Article
Endocrinology & Metabolism
Javiera Cortes-Rios, Maria Rodriguez-Fernandez
Summary: The timing of antihypertensive medications affects the long-term cardiovascular risk of hypertensive individuals. However, the underlying causes and mechanisms of this timing-dependent antihypertensive effect are not yet understood.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Jiayang Zhang, Ruoyu Sun, Tingting Jiang, Guangrui Yang, Lihong Chen
Summary: Blood pressure follows a circadian rhythm, with disruptions potentially leading to worsened cardiovascular and renal outcomes. This review summarizes current understanding of the circadian blood pressure regulation and provides a therapeutic overview of its relationship to cardiovascular and renal health and disease.
Review
Peripheral Vascular Disease
Takahiro Komori, Satoshi Hoshide, Yuda Turana, Guru Prasad Sogunuru, Kazuomi Kario
Summary: Cognitive impairment (CI) is a common comorbidity in heart failure (HF) patients and is associated with increased cardiovascular events and death. There are numerous factors that contribute to CI in HF patients, including decreased cerebral blood flow, inflammation, and activation of neurohumoral factors. Abnormal circadian blood pressure rhythm is also associated with CI.
HYPERTENSION RESEARCH
(2023)
Article
Endocrinology & Metabolism
Xinyi Sun, Weiwei Yu, Mingsi Wang, Jun Hu, Yunong Li
Summary: In this study, the relationships between rest-activity rhythm (RAR) and various domains of cognitive function in older Americans were examined. The results showed that weakened and/or disrupted RAR were associated with cognitive decline in different domains in Americans over the age of 60.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Peripheral Vascular Disease
Natasha Morales-Ghinaglia, Michael Larsen, Fan He, Susan L. Calhoun, Alexandros N. Vgontzas, Jason Liao, Duanping Liao, Edward O. Bixler, Julio Fernandez-Mendoza
Summary: The circadian timing of sleep, specifically sleep midpoint and regularity, can modify the association between visceral adiposity and elevated blood pressure in adolescents. Deviations in sleep irregularity during school days and sleep midpoint during break days can increase the impact of visceral adipose tissue on elevated blood pressure. These findings suggest the importance of considering the circadian timing of sleep in relation to cardiovascular health in adolescents.
Article
Clinical Neurology
Chris Ho Ching Yeung, Cici Bauer, Qian Xiao
Summary: People with disrupted circadian rhythms, such as shift workers, have a higher risk of hypertension. This study found an association between weakened rest-activity rhythms and higher odds of hypertension, providing insight into preventing hypertension and cardiovascular diseases.
JOURNAL OF SLEEP RESEARCH
(2023)
Article
Medicine, Research & Experimental
Masayo Koide, Osama F. Harraz, Fabrice Dabertrand, Thomas A. Longden, Hannah R. Ferris, George C. Wellman, David C. Hill-Eubanks, Adam S. Greenstein, Mark T. Nelson
Summary: Chronic hypertension disrupts brain microcirculation by reducing the activity of the capillary endothelial cell inward-rectifier potassium channel Kir2.1. Amlodipine, a calcium channel blocker, but not losartan, an angiotensin II type 1 receptor blocker, can prevent hypertension-related damage to functional hyperemia. The losartan-induced aldosterone breakthrough may lead to elevated plasma aldosterone levels and contribute to the decline in functional hyperemia.
JOURNAL OF CLINICAL INVESTIGATION
(2021)
Article
Anesthesiology
Barak Cohen, Eva Rivas, Xuan Pu, Kamal Maheshwari, Jorge A. Araujo-Duran, Oguz Turan, Andrew Volio, Esra Kutlu Yalcin, Alparslan Turan
Summary: Abnormal diurnal blood pressure patterns are common in adults during the initial 2 days after abdominal surgery, lack of normal night-time decrease in blood pressure is associated with less postoperative hypotension.
JOURNAL OF CLINICAL ANESTHESIA
(2022)
Article
Biochemistry & Molecular Biology
Siofra O. Murdoch, Eleonora M. Aiello, Francis J. Doyle III
Summary: Investigated the effects of different neurological pharmaceuticals on the dynamics of circadian phase and achieved control of the circadian oscillatory system through the development and validation of transport models and the design of a phase resetting framework.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Cell Biology
Zainab Taleb, Phillip Karpowicz
Summary: The circadian clock is a molecular timekeeper that regulates 24-hour rhythms in animals, impacting behavior and physiology, including metabolic and digestive systems. Animal models targeting circadian clock genes have shown their role in regulating liver diseases, inflammatory bowel disease, colorectal cancer, and obesity. Thus, the circadian clock plays a crucial role in maintaining metabolic and digestive health.
