Article
Chemistry, Physical
Pengyuan Liu, Yajun Wu, Xiaogang Xu, Xudong Fan, Chuan Sun, Xiaojie Chen, Jindan Xia, Shiting Bai, Li Qu, Huasong Lu, Jing Wu, Jun Chen, Ji-Gang Piao, Zhibing Wu
Summary: A novel nanotechnology-based strategy combining microwaves and photothermal therapy has been developed for the precise target treatment of castration-resistant prostate cancer (CRPC). The nanoplatform achieves accurate drug delivery, precise ablation, and controlled release of the chemotherapeutic agent doxorubicin (DOX) under near-infrared (NIR) irradiation, providing an accurate, controllable, efficient, non-invasive, and safe treatment platform for targeting CRPC.
Article
Polymer Science
Kyungsene Lee, Taehyung Kim, Young Min Kim, Kyungjik Yang, Inseok Choi, Young Hoon Roh
Summary: Multifunctional DNA nanogels have been developed for potential cancer-targeted delivery and stimuli-responsive release of cancer therapeutics, exhibiting features such as temperature-induced disassembly, aptamer-mediated cancer cell targeting, and light-triggered temperature increase.
MACROMOLECULAR RAPID COMMUNICATIONS
(2021)
Article
Nanoscience & Nanotechnology
Zeyu Xiao, Yuanyuan You, Yiyong Liu, Lizhen He, Dong Zhang, Qingqing Cheng, Dan Wang, Tianfeng Chen, Changzheng Shi, Liangping Luo
Summary: A unique nanovesicle delivery system was developed for near-infrared (NIR) light-triggered drug release with minimal premature drug release. By co-encapsulating superparamagnetic iron oxide (SPIO) nanoparticles, ultrasound contrast agent perfluorohexane (PFH), and cisplatin in a silicate-polyaniline vesicle, the controlled release of cisplatin was achieved.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Article
Chemistry, Physical
Jiuyu Cui, Jun Huang, Yonggan Yan, Wenqian Chen, Jie Wen, Xunwei Wu, Jikai Liu, Hanlian Liu, Chuanzhen Huang
Summary: A Fe3O4-loaded photothermal microneedle patch (Fe3O4@MN) has been developed for controlled drug delivery, achieving enhanced drug release efficiency. The Fe3O4@MN has sufficient mechanical strength to penetrate the skin, and its temperature can rapidly increase under NIR irradiation. In vitro experiments showed high drug release rates and increased penetration depth compared to a patch without Fe3O4 nanoparticles, indicating the potential application of the synthesized microneedle patch for transdermal drug delivery.
JOURNAL OF COLLOID AND INTERFACE SCIENCE
(2022)
Article
Pharmacology & Pharmacy
Jamileh Kadkhoda, Ayuob Aghanejad, Banafsheh Safari, Jaleh Barar, Seyed Hossien Rasta, Soodabeh Davaran
Summary: This study successfully developed a targeted photothermal therapy with a multifunctional drug delivery platform. The Mucin1 (MUC1) aptamer-modified poly (ethylene glycol)-gold nanoparticle system loaded with Paclitaxel (PTX) showed selective cytotoxicity towards MUC1-positive breast cancer cells and exhibited excellent cellular uptake ability when combined with near-infrared (NIR) irradiation. The synergistic effect of PTX/PEG-AuNPs@antiMUC1 was observed, leading to increased cell death compared to either photothermal therapy or chemotherapy alone. Protein expression analysis confirmed the potential of this synergistic combinational system in cancer therapy.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2022)
Article
Biochemical Research Methods
Yushen Jin, Chu Tang, Jie Tian, Bing Shao
Summary: Early identification and treatment of breast cancer are crucial for breast conserving therapy and improving patient prognosis. The developed Bi2S3@TaOx core-shell nanoparticles show promise as a theranostic agent for CT/photoacoustically monitored enhanced photothermal therapy, due to their high loading efficiency and excellent imaging capacities. These findings may stimulate further research into cancer therapeutic strategies using biocompatible functional nanomaterials.
BIOCONJUGATE CHEMISTRY
(2021)
Article
Chemistry, Medicinal
Chunlei Wu, Zhehong Cheng, Danyi Lu, Ke Liu, Yulian Cheng, Pengxin Wang, Yimin Zhou, Meiqing Li, Ximing Shao, Hongchang Li, Wu Su, Lijing Fang
Summary: Researchers discovered a simplified analogue of Coibamide A and designed two novel peptide-drug conjugates, with one showing better drug release in vitro and significant tumor growth suppression in mice-bearing human tumor xenografts, indicating great potential in cancer drug discovery.
