity or ionic movements can inhibit store-operated calcium entry (SOCE) by uncoupling the release of calcium from the endoplasmic reticulum. Certain agents inducing lysosomal membrane permeabilization interfere with SOCE through Stim1 oligomerization and activation of Orai, while others like the K+/H+ ionophore inhibit SOCE in a Stim1-dependent manner. Other lysosomal manipulation strategies do not affect SOCE, and the effects of lysosomal agents on SOCE can be reversed by a dynamin inhibitor.
JOURNAL OF CELL SCIENCE
(2021)
Article
Cell Biology
Hareram Birla, Jingsheng Xia, Xinghua Gao, Hui Zhao, Fengying Wang, Shivam Patel, Akwasi Amponsah, Alex Bekker, Yuan -Xiang Tao, Huijuan Hu
Summary: The study reveals that Orai1 acts as a Ca2+ leak channel in astrocytes, regulating the basal Ca2+ level and enhancing cytokine production under inflammatory conditions. This highlights the important role of Orai1 in astrocytic TLR4 function and suggests its potential as a therapeutic target for neuroinflammatory disorders, including chronic pain.
Review
Biochemistry & Molecular Biology
Fujian Lu, Yunzhan Li, Shengchen Lin, Heping Cheng, Shengyu Yang
Summary: SOCE is a critical mechanism for cells to replenish depleted Ca2+ stores and its dysregulation has been implicated in metastatic cancers. It plays a role in promoting cell migration and invasion by remodeling the actin cytoskeleton and cell adhesion dynamics. Additionally, recent evidence suggests that SOCE is essential for spatial and temporal coding of Ca2+ signals in cells.
BIOCHEMICAL SOCIETY TRANSACTIONS
(2021)
Article
Biochemistry & Molecular Biology
Yasin Gokce, Orhan Erkan, Kamil Savas, Taufiq Rahman, Nazmi Yaras
Summary: This study investigated the role of store-operated calcium entry (SOCE) in calcium handling in diabetic rat cardiomyocytes and found that SOCE function was reduced while Orai1 and Orai3 protein expression was upregulated in diabetes. Losartan treatment did not affect the protein expression pattern. The imbalance between SOCE function and protein expression levels may be due to impaired interaction between Stim and Orai proteins.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2022)
Review
Medicine, Research & Experimental
Sarika Chaudhari, Robert T. Mallet, Parisa Y. Shotorbani, Yu Tao, Rong Ma
Summary: Research has shown the significant role of store-operated calcium channels (SOCC) in the kidney, regulating the function of various cells through Ca2+ signaling and impacting renal function. SOCC is activated by depletion of Ca2+ stores, playing a crucial role in blood pressure regulation, fluid balance, electrolyte balance and other functions in the kidney.
EXPERIMENTAL BIOLOGY AND MEDICINE
(2021)
Article
Genetics & Heredity
Xuexue Zhu, Ke Ma, Kuo Zhou, Jibin Liu, Bernd Nuernberg, Florian Lang
Summary: The study showed that vasopressin enhances the expression of ORAI1 and STIM1, promoting Ca2+entry and osteogenic signaling. The effects of vasopressin-induced Ca2+ entry and osteogenic signaling can be disrupted by MRS1845 and GSK-650394.
JOURNAL OF MOLECULAR MEDICINE-JMM
(2021)
Review
Cell Biology
Carlos Bastian, Alicia Sampieri, Manuel Ortinez Benavides, Adan Guerrero, Luis Vaca
Summary: The use of super-resolution microscopy techniques has revealed a close and complex relationship between cytoskeleton reorganization and SOCE, and has identified many new proteins involved in SOCE regulation. Although there are still many unanswered questions in this dynamic field, recent developments in super-resolution microscopy promise to provide new answers soon.
Article
Genetics & Heredity
Yang Xue, Shendong Zhou, Wan Xie, Meijuan Meng, Nana Ma, Hongzhu Zhang, Yan Wang, Guangjun Chang, Xiangzhen Shen
Summary: By regulating the expression of STIM1 and Orai1, the effect of LPS-induced inflammation and ERS in bovine hepatocytes can be enhanced, indicating that STIM1/Orai1 can intervene and exacerbate inflammation and ERS in hepatocytes through SOCE.
