Article
Endocrinology & Metabolism
Sarah Charlier, Janina Vavanikunnel, Claudia Becker, Susan S. Jick, Christian Meier, Christoph R. Meier
Summary: The study found that patients with good glycemic control who were treated with metformin monotherapy had a lower risk of fractures, while glycemic control in patients receiving other antidiabetic medications was not associated with fracture risk.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Article
Multidisciplinary Sciences
Boonsub Sakboonyarat, Warabhorn Pima, Channarong Chokbumrungsuk, Taksin Pimpak, Sirikorn Khunsri, Supak Ukritchon, Worarachanee Imjaijitt, Mathirut Mungthin, Wisit Kaewput, Bhophkrit Bhopdhornangkul, Nattapol Sathavarodom, Pyatat Tatsanavivat, Ram Rangsin
Summary: Diabetes is a major global health issue with increasing prevalence, and the study in Thailand found that the rate of adequate glycemic control among patients with type 2 diabetes was on the rise. Factors associated with poor glycemic control included gender, age, region, level of care, health insurance scheme, duration of diabetes, body mass index, and presence of hypertension comorbidity.
SCIENTIFIC REPORTS
(2021)
Article
Endocrinology & Metabolism
David Simmons
Summary: The diagnosis of gestational diabetes mellitus has traditionally been based on an oral glucose tolerance test at 24-28 weeks of gestation, but with the increasing prevalence of type 2 diabetes in pregnancy, there is a need to identify undiagnosed diabetes as early as possible. Screening for undiagnosed diabetes in early pregnancy can help identify women with higher blood sugar levels but who do not meet the criteria for overt diabetes, leading to a greater risk of adverse pregnancy outcomes.
Article
Cardiac & Cardiovascular Systems
Jonas Ghouse, Paul Blanche, Morten W. Skov, Bent Lind, Allan Vaag, Jorgen K. Kanters, Jesper H. Svendsen, Lars Kober, Morten S. Olesen, Thomas A. Gerds, Anders G. Holst, Jonas B. Nielsen
Summary: The study investigated the association between a large and rapid decline in glycated hemoglobin (HbA(1C)) following initiation of oral antidiabetic drugs (OAD) and the risk of major adverse cardiovascular events (MACE) and death. Results showed that patients with a high pre-treatment HbA(1C) and steep decline had a lower short-term risk of MACE, while those with a low pre-treatment HbA(1C) and steep decline had a reduced long-term risk of MACE, but an increased risk of death and hypoglycemia in the short term.
EUROPEAN HEART JOURNAL-CARDIOVASCULAR PHARMACOTHERAPY
(2021)
Article
Medicine, General & Internal
Pedro Romero-Aroca, Raul Navarro-Gil, Albert Feliu, Aida Valls, Antonio Moreno, Marc Baget-Bernaldiz
Summary: Measuring variability in HbA(1c) can help identify patients at risk of developing diabetic retinopathy and microalbuminuria, with coefficient of variation of HbA(1c) as a target for severe DR.
Article
Endocrinology & Metabolism
Olivier G. Polle, Antoine Delfosse, Manon Martin, Jacques Louis, Inge Gies, Marieke den Brinker, Nicole Seret, Marie-Christine Lebrethon, Thierry Mouraux, Laurent Gatto, Philippe A. Lysy
Summary: This study evaluated whether indexes of glycemic variability could overcome residual beta-cell secretion estimates in the longitudinal evaluation of partial remission in pediatric patients with new-onset type 1 diabetes. The combination of CGM metrics and clinical parameters revealed key clinical milestones of glucose homeostasis and remission status during the first year of type 1 diabetes in the pediatric cohort.
Article
Geriatrics & Gerontology
Oliver Baretella, Heba Alwan, Martin Feller, Carole E. Aubert, Cinzia Del Giovane, Dimitrios Papazoglou, Antoine Christiaens, Arend-Jan Meinders, Stephen Byrne, Patricia M. Kearney, Denis O'Mahony, Wilma Knol, Benoit Boland, Baris Gencer, Drahomir Aujesky, Nicolas Rodondi
Summary: In multimorbid older patients with type 2 diabetes mellitus (T2DM), more than one third were overtreated, highlighting the high prevalence of this problem. Careful balancing of benefits and risks in the choice of glucose-lowering medication (GLM) may improve patient care, especially in the context of comorbidities such as severe renal impairment, and frequent non-GP healthcare contacts.
JOURNAL OF THE AMERICAN GERIATRICS SOCIETY
(2023)
Review
Nutrition & Dietetics
Elske L. van den Burg, Petra G. van Peet, Marjolein P. Schoonakker, Dionysia E. van de Haar, Mattijs E. Numans, Hanno Pijl
Summary: This systematic review aims to summarize the effects of intermittent energy restriction (IER) and periodic fasting (PF) on patients with type 2 diabetes (T2D). The review found that IER and PF may improve glucose control in the short term and potentially reduce the need for medication dosage.
