Article
Polymer Science
Maria Herrero-Herrero, Jose Antonio Gomez-Tejedor, Ana Valles-Lluch
Summary: Tailored membranes with a fiber diameter of 1.8 μm were electrospun from PLGA and PCLGA solutions by adjusting electrospinning and polymer solution parameters. PCLGA, with its amorphous morphology, required the addition of a salt to increase conductivity for successful electrospinning, presenting notable difficulties due to its structure. Interestingly, PCLGA, with a higher glycolic acid molar fraction, could be successfully electrospun, a feat not previously reported.
Article
Chemistry, Multidisciplinary
Rong Wang, Xiaojie Sun, Lanlan Chen, Wenbin Liang
Summary: In this study, biodegradable blends of PGA and PBAT with in situ compatibilization using MDI were prepared. The addition of PBAT was found to increase the complex viscosity and storage modulus of the blends, leading to improved compatibility and impact strength. The morphology of the dispersed phase evolved from spherical structure to in situ microfiber, enhancing interfacial adhesion and improving toughness.
Review
Engineering, Biomedical
Duoyi Zhao, Tongtong Zhu, Jie Li, Liguo Cui, Zhiyu Zhang, Xiuli Zhuang, Jianxun Ding
Summary: This article comprehensively reviews the research and applications of artificial bone-substitute materials based on PLGA and its composites, discussing their potential and challenges in bone regeneration.
BIOACTIVE MATERIALS
(2021)
Article
Chemistry, Physical
Motahare Masoumi, Mohsen Jahanshahi, Morteza Ghorbanzadeh Ahangari, Ghasem Najafpour Darzi
Summary: In this study, the interactions of PLGA monomer with CNT and SiO2NT were investigated using density functional theory. The results revealed a chemisorption interaction between PLGA and SiO2NT, while a physisorption interaction was observed between PLGA and CNT. Additionally, molecular dynamics simulations were used to study the mechanical properties of these materials, showing an increase in mechanical properties when PLGA interacts with SiO2NT.
APPLIED SURFACE SCIENCE
(2021)
Article
Polymer Science
Alastair Little, Alan M. Wemyss, David M. Haddleton, Bowen Tan, Zhaoyang Sun, Yang Ji, Chaoying Wan
Summary: The study investigates the effects of various reaction conditions on the synthesis of PLGA25, showing how factors such as reaction temperature, initiator concentration, and catalyst concentration impact the molecular weight, monomer conversion, and thermal properties.
Article
Biochemistry & Molecular Biology
Wen-Jyun Wang, Chung-Dann Kan, Chih-Yen Chen, Yi-Yao Meng, Jieh-Neng Wang, Wei-Ling Chen, Chia-Hsiang Chen, Wei-Peng Li
Summary: Synthetic PLGA MVs with biogenic MV-mimic vesicular structure were prepared successfully for drug delivery applications, showing great potential in delivering hydrophobic compounds like IC to cells. The in vitro results demonstrated that IC-loaded PLGA MVs significantly decreased the cell viability of A549 lung carcinoma cells, indicating their excellent potential as a drug delivery platform.
Article
Materials Science, Multidisciplinary
Eva M. M. Eger, Seema Agarwal
Summary: This study focuses on the characterization and reprocessing ability of PLGA in the form of dynamic covalent networks. The synthesized networks with dynamic bonding and debonding have enhanced thermomechanical properties and maintain the potential for thermal reprocessing and recycling like thermoplastics.
