Article
Nutrition & Dietetics
Shunling Yuan, Jialun Yang, Ye Jian, Yong Lei, Sisi Yao, Zelin Hu, Xia Liu, Changfa Tang, Wenfeng Liu
Summary: This study investigated the effects of treadmill exercise on neuroinflammation in APP/PS1 transgenic AD mice and found that exercise can enrich gut microbial diversity and alleviate neuroinflammation in the brain. Exercise led to reductions in pathogenic bacteria, increases in probiotic bacteria, increased levels of intestine-brain barrier proteins, and attenuated LPS displacement.
Review
Biochemistry & Molecular Biology
Jie Fang, Rui Sheng, Zheng-Hong Qin
Summary: This review highlights the role of Nox-derived ROS in regulating various signals in the central nervous system, with different Nox homologues leading to different signaling cascades. The varied roles of NOX enzyme homologues in different signaling pathways and conditions underscore the need for selective Nox inhibitors in treating CNS diseases.
ANTIOXIDANTS & REDOX SIGNALING
(2021)
Article
Biochemistry & Molecular Biology
Yanxia Guo, Min Yan, Li Li, Li Zhao, Yan Li
Summary: The excessive activation of microglia cell induced by adolescent intermittent ethanol (AIE) leads to neuroinflammation in the hippocampus. Regular exercise can improve learning and memory deficits in AIE models. This study explored the effects of treadmill exercise intervention on cognitive performance, microglia cell activation, and the expression of certain receptors in the hippocampus of AIE rats. The results suggest that treadmill exercise attenuates AIE-induced neuroinflammation and excessive microglia cell activation in the hippocampus, thereby improving cognitive performance in AIE rats.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Neurosciences
Wei Wang, Ziyan Lv, Jin Gao, Mengting Liu, Yuxin Wang, Chuanxi Tang, Jie Xiang
Summary: The study demonstrated that treadmill exercise effectively alleviates neuronal damage in the MPTP-induced PD mouse model by inhibiting NLRP3 inflammasome and microglial activation.
BRAIN RESEARCH BULLETIN
(2021)
Review
Biochemistry & Molecular Biology
Thomas Ho-yin Lee, Suk-yu Yau
Summary: A high-caloric diet and lack of physical activity can lead to obesity and diabetes, increasing the risk of hippocampal neurodegeneration and cognitive deficits. Caloric restriction and physical exercise are crucial non-pharmacological interventions to prevent the development of hippocampal neurodegeneration in obese and diabetic individuals, while exercise-induced exerkines from peripheral organs have beneficial effects on brain health. This review highlights how chronic inflammation in adipose tissue may contribute to neuroinflammation and hippocampal impairment, potentially leading to cognitive deficits in obese and diabetic conditions.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Patrick Haider, Julia B. Kral-Pointner, Manuel Salzmann, Florian Moik, Sonja Bleichert, Waltraud C. Schrottmaier, Christoph Kaun, Mira Brekalo, Michael B. Fischer, Walter S. Speidl, Christian Hengstenberg, Bruno K. Podesser, Kurt Huber, Ingrid Pabinger, Sylvia Knapp, Frank Brombacher, Christine Brostjan, Cihan Ay, Johann Wojta, Philipp J. Hohensinner
Summary: IL-4R alpha plays a homeostatic role in regulating the lifespan of monocytes, and its absence leads to a reduction in monocyte numbers and affects the occurrence of inflammatory responses.
Article
Endocrinology & Metabolism
Esmaeil Amraie, Iran Pouraboli, Hossein Salehi, Ziba Rajaei
Summary: This study investigated the neuroprotective effects of treadmill running and Levisticum officinale extract on lipopolysaccharide-induced memory impairments and neuroinflammation in rats. The results showed that treadmill running and Levisticum officinale extract could attenuate spatial learning and memory deficits, reduce inflammation-related molecular expression and oxidative stress levels, and enhance neurogenesis.
