Article
Biophysics
Ee-Seul Kang, Huijung Kim, Yoojoong Han, Yeon-Woo Cho, Hyungbin Son, Zhengtang Luo, Tae-Hyung Kim
Summary: Graphene derivatives show promise for stem-cell-based regenerative therapies, especially in bone regeneration. A graphene oxide-based hybrid platform was developed to guide the osteogenesis of human adipose-derived mesenchymal stem cells effectively. The GOHP exhibited efficiency comparable to high-quality CVD-grown graphene in inducing osteogenesis by upregulating specific genes.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2021)
Article
Materials Science, Multidisciplinary
Joanna Jagiello, Marcin Kusmierz, Ewa Kijenska-Gawronska, Magdalena Winkowska-Struzik, Wojciech Swieszkowski, Ludwika Lipinska
Summary: Graphene oxide (GO) shows good cell affinity in cell culturing, and can enhance its adhesion ability by modifying with biomolecules and peptides. For L929 cells, both graphene oxide and GO modified with RGD peptide demonstrate good biocompatibility and cellular response.
MATERIALS TODAY COMMUNICATIONS
(2021)
Article
Biochemistry & Molecular Biology
Keng-Liang Ou, Chiung-Fang Huang, Wen-Chien Lan, Bai-Hung Huang, Hsu-An Pan, Yung-Kang Shen, Takashi Saito, Hsin-Yu Tsai, Yung-Chieh Cho, Kuo-Sheng Hung, Hsin-Hua Chou
Summary: This study assessed the potential application of PF127 conjugated with GRGD peptide to form 3BE hydrogel in spheroid formation, biocompatibility, and cell invasion ability. The results showed that 3BE hydrogel had lower spheroid formation compared to Matrigel, but it exhibited good biocompatibility to various cells and comparable cell invasion ability and survival rate to Matrigel.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Chemistry, Physical
Min Chan Shin, Moon Sung Kang, Rowoon Park, Seon Yeong Chae, Dong-Wook Han, Suck Won Hong
Summary: A simple fabrication method for alternately patterned arrays of the arginine-glycine-aspartic acid (RGD) peptide and graphene oxide (GO) on a glass substrate was reported. Cells showed different cellular behaviors on the two patterns, indicating the potential for controlling cell migration and motility using this method.
APPLIED SURFACE SCIENCE
(2021)
Review
Materials Science, Biomaterials
Yuhong Qian, Shuhan Di, Li Wang, Zhuang Li
Summary: This study summarizes the interactions between graphene and polypeptides, as well as the synthesis methods of graphene-polypeptide nanocomposites in recent years. The potential applications of graphene-peptide hybrid nanocomposites in various fields are also highlighted.
JOURNAL OF MATERIALS CHEMISTRY B
(2021)
Article
Chemistry, Analytical
Gulcin Bolat, Oznur Akbal Vural, Yesim Tugce Yaman, Serdar Abaci
Summary: A sensor platform using PNT-GO structures for quantification of diabetic nephropathy and cancer-related microRNA-192 was prepared and characterized. The impedance signal was utilized to evaluate hybridization between miRNA-192 and its DNA probe, showing high sensitivity and a wide detection range. Evaluation in peripheral serum samples demonstrated the potential for future clinical and diverse biomedical applications.
MICROCHEMICAL JOURNAL
(2021)
Article
Engineering, Biomedical
Zichen Xu, Jinxia Huang, Tao Zhang, Wenfeng Xu, Xiaoling Liao, Yi Wang, Guixue Wang
Summary: This study aimed to construct a biomimetic nanomedicine for targeted thrombus treatment. Poly lactic-co-glycolic acid (PLGA) was used as the nanocarrier material, and urokinase and perfluoro-n-pentane (PFP) were co-loaded into PLGA to prepare phase change nanoparticles (PPUNPs). The RGD peptide-modified red blood cell membrane (RBCM) was then coated on the surface of PPUNPs to prepare a biomimetic nano-drug carrier (RGD-RBCM@PPUNPs). The results showed that RGD-RBCM@PPUNPs had good dispersibility, hemocompatibility, and cytocompatibility, and showed better thrombolytic function in vitro.
JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE
(2023)
Article
Nanoscience & Nanotechnology
C. H. Zhao, X. P. Zhang, L. Zhang
Summary: Functionalized graphene-based nanomaterials have gained attention in the biomedical field due to their biocompatibility and unique properties. This study reports a simple method to modify graphene oxide with RGD peptide, improving osteoblastic cell functions. The results show that the modified graphene oxide films significantly enhance cell functions.
