Review
Biochemistry & Molecular Biology
Adriana Fodor, Andrada Luciana Lazar, Cristina Buchman, Brandusa Tiperciuc, Olga Hilda Orasan, Angela Cozma
Summary: MetS is a complex entity that increases the risk of various diseases, including type two diabetes, cardiovascular diseases, and certain types of cancer. miRNAs play an important role in cancer genesis, progression, and metastasis, and the altered secretion of miRs in adipose tissue may explain their involvement in oncogenesis. The interaction between miRs expressed in adipose tissue, their dysregulation, and cancer pathogenesis are still intriguing, as miRNAs exhibit both carcinogenic and tumor suppressor effects.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biology
Il-Kwon Kim, Byeong-Wook Song, Soyeon Lim, Sang-Woo Kim, Seahyoung Lee
Summary: Cardiovascular diseases are the leading cause of death worldwide, and obesity is a known risk factor. Epicardial adipose tissue has been identified as an important factor in the development of cardiovascular disease. This review summarizes differentially expressed miRNAs in human epicardial adipose tissue under pathologic conditions, focusing on their targets and roles in tissue regulation. The study suggests that epicardial adipose tissue-derived miRNAs have potential diagnostic and therapeutic applications in cardiovascular diseases, but further research is needed to understand their overall impact and potential risks.
Article
Cardiac & Cardiovascular Systems
Hui Chen, Lei Liu, Min Li, Danjun Zhu, Gang Tian
Summary: This study found that epicardial adipose tissue (EAT) of metabolic syndrome (MetS) rats accumulated dysfunctional adipokines, leading to cardiac dysfunction. The EAT-derived leptin induced myocardial injury in MetS rats through the PKC/NADPH oxidase/ROS pathway by promoting mitochondrial oxidative stress and dysfunction, as well as stimulating inflammation by promoting activator protein 1 nuclear translocation.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2023)
Article
Biochemistry & Molecular Biology
Oscar Osorio-Conles, Arturo Vega-Beyhart, Ainitze Ibarzabal, Jose Maria Balibrea, Josep Vidal, Ana de Hollanda
Summary: The metabolic syndrome is a cluster of dangerous heart attack risk factors. This study compares the dysfunction of obesity-associated white adipose tissue (WAT) between women with severe obesity with or without metabolic syndrome. The results show that women with metabolic syndrome exhibit greater adipocyte hypertrophy, increased fibrosis, and higher expression of macrophage and hypoxia markers in subcutaneous adipose tissue.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Multidisciplinary Sciences
Iokfai Cheang, Xu Zhu, Xin Yue, Yuan Tang, Yujie Gao, Xinyi Lu, Shi Shi, Shengen Liao, Wenming Yao, Yanli Zhou, Haifeng Zhang, Yinsu Zhu, Yi Xu, Xinli Li
Summary: The purpose of this study was to investigate the prognostic values of ventricle epicardial fat volume (EFV) in patients with chronic heart failure (CHF) using cardiac magnetic resonance. A total of 516 CHF patients were recruited, and 136 (26.4%) of them experienced major adverse cardiovascular events (MACE) within a median follow-up of 24 months. The study found that EFV was significantly associated with MACE and showed promising predictive ability for MACE at different time points.
Review
Biochemistry & Molecular Biology
Sara Leo, Elena Tremoli, Letizia Ferroni, Barbara Zavan
Summary: Obesity and insulin resistance are risk factors for cardiovascular diseases, associated with inflamed and defective adipose tissue. Extracellular vesicles, involved in insulin resistance, diabetes, and CVDs, play a role in the onset and development of these pathologies. Inflammation triggers the transition of adipose tissue secretome, leading to an increase in pro-inflammatory mediators.
Article
Cardiac & Cardiovascular Systems
Maria Ines Rosa, Antonio Jose Grande, Leticia Dorsa Lima, Eduardo Ronconi Dondossola, Maria Laura Rodrigues Uggioni, Adrian Hernandez, Gary Tse, Tong Liu, Octavio Marques Pontes-Neto, Giuseppe Biondi-Zoccai, Mansueto Gomes Neto, Andre Rodrigues Duraes, Michel Pompeu B. O. Sa, Elmiro Santos Resende, Leonardo Roever
Summary: Epicardial adipose tissue (EAT) is correlated with increased risk of stroke, possibly related to stroke episodes; regardless of imaging methods, the association between EAT and stroke remains; metabolic syndrome and atrial fibrillation may increase the risk of stroke.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Article
Nutrition & Dietetics
Muhei Tanaka, Hiroshi Okada, Yoshitaka Hashimoto, Muneaki Kumagai, Hiromi Nishimura, Michiaki Fukui
Summary: This study found that intraperitoneal VAT (IVAT) and retroperitoneal VAT (RVAT) are differently associated with the prevalence of metabolic syndrome (MS) and its components. IVAT area index was independently associated with MS and its components, while RVAT area index was only associated with the blood pressure component.
