Article
Biochemistry & Molecular Biology
Joseph C. Boktor, Mark D. Adame, Destanie R. Rose, Cynthia M. Schumann, Karl D. Murray, Melissa D. Bauman, Milo Careaga, Sarkis K. Mazmanian, Paul Ashwood, Brittany D. Needham
Summary: This study explored the metabolic profiles of rhesus monkeys exposed to maternal immune activation (MIA) as a model for neurodevelopmental disorders. The results revealed differences in lipid, amino acid, and nucleotide metabolism between MIA-exposed offspring and control samples, with correlations to behavior scores and cytokine levels. Modest changes in fecal and intestinal microbial profiles were also observed, along with differential metabolomic profiles within males and females.
MOLECULAR PSYCHIATRY
(2022)
Article
Oncology
Rosemina Merchant, Carole Galligan, Manjunatha Ankathatti Munegowda, L. Bruce Pearce, Peter Lloyd, Paul Smith, Fahar Merchant, Minh D. To
Summary: MDNA11 is a next generation long-acting IL-2 immunotherapeutic that overcomes the limitations of current treatments by modifying receptor selectivity and extending the pharmacokinetic profile. It has been shown to control tumor growth and induce durable tumor clearance when used as a monotherapy or in combination with immune checkpoint inhibitors. Evaluation of MDNA11 in non-human primates demonstrates its good tolerability and the ability to stimulate a strong and durable immune response.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2022)
Article
Multidisciplinary Sciences
Lei Han, Xiaoyu Wei, Chuanyu Liu, Giacomo Volpe, Zhenkun Zhuang, Xuanxuan Zou, Zhifeng Wang, Taotao Pan, Yue Yuan, Xiao Zhang, Peng Fan, Pengcheng Guo, Yiwei Lai, Ying Lei, Xingyuan Liu, Feng Yu, Shuncheng Shangguan, Guangyao Lai, Qiuting Deng, Ya Liu, Liang Wu, Quan Shi, Hao Yu, Yunting Huang, Mengnan Cheng, Jiangshan Xu, Yang Liu, Mingyue Wang, Chunqing Wang, Yuanhang Zhang, Duo Xie, Yunzhi Yang, Yeya Yu, Huiwen Zheng, Yanrong Wei, Fubaoqian Huang, Junjie Lei, Waidong Huang, Zhiyong Zhu, Haorong Lu, Bo Wang, Xiaofeng Wei, Fengzhen Chen, Tao Yang, Wensi Du, Jing Chen, Shibo Xu, Juan An, Carl Ward, Zongren Wang, Zhong Pei, Chi-Wai Wong, Xiaolei Liu, Huafeng Zhang, Mingyuan Liu, Baoming Qin, Axel Schambach, Joan Isern, Liqiang Feng, Yan Liu, Xiangyu Guo, Zhen Liu, Qiang Sun, Patrick H. Maxwell, Nick Barker, Pura Munoz-Canoves, Ying Gu, Jan Mulder, Mathias Uhlen, Tao Tan, Shiping Liu, Huanming Yang, Jian Wang, Yong Hou, Xun Xu, Miguel A. Esteban, Longqi Liu
Summary: Studying tissue composition and function in non-human primates is crucial for understanding the nature of human species. This study presents a large-scale cell transcriptomic atlas of the non-human primate Macaca fascicularis, providing a vast annotated resource for studying a species closely related to humans. The atlas has been used to reconstruct cell-cell interaction networks, map the distribution of receptors for viruses causing human infectious diseases, and establish potential clinical associations with human genetic diseases.
Letter
Public, Environmental & Occupational Health
Chaturong Putaporntip, Chew Weng Cheng, Rattanaporn Rojrung, Napaporn Kuamsab, Somchai Jongwutiwes
Summary: Emerging zoonotic malaria caused by Plasmodium knowlesi, Plasmodium cynomolgi and Plasmodium inui has been observed in humans in Thailand over the past decade. The diagnosis of non-human primate malaria in ecotourists is difficult and requires molecular diagnostic techniques.
JOURNAL OF TRAVEL MEDICINE
(2023)
Article
Neurosciences
Xiaowei Song, Pamela Garcia-Saldivar, Nathan Kindred, Yujiang Wang, Hugo Merchant, Adrien Meguerditchian, Yihong Yang, Elliot A. Stein, Charles W. Bradberry, Suliann Ben Hamed, Hank P. Jedema, Colline Poirier
Summary: Longitudinal non-human primate neuroimaging has the potential to enhance our understanding of primate brain structure and function, but also comes with challenges that require the development of more methods and tools to address.
Article
Neurosciences
Adam Messinger, Nikoloz Sirmpilatze, Katja Heuer, Kep Kee Loh, Rogier B. Mars, Julien Sein, Ting Xu, Daniel Glen, Benjamin Jung, Jakob Seidlitz, Paul Taylor, Roberto Toro, Eduardo A. Garza-Villarreal, Caleb Sponheim, Xindi Wang, R. Austin Benn, Bastien Cagna, Rakshit Dadarwal, Henry C. Evrard, Pamela Garcia-Saldivar, Steven Giavasis, Renee Hartig, Claude Lepage, Cirong Liu, Piotr Majka, Hugo Merchant, Michael P. Milham, Marcello G. P. Rosa, Jordy Tasserie, Lynn Uhrig, Daniel S. Margulies, P. Christiaan Klink
Summary: Neuroimaging in non-human primates is specialized and requires custom solutions. Efforts have been made to transform the field towards more open and collaborative practices. PRIME-RE is an online platform for the exchange of knowledge and tools related to NHP neuroimaging.
