Article
Dentistry, Oral Surgery & Medicine
Ramya Ramadoss, Rajkumar Krishnan, Swarnalakshmi Raman, Rajashree Padmanaban, Nagarathinam Anbuelangovan, Rajalakshmanan Eswaramoorthy
Summary: This study aimed to determine whether the use of a custom designed TENS device could improve the quality of secreted saliva among elderly patients with oral dryness. The results showed significant differences in salivary pH, cortisol levels, microbial cultures, viscosity, and antioxidants after three months of intervention. Regardless of age, gender, or common underlying systemic illnesses, the quality of salivary analytes showed significant changes.
Article
Immunology
Hongming Du, Zhen Fu, Yi Zhong, Yi Yuan, Jing Zhao, Xu Ding, Sheng Li, Shiyu Gao, Yuchi Zhu, Haiyang Song, Heming Wu
Summary: This study aimed to investigate the effects of triamcinolone acetonide (TA) and saline irrigation on relieving xerostomia in Sjogren's syndrome (SS) patients. The results showed that irrigating the major salivary glands with TA or saline led to improved saliva flow and reduced dryness symptoms. Patients with milder xerostomia responded better to the treatment.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Medicine, General & Internal
Federica Canfora, Elena Calabria, Gianrico Spagnuolo, Noemi Coppola, Niccolo Giuseppe Armogida, Cristina Mazzaccara, Domenico Solari, Luca D'Aniello, Massimo Aria, Giuseppe Pecoraro, Michele Davide Mignogna, Stefania Leuci, Daniela Adamo
Summary: This study analyzed a large sample of 500 BMS patients with different symptom combinations and found that xerostomia is the most frequent additional symptom. The study also identified various sociodemographic, psychological, and medical factors associated with different symptom subgroups. Further research is needed to understand the underlying causes and develop tailored treatment approaches for BMS patients.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Dentistry, Oral Surgery & Medicine
E. R. Bolookat, L. J. Rich, V. K. Vincent-Chong, C. R. DeJohn, M. Merzianu, P. A. Hershberger, A. K. Singh, M. Seshadri
Summary: This study used ultrasound and photoacoustic imaging to assess the changes in salivary glands following radiation therapy in mice. The results showed that radiation led to a reduction in gland volume, an increase in vascular resistance, and a decrease in glandular oxygen consumption. These imaging findings were strongly correlated with salivary secretion and histologic evidence of acinar damage. Additionally, the host immune status had a significant impact on the magnitude and kinetics of radiation response.
JOURNAL OF DENTAL RESEARCH
(2023)
Review
Biochemistry & Molecular Biology
Mengru Zhou, Tian Tian, Chenchen Wu
Summary: This study investigates the location, secretion mechanism, regulation, and protective role of mucins in the endometrium, providing a foundational understanding for future research on the role and mechanism of endometrial mucins throughout the pregnancy cycle.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Agriculture, Multidisciplinary
Martine Morzel, Francis Canon, Sylvain Guyot
Summary: This review discusses the effects of polyphenols-saliva interactions on the bioaccessibility or bioavailability of nutrients. It highlights the interactions between salivary proteins and polyphenols, and their impact on digestive processes, such as starch digestion and protein digestibility.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2022)
Article
Dentistry, Oral Surgery & Medicine
Dragana Dakovic, Rasa Mladenovic, Ljubisa Ristic, Radoslav Jevtovic, Nebojsa Videnovic, Zoran Bukumiric
Summary: The study found that using an intraoral thermoformed splint with a magnet device effectively alleviated symptoms of xerostomia and stimulated the function of the submandibular salivary gland.
JOURNAL OF ORAL PATHOLOGY & MEDICINE
(2021)
Article
Rheumatology
K. Hakki Karagozoglu, Arjan Vissink, Tim Forouzanfar, Jan G. A. M. de Visscher, Floor Maarse, Henk S. Brand, Peter M. van de Ven, Derk H. Jan Jager
Summary: This study found that sialendoscopy of the major salivary glands in patients with Sjogren's syndrome can increase salivary flow and reduce xerostomia symptoms.
Article
Dentistry, Oral Surgery & Medicine
D. Head, P. D. Marsh, D. A. Devine, L. M. A. Tenuta
Summary: The study shows that hyposalivation accelerates the conversion of dental biofilm from a symbiotic to a dysbiotic composition, increasing the risk of root dentin demineralization. By using a mathematical model, the researchers demonstrated the profound effect of prolonged sugar clearance on the dynamics of dental biofilm composition.
