The Role of Presenilin in Protein Trafficking and Degradation—Implications for Metal Homeostasis

Alzheimer’s disease due to loss of function: A new synthesis of the available data

(2016) Kasper P. Kepp   PROGRESS IN NEUROBIOLOGY

Presenilin 1 Maintains Lysosomal Ca2+ Homeostasis via TRPML1 by Regulating vATPase-Mediated Lysosome Acidification

(2015) Ju-Hyun Lee et al.   Cell Reports

β-Amyloid Precursor Protein Does Not Possess Ferroxidase Activity but Does Stabilize the Cell Surface Ferrous Iron Exporter Ferroportin

(2014) Bruce X. Wong et al.   PLoS One

Autophagy failure in Alzheimer's disease and the role of defective lysosomal acidification

(2013) Devin M. Wolfe et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Presenilin Promotes Dietary Copper Uptake

(2013) Adam Southon et al.   PLoS One

Metalloproteomics: principles, challenges and applications to neurodegeneration

(2013) Amber Lothian et al.   Frontiers in Aging Neuroscience

Inhibition of Glycogen Synthase Kinase-3 Ameliorates β-Amyloid Pathology and Restores Lysosomal Acidification and Mammalian Target of Rapamycin Activity in the Alzheimer Disease Mouse Model

(2012) Limor Avrahami et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Lack of Evidence for Presenilins as Endoplasmic Reticulum Ca2+Leak Channels

(2012) Dustin Shilling et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Lysosomal calcium homeostasis defects, not proton pump defects, cause endo-lysosomal dysfunction in PSEN-deficient cells

(2012) Katrijn Coen et al.   JOURNAL OF CELL BIOLOGY

A Role for Presenilins in Autophagy Revisited: Normal Acidification of Lysosomes in Cells Lacking PSEN1 and PSEN2

(2012) X. Zhang et al.   JOURNAL OF NEUROSCIENCE

Metal dyshomeostasis and oxidative stress in Alzheimer’s disease

(2012) Mark A. Greenough et al.   NEUROCHEMISTRY INTERNATIONAL

Presenilin Deficiency or Lysosomal Inhibition Enhances Wnt Signaling through Relocalization of GSK3 to the Late-Endosomal Compartment

(2012) Radek Dobrowolski et al.   Cell Reports

Changes in the Expression of the Alzheimers Disease-Associated Presenilin Gene in Drosophila Heart Leads to Cardiac Dysfunction

(2011) A. Li et al.   Current Alzheimer Research

Presenilins Promote the Cellular Uptake of Copper and Zinc and Maintain Copper Chaperone of SOD1-dependent Copper/Zinc Superoxide Dismutase Activity

(2011) Mark A. Greenough et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mutagenesis Mapping of the Presenilin 1 Calcium Leak Conductance Pore

(2011) Omar Nelson et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Presenilin Is Necessary for Efficient Proteolysis through the Autophagy-Lysosome System in a  -Secretase-Independent Manner

(2011) K. M. Neely et al.   JOURNAL OF NEUROSCIENCE

Expression of functional TRPA1 receptor on human lung fibroblast and epithelial cells

(2011) Indranil Mukhopadhyay et al.   JOURNAL OF RECEPTORS AND SIGNAL TRANSDUCTION

Vesicular Zinc Promotes Presynaptic and Inhibits Postsynaptic Long-Term Potentiation of Mossy Fiber-CA3 Synapse

(2011) Enhui Pan et al.   NEURON

Autophagy impairment stimulates PS1 expression and γ-secretase activity

(2010) Kazunori Ohta et al.   Autophagy

Presenilins: how much more than γ-secretase?!

(2010) Katrijn Coen et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Iron-Export Ferroxidase Activity of β-Amyloid Precursor Protein Is Inhibited by Zinc in Alzheimer's Disease

(2010) James A. Duce et al.   CELL

Lysosomal Proteolysis and Autophagy Require Presenilin 1 and Are Disrupted by Alzheimer-Related PS1 Mutations

(2010) Ju-Hyun Lee et al.   CELL

Heavy metals zinc, cadmium, and copper stimulate pulmonary sensory neurons via direct activation of TRPA1

(2010) Qihai Gu et al.   JOURNAL OF APPLIED PHYSIOLOGY

Cognitive Loss in Zinc Transporter-3 Knock-Out Mice: A Phenocopy for the Synaptic and Memory Deficits of Alzheimer's Disease?

(2010) P. A. Adlard et al.   JOURNAL OF NEUROSCIENCE

Syntaxin 5 Is Required for Copper Homeostasis in Drosophila and Mammals

(2010) Melanie Norgate et al.   PLoS One

Lipid Rafts As a Membrane-Organizing Principle

(2010) D. Lingwood et al.   SCIENCE

The Syntaxin 5 Isoforms Syx5 and Syx5L have Distinct Effects on the Processing of β-amyloid Precursor Protein

(2009) Kei Suga et al.   JOURNAL OF BIOCHEMISTRY

Paradoxical Condensation of Copper with Elevated β-Amyloid in Lipid Rafts under Cellular Copper Deficiency Conditions

(2009) Ya Hui Hung et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Validation of TPEN as a Zinc Chelator in Fluorescence Probing of Calcium in Cells with the Indicator Fura-2

(2009) Carlos M. Matias et al.   JOURNAL OF FLUORESCENCE

Lysosome biogenesis and lysosomal membrane proteins: trafficking meets function

(2009) Paul Saftig et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Clioquinol and pyrithione activate TRPA1 by increasing intracellular Zn2+

(2009) D. A. Andersson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Calcium dysregulation in Alzheimer's disease: From mechanisms to therapeutic opportunities

(2009) Jin-Tai Yu et al.   PROGRESS IN NEUROBIOLOGY

Wnt signaling in Alzheimer's disease: Up or down, that is the question

(2008) Rick A.C.M. Boonen et al.   AGEING RESEARCH REVIEWS

Novel Role of Presenilins in Maturation and Transport of Integrin β1†

(2008) Kun Zou et al.   BIOCHEMISTRY

Amyloid Precursor Protein Trafficking, Processing, and Function

(2008) Gopal Thinakaran et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Niemann-Pick disease type C1 is a sphingosine storage disease that causes deregulation of lysosomal calcium

(2008) Emyr Lloyd-Evans et al.   NATURE MEDICINE

Endocytosis Is Required for Synaptic Activity-Dependent Release of Amyloid-β In Vivo

(2008) John R. Cirrito et al.   NEURON