Animal and in silico models for the study of sarcomeric cardiomyopathies

Compound heterozygosity deteriorates phenotypes of hypertrophic cardiomyopathy with founder MYBPC3 mutation: evidence from patients and zebrafish models

(2014) Akihiko Hodatsu et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Toward Functional Screening of Cardioactive and Cardiotoxic Drugs with Zebrafish in Vivo Using Pseudodynamic Three-Dimensional Imaging

(2014) Kuen-You Lin et al.   ANALYTICAL CHEMISTRY

Development and Applications of CRISPR-Cas9 for Genome Engineering

(2014) Patrick D. Hsu et al.   CELL

Harnessing CRISPR-Cas9 immunity for genetic engineering

(2014) Emmanuelle Charpentier et al.   CURRENT OPINION IN MICROBIOLOGY

High-resolution imaging of cardiomyocyte behavior reveals two distinct steps in ventricular trabeculation

(2014) D. W. Staudt et al.   DEVELOPMENT

Ubiquitin-proteasome system and hereditary cardiomyopathies

(2014) Saskia Schlossarek et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Methods to assess Drosophila heart development, function and aging

(2014) Karen Ocorr et al.   METHODS

RAF1 mutations in childhood-onset dilated cardiomyopathy

(2014) Perundurai S Dhandapany et al.   NATURE GENETICS

A guide to genome engineering with programmable nucleases

(2014) Hyongbum Kim et al.   NATURE REVIEWS GENETICS

Mybpc3 gene therapy for neonatal cardiomyopathy enables long-term disease prevention in mice

(2014) Giulia Mearini et al.   Nature Communications

Genetic Profiling for Risk Reduction in Human Cardiovascular Disease

(2014) Megan Puckelwartz et al.   Genes

Activation of Histone Deacetylase-6 Induces Contractile Dysfunction Through Derailment of α-Tubulin Proteostasis in Experimental and Human Atrial Fibrillation

(2013) Deli Zhang et al.   CIRCULATION

A Drosophila melanogaster Model of Diastolic Dysfunction and Cardiomyopathy Based on Impaired Troponin-T Function

(2013) Meera Cozhimuttam Viswanathan et al.   CIRCULATION RESEARCH

Gene Therapy in Large Animal Models of Human Cardiovascular Genetic Disease

(2013) M. M. Sleeper et al.   ILAR JOURNAL

Myosin-Binding Protein CDNA Variants in Domestic Cats (A31P, A74T, R820W) and their Association with Hypertrophic Cardiomyopathy

(2013) M. Longeri et al.   JOURNAL OF VETERINARY INTERNAL MEDICINE

Association of Dilated Cardiomyopathy with the Striatin Mutation Genotype in Boxer Dogs

(2013) K.M. Meurs et al.   JOURNAL OF VETERINARY INTERNAL MEDICINE

In vivo cardiac reprogramming contributes to zebrafish heart regeneration

(2013) Ruilin Zhang et al.   NATURE

A systematic genome-wide analysis of zebrafish protein-coding gene function

(2013) Ross N. W. Kettleborough et al.   NATURE

The zebrafish reference genome sequence and its relationship to the human genome

(2013) Kerstin Howe et al.   NATURE

Identification of heart rate–associated loci and their effects on cardiac conduction and rhythm disorders

(2013) Marcel den Hoed et al.   NATURE GENETICS

Repair of Mybpc3 mRNA by 5′-trans-splicing in a Mouse Model of Hypertrophic Cardiomyopathy

(2013) Giulia Mearini et al.   Molecular Therapy-Nucleic Acids

A 16-bp deletion in the caninePDK4gene is not associated with dilated cardiomyopathy in a European cohort of Doberman Pinschers

(2012) Marta Owczarek-Lipska et al.   ANIMAL GENETICS

The flexibility of two tropomyosin mutants, D175N and E180G, that cause hypertrophic cardiomyopathy

