标题
Gene therapy targeting mitochondrial pathway in Parkinson’s disease
作者
关键词
Gene therapy, Mitochondrial dysfunction, Parkinson’s disease, Parkin, PINK1, Alpha synuclein, PGC-1 alpha
出版物
JOURNAL OF NEURAL TRANSMISSION
Volume 124, Issue 2, Pages 193-207
出版商
Springer Nature
发表日期
2016-09-16
DOI
10.1007/s00702-016-1616-4
参考文献
相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。- Promotion of mitochondrial biogenesis by necdin protects neurons against mitochondrial insults
- (2016) Koichi Hasegawa et al. Nature Communications
- High expression of α-synuclein in damaged mitochondria with PLA2G6 dysfunction
- (2016) Hisae Sumi-Akamaru et al. Acta Neuropathologica Communications
- Parkin maintains mitochondrial levels of the protective Parkinson’s disease-related enzyme 17-β hydroxysteroid dehydrogenase type 10
- (2015) G Bertolin et al. CELL DEATH AND DIFFERENTIATION
- Gene therapy for neurological disorders
- (2015) Chi-Jing Choong et al. EXPERT OPINION ON BIOLOGICAL THERAPY
- The ubiquitin kinase PINK1 recruits autophagy receptors to induce mitophagy
- (2015) Michael Lazarou et al. NATURE
- Repression of rRNA transcription by PARIS contributes to Parkinson's disease
- (2015) Hojin Kang et al. NEUROBIOLOGY OF DISEASE
- Parkin loss leads to PARIS-dependent declines in mitochondrial mass and respiration
- (2015) Daniel A. Stevens et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Anti-Human α-Synuclein N-Terminal Peptide Antibody Protects against Dopaminergic Cell Death and Ameliorates Behavioral Deficits in an AAV-α-Synuclein Rat Model of Parkinson’s Disease
- (2015) Md Shahaduzzaman et al. PLoS One
- Alpha-synuclein in peripheral tissues and body fluids as a biomarker for Parkinson's disease - a systematic review
- (2014) N. Malek et al. ACTA NEUROLOGICA SCANDINAVICA
- Next-generation active immunization approach for synucleinopathies: implications for Parkinson’s disease clinical trials
- (2014) Markus Mandler et al. ACTA NEUROPATHOLOGICA
- Targeting alpha-synuclein with a microRNA-embedded silencing vector in the rat substantia nigra: Positive and negative effects
- (2014) Christina E. Khodr et al. BRAIN RESEARCH
- Potentiation of neurotoxicity in double-mutant mice with Pink1 ablation and A53T-SNCA overexpression
- (2014) Suzana Gispert et al. HUMAN MOLECULAR GENETICS
- Reducing C-Terminal-Truncated Alpha-Synuclein by Immunotherapy Attenuates Neurodegeneration and Propagation in Parkinson's Disease-Like Models
- (2014) D. Games et al. JOURNAL OF NEUROSCIENCE
- Reversible Behavioral Phenotypes in a Conditional Mouse Model of TDP-43 Proteinopathies
- (2014) J. A. Alfieri et al. JOURNAL OF NEUROSCIENCE
- Alpha-synuclein-induced neurodegeneration is exacerbated in PINK1 knockout mice
- (2014) Marusela Oliveras-Salvá et al. NEUROBIOLOGY OF AGING
- Functional connectivity in the basal ganglia network differentiates PD patients from controls
- (2014) K. Szewczyk-Krolikowski et al. NEUROLOGY
- A Randomized Clinical Trial of High-Dosage Coenzyme Q10 in Early Parkinson Disease
- (2014) et al. JAMA Neurology
- Axonopathy in an α-Synuclein Transgenic Model of Lewy Body Disease Is Associated with Extensive Accumulation of C-Terminal–Truncated α-Synuclein
- (2013) Dora Games et al. AMERICAN JOURNAL OF PATHOLOGY
- RNA interference targeting α-synuclein attenuates methamphetamine-induced neurotoxicity in SH-SY5Y cells
- (2013) Ling Chen et al. BRAIN RESEARCH
- Overexpression of parkin in the rat nigrostriatal dopamine system protects against methamphetamine neurotoxicity
- (2013) Bin Liu et al. EXPERIMENTAL NEUROLOGY
- Can parkin be a target for future treatment of Parkinson's disease?