JOURNAL OF MEDICINAL CHEMISTRY
(2021)
Review
Nanoscience & Nanotechnology
Yan Yang, Xi Zheng, Lu Chen, Xuefeng Gong, Hao Yang, Xingmei Duan, Yuxuan Zhu
Summary: Cancer is the second leading cause of death in the world and poses a serious threat to human health. Nanomedicine, particularly gold nanoparticles (AuNPs), has emerged as a promising technology for overcoming the limitations of conventional cancer therapies. This review discusses the current achievements and clinical trials of AuNPs in anticancer applications, as well as the challenges in translating basic findings into the clinic, providing a reference for future research.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2022)
Article
Chemistry, Multidisciplinary
Kishwor Poudel, Asmita Banstola, Milan Gautam, Zar Chi Soe, Le Minh Pham, Jee-Heon Jeong, Han-Gon Choi, Sae Kwang Ku, Chul Soon Yong, Tuan Hiep Tran, Jong Oh Kim
Summary: The study successfully constructed redox- and laser-responsive nanourchins capable of releasing MTX and ICG upon GSH induction and laser irradiation, leading to tumor growth inhibition. The combination of Bi2S3 and ICG generated heat and reactive oxygen species, further enhancing the anticancer activity of MTX against cancer cells. This targeted nanocarrier system showed promising results in in vitro and in vivo studies, with tumor-selective attributes and effective tumor ablation without affecting vital organs.
Article
Chemistry, Multidisciplinary
Shan He, Wei Pang, Xiaoyu Wu, Yang Yang, Wenjun Li, Hang Qi, Chongling Sun, Xuexin Duan, Yanyan Wang
Summary: This study proposes a hydrodynamic intracellular delivery system based on the gigahertz acoustic streaming effect, which allows for tunable delivery range by adjusting the acoustic streaming radius. With the assistance of acoustic streaming, AuNRs with different modifications can be targetedly delivered to specific organelles. Additionally, the large quantities of AuNRs introduced via acoustic streaming demonstrate a photothermal effect, which has the potential to shorten the treatment cycle of photothermal therapy. This efficient hydrodynamic technology provides a new idea for precise medical treatment.
Article
Pharmacology & Pharmacy
Ying Cheng, Dandan Bao, Xiaojie Chen, Yajun Wu, Yinghui Wei, Zhibing Wu, Fanzhu Li, Ji-Gang Piao
Summary: The study successfully fabricated a microwave-triggered heat shock protein (HSP)-targeted gold nano-system that activates HSP70 overexpression in TNBC, significantly improving the targeting ability, tumor accumulation, and anti-tumor efficacy of cmHSP-AuNC.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2021)
Article
Biotechnology & Applied Microbiology
Reza Taheri-Ledari, Wenjie Zhang, Maral Radmanesh, Nicole Cathcart, Ali Maleki, Vladimir Kitaev
Summary: The study utilized natural halloysite nanotubes as a carrier and achieved selective release through gold nanoparticles, successfully targeting ovarian tumors. The developed DTX@HNT/Au-SORT nanocomposite demonstrated efficient antitumor activity, enabling selective drug release to tumor cells through photothermal therapy.
JOURNAL OF NANOBIOTECHNOLOGY
(2021)
Article
Pharmacology & Pharmacy
Lu Tang, Aining Zhang, Yijun Mei, Qiaqia Xiao, Xiangting Xu, Wei Wang
Summary: The synergistic strategy involving MWNT and ICG derivative has led to the development of MWNT-HA-ICG/DOX nanocomplexes, showing promising therapeutic efficacy in cancer treatment through improved photothermal performance and strengthened cytotoxicity.
Article
Chemistry, Physical
Xiaohuan Sun, Juan Wang, Ziyao Wang, Chunhua Zhu, Juqun Xi, Lei Fan, Jie Han, Rong Guo
Summary: This study introduces a new synergistic therapy approach using gold nanorods encapsulated in polypyrrole shell for tumor treatment. The structure utilizes dual near-infrared absorptive species to enhance photothermal performance synergistically, and provides high drug encapsulation efficiency and targeted drug release through void space manipulation.
JOURNAL OF COLLOID AND INTERFACE SCIENCE
(2022)
Article
Biophysics
Salvatore Petralia, Giuseppe Forte, Morena Aiello, Giuseppe Nocito, Sabrina Conoci
Summary: Bioconjugate gold-based nanostructures that combine the plasmonic photothermal effect with photothermal-triggered DNA delivery are promising materials for medical applications. In this study, DNA-modified gold nanorods were prepared using surface hybridization to create a photo-delivery system for single stranded oligonucleotides. The presence of cationic charges on the surfactant at the gold surface was found to induce a remarkable de-hybridization of DNA strands.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2021)