Article
Cell Biology
Pei-Yi Lin, Z. Zack Ma, Melissa Mahgoub, Ege T. Kavalali, Lisa M. Monteggia
Summary: Ketamine's rapid antidepressant action is dependent on BDNF-TrkB signaling in CA1 neurons and a specific synaptic locus, suggesting the importance of synaptic potentiation in the hippocampus for its therapeutic effects.
Article
Neurosciences
Jing Wang, Yichen Cai, Jingyi Sun, Hua Feng, Xiaoyu Zhu, Qian Chen, Feng Gao, Qingbin Ni, Leilei Mao, Mingfeng Yang, Baoliang Sun
Summary: In this study, non-invasive treatment methods using AAV vectors carrying BDNF or TrkB genes were performed on stroke-injured rats. The combination therapy significantly improved upper limb motor functional recovery and neurotransmission efficiency, promoting axonal remodeling and restoration of synaptic structures.
EXPERIMENTAL NEUROLOGY
(2023)
Article
Biochemistry & Molecular Biology
Zhijian Jin, Yifan Lu, Xiongyan Wu, Tao Pan, Zhenjia Yu, Junyi Hou, Airong Wu, Jianfang Li, Zhongyin Yang, Chen Li, Min Yan, Chao Yan, Zhenggang Zhu, Bingya Liu, Weihua Qiu, Liping Su
Summary: In this study, anlotinib inhibited gastric cancer (GC) cell growth by inducing apoptosis and G2/M phase arrest in a dose- and time-dependent manner. The interaction between epithelial and stromal cells in the tumor microenvironment affects the response of GC cells to anlotinib. Secreted lactate from GC cells activates cancer-associated fibroblasts (CAFs) to produce BDNF in a NF-kappa B-dependent manner, reducing the sensitivity of GC cells to anlotinib. Targeting the BDNF-TrkB pathway increased the sensitivity of GC cells to anlotinib in a human patient-derived organoid model.
Article
Biochemistry & Molecular Biology
Nan Xiao, Der Thor, Wei Ye Yu
Summary: Neurotrophic factors were found to promote migration of human DPSCs, accelerating wound healing and increasing the expression of phosphorylated-ERK.
BIOMEDICAL JOURNAL
(2021)
Article
Neurosciences
Jongryul Hong, Yeonji Jeong, Won Do Heo
Summary: In this study, researchers found that deletion of TrkB in neurons projecting from the medial entorhinal cortex to the mPFC led to reduced remote memory recall in male mice. The deletion of TrkB also attenuated the participation of mPFC cells in the recall of remote fear memory and was associated with reduced reactivation of cells in the mPFC.
JOURNAL OF NEUROSCIENCE
(2022)
Article
Neurosciences
Dominik Fiedler, Manju Sasi, Robert Blum, Christopher M. Klinke, Marta Andreatta, Hans-Christian Pape, Maren D. Lange
Summary: Researchers have identified that the oval nucleus of the bed nucleus of the stria terminalis (ovBNST) is rich in brain-derived neurotrophic factor (BDNF) and tropomyosin receptor kinase B (TrkB) receptor, which interact to reduce neuronal excitability and mediate long-term depression (LTD) in ovBNST neurons. This suggests that BDNF/TrkB signaling is a critical regulator of synaptic activity in ovBNST, dampening excitability at short and long time scales, and providing a potential entry point for adaptation to stressful environmental encounters, particularly in mediating maladaptive behaviors associated with stress exposure.
JOURNAL OF NEUROSCIENCE
(2021)
Article
Cell Biology
Ji-Hyun Kim, Muhammad Irfan, Md Akil Hossain, Anne George, Seung Chung
Summary: The odontoblastic differentiation of dental pulp stem cells is affected by inflammation and can be enhanced through the activation of BDNF and TrkB receptors. This finding provides a novel therapeutic approach in dentin tissue engineering using dental pulp stem cells.
