Neuronal seipin knockout facilitates Aβ-induced neuroinflammation and neurotoxicity via reduction of PPARγ in hippocampus of mouse

Madecassoside ameliorates bleomycin-induced pulmonary fibrosis in mice through promoting the generation of hepatocyte growth factor via PPAR-γ in colon

(2016) Ying Xia et al.   BRITISH JOURNAL OF PHARMACOLOGY

Dose-Dependent Neuroprotection and Neurotoxicity of Simvastatin through Reduction of Farnesyl Pyrophosphate in Mice Treated with Intracerebroventricular Injection of Aβ 1-42

(2016) Huafeng Jin et al.   JOURNAL OF ALZHEIMERS DISEASE

Activation of PPAR  Ameliorates Spatial Cognitive Deficits through Restoring Expression of AMPA Receptors in Seipin Knock-Out Mice

(2016) L. Zhou et al.   JOURNAL OF NEUROSCIENCE

GSK3β inhibition protects the immature brain from hypoxic-ischaemic insult via reduced STAT3 signalling

(2016) Barbara D'Angelo et al.   NEUROPHARMACOLOGY

Genetic Absence of nNOS Worsens Fetal Alcohol Effects in Mice. II: Microencephaly and Neuronal Losses

(2015) Bahri Karacay et al.   ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH

Seipin knockout in mice impairs stem cell proliferation and progenitor cell differentiation in the adult hippocampal dentate gyrus via reduced levels of PPAR 

(2015) G. Li et al.   Disease Models & Mechanisms

Seipin is necessary for normal brain development and spermatogenesis in addition to adipogenesis

(2015) Chihiro Ebihara et al.   HUMAN MOLECULAR GENETICS

Simvastatin prevents β-amyloid25–35-impaired neurogenesis in hippocampal dentate gyrus through α7nAChR-dependent cascading PI3K-Akt and increasing BDNF via reduction of farnesyl pyrophosphate

(2015) Conghui Wang et al.   NEUROPHARMACOLOGY

Lack of seipin in neurons results in anxiety- and depression-like behaviors via down regulation of PPARγ

(2014) Libin Zhou et al.   HUMAN MOLECULAR GENETICS

Global Intracellular Slow-Wave Dynamics of the Thalamocortical System

(2014) M. Sheroziya et al.   JOURNAL OF NEUROSCIENCE

PPAR  Recruitment to Active ERK during Memory Consolidation Is Required for Alzheimer's Disease-Related Cognitive Enhancement

(2014) J. B. Jahrling et al.   JOURNAL OF NEUROSCIENCE

N-truncated amyloid β (Aβ) 4-42 forms stable aggregates and induces acute and long-lasting behavioral deficits

(2013) Yvonne Bouter et al.   ACTA NEUROPATHOLOGICA

Thiazolidinediones partially reverse the metabolic disturbances observed in Bscl2/seipin-deficient mice

(2013) X. Prieur et al.   DIABETOLOGIA

Cognitive Enhancement with Rosiglitazone Links the Hippocampal PPAR  and ERK MAPK Signaling Pathways

(2012) L. A. Denner et al.   JOURNAL OF NEUROSCIENCE

Neuroanatomical Characterisation of the Expression of the Lipodystrophy and Motor-Neuropathy Gene Bscl2 in Adult Mouse Brain

(2012) Alastair S. Garfield et al.   PLoS One

Inhibition of Lymphoma Cell Proliferation by Peroxisomal Proliferator-Activated Receptor-γ Ligands via Wnt Signaling Pathway

(2011) Jia-Jun Liu et al.   CELL BIOCHEMISTRY AND BIOPHYSICS

Cannabidiol Reduces Aβ-Induced Neuroinflammation and Promotes Hippocampal Neurogenesis through PPARγ Involvement

(2011) Giuseppe Esposito et al.   PLoS One

Seipin, adipogenesis and lipid droplets

(2011) Weihua Fei et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Glycogen synthase kinase-3 regulates inflammatory tolerance in astrocytes

(2010) E. Beurel et al.   NEUROSCIENCE

Glycogen Synthase Kinase-3  Facilitates IFN- -Induced STAT1 Activation by Regulating Src Homology-2 Domain-Containing Phosphatase 2

(2009) C.-C. Tsai et al.   JOURNAL OF IMMUNOLOGY

Lipopolysaccharide-induced interleukin-6 production is controlled by glycogen synthase kinase-3 and STAT3 in the brain

(2009) Eléonore Beurel et al.   Journal of Neuroinflammation

Neuronal PPAR  Deficiency Increases Susceptibility to Brain Damage after Cerebral Ischemia

(2009) X. Zhao et al.   JOURNAL OF NEUROSCIENCE

Iptakalim protects against MPP+-induced degeneration of dopaminergic neurons in association with astrocyte activation

(2008) Yan-Jing Yang et al.   INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY

Differential Regulation of STAT Family Members by Glycogen Synthase Kinase-3

(2008) Eléonore Beurel et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

IFN-γ synergizes with LPS to induce nitric oxide biosynthesis through glycogen synthase kinase-3-inhibited IL-10

(2008) Chiou-Feng Lin et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Characterization of seipin/BSCL2, a protein associated with spastic paraplegia 17

(2008) Daisuke Ito et al.   NEUROBIOLOGY OF DISEASE

PPARγ agonists as therapeutics for the treatment of Alzheimer’s disease

(2008) Gary Landreth et al.   Neurotherapeutics

Mechanisms of anti-inflammatory and neuroprotective actions of PPAR-gamma agonists

(2007) Ramya Kapadia   Frontiers in Bioscience-Landmark