Article
Radiology, Nuclear Medicine & Medical Imaging
Zexuan Hu, Peng Sun, Ajit George, Xiangling Zeng, Mengyan Li, Tsen-Hsuan Lin, Zezhong Ye, Xinhua Wei, Xinqing Jiang, Sheng-Kwei Song, Ruimeng Yang
Summary: Using diffusion basis spectrum imaging (DBSI) to examine the microstructural changes in the substantia nigra (SN) and global white matter (WM) tracts of patients with early-stage PD. The results showed that DBSI could potentially detect and quantify inflammatory cell infiltration, fiber/dendrite loss, and edema in both SN and WM tracts in patients with early-stage PD.
EUROPEAN RADIOLOGY
(2023)
Article
Clinical Neurology
Melanie A. Matyi, Jeffrey M. Spielberg
Summary: Deficits in negative emotion differentiation are associated with mental health outcomes, but the processes underlying individual differences in negative emotion differentiation are poorly understood. This study examines the relationship between white matter microstructure and negative emotion differentiation, providing insights into its component processes and its link to brain structure.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Article
Multidisciplinary Sciences
Maurizio Bergamino, Ryan R. Walsh, Ashley M. Stokes
Summary: Standard DTI and FW-DTI both showed decreased FA in AD, but higher AxD and RD were observed with standard DTI. The FW index was significantly elevated in AD, emphasizing the impact of free water on standard DTI in neurodegenerative pathologies. FW-DTI provided improved consistency in DTI metrics related to WM integrity in Alzheimer's disease.
SCIENTIFIC REPORTS
(2021)
Article
Clinical Neurology
Luyan Gu, Xiaojun Guan, Ting Gao, Cheng Zhou, Wenyi Yang, Dayao Lv, Jingjing Wu, Yi Fang, Tao Guo, Zhe Song, Xiaojun Xu, Jun Tian, Xinzhen Yin, Minming Zhang, Baorong Zhang, Jiali Pu, Yaping Yan
Summary: This study found that genetic risk in PD patients is associated with a younger age of onset, with the high-PRS group showing more extensive white matter microstructural degeneration compared to the low-PRS group. Furthermore, changes in white matter microstructure in specific areas were correlated with declining cognitive function and increasing dopaminergic deficits.
EUROPEAN JOURNAL OF NEUROLOGY
(2022)
Article
Neurosciences
Nick Teller, Jordan A. Chad, Alexander Wong, Hayden Gunraj, Xiang Ji, Maged Goubran, Asaf Gilboa, Eugenie Roudaia, Allison Sekuler, Nathan Churchill, Tom Schweizer, Fuqiang Gao, Mario Masellis, Benjamin Lam, Chris Heyn, Ivy Cheng, Robert Fowler, Sandra E. Black, Bradley J. MacIntosh, Simon J. Graham, J. Jean Chen
Summary: By comparing simulation and experimental data, it is found that correlated diffusion imaging method performs better in detecting the effect of COVID-19, which reveals less restricted diffusion in the frontal lobe and more restricted diffusion in the cerebellar white matter in patients, consistent with existing studies.
HUMAN BRAIN MAPPING
(2023)
Article
Clinical Neurology
Letizia Squarcina, Susanna Lucini Paioni, Marcella Bellani, Maria Gloria Rossetti, Josselin Houenou, Mircea Polosan, Mary L. Phillips, Michele Wessa, Paolo Brambilla
Summary: In this study, the state of white matter structures in bipolar disorder patients was investigated using TBSS and FD analyses. The results showed diffusion abnormalities primarily located in the temporo-parietal network, while no significant differences were found in the morphological complexity of white matter structures. Individual patients showed localized significant deviations in fractal dimension values.
JOURNAL OF AFFECTIVE DISORDERS
(2024)
Article
Neurosciences
Natalia Del Campo, Owen Phillips, Francoise Ory-Magne, Christine Brefel-Courbon, Monique Galitzky, Claire Thalamas, Katherine L. Narr, Shantanu Joshi, Manpreet K. Singh, Patrice Peran, Anne Pavy-LeTraon, Olivier Rascol
Summary: Multiple system atrophy (MSA) is a rare neurodegenerative disorder characterized by widespread accumulation of alpha-synuclein, primarily in oligodendrocytes. Whole brain deep and superficial white matter diffusivity abnormalities were observed in MSA patients but not in Parkinson's disease (PD) patients. These abnormalities were associated with motor and cognitive functions in MSA patients.
