Review
Chemistry, Analytical
Joshua O. Usoro, Brandon S. Sturgill, Kate C. Musselman, Jeffrey R. Capadona, Joseph J. Pancrazio
Summary: While MEAs hold promise for understanding neural circuitry and neuroprosthetics, designing and demonstrating chronically reliable technology remains a challenge. Variability exists in reported study durations across different MEA types and animal species, with significant differences in chronic implantation periods and linear decay in active electrode yield observed in rodent models implanted with commercially-available devices.
Article
Engineering, Biomedical
Jeffrey Lim, Po T. Wang, Luke Bashford, Spencer Kellis, Susan J. Shaw, Hui Gong, Michelle Armacost, Payam Heydari, An H. Do, Richard A. Andersen, Charles Y. Liu, Zoran Nenadic
Summary: This study presents a novel approach based on pre-whitening and null projection (PWNP) for suppressing stimulation artifacts in brain-computer interfaces. The results showed that the PWNP method achieved significant artifact suppression in EEG, ECoG, and MEA signals, outperforming the state-of-the-art technique while being easier to implement.
JOURNAL OF NEURAL ENGINEERING
(2023)
Article
Biophysics
Venkata Suresh Vajrala, Kamil Elkhoury, Sophie Pautot, Christian Bergaud, Ali Maziz
Summary: This paper reports a novel Hollow Ring-like type electrode for sensing and/or stimulating neural activity from three-dimensional neural networks. The ring electrode architecture enables easy access to three-dimensional neural networks with reduced mechanical contact on the biological tissue, and provides improved electrical interface with cells. The hollow ring design shows great potential for developing next-generation microelectrodes for applications in neural interfaces.
BIOSENSORS & BIOELECTRONICS
(2023)
Article
Engineering, Biomedical
Christopher L. Hughes, Sharlene N. Flesher, Jeffrey M. Weiss, John E. Downey, Michael Boninger, Jennifer L. Collinger, Robert A. Gaunt
Summary: The study aimed to evaluate the recording stability of intracortical electrodes implanted in the somatosensory cortex, revealing a decrease in recording quality over time, but with SIROF electrodes more likely to record high-amplitude signals than platinum electrodes. Additionally, the detection thresholds for stimulus-evoked sensations decreased over time.
JOURNAL OF NEURAL ENGINEERING
(2021)
Article
Biophysics
Mahdi Ghazal, Anna Susloparova, Camille Lefebvre, Michel Daher Mansour, Najami Ghodhbane, Alexis Melot, Corentin Scholaert, David Guerin, Sebastien Janel, Nicolas Barois, Morvane Colin, Luc Buee, Pierre Yger, Sophie Halliez, Yannick Coffinier, Sebastien Pecqueur, Fabien Alibart
Summary: The ratio of organic monomers in the electro-co-polymerization process can adjust the hydrophilicity and biocompatibility of the material without affecting the electrochemical impedance and stability of the electrodes. After incubation, the modified electrodes exhibit higher signal-to-noise ratio and spike counts compared to unmodified electropolymerized PEDOT.
BIOSENSORS & BIOELECTRONICS
(2023)
Article
Chemistry, Analytical
Yoontae Kim, Stella Alimperti, Paul Choi, Moses Noh
Summary: A highly flexible 22-channel ECoG microelectrode array was developed using novel fabrication techniques, and in vivo studies showed potential clinical application prospects.
Article
Clinical Neurology
Christopher L. Hughes, Sharlene N. Flesher, Robert A. Gaunt
Summary: This study evaluated the adaptability of tactile percepts evoked by ICMS in the somatosensory cortex over time, and found that intermittent stimulation paradigms were more effective at maintaining percepts compared to continuous stimulation at high frequencies.
Article
Neurosciences
Ramya L. Saldanha, Morgan E. Urdaneta, Kevin J. Otto
Summary: This study found that in rats implanted with custom-made planar silicon microelectrodes, electrode-sites at the tip of the device performed best for ICMS effectiveness, followed by edge sites and then center sites. While all sites showed a similar trend over time, edge and tip sites consistently elicited behavioral responses with less charge and remained more active over time compared to center sites.
