Article
Respiratory System
Donato Lacedonia, Giulia Scioscia, Piera Soccio, Massimo Conese, Lucia Catucci, Grazia P. Palladino, Filomena Simone, Carla M. I. Quarato, Sante Di Gioia, Roberto Rana, Francesco Sollitto, Maria P. Foschino-Barbaro
Summary: This study analyzed the expression of exosomal miRNAs in serum from IPF patients and found significant down-regulation of let-7d and unexpectedly, miR-16. A clustering of miR-16, miR-21, and miR-26a expression was also identified. These findings may help identify key players in the pathophysiology of IPF and potential targets for future medications.
BMC PULMONARY MEDICINE
(2021)
Article
Oncology
Boxing Su, Haibo Han, Yanqing Gong, Xuesong Li, Chaoyue Ji, Jingjing Yao, Jianghui Yang, Weiguo Hu, Wei Zhao, Jianxing Li, Gang Zhang, Liqun Zhou
Summary: Let-7d inhibits intratumoral macrophage M2 polarization and tumor angiogenesis in RCC by targeting IL-10 and IL-13.
CANCER IMMUNOLOGY IMMUNOTHERAPY
(2021)
Article
Biochemistry & Molecular Biology
Guanguan Qiu, Jiajie Fan, Guoping Zheng, Jiangping He, Fangping Lin, Menghua Ge, Lanfang Huang, Jiangmei Wang, Jie Xia, Ruoqiong Huang, Qiang Shu, Jianguo Xu
Summary: This study reveals the potential role of plasma EV-miRNAs in the pathogenesis of sepsis and demonstrates the diagnostic value of combining miR-483-3p and let-7d-3p as biomarkers for early sepsis diagnosis.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2022)
Article
Agriculture, Dairy & Animal Science
Jorge A. De los Santos Funes, Joao Paulo N. Andrade, Jodi Berndtson, John Parrish
Summary: The objective of this study was to investigate the differences in circulating microRNA (miRNA) between pregnant and nonpregnant heifers. Blood samples were collected from heifers 21 days after receiving an in vitro-produced embryo, and miRNA expression was evaluated. Results showed that the Let-7d-5p miRNA was significantly decreased in nonpregnant heifers compared to pregnant ones. This research provides insights into the potential of using miRNAs as biomarkers for early pregnancy in cattle.
JOURNAL OF ANIMAL SCIENCE
(2023)
Article
Biochemistry & Molecular Biology
Gabriela Diaz-Pina, Karla Rubio, Rosa M. Ordonez-Razo, Guillermo Barreto, Eduardo Montes, Carina Becerril, Alfonso Salgado, Hector Cabrera-Fuentes, Arnoldo Aquino-Galvez, Angeles Carlos-Reyes, Victor Ruiz
Summary: The study suggests that ADAR1 isoforms and Let-7d may have a synergistic role in the development of IPF, indicating that regulating both molecules could be a potential therapeutic approach for IPF.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Medicine, Research & Experimental
Zeyu Shi, Sally K. Y. To, Shuaishuai Zhang, Shan Deng, Margarita Artemenko, Minda Zhang, Juan Tang, Jin-Zhang Zeng, Alice S. T. Wong
Summary: Nur77 functions as a novel regulator of microRNA biogenesis in promoting CRC progression under hypoxia, potentially through inhibition of p63-dependent transcription. Knockdown of Nur77 or overexpression of let-7i-5p can inhibit CRC metastasis.
Article
Gastroenterology & Hepatology
Atike Gokcen Demiray, Aydin Demiray, Arzu Yaren, Burcu Yapar Taskoylu, Gamze Gokoz Dogu, Serkan Degirmencioglu, Umut Cakiroglu, Nail Ozhan, Canan Karan, Burcin Cakan Demirel, Tolga Dogan, Melek Ozdemir
Summary: This study demonstrates that microRNAs let-7c and 7d can serve as independent predictive biomarkers for metastatic pancreatic cancer. Patients with high let-7c-7d levels receiving FOLFIRINOX treatment had significantly longer overall survival.
TURKISH JOURNAL OF GASTROENTEROLOGY
(2022)
Review
Oncology
Truman Knowles, Tina Huang, Jin Qi, Shejuan An, Noah Burket, Scott Cooper, Javad Nazarian, Amanda M. Saratsis
Summary: Diffuse midline glioma (DMG) is a devastating pediatric brain tumor with an urgent need for new treatment options. LIN28B RNA binding protein is overexpressed in DMG and suppresses the let-7 family of microRNAs, which in turn suppress a multitude of oncogenes. This review summarizes the role of the LIN28B-let-7-oncogene axis in different glioma subtypes and recommends future research focusing on DMG as a potential therapeutic target.