JOURNAL OF DENTAL RESEARCH
(2021)
Article
Medicine, General & Internal
Pia Lopez Jornet, Laureano Hernandez, Francisco Gomez Garcia, Fe Galera Molero, Eduardo Pons-Fuster Lopez, Asta Tvarijonaviciute
Summary: The study demonstrated that the new toothpaste and gel developed for patients with xerostomia are effective in significantly relieving symptoms. The treatment group showed significant reductions in xerostomia scores and IL-6 concentration at the end of the study compared to the control group. Further clinical studies with larger samples and longer durations are recommended to confirm the benefits of the described treatment.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Oncology
Ruben D. Houvast, Kira Thijse, Jesse Groen, JiaXin Chua, Mireille Vankemmelbeke, Lindy G. Durrant, J. Sven D. Mieog, Bert A. Bonsing, Alexander L. Vahrmeijer, Peter J. K. Kuppen, A. Stijn L. P. Crobach, Cornelis F. M. Sier
Summary: The study found that several specific sugar molecules and mucins are significantly higher on pancreatic cancer cells compared to surrounding tissues, making them potential targets for visualization of lymph node metastases and improving pancreatic cancer treatment. Targeted molecular imaging may overcome current challenges in preoperative and intraoperative delineation of pancreatic ductal adenocarcinoma (PDAC).
Article
Immunology
Qi Lili, Lu Xiaohui, Mao Haiguang, Wang Jinbo
Summary: C. butyricum can adhere to the mucus secreted by HT-29 cells with the glycan playing an important role in this process. Knockdown experiments targeting MUC2, FUT2, or GALNT7 significantly reduced the adhesion of bacteria to HT-29 cells. When colonizing on the surface of HT-29 cells, C. butyricum can increase mucin production and induce glycosylation, indicating its ability to modulate the glycosylation profile of mucus secreted by HT-29 cells.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2021)
Article
Dentistry, Oral Surgery & Medicine
Susann Hertel, Matthias Hannig, Christian Hannig, Torsten Sterzenbach
Summary: This study found that there were higher concentrations of mucins 5b and 7 as well as secretory IgA in the oral acquired pellicle of children with active caries compared to caries-free children. However, there were no significant differences in the concentrations of these components in saliva samples between the two groups. These findings suggest that these components could serve as potential biomarkers for early childhood caries.
ARCHIVES OF ORAL BIOLOGY
(2022)
Article
Dentistry, Oral Surgery & Medicine
Akane Takemura, Kana Hashimoto, Alex Ho, Michele Bessinger, Sandra Law, Robert E. Schifferle, Sebastian G. Ciancio
Summary: This study evaluated the efficacy of a new oral rinse in reducing symptoms of xerostomia. The results showed that the test product was effective in reducing both subjective and objective measurements of dry mouth symptoms. The test oral rinse was found to be more effective than the placebo and active control.
Review
Biochemistry & Molecular Biology
Werner Hoffmann
Summary: Human saliva contains over 3000 identified proteins, with TFF peptides and FCGBP playing key roles in wound healing and antimicrobial defense. These proteins are promising candidates for improving artificial saliva formulations, particularly in enhancing wound healing and antimicrobial effects.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Dentistry, Oral Surgery & Medicine
Neslihan Yilmaz, Recep Polat, Mervi Gursoy, Wendy Kaman, Elif Gul Aydin, Dareen Fteita, Dogukan Yilmaz, Floris Bikker, Ulvi Kahraman Gursoy
Summary: This study evaluated the salivary concentrations of macrophage activation-related chemokines and proteolytic activity of MAPKK in children and adolescents with and without T1DM. The results showed that T1DM disrupted the salivary chemokine profile and dysregulated proteolytic MAPKK cleavage.
JOURNAL OF PERIODONTOLOGY
(2023)
Article
Multidisciplinary Sciences
Cuicui Fu, Xiaoyun Qin, Jin Zhang, Ting Zhang, Yeqing Song, Jiaqi Yang, Gang Wu, Dan Luo, Nan Jiang, Floris J. Bikker
Summary: Spinacia oleracea-derived carbon quantum dots (CQDs) CQD-1 and CQD-2 were synthesized using different shredding methods and microwave-assisted hydrothermal approach. CQD-1 exhibited higher photoluminescent (PL) emission intensity and smaller size distribution compared to CQD-2. CQD-1 promoted osteogenic differentiation of human bone marrow-derived mesenchymal stem cells without showing toxicity or histological effects on major organs.