FRONTIERS IN NEUROSCIENCE
(2021)
Article
Engineering, Biomedical
Tianshu Dong, Lei Chen, Paras R. Patel, Julianna M. Richie, Cynthia A. Chestek, Albert J. Shih
Summary: The machine described in this study automates the assembly of high-density carbon fiber (HDCF) arrays, eliminating the need for manual labor and improving accuracy and repeatability. The machine includes a roller-based carbon fiber extruder, a motion system with linear and rotary stages, an imaging system with digital microscope cameras, and a laser cutter. It is capable of precisely handling carbon fiber electrodes (CFEs) and accurately placing them on silicon support shanks. The use of this machine is significant for achieving fully automated HDCF array assembly and batch production.
JOURNAL OF NEURAL ENGINEERING
(2023)
Article
Chemistry, Multidisciplinary
Pegah Shokoohimehr, Bogdana Cepkenovic, Frano Milos, Justus Bednar, Hossein Hassani, Vanessa Maybeck, Andreas Offenhaeusser
Summary: The further development of neurochips requires high-density and high-resolution recordings over a long period of time. A combination of vertical nanostraws with nanocavities is proposed, allowing tight coupling with neurons and achieving high sensitivity and synaptic resolution in recording.
Article
Chemistry, Analytical
Andreas Schander, Julia M. Gancz, Marcel Tintelott, Walter Lang
Summary: This study investigated the effects of polyimide surface treatment on the long-term stability of implanted neural electrodes. By increasing the power and duration of oxygen plasma etching, the lifetime of the test samples was significantly extended.
Article
Physics, Applied
Dongxiao Zhang, Jiandong Yang, Yoshikazu Hirai, Ken-ichiro Kamei, Osamu Tabata, Toshiyuki Tsuchiya
Summary: Multi-organ-on-a-chip devices have gained attention for their ability to mimic human physiological conditions, but they lack on-chip analytical technologies for real-time monitoring. In this study, a microfabricated multi-organ-on-a-chip was developed by integrating a pneumatic-actuated micropump and a parylene-insulated microelectrode array (MEA) into a PDMS-based microfluidic device. The experimental results showed that the micropump performance was sufficient for simulating metabolite interaction, and the impedance magnitude measured was comparable to state-of-the-art MEA devices. This microfabrication method has potential applications in comprehensive in vitro drug testing.
JAPANESE JOURNAL OF APPLIED PHYSICS
(2023)
Article
Clinical Neurology
David P. McMullen, Tessy M. Thomas, Matthew S. Fifer, Daniel N. Candrea, Francesco Tenore, Robert W. Nickl, Eric A. Pohlmeyer, Christopher Coogan, Luke E. Osborn, Adam Schiavi, Teresa Wojtasiewicz, Chad R. Gordon, Adam B. Cohen, Nick F. Ramsey, Wouter Schellekens, Sliman J. Bensmaia, Gabriela L. Cantarero, Pablo A. Celnik, Brock A. Wester, William S. Anderson, Nathan E. Crone
Summary: This study demonstrates a novel intraoperative online functional mapping technique using high-density electrocorticography to localize finger representations in the primary somatosensory cortex, enabling accurate placement of stimulating microelectrodes for closed-loop brain-machine interface studies in humans.