ACS APPLIED POLYMER MATERIALS
(2023)
Article
Biophysics
Orkun Uyanik, Kubra Cigdem Pekkoc-Uyanik, Siddika Findik, Ahmet Avci, Zeynep Altuntas
Summary: In a study on rat Achilles tendon injury models, the application of poly (lactic acid-co-glycolic acid) significantly reduces peritendinous adhesions, promotes tendon healing, and demonstrates good biocompatibility in histopathological examination.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2022)
Article
Pharmacology & Pharmacy
Kostas Tsachouridis, Evi Christodoulou, Alexandra Zamboulis, Anna Michopoulou, Panagiotis Barmpalexis, Dimitrios N. Bikiaris
Summary: The present study evaluates the use of novel copolymers for the preparation of paclitaxel loaded nanoparticles. The copolymers showed good enzymatic hydrolysis and low cytotoxicity, making them suitable drug matrix/carriers. The prepared nanoparticles exhibited small size, good drug loading and encapsulation efficiency. In vitro dissolution analysis showed biphasic drug dissolution profiles.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Yiye Lu, Geoffrey W. Coates
Summary: Poly(lactic-co-glycolic acid) (PLGA) is widely used in various biomedical applications due to its biodegradability and biocompatibility. This study successfully developed a method to synthesize syndioenriched, alternating PLGA from racemic methyl-glycolide (rac-MeG), and confirmed the high degree of alternation of the comonomer sequence and moderate syndiotacticity within the polymer backbone stereoconfiguration through NMR investigations.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2023)
Article
Chemistry, Multidisciplinary
Yiye Lu, Geoffrey W. Coates
Summary: Poly(lactic-co-glycolic acid) (PLGA) is a biodegradable and biocompatible polymer used in biomedical applications. This study presents a method for synthesizing syndioenriched, alternating PLGA from racemic methyl-glycolide with the use of an optimized racemic aluminum catalyst. The resulting material has a high degree of alternation in copolymer sequence and moderate syndiotacticity, and is amorphous, making it suitable for drug complexation.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2023)
Article
Pharmacology & Pharmacy
Wan-Yi Liu, Yun-Shan Hsieh, Yu-Tse Wu
Summary: This study aimed to develop a nanoparticle formulation for the oral delivery of beta-carotene. The results showed that the formulation significantly enhanced the release and intestinal permeability of the drug, suggesting its potential for oral administration.
Article
Biochemistry & Molecular Biology
Seounghun Lee, Hyo-Jung Shin, Chan Noh, Song- Kim, Young-Kwon Ko, Sun-Yeul Lee, Chaeseong Lim, Boohwi Hong, Sin-Young Yang, Dong-Woon Kim, Won-Hyung Lee, Yoon-Hee Kim
Summary: The activation of NF-kappa B in microglia is crucial for the development of neuropathic pain. Inhibitor of I kappa B (I kappa B) blocks NF-kappa B activation, and IKBKB is responsible for breaking down I kappa B to inhibit NF-kappa B activity. Delivering IKBKB siRNA via PLGA nanoparticles effectively reduces pain response and inflammatory mediators in SNL rats, suggesting its potential as a treatment for neuropathic pain.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Materials Science, Multidisciplinary
Ying Mao, Robert Guidoin, Yan Li, Gaetan Brochu, Ze Zhang, Lu Wang
Summary: Blending L-alpha-phosphatidylcholine (PC) with PLGA to yield hybrid scaffolds alters the physical properties and wettability, affecting biodegradability and biocompatibility. The addition of PC decreases fiber diameter and increases porosity and hydrophilicity, although it also reduces mechanical strength of the scaffolds.
MATERIALS & DESIGN
(2021)
Article
Chemistry, Physical
Olawale Monsur Sanusi, Abdelkibir Benelfellah, Lazaros Papadopoulos, Zoi Terzopoulou, Lamprini Malletzidou, Isaak G. Vasileiadis, Konstantinos Chrissafis, Dimitrios N. Bikiaris, Nourredine Ait Hocine
Summary: In this study, a hybrid nanofiller of Mt and MWCNT was successfully prepared and incorporated into PLA matrix to improve the material properties. Physicochemical studies and structural analyzes revealed strong hybrid-polymer interaction and synergy between nanoclay and carbon nanotubes. Thermal characterizations and mechanical properties testing demonstrated that the Mt/MWCNT hybrid nanofillers effectively restricted the motion of PLA segments and enhanced the mechanical performance of the polymer matrix.