(2012) Xiaochuan (Edward) Li et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Animal Models of Heart Failure

(2012) Steven R. Houser et al.   CIRCULATION RESEARCH

Diagnostic work-up in cardiomyopathies: bridging the gap between clinical phenotypes and final diagnosis. A position statement from the ESC Working Group on Myocardial and Pericardial Diseases

(2012) C. Rapezzi et al.   EUROPEAN HEART JOURNAL

A splice site mutation in a gene encoding for PDK4, a mitochondrial protein, is associated with the development of dilated cardiomyopathy in the Doberman pinscher

(2012) Kathryn M. Meurs et al.   HUMAN GENETICS

Correlation of Molecular and Functional Effects of Mutations in Cardiac Troponin T Linked to Familial Hypertrophic Cardiomyopathy

(2012) Edward P. Manning et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mouse and computational models link Mlc2v dephosphorylation to altered myosin kinetics in early cardiac disease

(2012) Farah Sheikh et al.   JOURNAL OF CLINICAL INVESTIGATION

Increased myofilament Ca2+ sensitivity and diastolic dysfunction as early consequences of Mybpc3 mutation in heterozygous knock-in mice

(2012) Bodvaël Fraysse et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

In vivo genome editing using a high-efficiency TALEN system

(2012) Victoria M. Bedell et al.   NATURE

Novel molecular targets for atrial fibrillation therapy

(2012) Dobromir Dobrev et al.   NATURE REVIEWS DRUG DISCOVERY

Increased Expression of Integrin-Linked Kinase Improves Cardiac Function and Decreases Mortality in Dilated Cardiomyopathy Model of Rats

(2012) Rong Gu et al.   PLoS One

Multiple Loci Are Associated with Dilated Cardiomyopathy in Irish Wolfhounds

(2012) Ute Philipp et al.   PLoS One

Genetic Considerations in Hypertrophic Cardiomyopathy

(2012) Carolyn Y. Ho   PROGRESS IN CARDIOVASCULAR DISEASES

Heat Shock Protein–Inducing Compounds as Therapeutics to Restore Proteostasis in Atrial Fibrillation

(2012) Femke Hoogstra-Berends et al.   TRENDS IN CARDIOVASCULAR MEDICINE

Evaluation of 10 genes encoding cardiac proteins in Doberman Pinschers with dilated cardiomyopathy

(2011) M. Lynne O'Sullivan et al.   AMERICAN JOURNAL OF VETERINARY RESEARCH

Defective proteolytic systems in Mybpc3-targeted mice with cardiac hypertrophy

(2011) Saskia Schlossarek et al.   BASIC RESEARCH IN CARDIOLOGY

A Model of Calcium Activation of the Cardiac Thin Filament

(2011) Edward P. Manning et al.   BIOCHEMISTRY

In the Thick of It

(2011) Samantha P. Harris et al.   CIRCULATION RESEARCH

Thin Filament Mutations

(2011) Jil C. Tardiff   CIRCULATION RESEARCH

Contractile Dysfunction Irrespective of the Mutant Protein in Human Hypertrophic Cardiomyopathy With Normal Systolic Function

(2011) Sabine J. van Dijk et al.   Circulation-Heart Failure

Generation and Functional Characterization of Knock-in Mice Harboring the Cardiac Troponin I-R21C Mutation Associated with Hypertrophic Cardiomyopathy

(2011) Yingcai Wang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Adrenergic stress reveals septal hypertrophy and proteasome impairment in heterozygous Mybpc3-targeted knock-in mice

(2011) Saskia Schlossarek et al.   JOURNAL OF MUSCLE RESEARCH AND CELL MOTILITY

‘Integrative Physiology 2.0’: integration of systems biology into physiology and its application to cardiovascular homeostasis

(2011) Diederik W. D. Kuster et al.   JOURNAL OF PHYSIOLOGY-LONDON

2011 ACCF/AHA Guideline for the Diagnosis and Treatment of Hypertrophic Cardiomyopathy

(2011) Bernard J. Gersh et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Multi-scale computational models of familial hypertrophic cardiomyopathy: genotype to phenotype

