Article
Biochemistry & Molecular Biology
Mona A. Eldosoky, Reham Hammad, Asmaa A. Elmadbouly, Reda Badr Aglan, Sherihan G. Abdel-Hamid, Mohamed Alboraie, Donia Ahmed Hassan, Mohamed A. Shaheen, Areej Rushdi, Reem M. Ahmed, Alzahra Abdelbadea, Neamat A. Abdelmageed, Ahmed Elshafei, Elham Ali, Omaima I. Abo-Elkheir, Samy Zaky, Nadia M. Hamdy, Claude Lambert
Summary: Early HCC diagnosis is challenging, especially for AFP-negative cases. miRNA profiles may serve as potential molecular markers for HCC. This study aimed to evaluate the expression levels of four miRNAs (hsa-miR-21-5p, hsa-miR-155-5p, hsa-miR-192-5p, and hsa-miR-199a-5p) as biomarkers for HCC in CHCV patients with liver cirrhosis, particularly AFP-negative HCC cases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Oncology
Liang Chen, Kangyu Wang, Lei Li, Baibing Zheng, Qianru Zhang, Fang Zhang, Jinlong Chen, Shiwen Wang
Summary: This study investigated the diagnostic value of exosomal miRNAs in epithelial ovarian cancer (EOC). Plasma exosomes were isolated from EOC patients and healthy controls, and the expression of exosomal miRNAs was detected. Three miRNAs, miR-1260a, miR-7977, and miR-192-5p, were found to have potential diagnostic and prognostic value for EOC. The combination of these three exosomal miRNAs showed a high area under the curve, indicating good diagnostic efficiency. Additionally, the level of exosomal miR-7977 was correlated with the neutrophil-lymphocyte ratio, which decreased in EOC patients with a high ratio.
Article
Oncology
Shiwen Wang, Xingguo Song, Kangyu Wang, Baibing Zheng, Qinghai Lin, Miao Yu, Li Xie, Liang Chen, Xianrang Song
Summary: This study validated the diagnostic accuracy of exosomal miR-320d, miR-4479, and miR-6763-5p as potential biomarkers for EOC.
FRONTIERS IN ONCOLOGY
(2022)
Article
Cell Biology
Jing Cai, Lanqing Gong, Guodong Li, Jing Guo, Xiaoqing Yi, Zehua Wang
Summary: Poor prognosis of ovarian cancer is mainly due to metastasis, with ascites-derived exosomes playing a role in promoting metastasis through epithelial-mesenchymal transition. The key microRNA miR-6780b-5p in ADEs facilitates cancer metastasis by promoting EMT in ovarian cancer cells, indicating a potential mechanism for ovarian cancer progression.
CELL DEATH & DISEASE
(2021)
Article
Oncology
Sofia Elena Tesolato, Daniel Gonzalez-Gamo, Ana Barabash, Paula Claver, Sofia Cristina de la Serna, Inmaculada Dominguez-Serrano, Jana Dziakova, Carmen de Juan, Antonio Jose Torres, Pilar Iniesta
Summary: This study aims to analyze and correlate the expression levels of four miRNAs associated with cancer and obesity in colorectal cancer (CRC) patients and a control group. The results indicate the significance of hsa-miR-143-3p and hsa-miR-181a-5p in the clinical management of CRC.
Article
Immunology
Yeuni Yu, Sohee Park, Hansong Lee, Eun Jung Kwon, Hae Ryoun Park, Yun Hak Kim, Seung-Geun Lee
Summary: This study aimed to develop potential biomarkers for rheumatoid arthritis (RA) by sequencing small non-coding RNA (sncRNA) in circulating exosomes. The expression levels of hsa-miR-335-5p and hsa-miR-486-5p were found to be higher in RA patients compared to healthy controls, while the expression of the SRSF4 gene was decreased. These findings suggest that circulating exosomal miRNAs and SRSF4 could serve as valuable biomarkers for RA.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Rahul D. Kamdar, Brittney S. Harrington, Emma Attar, Soumya Korrapati, Jyoti Shetty, Yongmei Zhao, Bao Tran, Nathan Wong, Carrie D. House, Christina M. Annunziata
Summary: Epithelial ovarian cancer (EOC) is the fifth leading cause of cancer-related death in women worldwide, and chemoresistant, stem-like tumor-initiating cells (TICs) contribute to disease relapse. The NF-κB pathway and its transcription factors (RelA and RelB) have been found to promote TIC survival and chemoresistance. This study demonstrates that NF-κB signaling differentially regulates miRNA expression through RelA and RelB in EOC cells, and the miRNAs, hsa-miR-452-5p and hsa-miR-335-5p, play a role in TIC persistence. These findings provide new insights into preventing EOC recurrence.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Oncology
Wenyan Liao, Jun He, Cyrollah Disoma, Yi Hu, Junhua Li, Guodong Chen, Ying Sheng, Xinyu Cai, Chuanfu Li, Kai Cheng, Chunfen Yang, Yongxi Qin, Dong Han, Wu Wen, Chengming Ding, Mujun Li
Summary: This study demonstrated that hsa_circ_0107593 has low expression in cervical cancer tissues and cell lines, negatively correlated with tumor characteristics, and inhibits cell proliferation, migration, and invasion. It may serve as a diagnostic biomarker due to its tumor-suppressing activity by sponging hsa-miR-20a-5p, hsa-miR-93-5p, and hsa-miR-106b-5p in cervical cancer.