DIGEST JOURNAL OF NANOMATERIALS AND BIOSTRUCTURES
(2022)
Review
Materials Science, Multidisciplinary
Shuhan Di, Yuhong Qian, Li Wang, Zhuang Li
Summary: This article presents the interaction processes between 2D materials and biomolecules, and summarizes the method of synthesizing bionic materials using composite materials with biofunctions and their applications in various fields.
JOURNAL OF MATERIALS SCIENCE
(2022)
Article
Chemistry, Multidisciplinary
Mohammed Al-Yaari, Tawfik A. Saleh
Summary: Polyethyleneimine-grafted graphene oxide (PEI/GO) was synthesized by using graphene, polyethyleneimine, and trimesoyl chloride. The characterization results confirm the successful synthesis of PEI/GO and its strong interaction with lead (Pb2+) ions. The isotherm study reveals the adsorption process follows the Freundlich isotherm model, with a high maximum adsorption capacity. The prepared PEI/GO adsorbent shows promise for wastewater treatment due to its fast and high uptake removal capacity for Pb2+ ions and other heavy metals.
Article
Pharmacology & Pharmacy
Jouri S. Alanazi, Fulwah Yahya Alqahtani, Fadilah Sfouq Aleanizy, Awwad A. Radwan, Ahmed Bari, Qamraa Hamad Alqahtani, Hosam Gharib Abdelhady, Ibrahim Alsarra
Summary: This study aims to develop a new treatment modality for choroidal neovascularization (CNV) by utilizing targeted nanoparticles to deliver microRNA-539-5p (miR-539). The researchers found that miR-539 incorporated in nanoparticles reduced the viability of human retinal microvascular endothelial cells (HRMECs). Furthermore, functionalizing the nanoparticles with a specific targeting peptide enhanced the uptake of the nanoparticles.
Article
Environmental Sciences
Prateekshya Suman Sahu, Ravi Prakash Verma, Chetna Tewari, Nanda Gopal Sahoo, Biswajit Saha
Summary: This study proposed a two-step method for synthesizing EDTA@Fe3O4@GO as a chelating agent, demonstrating its high adsorption efficiency and reusability, providing new insights into large-scale wastewater treatment.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Amara Nasir, Muhammad Inaam-ul-Hassan, Asif Raza, Mehwish Tahir, Tariq Yasin
Summary: This study successfully prepared novel composite beads of chitosan and amidoxime grafted graphene oxide (AOGO) for the removal of copper pollutant from water. The composite beads exhibited a well-developed spherical structure and showed potential for copper removal from aqueous solutions.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Review
Materials Science, Biomaterials
Yiting Wang, Shuhan Di, Jinhui Yu, Li Wang, Zhuang Li
Summary: Graphene-based composites have gained increasing attention in recent years due to their high biocompatibility, large specific surface area, high electrical conductivity, and unique mechanical properties. The combination of biomacromolecules and graphene offers a promising approach to the preparation of novel graphene-based nanocomposites. These nanocomposites have unique functions and can be applied in medicine, biology, biosensors, environmental science, energy storage, and other fields.
JOURNAL OF MATERIALS CHEMISTRY B
(2023)
Article
Materials Science, Multidisciplinary
Amara Nasir, Asif Raza, Mehwish Tahir, Tariq Yasin, Muhammad Nadeem, Bashir Ahmad
Summary: This article introduces a novel conducting nanohybrid material prepared by graft polymerization on gamma-irradiated graphene oxide (GO). The results show that the optimal nanohybrid exhibits excellent electrical conductivity and electromagnetic interference shielding effectiveness, demonstrating better performance than the original material.
MATERIALS RESEARCH BULLETIN
(2023)
Article
Dentistry, Oral Surgery & Medicine
Menghong Wang, Jie Li, Yanyan Ye, Duanjing Chen, Jinlin Song
Summary: This study found that exosomes from stem cells derived from human exfoliated deciduous teeth (SHED-exo) can improve proliferation, migration, cell cycle, apoptosis, and osteogenic differentiation of human periodontal ligament cells (hPDLCs). This highlights the therapeutic value of SHED-exo in the regeneration of periodontal tissues using hPDLCs in clinical practice.