HUMAN BRAIN MAPPING
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Xuan Sun, Cui Zhao, Si-Yu Chen, Yan Chang, Yu-Liang Han, Ke Li, Hong-Mei Sun, Zhen-Fu Wang, Ying Liang, Jian-Jun Jia
Summary: This study validates the potential of FW-DTI indices as biomarkers of AD and demonstrates the good accuracy of FW-DTI in classifying MCI subtypes. There is a significant association between FW-DTI indices and memory and visuospatial function.
JOURNAL OF MAGNETIC RESONANCE IMAGING
(2023)
Article
Clinical Neurology
Si-ping Luo, Fan-fan Chen, Han-wen Zhang, Fan Lin, Guo-dong Huang, Yi Lei
Summary: This study used DSI to quantitatively study the changes in the trigeminal cistern segment in patients with TN and found significant reductions in quantitative parameters on the affected side compared to the unaffected side. DSI, with its high-resolution fiber tracking technology, can provide valuable information about the integrity of trigeminal white matter in TN patients.
FRONTIERS IN NEUROLOGY
(2022)
Article
Geriatrics & Gerontology
Stephanie Matijevic, Lee Ryan
Summary: The study found that age and sex have an impact on the cerebral white matter integrity of older adults, with a more significant effect on certain white matter tracts. Females exhibited lower global FA compared to males, but had higher MD in the anterior cingulum and superior longitudinal fasciculus. Age influenced both global FA and specific tract FA, while APOE epsilon 4 status did not show predictive power.
FRONTIERS IN AGING NEUROSCIENCE
(2021)
Article
Medicine, General & Internal
Sungeun Hwang, Chang-Hyun Park, Regina Eun-Young Kim, Hyeon Jin Kim, Yun Seo Choi, Sol-Ah Kim, Jeong Hyun Yoo, Ki Wha Chung, Byung-Ok Choi, Hyang Woon Lee
Summary: Structural changes were observed in cerebellar white matter in CMT patients with NEFL mutations, while abnormal diffusion tensor imaging findings were found in specific cerebellar regions associated with NEFL and GJB1 mutations. The presence of cerebellar ataxia was linked to cerebellar white matter abnormalities in the NEFL subgroup, highlighting the importance of neuroimaging in detecting these abnormalities in CMT patients.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Anatomy & Morphology
Tory O. Frizzell, Elisha Phull, Mishaa Khan, Xiaowei Song, Lukas A. Grajauskas, Jodie Gawryluk, Ryan C. N. D'Arcy
Summary: This study evaluated white matter neuroplasticity in healthy adults pre-post motor training, specifically focusing on motor learning in the non-dominant hand. Changes in neuroplasticity were observed in the internal capsule and corpus callosum, with significant amplitude reductions in low-frequency oscillations implicating optimized transmission through altered myelination. The findings open new avenues for white matter investigations and advance MRI clinical applications.
BRAIN STRUCTURE & FUNCTION
(2022)
Article
Neurosciences
Fan Guo, Tian Zhang, Chen Wang, Ziliang Xu, Yingjuan Chang, Minwen Zheng, Peng Fang, Yuanqiang Zhu
Summary: This study used diffusion tensor imaging (DTI) to identify brain structural network differences contributing to individual differences in vulnerability to sleep deprivation (SD). The vulnerable group showed lower global efficiency, network strength, and local efficiency, as well as longer shortest path length. A disrupted subnetwork with widespread connections was observed in the vulnerable group. The strength of rich club connectivity was negatively correlated with performance on the psychomotor vigilance task (PVT).
CNS NEUROSCIENCE & THERAPEUTICS
(2023)
Article
Computer Science, Interdisciplinary Applications
Temesgen Bihonegn, Sumit Kaushik, Avinash Bansal, Lubomir Vojtisek, Jan Slovak
Summary: The study aims to enhance the effectiveness of geodesic ray-tracing method in white matter fiber reconstruction by adjusting metrics on diffusion tensor spaces. By choosing appropriate metrics, enhancing robustness, and utilizing fourth order tensor data, more satisfactory results are achieved in white matter tract construction.
COMPUTER METHODS AND PROGRAMS IN BIOMEDICINE
(2021)
Article
Neurosciences
Yida Qu, Pan Wang, Hongxiang Yao, Dawei Wang, Chengyuan Song, Hongwei Yang, Zengqiang Zhang, Pindong Chen, Xiaopeng Kang, Kai Du, Lingzhong Fan, Bo Zhou, Tong Han, Chunshui Yu, Xi Zhang, Nianming Zuo, Tianzi Jiang, Yuying Zhou, Bing Liu, Ying Han, Jie Lu, Yong Liu
Summary: This study verified the utility of white matter (WM) as a neuroimaging marker in Alzheimer's disease (AD) using multisite diffusion tensor imaging datasets. The results showed significant degeneration patterns in AD and mild cognitive impairment (MCI) groups compared to normal controls (NC). Machine learning models using tract-based features were able to predict cognitive ability in AD and MCI groups.