FRONTIERS IN ONCOLOGY
(2021)
Article
Cell Biology
Gaoming Wang, Ludi Yang, Miao Hu, Renhao Hu, Yongkun Wang, Bo Chen, Xiaohua Jiang, Ran Cui
Summary: The study identified hsa-miR-100-5p as the only dysregulated miRNA in STAD samples and established a miR-100-5p-related prognostic signature. Differences in tumor immune environment and drug sensitivity between high- and low-risk groups were also observed. External cohorts were evaluated to validate the robustness of the prognostic signature developed in this study, which may provide new ideas for individualized therapeutic strategies for STAD patients.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Hyeji Jeon, Su Min Seo, Tae Wan Kim, Jaesung Ryu, Hyejeong Kong, Si Hyeong Jang, Yong Soo Jang, Kwang Seock Kim, Jae Hoon Kim, Seongho Ryu, Seob Jeon
Summary: The aim of this study was to develop a new diagnostic biomarker for identifying specific serum exosomal miRNAs in epithelial ovarian cancer (EOC) and investigate the target gene of the miRNA to understand the molecular mechanisms involved. The results showed that miRNA-1290 was significantly overexpressed in serum exosomes and tissues of EOC patients compared to those with benign ovarian neoplasms. Furthermore, the study suggested that serum exosomal miR-1290 could be considered as a potential biomarker for differentiating EOC from benign ovarian neoplasms, and SOCS4 might be a potential target gene of miR-1290 in EOC.
CURRENT ISSUES IN MOLECULAR BIOLOGY
(2022)
Article
Oncology
Aliza Mohd Yacob, Nor Asiah Muhamad, Kian Meng Chang, Hamidah Akmal Hisham, Yuslina Mat Yusoff, Latifah Ibrahim
Summary: The study used Next Generation Sequencing (NGS) to identify microRNAs (miRNAs) at the molecular response in CML adult patients receiving TKIs treatment. Specific miRNAs showed significant expression in the treatment response of CML patients and may serve as new therapeutic biomarkers.
Article
Oncology
Yue Wu, Ting Wang, Lin Xia, Mei Zhang
Summary: The study identified the significant role of long non-coding RNA WDFY3-AS2 in ovarian cancer cells, showing its impact on cisplatin resistance by regulating the expression of miR-139-5p/SDC4. Additionally, WDFY3-AS2 was found to have a promoting effect on cell proliferation, migration, and invasion.
CANCER CELL INTERNATIONAL
(2021)
Article
Multidisciplinary Sciences
Min Liu, Fei Mo, Xiaohan Song, Yun He, Yan Yuan, Jiaoyan Yan, Ye Yang, Jian Huang, Shu Zhang
Summary: The study utilized comprehensive bioinformatics analysis and experimental validation to identify hsa-miR-21-5p as significantly up-regulated in breast cancer tissues, cells, and exosomes. Further investigations confirmed the diagnostic value of plasma exosomal hsa-miR-21-5p in distinguishing healthy individuals from breast cancer patients, with a sensitivity of 86.7% and specificity of 93.3%.
Article
Biochemistry & Molecular Biology
Jovana Despotovic, Sandra Dragicevic, Aleksandra Nikolic
Summary: This study examined the impact of chemotherapy on TGF-beta signaling and related miRNAs in mCRC, finding time-dependent alterations in the expression of several miRNAs in SW620 cells. The long-term downregulation pattern of hsa-miR-93-5p and hsa-miR-17-5p could potentially serve as biomarkers for monitoring treatment response in mCRC patients undergoing combined chemotherapy.