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
(2022)
Article
Clinical Neurology
Yiwen Xu, Chen Gong, Jingxian Liao, Zhonglin Ge, Yu Tan, Yi Jiang, Mengqian Liu, Wen Zhong, Xianxian Zhang, Nan Dong, Xiaozhu Shen
Summary: This study aimed to investigate whether the disturbance of circadian rhythm of blood pressure can affect the cognitive function of patients with CSVD. The results showed that patients with atypical circadian rhythm of blood pressure, especially non-dipper and reverse-dipper types, had a higher risk of cognitive dysfunction.
Article
Multidisciplinary Sciences
Tianfei Hou, Wen Su, Marilyn J. Duncan, Vsevolozhskaya A. Olga, Zhenheng Guo, Ming C. Gong
Summary: The study reveals that restricting the timing of food intake can prevent nondipping blood pressure in diabetic mice and effectively restore disrupted blood pressure circadian rhythm.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Oncology
William H. Walker, Samuel A. Sprowls, Jacob R. Bumgarner, Jennifer A. Liu, O. Hecmarie Melendez-Fernandez, James C. Walton, Paul R. Lockman, A. Courtney DeVries, Randy J. Nelson
Summary: Chemotherapy is more effective in treating peripheral tumors than brain metastases due to the limited ability of chemotherapy to cross the blood-brain barrier. Optimal timing of chemotherapy can enhance anti-tumor efficacy in brain metastases of breast cancer.
FRONTIERS IN ONCOLOGY
(2021)
Review
Peripheral Vascular Disease
Justine Huart, Alexandre Persu, Jean-Philippe Lengele, Jean-Marie Krzesinski, Francois Jouret, George S. Stergiou
Summary: The nondipping blood pressure pattern refers to an inadequate decrease in BP levels during nighttime sleep, disrupting the circadian BP rhythm as observed in 24-hour ambulatory BP monitoring. Patients with this pattern experience poorer renal and cardiovascular outcomes regardless of their average 24-hour BP levels. The pathophysiology of nondipping BP involves disruptions in circadian rhythm, autonomic nervous system, and water and sodium regulation, and recent research has also suggested a potential role of gut microbiota in this pattern.
Review
Peripheral Vascular Disease
Hannah M. Costello, Michelle L. Gumz
Summary: The molecular circadian clock is crucial in blood pressure control, with central and peripheral clocks playing a key role. Dysregulation of the circadian rhythm of blood pressure is associated with adverse cardiorenal outcomes and increased risk of cardiovascular mortality. Understanding peripheral clock function in regulating the circadian rhythm of blood pressure will pave the way for targeted therapeutics in circadian blood pressure dysregulation and hypertension.
Article
Medicine, Research & Experimental
Sergey Deyev, Anzhelika Vorobyeva, Alexey Schulga, Galina Proshkina, Rezan Guler, John Lofblom, Bogdan Mitran, Javad Garousi, Mohamed Altai, Jos Buijs, Vladimir Chernov, Anna Orlova, Vladimir Tolmachev
MOLECULAR PHARMACEUTICS
(2019)
Article
Multidisciplinary Sciences
Anzhelika Vorobyeva, Alexey Schulga, Elena Konovalova, Rezan Guler, John Lofblom, Mattias Sandstrom, Javad Garousi, Vladimir Chernov, Olga Bragina, Anna Orlova, Vladimir Tolmachev, Sergey M. Deyev
SCIENTIFIC REPORTS
(2019)
Article
Chemistry, Medicinal
M. S. Lar'kina, S. V. Krivoshchekov, E. V. Podrezova, O. D. Bragina, V. I. Chernov, E. A. Nesterov, V. V. Bodenko, M. V. Belousov, M. S. Yusubov
PHARMACEUTICAL CHEMISTRY JOURNAL
(2019)
Article
Medicine, General & Internal
Vladimir I. Chernov, Evgeniy L. Choynzonov, Denis E. Kulbakin, Elena V. Obkhodskaya, Artem V. Obkhodskiy, Aleksandr S. Popov, Victor I. Sachkov, Anna S. Sachkova
Article
Medicine, General & Internal
N. G. Chanchikova, V. Chernov, E. A. Dudnikova, E. A. Karlova, A. S. Savelyeva, O. A. Silkina, R. Zelchan, O. D. Bragin, A. A. Medvedeva, E. Berezneeva
Summary: The study aimed to evaluate the diagnostic value of F-18-FDG PET/CT for monitoring the effectiveness and prognosis of lymphoma therapy. Results showed that patients with PET2- had a higher rate of complete metabolic response and lower rate of recurrence, indicating that it can help predict treatment outcomes.
BYULLETEN SIBIRSKOY MEDITSINY
(2021)
Review
Chemistry, Multidisciplinary
Vladimir M. Tolmachev, Vladimir I. Chernov, Sergey M. Deyev
Summary: This article comprehensively reviews the key aspects of the design of radionuclide compounds, including classification, attachment methods, and characteristics. It compares the abilities of different targeting molecules, describes the latest achievements in increasing the selectivity of antitumor effects, particularly focusing on the creation of targeted radionanomaterials, and proposes approaches to improve delivery to tumors.