- (2013) Shin-ichiro Kubo et al. EXPERT OPINION ON THERAPEUTIC TARGETS
- Mutant PINK1 upregulates tyrosine hydroxylase and dopamine levels, leading to vulnerability of dopaminergic neurons
- (2013) Zhi Dong Zhou et al. FREE RADICAL BIOLOGY AND MEDICINE
- α-Synuclein Vaccination Prevents the Accumulation of Parkinson Disease-Like Pathologic Inclusions in Striatum in Association With Regulatory T Cell Recruitment in a Rat Model
- (2013) Vanesa Sanchez-Guajardo et al. JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY
- Parkinson's Disease Gene Therapy: Success by Design Meets Failure by Efficacy
- (2013) Raymond T Bartus et al. MOLECULAR THERAPY
- The Parkinson's disease–linked proteins Fbxo7 and Parkin interact to mediate mitophagy
- (2013) Victoria S Burchell et al. NATURE NEUROSCIENCE
- Loss of PINK1 enhances neurodegeneration in a mouse model of Parkinson's disease triggered by mitochondrial stress
- (2013) Nicoleta Moisoi et al. NEUROPHARMACOLOGY
- Targeting Caspase-3 as Dual Therapeutic Benefits by RNAi Facilitating Brain-Targeted Nanoparticles in a Rat Model of Parkinson’s Disease
- (2013) Yang Liu et al. PLoS One
- Sulfhydration mediates neuroprotective actions of parkin
- (2013) M. Scott Vandiver et al. Nature Communications
- Mitochondrial Biology and Parkinson's Disease
- (2013) C. Perier et al. Cold Spring Harbor Perspectives in Medicine
- Recent Progress in Gene Therapy for Parkinson’s Disease
- (2012) Y. Nakata et al. CURRENT MOLECULAR MEDICINE
- Expression of Pink1 with α-synuclein in the dopaminergic neurons of Drosophila leads to increases in both lifespan and healthspan
- (2012) A.M. Todd et al. GENETICS AND MOLECULAR RESEARCH
- Sustained expression of PGC-1 in the rat nigrostriatal system selectively impairs dopaminergic function
- (2012) C. Ciron et al. HUMAN MOLECULAR GENETICS
- Inactivation ofPink1Genein VivoSensitizes Dopamine-producing Neurons to 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) and Can Be Rescued by Autosomal Recessive Parkinson Disease Genes,ParkinorDJ-1
- (2012) M. Emdadul Haque et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Overexpression of Parkin Ameliorates Dopaminergic Neurodegeneration Induced by 1- Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine in Mice
- (2012) Minjuan Bian et al. PLoS One
- Parkin Promotes Degradation of the Mitochondrial Pro-Apoptotic ARTS Protein
- (2012) Stav Kemeny et al. PLoS One
- Pgc-1α Overexpression Downregulates Pitx3 and Increases Susceptibility to MPTP Toxicity Associated with Decreased Bdnf
- (2012) Joanne Clark et al. PLoS One
- Pathological -Synuclein Transmission Initiates Parkinson-like Neurodegeneration in Nontransgenic Mice
- (2012) K. C. Luk et al. SCIENCE
- Mitochondrial dysfunction associated with increased oxidative stress and α-synuclein accumulation in PARK2 iPSC-derived neurons and postmortem brain tissue
- (2012) Yoichi Imaizumi et al. Molecular Brain
- Parkinson's Disease–Associated Kinase PINK1 Regulates Miro Protein Level and Axonal Transport of Mitochondria
- (2012) Song Liu et al. PLoS Genetics
- PARK6 PINK1 mutants are defective in maintaining mitochondrial membrane potential and inhibiting ROS formation of substantia nigra dopaminergic neurons
- (2011) Hung-Li Wang et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
- A microRNA embedded AAV alpha-synuclein gene silencing vector for dopaminergic neurons
- (2011) Ye Han et al. BRAIN RESEARCH
- An alpha-synuclein AAV gene silencing vector ameliorates a behavioral deficit in a rat model of Parkinson's disease, but displays toxicity in dopamine neurons
- (2011) Christina E. Khodr et al. BRAIN RESEARCH
- PARIS (ZNF746) Repression of PGC-1α Contributes to Neurodegeneration in Parkinson's Disease
- (2011) Joo-Ho Shin et al. CELL
- Transgenic expression and activation of PGC-1α protect dopaminergic neurons in the MPTP mouse model of Parkinson’s disease
- (2011) Giuseppa Mudò et al. CELLULAR AND MOLECULAR LIFE SCIENCES
- Safety and Tolerability of Magnetic Resonance Imaging-Guided Convection-Enhanced Delivery of AAV2-hAADC with a Novel Delivery Platform in Nonhuman Primate Striatum
- (2011) Waldy San Sebastian et al. HUMAN GENE THERAPY
- Mutant A53T α-Synuclein Induces Neuronal Death by Increasing Mitochondrial Autophagy