CELL BIOCHEMISTRY AND BIOPHYSICS
(2021)
Article
Biotechnology & Applied Microbiology
Shanqiang Qu, Ouwen Qiu, Jing Huang, Jin Liu, Huafu Wang
Summary: The study found that hsa-miR-196a-5p is upregulated in glioma and is associated with patient age, WHO grade, histopathology, IDH mutation status, and 1p/19q codeletion. Overexpression of hsa-miR-196a-5p may be involved in MAPK signaling, focal adhesion, and cancer-related pathways.
Article
Oncology
Aferin Beilerli, Ilgiz Gareev, Ozal Beylerli, Guang Yang, Valentin Pavlov, Gjumrakch Aliev, Aamir Ahmad
Summary: CircRNAs are closed non-coding RNA molecules formed by reverse splicing of mRNAs, and they play important roles in regulating diseases, especially cancer. They function through sequestering miRNAs and proteins, regulating gene transcription, and affecting cellular functions. Aberrant expression of circRNAs in pathological conditions suggests their potential value as diagnostic and therapeutic targets.
SEMINARS IN CANCER BIOLOGY
(2022)
Article
Oncology
Shaniya Ahmad, Madiha Abbas, Mohammad Fahad Ullah, Moammir H. Aziz, Ozal Beylerli, Majid Ali Alam, Mansoor Ali Syed, Shahab Uddin, Aamir Ahmad
Summary: The role of long non-coding RNAs (lncRNAs) in cancer metastasis, particularly in the context of NF-kappa B signaling and epithelial-mesenchymal transition (EMT), is a hot topic of research. NKILA has emerged as a well-studied lncRNA that regulates NF-kappa B and inhibits EMT-induced metastasis. lncRNAs like FOXD2-AS1, KRT19P3, MALAT1, SNHG15, CRNDE, and AC007271.3 are also implicated in the regulation of NF-kappa B signaling and cancer metastasis.
SEMINARS IN CANCER BIOLOGY
(2022)
Article
Chemistry, Medicinal
Svetlana Meshcheryakova, Alina Shumadalova, Ozal Beylerli, Ilgiz Gareev, Shiguang Zhao, Jianing Wu
Summary: Researchers proposed developing new antibiotic compounds based on known natural substances to tackle the issue of antimicrobial resistance. By reengineering natural products, they obtained 12 new uracil S-derivatives with high in vitro antimicrobial properties against various bacteria, with some showing MIC values of 0.1-10 micrograms per milliliter.
DRUG DEVELOPMENT RESEARCH
(2022)
Article
Public, Environmental & Occupational Health
Liang Yanchao, Zhang Sibin, Ilgiz Gareev, Xiang Huan, Zhao Junfei, Liu Chunyang, Ozal Beylerli, Albert Sufianov, Yuan Chao, Gai Yuyan, Xu Xun, Aamir Ahmad, Liang Peng, Yang Guang
Summary: This study analyzes the relationship between COVID-19 infection and carotid atherosclerosis patients, revealing the harm of novel coronavirus infection to carotid atherosclerosis patients and proposing potential treatment options and drugs.
JOURNAL OF INFECTION AND PUBLIC HEALTH
(2022)
Review
Cell Biology
Galina Sufianova, Ilgiz Gareev, Ozal Beylerli, Jianing Wu, Alina Shumadalova, Albert Sufianov, Xin Chen, Shiguang Zhao
Summary: Polyphenols are beneficial compounds synthesized by plants that have antioxidant and anti-inflammatory effects. They help fight cell damage and have a potential preventive effect on certain forms of cancer by influencing the complex processes of tumor development.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Review
Cell Biology
Ozal Beylerli, Aferin Beilerli, Alina Shumadalova, Xiaoxiong Wang, Mingchun Yang, Hanran Sun, Lei Teng
Summary: Glioblastoma is a common and aggressive tumor of the central nervous system with limited treatment options, and combination therapies may be more effective. Natural polyphenolic compounds show potential as anticancer drugs, but their effectiveness is limited by bioavailability and blood-brain barrier permeability.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Albert Sufianov, Sema Begliarzade, Tatiana Ilyasova, Yanchao Liang, Ozal Beylerli
Summary: This review examines the changes in micro-RNA expression profiles characteristic of gliomas, particularly in the context of glioblastoma (GBM). The functions of miRNAs in GBM pathways linked to dysregulation of cell cycle control, apoptosis, and resistance to treatment are summarized, along with the potential use of miRNAs as biomarkers in clinical settings.