CLINICAL NUTRITION
(2021)
Article
Food Science & Technology
Rosario Pardo, Marc Velilla, Laura Herrero, Luis Cervela, Marcelo L. Ribeiro, Rafael Simo, Josep A. Villena
Summary: Calorie restriction (CR) and SIRT1 have distinct yet converging effects on white adipose tissue (WAT) gene expression, with CR enhancing mitochondrial biogenesis and reducing WAT inflammation, while SIRT1 downregulates extracellular matrix-related gene networks. These findings suggest that while SIRT1 may not mediate most of CR's effects on WAT gene expression, the two pathways work together to ameliorate WAT inflammation.
MOLECULAR NUTRITION & FOOD RESEARCH
(2021)
Article
Endocrinology & Metabolism
Lucia Baila-Rueda, Ana Cenarro, Itziar Lamiquiz-Moneo, Victoria Marco-Benedi, Irene Gracia-Rubio, Maria Carmen Casamayor-Franco, Jose M. Arbones-Mainar, Fernando Civeira, Martin Laclaustra
Summary: This study found that cholesterol and oxidized metabolites in adipose tissue are associated with metabolic characteristics. Insulin is positively correlated with hydroxycholesterol, and leptin is also positively correlated with hydroxycholesterol. There is a positive correlation between tissue cholesterol and hydroxycholesterol.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Multidisciplinary Sciences
Yuki Komatsu, Kiyoshi Aoyama, Mamoru Yoneda, Shogo Ito, Yusuke Sano, Yumeno Kawai, Xixi Cui, Yuichiro Yamada, Nozomi Furukawa, Katsuhide Ikeda, Kohzo Nagata
Summary: The removal of interscapular brown adipose tissue (iBAT) attenuated the exacerbation of cardiac inflammation and fibrosis induced by salt loading in DS/obese rats, but did not affect the development of hypertension. Salt loading led to adipocyte hypertrophy and increased inflammation in white adipose tissue, while the conversion of iBAT to white adipose tissue-like tissue contributed to elevated levels of circulating interleukin-6, exacerbating cardiac pathology.
ANNALS OF THE NEW YORK ACADEMY OF SCIENCES
(2021)
Article
Cardiac & Cardiovascular Systems
Takashi Kataoka, Ken Harada, Akihito Tanaka, Tomohiro Onishi, Shun Matsunaga, Hiroshi Funakubo, Kazuhiro Harada, Tomoyuki Nagao, Norihiro Shinoda, Nobuyuki Marui, Kiyoshi Niwa, Hiroshi Tashiro, Yusuke Hitora, Kenji Furusawa, Hideki Ishii, Tetsuya Amano, Toyoaki Murohara
Summary: The study found that Epicardial adipose tissue (EAT) volume is significantly associated with coronary artery spasm, while total abdominal adipose tissue (AAT) may not have a significant impact.
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2021)
Article
Physiology
Qian-Chen Wang, Zhen-Yu Wang, Qian Xu, Ruo-Bing Li, Guo-Gang Zhang, Rui-Zheng Shi
Summary: This study compared the histological and gene expression differences of epicardial adipose tissue (EAT) between patients with and without coronary artery disease (CAD). The CAD group showed larger epicardial adipocytes and a total of 747 differentially expressed genes (DEGs) were identified in CAD EAT, with more pro-inflammatory and immunological genes and pathways involved. Ten hub DEGs were also identified. EAT in CAD exhibits unique gene expression profiles and may play a key role in the pathological process of CAD.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Jose Ignacio Martinez-Montoro, Luis Ocana-Wilhelmi, Rocio Soler-Humanes, Hanieh Motahari-Rad, Andres Gonzalez-Jimenez, Jose Rivas-Becerra, Alba Rodriguez-Munoz, Francisco J. Moreno-Ruiz, Monica Tome, Jorge Rodriguez-Capitan, Eduardo Garcia-Fuentes, Francisco J. Tinahones, Lourdes Garrido-Sanchez, Mora Murri
Summary: ZAG, an adipokine involved in adipocyte metabolism, has been found to be associated with metabolic parameters in obese patients. Lower levels of SAT and VAT ZAG expression are related to adverse metabolic profiles. However, the baseline expression of ZAG did not seem to affect the outcomes of bariatric surgery.