Article
Biochemistry & Molecular Biology
Richard J. Lightbody, Janice M. W. Taylor, Yvonne Dempsie, Annette Graham
Summary: Excessive accumulation of cholesterol and cholesteryl ester in macrophage 'foam' cells is a key feature of early atherosclerotic lesions, accompanied by epigenetic changes and altered expression of microRNA hsa-let-7d-5p. Induction of let-7d-5p and repression of its target gene HMGA2 in macrophages serves as a protective response to reduce cholesterol influx and dysregulations may contribute to atherosclerosis and other diseases such as cancer.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS
(2021)
Article
Biochemistry & Molecular Biology
Sergio Israel Rangel-Guerrero, Pablo Alberto Franco-Urquijo, Encarnacion Martinez-Salas, Luis Marat Alvarez-Salas
Summary: The study revealed the importance of the Let-7:LIN28 regulatory loop in miRNA regulation, investigated the binding differences between LIN28B and pre-let-7 members, and uncovered diverse structural patterns within the pre-let-7 family through SHAPE mapping.
NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS
(2021)
Article
Cell Biology
Dahai Wang, Mayuri Tanaka-Yano, Eleanor Meader, Melissa A. Kinney, Vivian Morris, Edroaldo Lummertz da Rocha, Nan Liu, Tianxin Liu, Qian Zhu, Stuart H. Orkin, Trista E. North, George Q. Daley, R. Grant Rowe
Summary: Hematopoiesis changes over life to meet the demands of maturation and aging. The study reveals that the remodeling of the definitive hematopoietic stem and progenitor cell (HSPC) compartment is regulated by the Lin28b/let-7 axis, and the Cbx2 gene plays a crucial role in this process.
Article
Genetics & Heredity
Nadine Maier, Constantin Gatterer, Patrick Haider, Manuel Salzmann, Christoph Kaun, Walter S. Speidl, Gere Sunder-Plassmann, Bruno K. Podesser, Johann Wojta, Senta Graf, Max Lenz, Philipp J. Hohensinner
Summary: The study found that let-7a and let-7d miRNAs significantly increased in Fabry disease patients after enzyme replacement therapy, suggesting their potential as markers for enzyme activity and inflammation. Additionally, experimental results showed that Gb3 affects miRNA expression by activating NF-kappa B.
Article
Developmental Biology
Minmin Song, Chenrui Cao, Zhenhua Zhou, Simin Yao, Peipei Jiang, Huiyan Wang, Guangfeng Zhao, Yali Hu
Summary: This study demonstrates the overexpression of HMGA2 in endometrial epithelial cells of intrauterine adhesion patients, promoting the formation of intrauterine adhesions. It also suggests that let-7d microRNA can suppress the effects of HMGA2, potentially serving as a therapeutic strategy for intrauterine adhesions.
MOLECULAR HUMAN REPRODUCTION
(2021)
Article
Pharmacology & Pharmacy
Wenqian Zhang, Qiaozhu Wang, Xin Xing, Lijun Yang, Min Xu, Chunhui Cao, Rong Wang, Weicheng Li, Xiaolin Niu, Dengfeng Gao
Summary: miR-26a plays an antagonistic role in hypertensive vascular remodelling by inhibiting extracellular matrix deposition via targeting CTGF and reducing VSMC proliferation by regulating the EZH2/p21 pathway. AngII-mediated Smad3 activation suppresses miR-26a expression, promoting Smad3 activation through targeted regulation of Smad4, leading to further down-regulation of miR-26a.
BRITISH JOURNAL OF PHARMACOLOGY
(2021)
Article
Multidisciplinary Sciences
Yueh-Hua Chung, Yuan-Tso Cheng, Ying-Hsien Kao, Wan-Chi Tsai, Gong-Kai Huang, Yen-Ta Chen, Yuan-Chi Shen, Ming-Hong Tai, Po-Hui Chiang
Summary: This study investigates the expression of miR-26a-5p in upper tract urothelial carcinoma (UTUC) and its associated signaling network. The results demonstrate significant down-regulation of miR-26a-5p in UTUC tumors and its ability to inhibit cell proliferation and migration by reversing epithelial-to-mesenchymal transition (EMT) process.
SCIENTIFIC REPORTS
(2022)
Article
Chemistry, Multidisciplinary
Lu Zhang, Yi-ning Wang, Jia-ming Ju, Azaliia Shabanova, Yue Li, Ruo-nan Fang, Jia-bin Sun, Ying-ying Guo, Tong-zhu Jin, Yan-yan Liu, Tian-yu Li, Hong-li Shan, Hai-hai Liang, Bao-feng Yang
Summary: Mzb1 plays a crucial role in cardiomyocytes post-MI by improving mitochondrial function and reducing inflammatory signaling pathways, suggesting it as a promising therapeutic target in ischemic cardiomyopathy.