Article
Immunology
Yao He, Mengjiao Zhou, Zixiang Jian, Lingli Fang, Lan Huang, Jinlin Song
Summary: This study investigates the role of C-reactive protein (CRP) in temporomandibular joint (TMJ) inflammation. The results show that CRP has a regulatory effect on TMJ inflammation, with CRP-deficient rats exhibiting milder inflammatory symptoms. Additionally, the study reveals changes in inflammatory cytokine levels and reduced macrophage activation and osteoclast differentiation in CRP-deficient rats.
JOURNAL OF IMMUNOLOGY RESEARCH
(2022)
Article
Engineering, Biomedical
Lu Wang, Yuzhou Li, Mingxing Ren, Xu Wang, Lingjie Li, Fengyi Liu, Yiqing Lan, Sheng Yang, Jinlin Song
Summary: This study designed a novel dual responsive and dual drug-loading nanocarrier system for precise and controlled drug delivery to treat periodontitis in patients with diabetes. In vitro and in vivo studies confirmed the effectiveness of this nanocarrier, which can inhibit the formation of subgingival microbial colonies and promote osteogenic differentiation of cells, ameliorating periodontal bone resorption.
BIOACTIVE MATERIALS
(2022)
Article
Nanoscience & Nanotechnology
He Wang, Bo Hu, Hong Li, Ge Feng, Shengyuan Pan, Ziqi Chen, Bo Li, Jinlin Song
Summary: In this study, hydroxyapatite nanofibers (HANFs) were incorporated into GelMA hydrogel to improve its mechanical properties and bone regenerative ability. The results showed that a certain amount of mineralized nanofibers significantly improved the biocompatibility and bone repair effect of the composite hydrogel, but increasing the amount of nanofibers did not lead to further improvement in performance.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2022)
Review
Chemistry, Multidisciplinary
Yuanyuan Yin, Sihan Yang, Dongqing Ai, Han Qin, Yu Sun, Xuyun Xia, Xiaohui Xu, Wei Ji, Jinlin Song
Summary: Periodontitis is an inflammatory disease that destroys periodontal tissue, caused by biofilm and host-mediated factors. The design of functional hydrogel biomaterials based on the disease pathophysiology is important for enhancing the therapeutic effects in periodontitis treatment. Hydrogels, as promising localized drug delivery systems and tissue engineering scaffolds, have gained significant interest for controlled and sustained release of bioactive agents in periodontal applications.
ADVANCED FUNCTIONAL MATERIALS
(2023)
Article
Dentistry, Oral Surgery & Medicine
Shengyuan Pan, Xiang Gao, Jicheng Sun, Zun Yang, Bo Hu, Jinlin Song
Summary: The expansion effects of several new microimplant-assisted rapid palatal expanders (MARPEs) manufactured by 3-dimensional printing technology were evaluated using finite element analysis (FEA). The study found that these MARPEs had advantages over traditional expanders in terms of orthopedic expansion effects, parallelism, and posterior teeth tipping rate. Among them, models C and D showed the best expansion effects and biomechanical effects.
AMERICAN JOURNAL OF ORTHODONTICS AND DENTOFACIAL ORTHOPEDICS
(2023)
Article
Biochemistry & Molecular Biology
Guangyue Li, Han Qin, Mengjiao Zhou, Tingwei Zhang, Yang Zhang, Huifen Ding, Ling Xu, Jinlin Song
Summary: Research has shown that irisin can mitigate alveolar bone loss and oxidative stress in diabetes-induced periodontitis by activating the SIRT3 signaling cascade, and improve cellular functions in diabetic periodontal ligament cells. These findings highlight the therapeutic potential of irisin in the treatment of periodontitis in diabetes.
FREE RADICAL BIOLOGY AND MEDICINE
(2023)
Review
Dentistry, Oral Surgery & Medicine
Sisi Chen, Xiang Gao, Jinlin Song
Summary: The objective of this meta-analysis was to compare the differences in oxidative stress biomarkers between patients with type 2 diabetes mellitus with chronic periodontitis (DMCP) and chronic periodontitis (CP). A systematic search was conducted on PubMed, Cochrane, and Embase databases, and 19 studies met the inclusion criteria. The results showed that levels of catalase (CAT) were reduced in the DMCP group compared with the CP group, while there was no significant difference in the levels of superoxide dismutase (SOD), total antioxidant capacity (TAOC), malondialdehyde (MDA), and glutathione (GSH) between the two groups. High heterogeneity was observed in some of the studies evaluated. Despite the limitations, the results support the association between T2DM and OS-related biomarkers, especially CAT, in CP subjects, suggesting the importance of OS in the pathogenesis and development of DMCP.