Article
Dentistry, Oral Surgery & Medicine
Cuicui Fu, Xiaoyun Qin, Wenlong Shao, Jin Zhang, Ting Zhang, Jiaqi Yang, Chong Ding, Yeqing Song, Xuejun Ge, Gang Wu, Floris J. J. Bikker, Nan Jiang
Summary: The therapeutic effects of carbon quantum dots (CQDs) in immunomodulation on non-obese diabetic (NOD) mice, a model for Sjogren's syndrome (SS), were evaluated. CQDs generated from Setaria viridis showed no cytotoxicity and alleviated inflammation in the submandibular glands of NOD mice. CQDs also reduced the levels of anti-SSA and anti-SSB, increased saliva flow rates, decreased CD3(+) and CD4(+) T cells, and increased the percentage of Foxp3(+) cells in NOD mice.
Review
Microbiology
Caroline A. A. de Jongh, Teun J. J. de Vries, Floris J. J. Bikker, Susan Gibbs, Bastiaan P. P. Krom
Summary: This review describes four possible mechanisms by which Porphyromonas gingivalis can translocate from the oral cavity to other organs in the body. These mechanisms include degradation of adhesion molecules, transcytosis, uptake by professional phagocytes, and adherence to Candida albicans. Further research could help identify targets to inhibit P. gingivalis dissemination and prevent the onset of systemic diseases.
JOURNAL OF ORAL MICROBIOLOGY
(2023)
Review
Dentistry, Oral Surgery & Medicine
Cuicui Fu, Henk S. Brand, Floris J. Bikker
Summary: This scoping review provides an overview of the research and potential applications of carbon dots (CDs) for oral health purposes. The findings show the promising potential of CDs in oral health, including inducing bacterial killing, killing oral cancer cells, and inducing dental pulp and periodontal bone regeneration. CDs have the potential to be utilized in the future for various oral health purposes and have broad-spectrum applicability beyond oral health.
Article
Oncology
Sarah Pringle, Floris J. Bikker, Wouter Vogel, Bernadette S. de Bakker, Ingrid Hofland, Bert van der Vegt, Hendrika Bootsma, Frans Kroese, Arjan Vissink, Matthijs Valstar
Summary: Based on histological and immunohistochemical analyses, the tubarial glands resemble salivary glands in terms of tissue and cellular expression, specifically resembling the palatal and labial glands.
RADIOTHERAPY AND ONCOLOGY
(2023)
Article
Materials Science, Multidisciplinary
Pardis Keikhosravani, Fatemeh Jahanmard, Tim Bollen, Kamran Nazmi, Edwin J. A. Veldhuizen, Prasad Gonugunta, Prasaanth Ravi Anusuyadevi, Bart C. H. van der Wal, Charles Vogely, Floris J. Bikker, Peyman Taheri, Harrie Weinans, Saber Amin Yavari
Summary: An antibacterial coating is developed by layer-by-layer assembly of polymers PDLG and GelMA with the loaded peptide CATH-2. The coating exhibits strong antibacterial activity and biocompatibility, making it suitable for preventing infections associated with implants.
ADVANCED MATERIALS TECHNOLOGIES
(2023)
Article
Microbiology
Kahena R. Soldati, Yaling Jiang, Bernd W. Brandt, Rob A. M. Exterkate, Mark J. Buijs, Kamran Nazmi, Wendy E. Kaman, Lei Cheng, Floris J. Bikker, Wim Crielaard, Daniela L. Zandim-Barcelos, Dong Mei Deng
Summary: This study evaluated the modulation effects of antimicrobial peptide LL-31 and its D-enantiomer (D-LL-31) on saliva-derived microcosm biofilms. The results showed that D-LL-31 had a better performance than LL-31 in reducing the total viable cell counts, P. gingivalis amount, and DPP4 activity of biofilms spiked with P. gingivalis. However, the modulation function of the peptides may be impaired in severely dysbiotic biofilms.