ACTA PHARMACOLOGICA SINICA
(2021)
Article
Cell Biology
Lijia Zhang, Lifang Lv, Nan Zheng, Ruotong Li, Rui Yang, Tianyu Li, Yingnan Li, Yingqi Liu, Hongwei Luo, Xuelian Li, Yuhong Zhou, Hongli Shan, Bing Bai, Haihai Liang
Summary: Sox4 plays a role in promoting cardiomyocyte apoptosis during myocardial infarction by regulating Bim expression, and silencing Sox4 can attenuate cardiomyocyte apoptosis, suggesting it as a potential therapeutic target for MI.
JOURNAL OF CELLULAR PHYSIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Jian Sun, Tongzhu Jin, Wei Su, Yingying Guo, Zhihui Niu, Jiayu Guo, Liangliang Li, Jiayi Wang, Lu Ma, Tong Yu, Xuelian Li, Yuhong Zhou, Hongli Shan, Haihai Liang
Summary: This study highlighted the crucial role of lncRNA PFI in mitigating pulmonary fibrosis by negatively regulating the expression and activity of SRSF1, reducing the formation of the EDA+Fn1 splicing isoform. These findings suggest that PFI and SRSF1 could be potential targets for the treatment of lung fibrosis.
CELL DEATH AND DIFFERENTIATION
(2021)
Review
Pharmacology & Pharmacy
Jinjing Wei, Yongting Zhao, Haihai Liang, Weijie Du, Lihong Wang
Summary: This article provides the most updated data on cell death in diabetic cardiomyopathy (DCM) and emphasizes the critical role of cell death in the pathophysiological process. It offers valuable insights and directions for future studies.
ACTA PHARMACEUTICA SINICA B
(2022)
Article
Biochemistry & Molecular Biology
Chengyu Wang, Tong Zhu, Zhangxiang Zhao, Bo Chen, Tingting Chen, Qi Dong, Mingyue Liu, Shuping Zhuang, Fan Yang, Yaoyao Liu, Min Yang, Yunyan Gu, Haihai Liang
Summary: The Hippo signaling pathway plays a crucial role in carcinogenesis, with downstream effector YAP1 being identified as potentially inhibiting CD8+ T cell infiltration in uterine corpus endometrial carcinoma by upregulating CREB1. Furthermore, esophageal carcinoma patients were classified into three subtypes based on a Hippo-immune gene panel, each with distinct characteristics in immune cell infiltration, immune pathways, and prognosis, suggesting a new classification of immune subtypes with prognostic implications in esophageal carcinoma.
Article
Physiology
Qian Xu, Kunping Zhuo, Ruiping Cai, Xiaomin Su, Lu Zhang, Yueyang Liu, Lin Zhu, Fu Ren, Ming-Sheng Zhou
Summary: Research has shown that in hypertensive mice and human umbilical vein endothelial cells, YAP/TAZ activation induced by AngII may lead to endothelial dysfunction and vascular inflammation through PP2A-dependent dephosphorylation. Treatment with verteporfin improves endothelial function and reduces vascular inflammation, while LB-100 can prevent YAP/TAZ activation.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Tian-yu Li, Wei Su, Liang-liang Li, Xiao-guang Zhao, Na Yang, Jia-xin Gai, Xin Lv, Jing Zhang, Meng-qin Huang, Qing Zhang, Wei-hang Ji, Xiao-ying Song, Yu-hong Zhou, Xue-lian Li, Hong-li Shan, Hai-hai Liang
Summary: Abnormal activation of cardiac fibroblasts is the main cause of cardiac fibrosis. This study reveals the important roles of platelet-activating factor (PAF) and the Hippo pathway in cardiac fibrosis. PAF induces fibrosis through activation of the effector YAP1 and promotes its nuclear translocation via PAFR interaction. Furthermore, YAP1 promotes the expression of PAFR. Inhibiting PAFR or YAP1 can impede cardiac fibrosis and improve cardiac function. These findings suggest the potential of PAFR/YAP1 as therapeutic targets for cardiac fibrosis.
ACTA PHARMACOLOGICA SINICA
(2022)
Article
Oncology
Tingting Chen, Tong Yu, Shuping Zhuang, Yiding Geng, Junwen Xue, Jiayi Wang, Liqiang Ai, Bo Chen, Zhangxiang Zhao, Yawei Li, Jinghao Wang, Haihai Liang, Yan Xu, Yunyan Gu
Summary: This study developed a qualitative signature for detecting BRCAness in OvCa and showed that patients classified as BRCAness had improved overall survival and progression-free survival, as well as increased sensitivity to immune checkpoint blockade.