(2011) S. G. Campbell et al.   Journal of the Royal Society Interface

Cardiac Myosin Activation: A Potential Therapeutic Approach for Systolic Heart Failure

(2011) F. I. Malik et al.   SCIENCE

Mutations in NEXN, a Z-Disc Gene, Are Associated with Hypertrophic Cardiomyopathy

(2010) Hu Wang et al.   AMERICAN JOURNAL OF HUMAN GENETICS

A Global In Vivo Drosophila RNAi Screen Identifies NOT3 as a Conserved Regulator of Heart Function

(2010) G. Gregory Neely et al.   CELL

State of the Journal 2011

(2010) Douglas P. Zipes   HEART RHYTHM

Prevalence of Dilated Cardiomyopathy in Doberman Pinschers in Various Age Groups

(2010) G. Wess et al.   JOURNAL OF VETERINARY INTERNAL MEDICINE

A method and server for predicting damaging missense mutations

(2010) Ivan A Adzhubei et al.   NATURE METHODS

Cardiac Myosin-Binding Protein C Mutations and Hypertrophic Cardiomyopathy

(2009) Sabine J. van Dijk et al.   CIRCULATION

Nonsense-Mediated mRNA Decay and Ubiquitin–Proteasome System Regulate Cardiac Myosin-Binding Protein C Mutant Levels in Cardiomyopathic Mice

(2009) Nicolas Vignier et al.   CIRCULATION RESEARCH

Evidence From Human Myectomy Samples That MYBPC3 Mutations Cause Hypertrophic Cardiomyopathy Through Haploinsufficiency

(2009) Steven Marston et al.   CIRCULATION RESEARCH

Echocardiographic Strain Imaging to Assess Early and Late Consequences of Sarcomere Mutations in Hypertrophic Cardiomyopathy

(2009) Carolyn Y. Ho et al.   Circulation-Cardiovascular Genetics

Prevention of Myofilament Dysfunction by β-Blocker Therapy in Postinfarct Remodeling

(2009) Dirk J. Duncker et al.   Circulation-Heart Failure

Large Animal Models of Heart Failure

(2009) Jennifer A. Dixon et al.   Circulation-Heart Failure

Distinct phases of cardiomyocyte differentiation regulate growth of the zebrafish heart

(2009) E. de Pater et al.   DEVELOPMENT

Prevalence of the Myosin-Binding Protein C Mutation in Maine Coon Cats

(2009) R. Fries et al.   JOURNAL OF VETERINARY INTERNAL MEDICINE

Predicting the effects of coding non-synonymous variants on protein function using the SIFT algorithm

(2009) Prateek Kumar et al.   Nature Protocols

Controlling morpholino experiments: don't stop making antisense

(2008) J. S. Eisen et al.   DEVELOPMENT

Rotation and Asymmetric Development of the Zebrafish Heart Requires Directed Migration of Cardiac Progenitor Cells

(2008) Kelly A. Smith et al.   DEVELOPMENTAL CELL

Calpain mediates cardiac troponin degradation and contractile dysfunction in atrial fibrillation

(2008) Lei Ke et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Ubiquitin-Proteasome System Impairment Caused by a Missense Cardiac Myosin-binding Protein C Mutation and Associated with Cardiac Dysfunction in Hypertrophic Cardiomyopathy

(2008) Udin Bahrudin et al.   JOURNAL OF MOLECULAR BIOLOGY

Prospective Echocardiographic and Tissue Doppler Imaging Screening of a Population of Maine Coon Cats Tested for the A31P Mutation in the Myosin-Binding Protein C Gene: A Specific Analysis of the Heterozygous Status

(2008) C. Carlos Sampedrano et al.   JOURNAL OF VETERINARY INTERNAL MEDICINE