期刊
JOURNAL OF NATURAL PRODUCTS
卷 79, 期 7, 页码 1719-1723出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.jnatprod.5b01051
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资金
- National Health Research Institutes
The new flavone-glycoside aciculatin (1), from Chrysopogon aciculatus, has been shown to have cytotoxic, anti-inflammatory, and antiarthritis activity. Further biological studies have been limited because of the limited availability of 1 from natural sources. Herein the first total synthesis of 1 in an overall yield of 8.3% is described. The synthesis involved the regio- and stereoselective glycosylation Fries-type O-to-C rearrangement to construct the C-aryl glycosidic linkage, followed by a Baker-Venkataraman rearrangement and cyclodehydration to form the flavone scaffold.
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