JOURNAL OF NEUROSURGERY
(2021)
Article
Chemistry, Multidisciplinary
Peng Sun, Liang Ma, Wanhai Zhou, Meijia Qiu, Zilong Wang, Dongliang Chao, Wenjie Mai
Summary: The addition of glucose in ZnSO4 electrolyte can improve the performance of Zn ion batteries by suppressing Zn dendrite growth and side reactions, enhancing stability.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Article
Neurosciences
Doris Lam, Heather A. Enright, Jose Cadena, Vivek Kurien George, David A. Soscia, Angela C. Tooker, Michael Triplett, Sandra K. G. Peters, Piyush Karande, Alexander Ladd, Chandrakumar Bogguri, Elizabeth K. Wheeler, Nicholas O. Fischer
Summary: The study introduces a novel computational analytical pipeline to analyze 3D neural network activity. The results demonstrate differences in network activity within and between cross sections of the 3D hydrogel-based tissue, with a preference for GABA and/or glutamate synaptic transmission.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2023)
Article
Engineering, Biomedical
Curtis D. Lee, Seth A. Hara, Lawrence Yu, Jonathan T. W. Kuo, Brian J. Kim, Tuan Hoang, Victor Pikov, Ellis Meng
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS
(2016)
Article
Engineering, Electrical & Electronic
Seth A. Hara, Brian J. Kim, Jonathan T. W. Kuo, Ellis Meng
JOURNAL OF MICROELECTROMECHANICAL SYSTEMS
(2015)
Article
Instruments & Instrumentation
Michael P. Marsh, James N. Kruchowski, Seth A. Hara, Malcom B. McIntosh, Renae M. Forsman, Terry L. Reed, Christopher Kimble, Kendall H. Lee, Kevin E. Bennet, Jonathan R. Tomshine
REVIEW OF SCIENTIFIC INSTRUMENTS
(2017)
Article
Engineering, Biomedical
B. J. Kim, J. T. W. Kuo, S. A. Hara, C. D. Lee, L. Yu, C. A. Gutierrez, T. Q. Hoang, V. Pikov, E. Meng
JOURNAL OF NEURAL ENGINEERING
(2013)
Article
Biochemical Research Methods
Jonathan T. W. Kuo, Brian J. Kim, Seth A. Hara, Curtis D. Lee, Christian A. Gutierrez, Tuan Q. Hoang, Ellis Meng
Article
Chemistry, Analytical
Evan N. Nicolai, Nicholas J. Michelson, Megan L. Settell, Seth A. Hara, James K. Trevathan, Anders J. Asp, Kaylene C. Stocking, J. Luis Lujan, Takashi D. Y. Kozai, Kip A. Ludwig
Review
Chemistry, Analytical
Erin K. Purcell, Michael F. Becker, Yue Guo, Seth A. Hara, Kip A. Ludwig, Collin J. McKinney, Elizabeth M. Monroe, Robert Rechenberg, Cory A. Rusinek, Akash Saxena, James R. Siegenthaler, Caryl E. Sortwell, Cort H. Thompson, James K. Trevathan, Suzanne Witt, Wen Li
Summary: Carbon-based electrodes, like carbon fiber microelectrodes, have a long history of use in neurochemical sensing, but are limited in fabrication, flexibility, and stability. Boron-doped diamond electrodes offer improved electrochemical properties and biocompatibility, allowing for high-throughput batch fabrication and customization of electrode arrays for neurochemical sensing applications. Opportunities exist to further enhance the performance of diamond electrodes through various methods such as anodic pretreatment and waveform optimization.
Article
Chemistry, Analytical
Amirreza Ghaznavi, Jie Xu, Seth A. A. Hara
Summary: Three-dimensional printing technology is used in microfluidic mold fabrication for its advantages such as design freedom, speed, and low-cost. In this paper, we propose a non-sacrificial approach using Stereolithography (SLA) printers to assemble modular microfluidic molds, which simplifies the mold fabrication process and addresses the limitations in fabricating complex and time-consuming micro/mesoscale devices. The paper discusses the process flow, optimization of print time and feature resolution, alignments of modular devices, and the advantages and limitations of the proposed technique.
Proceedings Paper
Engineering, Biomedical
Seth A. Hara, Brian J. Kim, Jonathan T. W. Kuo, Curtis D. Lee, Christian A. Gutierrez, Tuan Hoang, Victor Pikov, Ellis Meng
2013 6TH INTERNATIONAL IEEE/EMBS CONFERENCE ON NEURAL ENGINEERING (NER)
(2013)
Proceedings Paper
Engineering, Biomedical
Brian J. Kim, Seth A. Hara, Benny Chen, Jonathan T. W. Kuo, Curtis Lee, Christian A. Gutierrez, Tuan Hoang, Malancha Gupta, Victor Pikov, Ellis Meng
2013 6TH INTERNATIONAL IEEE/EMBS CONFERENCE ON NEURAL ENGINEERING (NER)
(2013)
Proceedings Paper
Engineering, Biomedical
Seth A. Hara, Brian J. Kim, Jonathan T. W. Kuo, Curtis Lee, Christian A. Gutierrez, Tuan Hoang, Ellis Meng
2012 ANNUAL INTERNATIONAL CONFERENCE OF THE IEEE ENGINEERING IN MEDICINE AND BIOLOGY SOCIETY (EMBC)
(2012)