APPLIED CLAY SCIENCE
(2021)
Article
Nanoscience & Nanotechnology
Sujat Sen, Sung Yeol Kim, Lia R. Palmore, Shenghua Jin, Nitin Jadhav, Eric Chason, G. Tayhas R. Palmore
ACS APPLIED MATERIALS & INTERFACES
(2016)
Article
Polymer Science
Eun-Jin Lee, Kyung-Hun Park, Young-Hee Lee, Kyung-Geun Kim, Yeon Uk Jeong, Sung Yeol Kim, Han-Do Kim
JOURNAL OF APPLIED POLYMER SCIENCE
(2017)
Article
Polymer Science
Yu-Mi Bae, Young-Hee Lee, Han-Seong Kim, Dong-Jin Lee, Sung Yeol Kim, Han-Do Kim
JOURNAL OF APPLIED POLYMER SCIENCE
(2017)
Article
Chemistry, Multidisciplinary
Eun Sung Kang, Yong-Tae Kim, Youn-Seon Ko, Nam Hyeong Kim, Geonhee Cho, Yang Hoon Huh, Ji-Hun Kim, Jiyoung Nam, Trung Thanh Thach, David Youn, Young Dok Kim, Wan Soo Yun, William F. DeGrado, Sung Yeol Kim, Paula T. Hammond, Jaeyoung Lee, Young-Uk Kwon, Don-Hyung Ha, Yong Ho Kim
Article
Chemistry, Multidisciplinary
Neung Kwon, Yeon Uk Jeong, Sang-Il Choi, Sung Yeol Kim, Yong Joong Lee
BULLETIN OF THE KOREAN CHEMICAL SOCIETY
(2018)
Article
Thermodynamics
Do Won Heo, Min Gi Kang, Ho Lee, Sung Yeol Kim
ADVANCES IN MECHANICAL ENGINEERING
(2018)
Article
Green & Sustainable Science & Technology
Haroon Khan, Chul Min Kim, Sung Yeol Kim, Sanket Goel, Prabhat K. Dwivedi, Ashutosh Sharma, Young Ho Kim, Gyu Man Kim
INTERNATIONAL JOURNAL OF PRECISION ENGINEERING AND MANUFACTURING-GREEN TECHNOLOGY
(2019)
Article
Multidisciplinary Sciences
Kyung-Geun Kim, SungYeol Kim
SCIENTIFIC REPORTS
(2019)
Correction
Green & Sustainable Science & Technology
Haroon Khan, Chul Min Kim, Sung Yeol Kim, Sanket Goel, Prabhat K. Dwivedi, Ashutosh Sharma, Young Ho Kim, Gyu Man Kim
INTERNATIONAL JOURNAL OF PRECISION ENGINEERING AND MANUFACTURING-GREEN TECHNOLOGY
(2019)
Correction
Multidisciplinary Sciences
Kyung-Geun Kim, Sung Yeol Kim
SCIENTIFIC REPORTS
(2019)
Article
Environmental Sciences
Ranjith Kumar Dharman, Kiran P. Shejale, Sung Yeol Kim
Summary: In this study, CuS/MoS2 nanocomposite sonocatalysts were developed, and their catalytic efficiency was enhanced by increasing the CuS concentration. The nanocomposite catalyst showed good removal efficiency for environmental pollutants rhodamine B and hexavalent chromium, with stable performance and recyclability.
Article
Chemistry, Physical
Kyung-Geun Kim, Gyeong Hun Park, Dickens O. Agumba, Sung Yeol Kim
Summary: In this study, the deformation and delamination of polypyrrole film electrodes were investigated using in-situ measurements. The results revealed that the film deformation was caused by the evaporation of moisture near the polymer chain, and the delamination was identified through rapid stress drop. The study also quantified the interfacial fracture energy and successfully identified electrochemical-cycling-induced delamination.
SURFACES AND INTERFACES
(2022)
Article
Energy & Fuels
Jongeun Choi, Giyong Kim, Sung Yeol Kim
Summary: Recently, the abnormal behaviors and the degradation of a graphite-silicone composite anode during repeated charging/discharging cycles were investigated. The capacity retention, Coulombic efficiency, irreversible, and differential capacity were analyzed to examine the contribution of each Gr and Si on the capacity. The study found that silicone is the major contributor to the initial drop in capacity, and the capacity contribution of graphite can decrease rapidly under certain conditions. The recovery of capacity after an initial decrease was found to be related to the recovery of graphite reactions.
Article
Green & Sustainable Science & Technology
Jinah Kim, Hyosik Park, Giyong Kim, Ju-Hyuck Lee, Jinhyoung Park, Sung Yeol Kim
Summary: Recently, stretchable triboelectric nanogenerators (TENGs) have been widely studied as sustainable energy sources for emerging sensors and electronic applications. In this research, a high-performance TENG (SRC-TENG) with excellent stretchability was developed using a composite electrode made of silicone rubber and carbon nanotube (CNT). The SRC-TENG demonstrated outstanding performance, delivering a maximum output of 3.52 W/m(2) at 100 M Omega, comparable to or even higher than other ultrastretchable TENGs. Optimizing the thickness of the composite material further enhanced the output performance by increasing the interfacial area and contact area. The fabricated SRC-TENGs also showed high output performance even when stretched and exhibited excellent long-term stability.
INTERNATIONAL JOURNAL OF PRECISION ENGINEERING AND MANUFACTURING-GREEN TECHNOLOGY
(2023)
Article
Physics, Applied
Junhyeok Choi, Yong Min Lee, Sung Yeol Kim
Summary: This study demonstrates a multiphysics model that replicates the cracking of silicon nanoparticles in battery applications. Different types of cracks are induced by different charging rates, with the critical rates rapidly decreasing as the particle radius increases. The results provide guidance for the fabrication and operation of silicon nanoparticle-based anodes for lithium ion batteries, in agreement with previous experimental findings.
APPLIED PHYSICS LETTERS
(2023)