RUSSIAN CHEMICAL REVIEWS
(2022)
Article
Environmental Sciences
Natalia V. Efimova, Viktor S. Rukavishnikov
Summary: Climate change has led to an increase in wildfires, resulting in longer and larger fire seasons. The study assessed the air pollution and health risks caused by smoke exposure during fire season, with findings showing significant increases in pollutant concentrations during wildfire periods, with higher health risks in industrial centers similar to Bratsk.
Review
Medicine, General & Internal
R. Zelchan, A. A. Medvedeva, O. D. Bragina, A. N. Ribina, A. Ryabova, V. Chernov, E. L. Choynzonov
Summary: This review analyzes the global experience in the application of nuclear medicine techniques for diagnosis of brain tumors and non-tumor pathologies, comparing modern approaches and trends in the development of specific radiopharmaceuticals. It discusses the advantages and disadvantages of currently used techniques and radiopharmaceuticals for imaging central nervous system disorders, and provides recommendations for the use of nuclear medicine techniques in patients with brain tumors. Additionally, the review highlights the experience of domestic scientific schools in developing radiopharmaceuticals for neuro-oncology and neurodegenerative diseases.
BYULLETEN SIBIRSKOY MEDITSINY
(2021)
Article
Medicine, General & Internal
Olga G. Bogdanova, Natalia Efimova, Inna Yu Tarmaeva
Summary: The study revealed a high level of nitrate contamination in vegetable products in Baikalia, particularly in the Republic of Buryatia, posing unacceptable health risks to children. Further dynamic studies and monitoring are needed to develop predictive indicators for child health in the affected areas.
RUSSIAN OPEN MEDICAL JOURNAL
(2021)
Article
Environmental Sciences
Natalia Efimova, Viacheslav Paramonov, Viktor Rukavishnikov, Roman Fedorov, Gennadiy Ruzhnikov, Andrei Tsyrendorzhiyev
Summary: The latest forecasts indicate wildfire activity in many parts of the world, posing health risks to the population. Lack of digital decision-making systems makes it difficult to predict the impact and provide timely medical care. This study assesses health risks associated with sub-daily exposure to wildfire smoke near populated areas. The frequency of additional medical care requests ranged from 0.137 to 0.933 per 1000 population during the fire period in settlements with risk levels >0.01.
EMERGING CONTAMINANTS
(2023)
Meeting Abstract
Radiology, Nuclear Medicine & Medical Imaging
Anna Orlova, Ayman Abouzayed, Sara Rinne, Nadezhda Lushnikova, Evgeny Usynin, A. Doroshenko, Jesper Borin, Jens Sorensen, Vladimir Tolmachev, Vladimir Chernov, Anastasia Rybina
NUCLEAR MEDICINE AND BIOLOGY
(2022)
Proceedings Paper
Meteorology & Atmospheric Sciences
Viktor S. Rukavishnikov, Natalya Efimova, Viacheslav V. Paramonov, Roman K. Fedorov
Summary: Monitoring and analyzing data on environmental pollution during forest fires and their health impacts in different geographical areas is crucial for determining adverse health effects and identifying vulnerable population groups. A service-oriented geoportal system is being developed to assess the impact of air quality on public health. Specialized original services have been created to allow users to operate the file system on the server through their browsers.
27TH INTERNATIONAL SYMPOSIUM ON ATMOSPHERIC AND OCEAN OPTICS, ATMOSPHERIC PHYSICS
(2021)
Meeting Abstract
Radiology, Nuclear Medicine & Medical Imaging
Vladimir Tolmachev, Olga Bragina, Alexey Schulga, Elena Konovalova, Evgeniy Garbukov, Anzhelika Vorobyeva, Anna Orlova, Sergey Deyev, Vladimir Chernov
NUCLEAR MEDICINE AND BIOLOGY
(2021)
Article
Environmental Sciences
Valentina Grebenshchikova, Mikhail Kuzmin, Viktor S. Rukavishnikov, Natalia Efimova, Irina Donskikh, Artemiy A. Doroshkov
Summary: The study investigated soil pollution in two urban areas of the Baikal region in Russia, focusing on the impact of industrial activities, particularly aluminum and cable plants. It also examined the effect of fluorite in the environment on children's health, revealing elevated levels of aluminum, sodium, beryllium, and lithium in high fluoride content regions.
AIR SOIL AND WATER RESEARCH
(2021)
Article
Social Sciences, Interdisciplinary
Natalya S. Efimova, Vyacheslav D. Kalachanov
AMAZONIA INVESTIGA
(2019)