- (2011) Vinay Choubey et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Direct Membrane Association Drives Mitochondrial Fission by the Parkinson Disease-associated Protein α-Synuclein
- (2011) Ken Nakamura et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Parkin-Mediated Protection of Dopaminergic Neurons in a Chronic MPTP-Minipump Mouse Model of Parkinson Disease
- (2011) Toru Yasuda et al. JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY
- Vaccination for Parkinson's disease
- (2011) A. Schneeberger et al. PARKINSONISM & RELATED DISORDERS
- Passive Immunization Reduces Behavioral and Neuropathological Deficits in an Alpha-Synuclein Transgenic Model of Lewy Body Disease
- (2011) Eliezer Masliah et al. PLoS One
- Parkin is transcriptionally regulated by ATF4: evidence for an interconnection between mitochondrial stress and ER stress
- (2010) L Bouman et al. CELL DEATH AND DIFFERENTIATION
- Inhibition of mitochondrial fusion by α-synuclein is rescued by PINK1, Parkin and DJ-1
- (2010) Frits Kamp et al. EMBO JOURNAL
- DJ-1 acts in parallel to the PINK1/parkin pathway to control mitochondrial function and autophagy
- (2010) Kelly Jean Thomas et al. HUMAN MOLECULAR GENETICS
- In Vivo RNAi-Mediated α-Synuclein Silencing Induces Nigrostriatal Degeneration
- (2010) Oleg S Gorbatyuk et al. MOLECULAR THERAPY
- A double-blind, placebo-controlled study to assess the mitochondria-targeted antioxidant MitoQ as a disease-modifying therapy in Parkinson's disease
- (2010) Barry J. Snow et al. MOVEMENT DISORDERS
- Mitochondrial alpha-synuclein accumulation impairs complex I function in dopaminergic neurons and results in increased mitophagy in vivo
- (2010) Shankar J. Chinta et al. NEUROSCIENCE LETTERS
- PGC-1 , A Potential Therapeutic Target for Early Intervention in Parkinson's Disease
- (2010) B. Zheng et al. Science Translational Medicine
- Reduction of Protein Translation and Activation of Autophagy Protect against PINK1 Pathogenesis in Drosophila melanogaster
- (2010) Song Liu et al. PLoS Genetics
- Parkin Protects against LRRK2 G2019S Mutant-Induced Dopaminergic Neurodegeneration in Drosophila
- (2009) C.-H. Ng et al. JOURNAL OF NEUROSCIENCE
- Small peptide inhibitor of JNKs protects against MPTP-induced nigral dopaminergic injury via inhibiting the JNK-signaling pathway
- (2009) Jing Pan et al. LABORATORY INVESTIGATION
- α-Synuclein is differentially expressed in mitochondria from different rat brain regions and dose-dependently down-regulates complex I activity
- (2009) Guangwei Liu et al. NEUROSCIENCE LETTERS
- PINK1-dependent recruitment of Parkin to mitochondria in mitophagy
- (2009) C. Vives-Bauza et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Transcribe to Survive: Transcriptional Control of Antioxidant Defense Programs for Neuroprotection in Parkinson’s Disease
- (2008) Joanne Clark et al. ANTIOXIDANTS & REDOX SIGNALING
- Mitochondrial translocation of α-synuclein is promoted by intracellular acidification
- (2008) Nelson B. Cole et al. EXPERIMENTAL CELL RESEARCH
- Pink1 suppresses α-synuclein-induced phenotypes in a Drosophila model of Parkinson’s disease
- (2008) Amy M. Todd et al. GENOME
- Mitochondrial Import and Accumulation of α-Synuclein Impair Complex I in Human Dopaminergic Neuronal Cultures and Parkinson Disease Brain
- (2008) Latha Devi et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Transplanted dopaminergic neurons develop PD pathologic changes: A second case report
- (2008) Jeffrey H. Kordower et al. MOVEMENT DISORDERS
- Lewy body–like pathology in long-term embryonic nigral transplants in Parkinson's disease
- (2008) Jeffrey H Kordower et al. NATURE MEDICINE
- Effects of calpain inhibition on dopaminergic markers and motor function following intrastriatal 6-hydroxydopamine administration in rats
- (2008) R.J. Grant et al. NEUROSCIENCE
- Cytoplasmic Pink1 activity protects neurons from dopaminergic neurotoxin MPTP
- (2008) M. E. Haque et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Loss of PINK1 causes mitochondrial functional defects and increased sensitivity to oxidative stress
- (2008) C. A. Gautier et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Discover Peeref hubs
Discuss science. Find collaborators. Network.
Join a conversationFind the ideal target journal for your manuscript
Explore over 38,000 international journals covering a vast array of academic fields.
Search