Article
Medicine, Research & Experimental
Dominik Lautsch, Robert Boggs, Tongtong Wang, Claudio Gonzalez, Gary Milligan, Swapnil Rajpathak, Seema Malkani, Euan McLeod, James Carroll, Victoria Higgins
Summary: The study explored the real-world glycemic control situation of patients with type 2 diabetes mellitus, revealing that only about 40% of patients achieved their individualized HbA(1c) goal, with treatment intensification often delayed until HbA(1c) was 8% or higher. Patients aware of their HbA(1c) goal showed slightly better adherence to antihyperglycemic medication, but in reality, awareness did not lead to improved goal attainment.
ADVANCES IN THERAPY
(2022)
Article
Endocrinology & Metabolism
Anita Jeyam, Fraser W. Gibb, John A. McKnight, Brian Kennon, Joseph E. O'Reilly, Thomas M. Caparrotta, Andreas Hohn, Stuart J. McGurnaghan, Luke A. K. Blackbourn, Sara Hatam, Rory J. McCrimmon, Graham Leese, Robert S. Lindsay, John Petrie, John Chalmers, Sam Philip, Sarah H. Wild, Naveed Sattar, Paul M. McKeigue, Helen M. Colhoun
Summary: The study aimed to evaluate the use of continuous subcutaneous insulin infusion (CSII) in individuals with type 1 diabetes in Scotland and its impact on glycaemic control. Results showed CSII treatment led to significant reductions in HbA(1c) levels, particularly in those with high baseline levels, and was also associated with lower rates of DKA and SHH events.
Article
Endocrinology & Metabolism
Anita Jeyam, Fraser W. Gibb, John A. McKnight, Joseph E. O'Reilly, Thomas M. Caparrotta, Andreas Hohn, Stuart J. McGurnaghan, Luke A. K. Blackbourn, Sara Hatam, Brian Kennon, Rory J. McCrimmon, Graham Leese, Sam Philip, Naveed Sattar, Paul M. McKeigue, Helen M. Colhoun
Summary: Results of the study showed that for type 1 diabetes patients using flash monitors, there was a significant reduction in HbA(1c) levels and a noticeable decrease in DKA rates after FM initiation. The use of FM has important implications for improving blood sugar management in diabetic patients.
Article
Endocrinology & Metabolism
Yukari Kobayashi, Jin Long, Shozen Dan, Neil M. Johannsen, Ruth Talamoa, Sonia Raghuram, Sukyung Chung, Kyla Kent, Marina Basina, Cynthia Lamendola, Francois Haddad, Mary B. Leonard, Timothy S. Church, Latha Palaniappan
Summary: This study aimed to investigate the optimal exercise regimen for individuals with "normalweight type 2 diabetes" (BMI < 25 kg/m²). The results showed that strength training alone significantly reduced HbA1c levels and increased lean mass, and strength training was superior to aerobic training alone or combination training.
Article
Endocrinology & Metabolism
Soraya Soulimane, Beverley Balkau, Yakima D. Vogtschmidt, Monika Toeller, John H. Fuller, Sabita S. Soedamah-Muthu
Summary: This study aimed to determine whether favorable cardiovascular health metrics or clustering of these metrics can reduce the risk of cardiovascular disease (CVD) in individuals with type 1 diabetes. The results showed that individuals with lower HbA(1c) and blood pressure had significantly lower CVD risk. Furthermore, a greater clustering of favorable metrics was associated with a lower risk of CVD.
Article
Cardiac & Cardiovascular Systems
Ramkumar V. Venkateswaran, M. V. Moorthy, Neal A. Chatterjee, Julie Pester, Alan H. Kadish, Daniel C. Lee, Nancy R. Cook, Christine M. Albert
Summary: In patients with coronary artery disease and left ventricular ejection fraction of >30% to 35%, those with diabetes mellitus and/or elevated HbA1c are at a much higher absolute risk of non-sudden/arrhythmic death compared to sudden/arrhythmic death. Clinical risk markers, rather than HbA1c, are associated with sudden/arrhythmic death risk in patients with diabetes mellitus.
JACC-CLINICAL ELECTROPHYSIOLOGY
(2021)
Article
Endocrinology & Metabolism
Emma L. Jamieson, Erica P. Spry, Andrew B. Kirke, Emma Griffiths, Cynthia Porter, Carly Roxburgh, Sally Singleton, Kylie Sterry, David N. Atkinson, Julia V. Marley
Summary: This study aimed to investigate the role of early pregnancy HbA(1c) in predicting gestational diabetes mellitus (GDM) and adverse birth outcomes in Australian women. The results showed that HbA(1c) >= 5.6% can predict the risk of GDM significantly, especially in Aboriginal women, and increase the risk of having a large-for-gestational-age (LGA) newborn. Additionally, there were clear differences between Aboriginal and non-Aboriginal women in terms of elevated HbA(1c) levels and developing hyperglycemia during pregnancy.
DIABETES RESEARCH AND CLINICAL PRACTICE
(2021)