Review
Immunology
Laure Albrecht, Elodie Bishop, Basile Jay, Blaise Lafoux, Marie Minoves, Caroline Passaes
Summary: SARS-CoV-2 causing COVID-19 emerged from China in December 2019 and quickly spread worldwide, leading to a pandemic with unprecedented impacts on public health and economy. Urgent development of curative treatments and vaccines is needed to address the disease.
Review
Immunology
Mark J. Prescott, Carolyn Clark, William E. Dowling, Amy C. Shurtleff
Summary: High standards and adherence to the 3Rs principles are crucial in maximizing the scientific value of NHP vaccine studies, while also ensuring ethical and high-quality research. Collaboration between organizations like NC3Rs and CEPI has led to initiatives that support vaccine developers in implementing 3Rs principles to minimize harm and improve animal welfare. Challenges in implementing refinement due to high-level biocontainment for certain pathogens can be overcome with careful animal selection and implementation of contemporary good practices.
Review
Agriculture, Dairy & Animal Science
Alba Garcia de la Chica, Luciana I. Oklander, Martin M. Kowalewski, Eduardo Fernandez-Duque
Summary: The five primate species in Argentina are facing various threats and conflicts that hinder their ability to coexist with human populations. This study presents a detailed compilation of the conflicts between humans and non-human primates in Argentina and describes ongoing national and regional efforts to mitigate those effects.
Article
Biochemistry & Molecular Biology
Julien Lemaitre, Thibaut Naninck, Benoit Delache, Justina Creppy, Philippe Huber, Marion Holzapfel, Camille Bouillier, Vanessa Contreras, Frederic Martinon, Nidhal Kahlaoui, Quentin Pascal, Sabine Tricot, Frederic Ducancel, Laurent Vecellio, Roger Le Grand, Pauline Maisonnasse
Summary: Respiratory pathogens pose a significant burden and require a fast and predictive preclinical research pipeline. Animal models are crucial for the development of disease management strategies.
MOLECULAR IMMUNOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Margaux Teil, Marie-Laure Arotcarena, Benjamin Dehay
Summary: NHP models play a crucial role in studying synucleinopathy, providing insights into its pathogenicity and contributing to the development of therapeutic strategies for the disease.
Article
Immunology
Paula Niewold, Marieke E. E. Ijsselsteijn, Frank A. W. Verreck, Tom H. M. Ottenhoff, Simone A. A. Joosten
Summary: Spatial organization contributes to cellular function, and studying cellular organization is crucial for understanding health and disease processes. Imaging mass cytometry allows high dimensional imaging of tissue, and non-human primate models provide valuable material for research. Knowledge on suitable antibodies for non-human primate tissue is limited, but a panel development pipeline has been presented here to facilitate imaging of non-human primate tissue.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Public, Environmental & Occupational Health
Spinello Antinori, Cecilia Bonazzetti, Andrea Giacomelli, Mario Corbellino, Massimo Galli, Carlo Parravicini, Anna Lisa Ridolfo
Summary: Research on non-human primate malaria parasites has increased our understanding of the biology and origins of human malaria. The discovery that some NHP malaria parasites can be transmitted to humans raises concerns about controlling human malaria, while advancements in molecular techniques have enhanced our knowledge of the diversity and distribution of these parasites and their relationship with human malaria.
JOURNAL OF TRAVEL MEDICINE
(2021)
Article
Neurosciences
Larry S. Sherman, Weiping Su, Amanda L. Johnson, Samuel M. Peterson, Cassandra Cullin, Tiffany Lavinder, Betsy Ferguson, Anne D. Lewis
Summary: Three spontaneous cases of male neonatal rhesus macaques with clinical symptoms of hypomyelinating disease were reported, which were found to be related to each other genetically and carry a rare variant in the PLP1 gene. These animals represent the first non-human primate model of PMD, providing a valuable opportunity for preclinical studies aimed at promoting myelination in pediatric hypomyelinating diseases.
NEUROBIOLOGY OF DISEASE
(2021)
Article
Immunology
Stephanie G. Trouche, Allal Boutajangout, Ayodeji Asuni, Pascaline Fontes, Einar M. Sigurdsson, Jean-Michel Verdier, Nadine Mestre-Frances
Summary: Non-human primates have translational value for evaluating new therapeutic approaches, especially in aging primates with Alzheimer's disease-like pathology. In a study using aged mouse lemurs, immunization with an A beta derivative vaccine resulted in a reduction in intraneuronal A beta and microgliosis, without causing microhemorrhages. The vaccinated primates also showed cognitive improvement, possibly linked to A beta clearance. The A beta derivative vaccine appeared to be safe and had no detrimental effects on the general health of the animals.
BRAIN BEHAVIOR AND IMMUNITY
(2023)