Article
Chemistry, Medicinal
Ali Javed, Melanie D. Balhuizen, Arianne Pannekoek, Floris J. Bikker, Dani A. C. Heesterbeek, Henk P. Haagsman, Femke Broere, Markus Weingarth, Edwin J. A. Veldhuizen
Summary: This study systematically investigates the influence of O-antigen and Lipid A composition on the antibacterial and anti-endotoxin activity of four HDPs. The results show that O-antigen does not affect antibacterial activity, while Lipid A modification can affect the immunomodulatory role of HDPs. The findings have important implications for the application of HDPs in the treatment of infectious diseases.
Article
Dentistry, Oral Surgery & Medicine
Lili Yu, Yigit Firatli, Samira Elmanfi, Mervi Gursoy, Meltem Ozdemir Kabalak, Gokhan Kasnak, Pirkko Pussinen, Floris J. Bikker, Feriha Caglayan, Erhan Firatli, Ulvi Kahraman Gursoy
Summary: The study aimed to localize MCPIP-1 and MALT-1 in gingival tissues and profile their protein expression levels in relation to inflammation, P. gingivalis colonization, and IL-8 levels. The results showed that MCPIP-1 was present in the epithelium and connective tissue, while MALT-1 was observed in all layers of the gingival epithelium and around inflammatory cells. There was no difference in MCPIP-1 and MALT-1 levels based on gingival inflammation severity, but MALT-1 levels were elevated with an increase in P. gingivalis levels and showed an association with IL-8 levels.
CLINICAL ORAL INVESTIGATIONS
(2023)
Article
Dentistry, Oral Surgery & Medicine
Z. Assy, J. S. van Santen, H. S. Brand, F. J. Bikker
Summary: This study aims to investigate whether there is an association between the perceived oral dryness and discomfort of Sjogren's disease patients and their use of specific interventions. A cross-sectional study was performed among 92 Sjogren's disease patients, who completed questionnaires to assess the severity of their oral dryness and an inventory of dry-mouth interventions. The study found that there was great variation in the use of dry-mouth interventions by the participants and the severity of the oral dryness and/or patients' discomfort seemed to affect their choice of intervention.
CLINICAL ORAL INVESTIGATIONS
(2023)
Article
Dentistry, Oral Surgery & Medicine
Neslihan Yilmaz, Recep Polat, Mervi Gursoy, Wendy Kaman, Elif Gul Aydin, Dareen Fteita, Dogukan Yilmaz, Floris Bikker, Ulvi Kahraman Gursoy
Summary: This study aimed to evaluate salivary concentrations of macrophage activation-related chemokines and MAPKK-degrading proteolytic activity in children and adolescents with and without T1DM. The results showed that salivary concentrations of certain chemokines were elevated and others were decreased in the T1DM group, and the proteolytic activity of MAPKK cleavage was also increased.
JOURNAL OF PERIODONTOLOGY
(2023)
Article
Nutrition & Dietetics
Christine Lundtorp Olsen, Laura Massarenti, Vincent Frederik Dahl Vendius, Ulvi Kahraman Gursoy, Annina Van Splunter, Floris J. Bikker, Mervi Gursoy, Christian Damgaard, Merete Markvart, Daniel Belstrom
Summary: The study aimed to test if probiotics can counteract oral dysbiosis and restore oral homeostasis. The findings suggest that consumption of probiotics during short-term sugar stress can have a stabilizing effect on the supragingival microbiota.
Article
Nutrition & Dietetics
Christine Lundtorp Olsen, Laura Massarenti, Vincent Frederik Dahl Vendius, Ulvi Kahraman Gursoy, Annina Van Splunter, Floris J. Bikker, Mervi Gursoy, Christian Damgaard, Merete Markvart, Daniel Belstrom
Summary: The present study aimed to investigate whether probiotics can protect against experimental gingivitis caused by neglecting oral hygiene for 14 days and support the restoration of oral homeostasis afterwards. The results suggest that probiotics play a role in maintaining the resilience of the oral microbiota during the resolution period of gingivitis.
Review
Genetics & Heredity
Juliette M. H. Fey, Floris J. Bikker, Daniela Hesse
Summary: This scoping review comprehensively appraises the different methods of saliva collection among children and adolescents. It finds that the absorption and suction methods are most preferred for young and uncooperative children.
MOLECULAR DIAGNOSIS & THERAPY
(2023)