NEUROSCIENCE BULLETIN
(2023)
Review
Clinical Neurology
H. Baradaran, A. Gupta
AMERICAN JOURNAL OF NEURORADIOLOGY
(2020)
Article
Clinical Neurology
Hediyeh Baradaran, Tyrel Foster, Paul Harrie, J. Scott McNally, Matthew Alexander, Ankur Pandya, Yoshimi Anzai, Ajay Gupta
Summary: This study evaluated the reporting of carotid plaque features on neck CTAs at an academic institution, finding that while nearly all reports mentioned the degree of luminal stenosis, only a minority mentioned specific plaque features. There is a lack of comprehensive reporting on plaque features despite their importance in stroke risk assessment.
Article
Cardiac & Cardiovascular Systems
Hediyeh Baradaran, Laura B. Eisenmenger, Peter J. Hinckley, Adam H. de Havenon, Gregory J. Stoddard, Lauren S. Treiman, Gerald S. Treiman, Dennis L. Parker, Joseph Scott McNally
Summary: Recent evidence suggests that specific plaque features detected on imaging may be more highly associated with ischemic stroke than stenosis. The study found that intraluminal thrombus, maximum soft plaque thickness, and the rim sign are important markers for discriminating ipsilateral carotid sources of stroke, providing better diagnostic information than carotid stenosis measurement alone. These alternative markers may better diagnose vulnerable carotid plaque and guide treatment decisions.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2021)
Article
Biophysics
Seong-Eun Kim, Dennis L. Parker, John A. Roberts, Gerald S. Treiman, Matthew Alexander, Hediyeh Baradaran, Adam de Havenon, J. Scott McNally
Summary: The study found that symptomatic plaques had significantly lower ADC values compared to asymptomatic plaques, and IPH-positive plaques had significantly lower ADC values compared to IPH-negative plaques. Diffusion characteristics may improve detection of destabilized plaque, leading to higher stroke risk.
NMR IN BIOMEDICINE
(2021)
Article
Medical Informatics
David A. Dorr, Christopher D'Autremont, Christie Pizzimenti, Nicole Weiskopf, Robert Rope, Steven Kassakian, Joshua E. Richardson, Rob McClure, Floyd Eisenberg
Summary: This study examines the suitability and adequacy of data and logic required for a FHIR-based patient-facing clinical decision support application for high blood pressure. The results show inconsistent data quality from electronic health records for implementing recommendations for hypertension, highlighting the need for further validation and testing to ensure precision.
APPLIED CLINICAL INFORMATICS
(2021)
Review
Neurosciences
Kosmas I. Paraskevas, Dimitri P. Mikhailidis, Pier Luigi Antignani, Hediyeh Baradaran, Reinoud P. H. Bokkers, Richard P. Cambria, Alan Dardik, Alun H. Davies, Hans-Henning Eckstein, Gianluca Faggioli, Jose Fernandes e Fernande, Gustav Fraedrich, George Geroulakos, Peter Gloviczki, Jonathan Golledge, Mateja K. Jezovnik, Stavros K. Kakkos, Niki Katsiki, Michael Knoflach, M. Eline Kooi, Gaetano Lanza, Christos D. Liapis, Ian M. Loftus, Armando Mansilha, Antoine Millon, Andrew N. Nicolaides, Rodolfo Pini, Pavel Poredos, Jean-Baptiste Ricco, Thomas S. Riles, Peter Arthur Ringleb, Tatjana Rundek, Luca Saba, Felix Schlachetzki, Mauro Silvestrini, Francesco Spinelli, Francesco Stilo, Sherif Sultan, Jasjit S. Suri, Clark J. Zeebregts, Seemant Chaturvedi
Summary: International guidelines for the management of asymptomatic carotid stenosis (ACS) vary, and a multispecialty position statement aims to reconcile conflicting views. Several high-risk features associated with an increased risk of long-term ipsilateral ischemic stroke in ACS patients have been identified. Some guidelines recommend prophylactic carotid intervention in high-risk patients. The optimal management of ACS patients remains controversial.
JOURNAL OF STROKE & CEREBROVASCULAR DISEASES
(2022)
Article
Medical Informatics
Joshua E. Richardson, Luke Rasmussen, David A. Dorr, Jenna T. Sirkin, Donna Shelley, Adovich Rivera, Winfred Wu, Samuel Cykert, Deborah J. Cohen, Abel N. Kho
Summary: This study aimed to characterize strategies developed by seven regional cooperatives participating in the EvidenceNOW initiative to generate and report EHR-based eCQMs for QI in small-to-medium size practices. The study found that cooperatives ultimately used hybrid strategies to generate and report eCQMs, as neither EHRs alone nor centralized sources alone could effectively operationalize eCQMs for QI.