Review
Biochemistry & Molecular Biology
Ningxia Zhang, Hongming Pan, Xiaojing Liang, Jiansheng Xie, Weidong Han
Summary: Store-operated Ca2+ entry (SOCE) is a major calcium signaling pathway that regulates various biological processes. TMEM family proteins, including STIM and ORAI, play essential roles in SOCE. TMEM proteins are a large family of transmembrane proteins that span biological membranes. However, the functional knowledge about TMEM proteins is still limited.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2022)
Article
Pharmacology & Pharmacy
Magda Zammataro, Sara Merlo, Massimo Barresi, Carmela Parenti, Huijuan Hu, Maria A. Sortino, Santina Chiechio
FRONTIERS IN PHARMACOLOGY
(2017)
Article
Biochemistry & Molecular Biology
Kathryn E. Capasso, Melissa T. Manners, Rehman A. Quershi, Yuzhen Tian, Ruby Gao, Huijuan Hu, James E. Barrett, Ahmet Sacan, Seena K. Ajit
JOURNAL OF MOLECULAR NEUROSCIENCE
(2015)
Article
Neurosciences
Hui-Juan Hu, Robert W. Gereau
JOURNAL OF NEUROPHYSIOLOGY
(2011)
Article
Neurosciences
Jingsheng Xia, Rong Pan, Xinghua Gao, Olimpia Meucci, Huijuan Hu
JOURNAL OF PHYSIOLOGY-LONDON
(2014)
Article
Anesthesiology
Ruby Gao, Xinghua Gao, Jingsheng Xia, Yuzhen Tian, James E. Barrett, Yue Dai, Huijuan Hu
Article
Multidisciplinary Sciences
David von Schack, Michael J. Agostino, B. Stuart Murray, Yizheng Li, Padmalatha S. Reddy, Jin Chen, Sung E. Choe, Brian W. Strassle, Christine Li, Brian Bates, Lynn Zhang, Huijuan Hu, Smita Kotnis, Brendan Bingham, Wei Liu, Garth T. Whiteside, Tarek A. Samad, Jeffrey D. Kennedy, Seena K. Ajit
Article
Multidisciplinary Sciences
Frances M. Munoz, Ruby Gao, Yuzhen Tian, Brian A. Henstenburg, James E. Barrett, Huijuan Hu
SCIENTIFIC REPORTS
(2017)
Article
Biochemistry & Molecular Biology
Frances M. Munoz, Priya A. Patel, Xinghua Gao, Yixiao Mei, Jingsheng Xia, Sofia Gilels, Huijuan Hu
PURINERGIC SIGNALLING
(2020)
Article
Cell Biology
Hareram Birla, Jingsheng Xia, Xinghua Gao, Hui Zhao, Fengying Wang, Shivam Patel, Akwasi Amponsah, Alex Bekker, Yuan -Xiang Tao, Huijuan Hu
Summary: The study reveals that Orai1 acts as a Ca2+ leak channel in astrocytes, regulating the basal Ca2+ level and enhancing cytokine production under inflammatory conditions. This highlights the important role of Orai1 in astrocytic TLR4 function and suggests its potential as a therapeutic target for neuroinflammatory disorders, including chronic pain.
Article
Pharmacology & Pharmacy
Rong Pan, Yuzhen Tian, Ruby Gao, Haitao Li, Xianguo Zhao, James E. Barrett, Huijuan Hu
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS
(2012)
Article
Neurosciences
Hui-Juan Hu, Benedict J. Alter, Yarimar Carrasquillo, Chang-Sheng Qiu, Robert W. Gereau
JOURNAL OF NEUROSCIENCE
(2007)
Article
Neurosciences
HJ Hu, Y Carrasquillo, F Karim, WE Jung, JM Nerbonne, TL Schwarz, RW Gereau
Article
Neurosciences
Farzana Karim, Hui-Juan Hu, Hita Adwanikar, David Kaplan, Robert W. Gereau
Article
Chemistry, Multidisciplinary
DZ Dai, HJ Hu, J Zhao, XM Hao, DM Yang, PA Zhou, CH Wu
ACTA PHARMACOLOGICA SINICA
(2004)