期刊
JOURNAL OF NEUROIMMUNOLOGY
卷 299, 期 -, 页码 112-117出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jneuroim.2016.08.004
关键词
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资金
- Fundacio Hospital Universitari de Tarragona Joan XXIII
- Fundacio Institut d'Investigacio Biomedica de Bellvitge (IDIBELL)
In the present study, CSF concentrations of NFL, t-tau, p-tau, GFAP, S-100B, YKL-40, MCP-1, alpha-sAPP, beta-sAPP, and A beta 38, A beta 40, A beta 42 were measured in 324 MS patients to test whether a correlation among the biomarkers exists and whether the profile of CSF biomarkers varies among the different types of MS. The CSF concentrations of NFL were significantly higher in RRMS while CSF concentrations of GFAP were higher in PPMS. CSF concentrations of NFL correlated with YKL-40 in CIS patients while CSF concentrations of GFAP correlated with YKL-40 in RRMS patients. (C) 2016 Elsevier B.V. All rights reserved.
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