Article
Endocrinology & Metabolism
Melissa J. Marchese, Shuman Li, Bin Liu, Jun J. Zhang, Liping Feng
Summary: The study found that BDNF receptors are present in different regions of human placental villi, indicating diverse functions of BDNF signaling in placental development. While exposure to PFOS, PFOA, PFBS, and a PFAS mixture did not significantly affect the BDNF pathway in placental trophoblast cells, exposure to PFNA may affect TrkB phosphorylation. Further research is needed to understand how PFAS impacts other critical signaling pathways during fetal neurodevelopment.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Reproductive Biology
Sha Wang, Hua Duan, Bohan Li, Wei Hong, Xiao Li, Yiyi Wang, Zheng Chen Guo
Summary: BDNF and TrKB are closely related to dysmenorrhoea caused by endometriosis and may play an important role in the pathobiology or pathophysiology of this disease.
JOURNAL OF OVARIAN RESEARCH
(2022)
Article
Food Science & Technology
Lan Tang, Shengnan Li, Jie Yu, Yujie Zhang, Lilin Yang, Dayan Tong, Jie Xu
Summary: This study found that chronic exposure to nonylphenol (NP) can increase anxiety behavior in rats and reduce the expression of key proteins/genes in the BDNF/TrkB/CREB signaling network.
FOOD AND CHEMICAL TOXICOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Md. Jakaria, Abdel A. Belaidi, Adam Southon, Krista A. Dent, Darius J. R. Lane, Ashley I. Bush, Scott Ayton
Summary: This study found that some TrkB modulators have protective effects against ferroptosis, but their mechanism is unrelated to the TrkB receptor and is instead due to their antioxidant properties. These modulators could be potential therapeutics for various diseases in the future.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Fisheries
Shupeng Zhang, Yongpei Lu, Yingzi Li, Yanling Liu, Qin Yao, Qin Kang, Shuhuang Chen, Youlian Liu, Yixiao Xiong, Defang Chen, Xin Zhang, Ni Tang, Zhiqiong Li
Summary: This study confirms the anorexigenic effect of brain-derived neurotrophic factor (BDNF) in Siberian sturgeon. Injection of BDNF suppresses feeding and affects the expression of peptide genes.
Review
Biochemistry & Molecular Biology
Pietro Cacialli
Summary: This study examines the role of neurotrophins in zebrafish and mammals after TBI, revealing that while the reparative mechanisms in the mammalian brain are limited, adult fish brains have high regenerative properties.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Neurosciences
Lino Tessarollo, Sudhirkumar Yanpallewar
Summary: Brain-derived neurotrophic factor (BDNF) plays a critical role in the development of the nervous system and has potential therapeutic effects on neurodegenerative diseases. The widely expressed receptor isoform TrkB.T1 may play an important role in regulating BDNF signaling.
FRONTIERS IN NEUROSCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Zheng-Kui Weng, Te-Hsien Lin, Kuo-Hsuan Chang, Ya-Jen Chiu, Chih-Hsin Lin, Pei-Hsuan Tseng, Ying-Chieh Sun, Wenwei Lin, Guey-Jen Lee-Chen, Chiung-Mei Chen
Summary: This study found that compounds ZN-015, VB-030, and VB-037 can alleviate Tau protein neurotoxicity and promote neurite outgrowth by enhancing BDNF/TRKB signaling pathway activation.
Article
Cell Biology
Minseok Song, Joanna Giza, Catia C. Proenca, Deqiang Jing, Mark Elliott, Iva Dincheva, Sergey V. Shmelkov, Jihye Kim, Ryan Schreiner, Shu-Hong Huang, Eero Castren, Rytis Prekeris, Barbara L. Hempstead, Moses V. Chao, Jason B. Dictenberg, Shahin Rafii, Zhe-Yu Chen, Enrique Rodriguez-Boulan, Francis S. Lee
DEVELOPMENTAL CELL
(2015)
Editorial Material
Neurosciences
Minseok Song, Francis S. Lee
NEUROPSYCHOPHARMACOLOGY
(2016)
Article
Biochemistry & Molecular Biology
M. Song, K. Martinowich, F. S. Lee
MOLECULAR PSYCHIATRY
(2017)
Article
Cell Biology