BRITISH JOURNAL OF CANCER
(2022)
Article
Pharmacology & Pharmacy
Yue Zhang, Zhiying Wang, Dingming Lan, Jingjing Zhao, Lexun Wang, Xiaoqi Shao, Dongwei Wang, Kaili Wu, Mengxian Sun, Xueying Huang, Meiling Yan, Haihai Liang, Xianglu Rong, Hongtao Diao, Jiao Guo
Summary: MiR-24-3p expression is downregulated in cardiac fibrosis and its forced expression can inhibit fibroblast proliferation and migration, as well as reduce collagen and alpha-SMA levels. MiR-24-3p can alleviate cardiac fibrosis by suppressing mitophagy and autophagic flux.
PHARMACOLOGICAL RESEARCH
(2022)
Article
Pharmacology & Pharmacy
Ya-Jia Xie, Min Huang, Dan Li, Jin-Cai Hou, Hai-Hai Liang, Ali Adnan Nasim, Ju-Min Huang, Chun Xie, Elaine Lai-Han Leung, Xing-Xing Fan
Summary: Bacteria-based immunotherapy combined with nanotechnology shows promise in enhancing the efficacy of cancer treatment.
PHARMACOLOGICAL RESEARCH
(2022)
Article
Pharmacology & Pharmacy
Jian Sun, Tongzhu Jin, Zhihui Niu, Jiayu Guo, Yingying Guo, Ruoxuan Yang, Qianqian Wang, Huiying Gao, Yuhan Zhang, Tianyu Li, Wenxin He, Zhixin Li, Wenchao Ma, Wei Su, Liangliang Li, Xingxing Fan, Hongli Shan, Haihai Liang
Summary: This study found that lncRNA DACH1 is downregulated in patients with pulmonary fibrosis and in a mouse model of the disease. LncDACH1 inhibits lung fibrosis by interacting with SRSF1 to suppress CTNNB1 accumulation.
ACTA PHARMACEUTICA SINICA B
(2022)
Article
Cell Biology
Jian Sun, Yingying Guo, Tingting Chen, Tongzhu Jin, Lu Ma, Liqiang Ai, Jiayu Guo, Zhihui Niu, Ruoxuan Yang, Qianqian Wang, Xiaojiang Yu, Huiying Gao, Yuhan Zhang, Wei Su, Xiaoying Song, Weihang Ji, Qing Zhang, Mengqin Huang, Xingxing Fan, Zhimin Du, Haihai Liang
Summary: In this study, we identified TP53TG1 as a crucial lncRNA involved in the regulation of fibroblast activation and idiopathic pulmonary fibrosis (IPF). TP53TG1 overexpression inhibited fibroblast proliferation and differentiation, reduced the expression of IPF-related proteins, and prevented and reversed lung fibrosis. Mechanistically, TP53TG1 bound to MYH9 to suppress its protein expression and inhibit fibroblast activation.
CELL DEATH & DISEASE
(2022)
Article
Cell Biology
Tong Yu, Yanyan Liu, Junwen Xue, Xiang Sun, Di Zhu, Lu Ma, Yingying Guo, Tongzhu Jin, Huiying Cao, Yingzhun Chen, Tong Zhu, Xuelian Li, Haihai Liang, Zhimin Du, Hongli Shan
Summary: This study found that Gankyrin is upregulated in non-small cell lung cancer (NSCLC) and plays a role in promoting cancer progression through the regulation of YAP1 and glycolysis. The inhibition of Gankyrin could potentially be a therapeutic strategy for NSCLC.
CELL DEATH DISCOVERY
(2022)
Article
Multidisciplinary Sciences
Yueyang Liu, Jingyu Yang, Xiaohang Che, Jianhua Huang, Xianyang Zhang, Xiaoxiao Fu, Jialing Cai, Yang Yao, Haotian Zhang, Ruiping Cai, Xiaomin Su, Qian Xu, Fu Ren, Renzhi Cai, Andrew Schally, Ming-Sheng Zhou
Summary: The GHRH agonist MR-409 has remarkable neuroprotective effects in ischemic stroke mice by enhancing endogenous neurogenesis. It reduces mortality, ischemic insult, and hippocampal atrophy while improving neurological functional recovery.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Biochemistry & Molecular Biology
Qi Dong, Mingyue Liu, Bo Chen, Zhangxiang Zhao, Tingting Chen, Chengyu Wang, Shuping Zhuang, Yawei Li, Yuquan Wang, Liqiang Ai, Yaoyao Liu, Haihai Liang, Lishuang Qi, Yunyan Gu
Summary: PARP inhibitors are designed based on synthetic lethality, aiming to broaden patient benefits and overcome drug resistance. Genetic interactions, such as synthetic lethality and synthetic viability, play a role in drug response. By developing novel computational methods and utilizing functional screens, sensitive and resistant genes related to PARP inhibitors have been identified, providing new insights for precision therapeutics.
COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL
(2021)