JOURNAL OF PERIODONTAL RESEARCH
(2023)
Article
Engineering, Biomedical
Ping He, Fengyi Liu, Mingzheng Li, Mingxing Ren, Xu Wang, Yangjia Deng, Xianghao Wu, Yuzhou Li, Sheng Yang, Jinlin Song
Summary: This study demonstrates that the persistent opening of mPTPs triggered by mitoCa(2+) overload can be effectively controlled by mitochondrial-targeted nanogluttons. These nanogluttons significantly inhibit the inflammatory activation of macrophages and alleviate periodontal inflammation in mice, leading to reduced osteoclast activity and bone loss.
ADVANCED HEALTHCARE MATERIALS
(2023)
Article
Biochemistry & Molecular Biology
Boyang Sun, Siqi Ying, Qian Ma, Han Li, Jie Li, Jinlin Song
Summary: Periodontitis is an oral chronic inflammatory disease with tissue destruction being inhibited and tissue regeneration being promoted as important means for its treatment. Metformin, with its hypoglycemic and anti-inflammatory effects, can inhibit oxidative stress and activate autophagy through the AMPK/mTOR pathway. This study explores the relationship between metformin and HMGB1 in the process of periodontitis, and its findings provide evidence for metformin as a potential drug for the treatment of periodontitis and HMGB1 as a potential target for periodontal intervention.
Article
Dentistry, Oral Surgery & Medicine
Lingjie Li, Lurong Jia, Siyu Hou, Tingwei Zhang, Mengjiao Zhou, Tao Chen, Jinlin Song
Summary: This study compared the time-dependent variation in inducible nitric oxide synthase (iNOS) production between the gingiva and other periodontal tissues and explored the potential association with C-reactive protein (CRP) in early periodontal disease. The results showed that iNOS and CRP levels increased rapidly in periodontal tissues, especially in the gingiva, and CRP deficiency accelerated iNOS reduction and delayed alveolar bone loss. This CRP effect on iNOS was accompanied by a change in autophagy, which was reduced by CRP knockout.
JOURNAL OF PERIODONTOLOGY
(2023)
Article
Medicine, Research & Experimental
Jie Zhou, Yanlin Zhu, Dongqing Ai, Mengjiao Zhou, Han Li, Guangyue Li, Leilei Zheng, Jinlin Song
Summary: This study investigated the effects of AGEs on BMSCs and elucidated the role of m(6)A modification in diabetes-associated periodontitis.
JOURNAL OF TRANSLATIONAL MEDICINE
(2023)
Article
Dentistry, Oral Surgery & Medicine
Dongqing Ai, Yuanyuan Yin, Xuyun Xia, Sihan Yang, Yu Sun, Jie Zhou, Han Qin, Xiaohui Xu, Jinlin Song
Summary: This study aimed to explore an appropriate model of Type 2 diabetes (T2DM) in human periodontal ligament stem cells (hPDLSCs) and uncover the mechanisms linking T2DM and periodontitis. The researchers found that palmitic acid is a promising candidate for developing T2DM model in hPDLSCs, as it induced inflammation, insulin resistance, and pyroptosis, while inhibiting osteogenic differentiation.
Article
Dentistry, Oral Surgery & Medicine
Xiaoyue Xiao, Jianwei Chen, Qiming Zhai, Liangjing Xin, Xinhui Zheng, Si Wang, Jinlin Song
Summary: This study aimed to investigate the role of signal transducer and activator of transcription 3 (STAT3) activation in osteoblast-mediated bone formation during palatal expansion and relapse. The results showed that STAT3 inactivation reduced bone formation and may be a potential therapeutic target for force-induced bone formation.
JOURNAL OF APPLIED ORAL SCIENCE
(2023)
Article
Dentistry, Oral Surgery & Medicine
Qian Ma, Yiyao Hu, Han Li, Yunchun Kuang, Jie Li, Jinlin Song
Summary: In this study, it was found that DEL-1 promotes osteogenic differentiation of hPDLSCs in high glucose and inflammation environments, and it can rescue alveolar bone loss in ligature-induced experimental periodontitis with T2DM, providing a novel therapeutic target for periodontitis with T2DM.
JOURNAL OF PERIODONTAL RESEARCH
(2023)