Yong Ryoul Yang, Minseok Song, Ho Lee, Yoon Jeon, Eun-Jeong Choi, Hyun-Jun Jang, Hyo Youl Moon, Ha-Young Byun, Eung-Kyun Kim, Dae Hyun Kim, Mi Nam Lee, Ara Koh, Jaewang Ghim, Jang Hyun Choi, Whaseon Lee-Kwon, Kyong Tai Kim, Sung Ho Ryu, Pann-Ghill Suh
Article
Biochemistry & Molecular Biology
Ji Hae Kim, Jung Ok Lee, Soo Kyung Lee, Ji Wook Moon, Ga Young You, Su Jin Kim, Sun-Hwa Park, Ji Man Park, Se Young Lim, Pann-Ghill Suh, Kyung-Ok Uhm, Min Seok Song, Hyeon Soo Kim
JOURNAL OF BIOLOGICAL CHEMISTRY
(2011)
Article
Multidisciplinary Sciences
Minseok Song, Carol A. Mathews, S. Evelyn Stewart, Sergey V. Shmelkov, Jason G. Mezey, Juan L. Rodriguez-Flores, Steven A. Rasmussen, Jennifer C. Britton, Yong-Seok Oh, John T. Walkup, Francis S. Lee, Charles E. Glatt
Article
Multidisciplinary Sciences
YoneJung Yoon, Morgan C. McKenna, David A. Rollins, Minseok Song, Tal Nuriel, Steven S. Gross, Guoqiang Xu, Charles E. Glatt
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2013)
Review
Biochemistry & Molecular Biology
Minseok Song
Article
Cell Biology
Carlos Martin-Rodriguez, Minseok Song, Begona Anta, Francisco J. Gonzalez-Calvo, Ruben Deogracias, Deqiang Jing, Francis S. Lee, Juan Carlos Arevalo
JOURNAL OF CELL SCIENCE
(2020)
Article
Cell Biology
Hyun-ju Lee, Seong Gak Jeon, Jieun Kim, Ri Jin Kang, Seong-Min Kim, Kyung-Min Han, HyunHee Park, Ki-taek Kim, You Me Sung, Hye Yeon Nam, Young Ho Koh, Minseok Song, Kyoungho Suk, Hyang-Sook Hoe
Summary: Ibrutinib was found to reduce Aβ plaque levels, decrease neuroinflammatory responses, lower tau phosphorylation, improve memory, and promote dendritic spine development in mouse models of Alzheimer's disease, suggesting it may be a potential therapy for AD.
Review
Medicine, General & Internal
Yang Woo Kwon, Han-Seul Jo, Sungwon Bae, Youngsuk Seo, Parkyong Song, Minseok Song, Jong Hyuk Yoon
Summary: Proteomics plays a crucial role in molecular sciences, providing valuable information on proteins. Cancer proteomics has unveiled key insights into tumor growth and metastasis, aiding in the identification of biomarkers and therapeutic targets. Integrating proteomics with other omics is generating extensive data on molecular mechanisms and target modulators.
FRONTIERS IN MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Minseok Song, Pann-Ghill Suh
Summary: This study demonstrates that O-GlcNAc plays a crucial role in regulating migration of ovarian cancer cells. The accumulation of O-GlcNAc reduces the formation of membrane protrusion structures and migration of the cells.
Review
Neurosciences
Hye Kyung Lim, Jong Hyuk Yoon, Minseok Song
Summary: The mammalian brain is composed of distinct regions with specific molecular mechanisms responsible for higher-order tasks. Dysfunction of genes involved in neural signaling can lead to brain disorders, such as autism spectrum disorder. Key genes associated with this disorder have been identified through genetic studies and animal models have deepened our understanding of their impact on disease susceptibility and compensation.
FRONTIERS IN MOLECULAR NEUROSCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Yong-Seok Oh, Kyun Heo, Eung-Kyun Kim, Jin-Hyeok Jang, Sun Sik Bae, Jong Bae Park, Yun Hee Kim, Minseok Song, Sang Ryong Kim, Sung Ho Ryu, In-Hoo Kim, Pann-Ghill Suh
EXPERIMENTAL AND MOLECULAR MEDICINE
(2017)
Article
Biochemistry & Molecular Biology
Pei-Yang Gao, Ya-Nan Ou, Yi-Ming Huang, Zhi-Bo Wang, Yan Fu, Ya-Hui Ma, Qiong-Yao Li, Li-Yun Ma, Rui-Ping Cui, Yin-Chu Mi, Lan Tan, Jin-Tai Yu
Summary: Liver function may play a role in the progression of Alzheimer's disease. The study found that as AD progressed, certain liver function markers increased while others decreased. The relationship between liver function and CSF AD biomarkers indicates a potential mediation effect on cognition.
JOURNAL OF NEUROCHEMISTRY
(2024)