Article
Cardiac & Cardiovascular Systems
Andrew Lin, Nathan D. Wong, Aryabod Razipour, Priscilla A. McElhinney, Frederic Commandeur, Sebastien J. Cadet, Heidi Gransar, Xi Chen, Stephanie Cantu, Robert J. H. Miller, Nitesh Nerlekar, Dennis T. L. Wong, Piotr J. Slomka, Alan Rozanski, Balaji K. Tamarappoo, Daniel S. Berman, Damini Dey
Summary: Metabolic syndrome, NAFLD, and AI-based EAT measures are predictors of long-term MACE risk in asymptomatic individuals, with potential for improving cardiovascular risk stratification in routine reporting of CAC scoring CT.
CARDIOVASCULAR DIABETOLOGY
(2021)
Editorial Material
Cardiac & Cardiovascular Systems
Andrea Giulio Quarti, Emanuela Angeli, Francesco Dimitri Petridis, Lucio Careddu, Valeria Mangerini, Gaetano Domenico Gargiulo
ANNALS OF THORACIC SURGERY
(2022)
Letter
Gastroenterology & Hepatology
Zoe Hall, Fiona Oakley, Michele Vacca, Julian L. Griffin
Article
Cardiac & Cardiovascular Systems
Lucio Careddu, Emanuela Angeli, Elisabetta Mariucci, Andrea Giulio Quarti, Antonino Loforte, Francesco Dimitri Petridis, Valeria Francesca Mangerini, Andrea Donti, Gaetano Domenico Gargiulo
Summary: The study reports a rare case of successful staged treatment of partial anomalous pulmonary venous return into the azygous vein in a 28-year-old girl. By occluding the proximal part of the azygous vein with a percutaneous approach, and then redirecting the azygous vein flow into the left atrium through surgery, this rare congenital heart disease was effectively treated.
JOURNAL OF CARDIAC SURGERY
(2022)
Article
Nutrition & Dietetics
Carlo De Matteis, Lucilla Crudele, Marica Cariello, Stefano Battaglia, Giuseppina Piazzolla, Patrizia Suppressa, Carlo Sabba, Elena Piccinin, Antonio Moschetta
Summary: This study investigated the association between vitamin D levels and inflammatory status in a population of adults. The results showed an inverse relationship between vitamin D levels and the monocytes-to-high density lipoprotein ratio (MHR). When stratified by gender and body composition, men showed a significant relationship only in cases of central obesity, while women exhibited a lifelong negative correlation between circulating vitamin D levels and MHR, regardless of metabolic status.
Article
Biochemistry & Molecular Biology
Gabriele Mocciaro, Simona D'Amore, Benjamin Jenkins, Richard Kay, Antonio Murgia, Luis Vicente Herrera-Marcos, Stefanie Neun, Alice P. Sowton, Zoe Hall, Susana Alejandra Palma-Duran, Giuseppe Palasciano, Frank Reimann, Andrew Murray, Patrizia Suppressa, Carlo Sabba, Antonio Moschetta, Albert Koulman, Julian L. Griffin, Michele Vacca
Summary: Metabolic syndrome (MetS) is characterized by cardiovascular risk factors such as central obesity and atherogenic dyslipidemia. This study used an integrated omics approach to study lipoprotein remodeling and HDL composition in subjects with MetS. The results showed abnormal lipid levels and impaired phospholipid metabolism in HDL, which may be related to the decreased activity of lecithin cholesterol acyltransferase (LCAT).
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Nutrition & Dietetics
Carlo De Matteis, Lucilla Crudele, Stefano Battaglia, Tiziana Loconte, Arianna Rotondo, Roberta Ferrulli, Raffaella Maria Gadaleta, Giuseppina Piazzolla, Patrizia Suppressa, Carlo Sabba, Marica Cariello, Antonio Moschetta
Summary: Adherence to the Mediterranean diet is associated with reduced mortality, particularly in individuals with cardiovascular disease, obesity, and diabetes. Existing validated Mediterranean diet scores did not show a significant association with adiposity, leading to the proposal of a new questionnaire, the Chrono Med-Diet score (CMDS), which focuses on dietary chronobiology and physical activity. CMDS was found to be linked to increased waist circumference, dysmetabolic conditions, cardiovascular risk, and Fatty Liver Index.
Article
Infectious Diseases
Davide Fiore Bavaro, Nicolo De Gennaro, Alessandra Belati, Lucia Diella, Roberta Papagni, Luisa Frallonardo, Michele Camporeale, Giacomo Guido, Carmen Pellegrino, Maricla Marrone, Alessandro Dell'Erba, Loreto Gesualdo, Nicola Brienza, Salvatore Grasso, Giuseppe Columbo, Antonio Moschetta, Giovanna Elisiana Carpagnano, Antonio Daleno, Anna Maria Minicucci, Giovanni Migliore, Annalisa Saracino
Summary: The introduction of a pro-active Infectious Disease (ID) consultation in a COVID-19 hospital can reduce the mortality risk of patients with MDROs infections by optimizing treatment and diagnostic strategies to improve patient outcomes.