METABOLIC BRAIN DISEASE
(2023)
Article
Medicine, General & Internal
Michal J. Pytka, Remigiusz A. Domin, Jacek L. Tarchalski, Marta I. Lubarska, Mikolaj S. Zolynski, Jan Nizinski, Jaroslaw Piskorski, Andrzej Wykretowicz, Przemyslaw Guzik
Summary: Exercise tolerance is limited in obesity and improves after weight reduction. This study compared the relative changes in exercise capacity variables during cardiopulmonary exercise tests after a sheer weight reduction of 12 kg. The results showed that weight reduction shifted the exercise parameters from high-mixed aerobic-anaerobic to the aerobic zone, with the most beneficial changes found in breathing mechanics parameters, followed by cardiovascular function and gas exchange. However, the relative changes were not correlated with the magnitude of the weight change.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Plant Sciences
Hui Liu, Zihong Zhang, Caixia Zang, Lu Wang, Hanyu Yang, Chanjuan Sheng, Junmei Shang, Zhe Zhao, Fangyu Yuan, Yang Yu, Xinsheng Yao, Xiuqi Bao, Dan Zhang
Summary: Jiuchongtian is a diligent and inquisitive individual who constantly seeks excellence and noble pursuits. He is always eager for knowledge, strives for higher realms, and continuously improves himself to become a true expert.
JOURNAL OF ETHNOPHARMACOLOGY
(2021)
Article
Neurosciences
Leyla Sahin, Ozge Selin Cevik, Kenan Cevik, Celal Guven, Eylem Taskin, Sayad Kocahan
Summary: This study investigated the protective effects of mild treadmill exercise on acute sleep deprivation rats, finding that exercise can alleviate memory impairment but there is a lack of correlation between hippocampal gene expression levels and memory impairment.
Article
Endocrinology & Metabolism
Jing Wang, Qiang Zhang, Jie Xia, Haiji Sun
Summary: This study found that moderate treadmill exercise can prevent obesity and high blood sugar, improve the imbalance and damage of gut microbiota caused by a high-fat diet. In addition, exercise can reverse the intestinal pathology in obese mice and increase the number of goblet cells. Furthermore, the protein expression levels of colonic ZO-1 and occludin were enhanced and the AMPK/CDX2 signaling pathway was significantly upregulated in obese mice that underwent exercise.
DIABETES METABOLIC SYNDROME AND OBESITY-TARGETS AND THERAPY
(2022)
Article
Psychology, Biological
Linlin Zhang, Yanzhong Liu, Xin Wang, Dan Wang, Hao Wu, Haichun Chen, Jiaxin Chen, Yiping Liu
Summary: This study demonstrates that physical exercise improves cognitive function in an Alzheimer's disease model by activating the TREM2 pathway, inhibiting microglial activation, and reducing neuroinflammation.
PHYSIOLOGY & BEHAVIOR
(2022)
Article
Biochemistry & Molecular Biology
Zubeyde Ercan, Ozgur Bulmus, Emine Kacar, Ihsan Serhatlioglu, Gokhan Zorlu, Haluk Kelestimur
Summary: This study found that chronic treadmill exercise can effectively reverse behavioral impairments caused by CRS and induce molecular changes in the brain. This suggests that exercise has positive effects on emotion and mood and can improve stress-induced anomalies.
JOURNAL OF MOLECULAR NEUROSCIENCE
(2023)
Review
Agronomy
Lu Yang, Na Li, Yang Liu, Pengfei Miao, Ji Liu, Zhi Wang
Summary: Waterlogging is a significant threat to global crop growth and production, caused by extreme weather conditions. It hinders plant growth and development by limiting oxygen and light availability. To cope with waterlogging stress, plants regulate their morphological structure, photosynthesis, respiration, energy metabolism, and plant hormone biosynthesis/signal transduction. This review examines the molecular mechanisms and key genes involved in crop survival under waterlogging conditions and highlights the importance of stress memory and cross-stress mechanisms in plant response to abiotic stress. The study of these interactions provides insights for improving crop resistance to waterlogging through genetic breeding.
Article
Physiology
Gabriella F. Bellissimo, Jeremy Ducharme, Zachary Mang, Desmond Millender, Jessica Smith, Matthew J. Stork, Johnathan P. Little, Michael R. Deyhle, Ann L. Gibson, Flavio de Castro Magalhaes, Fabiano Amorim
Summary: This study compared the acute physiological, perceptual, and enjoyment responses between bodyweight high-intensity interval exercise (BW-HIIE) and treadmill running high-intensity interval exercise (RUN-HIIE). The results showed that BW-HIIE elicited higher oxygen consumption, blood lactate, heart rate, and rating of perceived exertion compared to RUN-HIIE, while the physical activity enjoyment was similar between the two exercises.
FRONTIERS IN PHYSIOLOGY
(2022)