APPLIED CLINICAL INFORMATICS
(2022)
Article
Health Policy & Services
Jodyn E. Platt, Anthony E. Solomonides, Philip D. Walker, Philip S. Amara, Joshua E. Richardson, Blackford Middleton
Summary: Introduction: Knowledge repositories are relatively new to the digital health ecosystem and are necessary for learning health systems. This study assessed the current policies and practices governing these repositories and identified best practices. The results showed that repositories adhere to transparency, responsibility, user focus, sustainability, and technology principles to varying degrees.
LEARNING HEALTH SYSTEMS
(2023)
Article
Clinical Neurology
Hediyeh Baradaran, Sinead Culleton, Greg Stoddard, Matthew D. Alexander, J. Rafael Romero, J. Rock Hadley, Seong-Eun Kim, Dennis L. Parker, J. Scott McNally
Summary: Covert brain infarctions (CBIs) and cerebral microbleeds (CMBs) are subclinical sequelae of ischemic and hemorrhagic cerebral small vessel disease, respectively. This study aimed to determine the association of specific vulnerable carotid plaque features to CBIs and CMBs. The results showed that intraplaque hemorrhage (IPH) and plaque ulceration were associated with CBIs but not CMBs, suggesting that advanced atherosclerosis contributes predominantly to ischemic markers of subclinical vascular injury.
Article
Medical Informatics
David A. Dorr, Joshua E. Richardson, Michelle Bobo, Christopher D'Autremont, Robert Rope, M. J. Dunne, Steven Z. Kassakian, Lipika Samal
Summary: The study aimed to understand the variations and rationales of healthcare providers in relation to hypertension guidelines recommendations, as well as their perceptions of patient role and use of digital tools.
APPLIED CLINICAL INFORMATICS
(2022)
Article
Clinical Neurology
S. Culleton, H. Baradaran, S-E Kim, G. Stoddard, J. Roberts, G. Treiman, D. Parker, K. Duff, J. S. McNally
Summary: This study investigated the effect of carotid intraplaque hemorrhage on postintervention cognition. The results showed significant improvements in various cognitive aspects for patients without intraplaque hemorrhage, while patients with intraplaque hemorrhage did not show significant improvements and even experienced a decline in attention index.
AMERICAN JOURNAL OF NEURORADIOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Moayad Homssi, Amar Vora, Cenai Zhang, Hediyeh Baradaran, Hooman Kamel, Ajay Gupta
Summary: Through studying 117 patients who met the criteria for cryptogenic stroke, it was found that spotty calcifications near the carotid bifurcations were associated with ipsilateral ischemic stroke, suggesting that spotty calcifications may serve as imaging markers for high-risk plaques.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2023)
Article
Health Care Sciences & Services
Andrey Soares, Majid Afshar, Chris Moesel, Michael A. Grasso, Eric Pan, Anthony Solomonides, Joshua E. Richardson, Eleanor Barone, Edwin A. Lomotan, Lisa M. Schilling
Summary: This article presents the CDS-Sandbox, a cloud-based virtual machine designed to assist Clinical Decision Support (CDS) developers and implementers in learning and utilizing FHIR- and CQL-based open-source tools and technologies. Successful demonstrations of the tools for authoring and testing CDS artifacts were conducted using the CDS-Sandbox at the 2020 and 2021 AMIA Annual Symposia. Positive feedback and demonstrated understanding of the workshop materials were received from participants. The CDS-Sandbox and tutorial materials enable learning and implementation of CDS concepts and practices for the clinical informatics community.
Review
Clinical Neurology
Moayad Homssi, Atin Saha, Diana Delgado, Arindam RoyChoudhury, Charlene Thomas, Matthew Lin, Hediyeh Baradaran, Hooman Kamel, Ajay Gupta
Summary: The presence of calcification in carotid plaque is not significantly associated with ipsilateral cerebrovascular ischemic events. However, in studies with significant carotid artery stenosis, the presence of calcification is associated with a reduced risk of ischemic stroke.
Meeting Abstract
Health Care Sciences & Services
Justin Smith, Wynne Norton, Whitney Batestilli, Lila Rutten, Sandra Mitchell, Don Dizon, Aaron Leppin, Christine Cronin, September Smith, Jennifer Ridgeway, Raymond Osarogiagbon, Nadine McCleary, Joan M. Griffin, Joshua Richardson, Frank Penedo, Bryan Weiner, Deborah Schrag, Lisa DiMartino
IMPLEMENTATION SCIENCE
(2022)