Letter
Gastroenterology & Hepatology
Lucilla Crudele, Carlo De Matteis, Antonio Moschetta
Article
Endocrinology & Metabolism
Gabriele Mocciaro, Michael Allison, Benjamin Jenkins, Vian Azzu, Isabel Huang-Doran, Luis Vicente Herrera-Marcos, Zoe Hall, Antonio Murgia, Davies Susan, Mattia Frontini, Antonio Vidal-Puig, Albert Koulman, Julian L. Griff, Michele Vacca
Summary: Non-alcoholic fatty liver disease (NAFLD) is a liver condition caused by impaired hepatic lipid fluxes and is a risk factor for chronic liver disease and atherosclerosis. This study characterizes the HDL lipidomic signature in NAFLD and its correlation with metabolic and liver disease markers. The findings suggest a possible defect in the transfer of PUFA from peripheral tissues to the liver in NAFLD.
MOLECULAR METABOLISM
(2023)
Review
Medicine, General & Internal
Lucilla Crudele, Raffaella Maria Gadaleta, Marica Cariello, Antonio Moschetta
Summary: The gut-liver axis plays a significant role in the development and treatment of diabetes, and the gut microbiota is a key factor. There are ongoing studies evaluating the therapeutic efficacy of probiotics in diabetes and its complications.
Meeting Abstract
Gastroenterology & Hepatology
Nancy R. Gough, Xiyan Xiang, Shuyun Rao, Xiaochun Yang, Kazufumi Ohshiro, Patricia S. Latham, Wilma Jogunoori, Kirti Shetty, Michele Vacca, Antonio Vidal-Puig, Gareth Guenigault, Lopa Mishra
Meeting Abstract
Gastroenterology & Hepatology
Michele Vacca, Ioannis Kamzolas, Lea Morch Harder, Fiona Oakley, Christian Trautwein, Maximilian Hatting, Trenton Ross, Barbara Bernardo, Anouk Oldenburger, Sara Toftegaard Hjuler, Iwona Ksiazek, Daniel Linden, Detlef Schuppan, Sergio Rodriguez-Cuenca, Maria Manuela Tonini, Aimo Kannt, Tamara Rodriguez-Castaneda, Cecilia M. P. Rodrigues, Simon Cockell, Olivier Govaere, Ann K. Daly, Michael Allison, Kristian Honnens De Lichtenberg, Yong Ook Kim, Anna Lindblom, Stephanie Oldham, Anne-Christine Andreasson, Franklin Schlerman, Jonathon Marioneaux, Arun Sanyal, Marta B. Afonso, Anthony Rinaldi, Yuichiro Amano, Valerie Paradis, Alastair Burt, Davies Susan, Ann Driessen, Hiroaki Yashiro, M. Julia Brosnan, Carla Yunis, Pierre Bedossa, Dina Tiniakos, Quentin Anstee, Evangelia Petsalaki, Peter Davidsen, Jim Perfield, Antonio Vidal-Puig
JOURNAL OF HEPATOLOGY
(2022)
Meeting Abstract
Gastroenterology & Hepatology
Gabriele Mocciaro, Michael Allison, Benjamin Jenkins, Vian Azzu, Isabel Huang-Doran, Richard Kay, Antonio Murgia, Davies Susan, Mattia Frontini, Antonio Vidal-Puig, Albert Koulman, Julian L. Griffin, Michele Vacca
JOURNAL OF HEPATOLOGY
(2022)
Meeting Abstract
Gastroenterology & Hepatology
Elisabetta Caon, Maria Martins, Kessarin Thanapirom, Ana Levi, Walid Al-Akkad, Jeries Abu-Hanna, Pernille Juhl, Ida Villesen, Diana Leeming, Guido Alessandro Baselli, Jan-Willem Taanman, Michele Vacca, Luca Valenti, Stefano Romeo, Giuseppe Mazza, Massimo Pinzani, Krista Rombouts
JOURNAL OF HEPATOLOGY
(2022)
Article
Gastroenterology & Hepatology
Katherine Johnson, Peter J. Leary, Olivier Govaere, Matthew J. Barter, Sarah H. Charlton, Simon J. Cockell, Dina Tiniakos, Michalina Zatorska, Pierre Bedossa, M. Julia Brosnan, Jeremy F. Cobbold, Mattias Ekstedt, Guruprasad P. Aithal, Karine Clement, Joern M. Schattenberg, Jerome Boursier, Vlad Ratziu, Elisabetta Bugianesi, Quentin M. Anstee, Ann K. Daly
Summary: The study found that serum miR-193a-5p levels are strongly correlated with NAFLD activity grade and fibrosis stage. MiR-193a-5p may play a role in the hepatic response to oxidative stress and is a potential circulating biomarker for progressive NAFLD.
