Article
Multidisciplinary Sciences
Maise Al Bakir, Ariana Huebner, Carlos Martinez-Ruiz, Kristiana Grigoriadis, Thomas B. K. Watkins, Oriol Pich, David A. Moore, Selvaraju Veeriah, Sophia Ward, Joanne Laycock, Diana Johnson, Andrew Rowan, Maryam Razaq, Mita Akther, Cristina Naceur-Lombardelli, Paulina Prymas, Antonia Toncheva, Sonya Hessey, Michelle Dietzen, Emma Colliver, Alexander Frankell, Abigail Bunkum, Emilia L. Lim, Takahiro Karasaki, Christopher Abbosh, Crispin T. Hiley, Mark S. Hill, Daniel E. Cook, Gareth A. Wilson, Roberto Salgado, Emma Nye, Richard Kevin Stone, Dean A. Fennell, Gillian Price, Keith M. Kerr, Babu Naidu, Gary Middleton, Yvonne Summers, Colin R. Lindsay, Fiona H. Blackhall, Judith Cave, Kevin G. Blyth, Arjun Nair, Asia Ahmed, Magali N. Taylor, Alexander James Procter, Mary Falzon, David Lawrence, Neal Navani, Ricky M. Thakrar, Sam M. Janes, Dionysis Papadatos-Pastos, Martin D. Forster, Siow Ming Lee, Tanya Ahmad, Sergio Quezada, Karl S. Peggs, Peter Van Loo, Caroline Dive, Allan Hackshaw, Nicolai J. Birkbak, Simone Zaccaria, Mariam Jamal-Hanjani, Nicholas McGranahan, Charles Swanton, Jason F. Lester, Amrita Bajaj, Apostolos Nakas, Azmina Sodha-Ramdeen, Keng Ang, Mohamad Tufail, Mohammed Fiyaz Chowdhry, Molly Scotland, Rebecca Boyles, Sridhar Rathinam, Claire Wilson, Domenic Marrone, Sean Dulloo, Gurdeep Matharu, Jacqui A. Shaw, Joan Riley, Lindsay Primrose, Ekaterini Boleti, Heather Cheyne, Mohammed Khalil, Shirley Richardson, Tracey Cruickshank, Sarah Benafif, Kayleigh Gilbert, Akshay J. Patel, Aya Osman, Christer Lacson, Gerald Langman, Helen Shackleford, Madava Djearaman, Salma Kadiri, Angela Leek, Jack Davies Hodgkinson, Nicola Totten, Angeles Montero, Elaine Smith, Eustace Fontaine, Felice Granato, Helen Doran, Juliette Novasio, Kendadai Rammohan, Leena Joseph, Paul Bishop, Rajesh Shah, Stuart Moss, Vijay Joshi, Philip Crosbie, Fabio Gomes, Kate Brown, Mathew Carter, Anshuman Chaturvedi, Lynsey Priest, Pedro Oliveira, Matthew G. Krebs, Alexandra Clipson, Jonathan Tugwood, Alastair Kerr, Dominic G. Rothwell, Elaine Kilgour, Hugo J. W. L. Aerts, Roland F. Schwarz, Tom L. Kaufmann, Rachel Rosenthal, Zoltan Szallasi, Judit Kisistok, Mateo Sokac, Miklos Diossy, Jonas Demeulemeester, Aengus Stewart, Alastair Magness, Angeliki Karamani, Benny Chain, Brittany B. Campbell, Carla Castignani, Chris Bailey, Clare Puttick, Clare E. Weeden, Claudia Lee, Corentin Richard, David R. Pearce, Despoina Karagianni, Dhruva Biswas, Dina Levi, Elena Hoxha, Elizabeth Larose Cadieux, Eva Gronroos, Felip Galvez-Cancino, Foteini Athanasopoulou, Francisco Gimeno-Valiente, George Kassiotis, Georgia Stavrou, Gerasimos Mastrokalos, Haoran Zhai, Helen L. Lowe, Ignacio Matos, Jacki Goldman, James L. Reading, James R. M. Black, Javier Herrero, Jayant K. Rane, Jerome Nicod, Jie Min Lam, John A. Hartley, Katey S. S. Enfield, Kayalvizhi Selvaraju, Kerstin Thol, Kevin Litchfield, Kevin W. Ng, Kezhong Chen, Krijn Dijkstra, Krupa Thakkar, Leah Ensell, Mansi Shah, Marcos Vasquez, Maria Litovchenko, Mariana Werner Sunderland, Michelle Leung, Mickael Escudero, Mihaela Angelova, Miljana Tanic, Monica Sivakumar, Nnennaya Kanu, Olga Chervova, Olivia Lucas, Othman Al-Sawaf, Philip Hobson, Piotr Pawlik, Robert Bentham, Robert E. Hynds, Roberto Vendramin, Sadegh Saghafinia, Saioa Lopez, Samuel Gamble, Seng Kuong Anakin Ung, Sharon Vanloo, Stefan Boeing, Stephan Beck, Supreet Kaur Bola, Tamara Denner, Teresa Marafioti, Thanos P. Mourikis, Victoria Spanswick, Vittorio Barbe, Wei-Ting Lu, William Hill, Wing Kin Liu, Yin Wu, Yutaka Naito, Zoe Ramsden, Catarina Veiga, Gary Royle, Charles-Antoine Collins-Fekete, Francesco Fraioli, Paul Ashford, Tristan Clark, Elaine Borg, James Wilson, Davide Patrini, Emilie Martinoni Hoogenboom, Fleur Monk, James W. Holding, Junaid Choudhary, Kunal Bhakhri, Marco Scarci, Martin Hayward, Nikolaos Panagiotopoulos, Pat Gorman, Reena Khiroya, Robert C. M. Stephens, Yien Ning Sophia Wong, Steve Bandula, Abigail Sharp, Sean Smith, Nicole Gower, Harjot Kaur Dhanda, Kitty Chan, Camilla Pilotti, Rachel Leslie, Anca Grapa, Hanyun Zhang, Khalid AbdulJabbar, Xiaoxi Pan, Yinyin Yuan, David Chuter, Mairead MacKenzie, Serena Chee, Aiman Alzetani, Lydia Scarlett, Jennifer Richards, Papawadee Ingram, Silvia Austin, Eric Lim, Paulo De Sousa, Simon Jordan, Alexandra Rice, Hilgardt Raubenheimer, Harshil Bhayani, Lyn Ambrose, Anand Devaraj, Hema Chavan, Sofina Begum, Silviu Buderi, Daniel Kaniu, Mpho Malima, Sarah Booth, Andrew G. Nicholson, Nadia Fernandes, Pratibha Shah, Chiara Proli, Madeleine Hewish, Sarah Danson, Michael J. Shackcloth, Lily Robinson, Peter Russell, Craig Dick, John Le Quesne, Alan Kirk, Mo Asif, Rocco Bilancia, Nikos Kostoulas, Mathew Thomas
Summary: Through longitudinal evolutionary analysis of 126 non-small cell lung cancer tumors, it was found that 25% of cases showed early metastatic divergence before the last clonal sweep in the primary tumor, which was enriched in patients who were smokers at the time of initial diagnosis. Polyclonal dissemination was associated with tumor recurrence, while primary lymph node disease played a limited role in metastatic relapse. Our study highlights the importance of selection in metastatic clone evolution within untreated primary tumors.