NON-CODING RNA RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Irina Gilyazova, Elizaveta Ivanova, Valentin Pavlov, Guzel Khasanova, Aliya Khasanova, Adel Izmailov, Dilara Asadullina, Gulshat Gilyazova, Guoqing Wang, Ilgiz Gareev, Ozal Beylerli, Elza Khusnutdinova
Summary: The study analyzed the expression levels of miRNA-146a, miRNA-126, miRNA-218, miRNA-410, miRNA-503, and miRNA-155 in HFRS patients at different stages and with different severity. The results showed that miRNA-155 and miRNA-146a may be potential prognostic biomarkers in HFRS. Further investigations are needed to evaluate the changes in miRNA expression and the network of genes that can be potential targets for the studied miRNAs in order to elucidate the molecular mechanisms that can influence the occurrence and development of HFRS.
NON-CODING RNA RESEARCH
(2023)
Review
Biochemistry & Molecular Biology
Albert Sufianov, Sema Begliarzade, Valentin Kudriashov, Aferin Beilerli, Tatiana Ilyasova, Yanchao Liang, Ozal Beylerli
Summary: Circular RNAs, as non-coding RNAs, play an important role in the development of tumors, neurological diseases, and cardiovascular diseases. Research progress in the field of oral squamous cell carcinoma provides new insights for its biological treatment.
NON-CODING RNA RESEARCH
(2023)
Review
Biochemistry & Molecular Biology
Albert Sufianov, Aferin Beilerli, Sema Begliarzade, Tatiana Ilyasova, Valentin Kudriashov, Yanchao Liang, Ozal Beylerli
Summary: Human periodontal ligament-derived cells are important seed cells for periodontal regeneration, and their osteogenic potential is regulated by noncoding RNAs. Noncoding RNAs play a significant role in the regulation of osteogenic differentiation of human periodontal ligament-derived cells.
NON-CODING RNA RESEARCH
(2023)
Review
Biochemistry & Molecular Biology
Albert Sufianov, Sema Begliarzade, Aferin Beilerli, Yanchao Liang, Tatiana Ilyasova, Ozal Beylerli
Summary: Lung cancer is a major cause of death and morbidity globally. Both smoking and epigenetic/genetic mechanisms contribute to its development. Circular RNAs (circRNAs) play a significant role in the diagnosis, treatment, and prognosis of lung cancer, providing potential therapeutic targets and molecular markers.
NON-CODING RNA RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Polat Ipek, Resit Yildiz, Mehmet Firat Baran, Abdulkerim Hatipoglu, Ayse Baran, Albert Sufianov, Ozal Beylerli
Summary: In recent decades, there has been an increasing research interest in metal nanoparticles as alternatives to cancer treatments and antibiotics. This article presents a comprehensive characterization of silver nanoparticles (AgNPs) produced from Papaver rhoeas leaf extract using various spectroscopic, microscopic, structural, and analytic techniques. The study reveals that PR-AgNPs are spherical with a maximum surface plasmon resonance of 464.03 nm, and have high thermal stability and antibacterial activity. The cytotoxic and proliferative effects of PR-AgNPs on various cancer cell lines are also evaluated. The findings highlight the potential of PR-AgNPs in nanomedicine and nanochemistry.
Article
Medicine, Research & Experimental
I. R. Gilyazova, E. A. Ivanova, A. N. Khasanova, G. M. Khasanova, A. A. Izmailov, R. Ya Safikhanov, I. F. Gareev, O. A. Beylerli, D. A. Valishin, R. F. Khusnarizanova, S. Sh Galimova, Wang Guoqing, Huang Honglan, Pan Jiahui, Shao Tong, Yao Haochen, Wang Wenfang, V. N. Pavlov, E. K. Khusnutdinova
Summary: The association between polymorphic variants of miRNA-146a, miRNA-218, miRNA-410, miRNA-503 target genes and hemorrhagic fever caused by PUUV infection was studied. The genotype rs1127327*AA of the CCDC6 gene was found to be associated with a reduced risk of severe disease. Further investigation is needed to understand the molecular mechanisms underlying the effect of miRNA target genes on the onset and progression of HFRS.
YAKUT MEDICAL JOURNAL
(2022)
Article
Biology
Ilgiz Gareev, Ozal Beylerli, Chunlei Wang, Andrei Sokhatskii, Yanchao Liang, Huan Xiang, Chunyang Liu, Xun Xu, Yang Guang
Summary: This review summarizes the roles of miRNAs in the pathogenesis of brain AVMs and discusses their potential clinical application as non-invasive biomarkers.
