Article
Cardiac & Cardiovascular Systems
Xavier Revelo, Preethy Parthiban, Chen Chen, Fanta Barrow, Gavin Fredrickson, Haiguang Wang, Dogacan Yucel, Adam Herman, Jop H. van Berlo
Summary: This study assessed the role of cardiac immune cells in the early hypertrophy response to cardiac pressure overload and found that cardiac resident macrophages play a key role in stimulating angiogenesis and inhibiting fibrosis in response to cardiac pressure overload.
CIRCULATION RESEARCH
(2021)
Article
Chemistry, Multidisciplinary
Ajit Magadum, Neha Singh, Ann Anu Kurian, Mohammad Tofael Kabir Sharkar, Nishat Sultana, Elena Chepurko, Keerat Kaur, Magdalena M. Zak, Yoav Hadas, Djamel Lebeche, Susmita Sahoo, Roger Hajjar, Lior Zangi
Summary: Heart failure remains a major issue globally, with cardiac hypertrophy and fibrosis being key factors. The regulator Pip4k2c, associated with mTORC1, plays a role in these processes. Studies show that deleting Pip4k2c does not affect embryonic cardiac development, but leads to increased rates of CH, CF, and sudden death in adult mice. Upregulating Pip4k2c improves heart function, reverses CH and CF, and enhances survival through inhibiting TGF beta 1 via specific pathways. Loss-and-gain-of-function studies identify Pip4k2c as a potential therapeutic target for CF, CH, and HF, utilizing modRNA as an effective gene therapy approach.
Article
Cardiac & Cardiovascular Systems
Lin Yuan, Shichen Bu, Meng Du, Yilong Wang, Chenhui Ju, Dandan Huang, Wenjing Xu, Xin Tan, Minglu Liang, Shan Deng, Liu Yang, Kai Huang
Summary: This study investigated the role of RNF207 in the development of pathological cardiac hypertrophy and dysfunction. The results showed that RNF207 exacerbated cardiac hypertrophy and fibrosis, while RNF207 knockdown alleviated these conditions.
CARDIOVASCULAR RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Mari E. Strand, Maarten Vanhaverbeke, Michiel T. H. M. Henkens, Maurits A. Sikking, Karoline B. Rypdal, Bjorn Braathen, Vibeke M. Almaas, Theis Tonnessen, Geir Christensen, Stephane Heymans, Ida G. Lunde
Summary: Circulating biomarkers reflecting cardiac inflammation are needed to improve the diagnostics and guide the treatment of heart failure patients. The shedding of syndecan-4 from cardiac myocytes and fibroblasts was attenuated by immunomodulatory therapy. However, the levels of syndecan-4 did not reflect cardiac inflammatory status in patients with heart disease.
Article
Cell Biology
Peilei Lu, Fan Ding, Yang Kevin Xiang, Liying Hao, Meimi Zhao
Summary: This article discusses the roles of various ncRNAs, including miRNAs, lncRNAs, and circRNAs, in modulating cardiac hypertrophy and heart failure in cardiovascular diseases.
Article
Medicine, Research & Experimental
Yizhou Feng, Yuan Yuan, Hongxia Xia, Zhaopeng Wang, Yan Che, Zhefu Hu, Jiangyang Deng, Fangfang Li, Qingqing Wu, Zhouyan Bian, Heng Zhou, Difei Shen, Qizhu Tang
Summary: OSMR deficiency exacerbates pressure overload-induced cardiac hypertrophy by modulating macrophages and OSM/LIFR/STAT3 signaling, suggesting that OSMR may be a potential target for treating pathological cardiac hypertrophy and heart failure.
JOURNAL OF TRANSLATIONAL MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Jiayi Liu, Wei Li, Ke-Qiong Deng, Song Tian, Hui Liu, Hongjie Shi, Qian Fang, Zhen Liu, Ze Chen, Tian Tian, Shanyu Gan, Fengjiao Hu, Manli Hu, Xu Cheng, Yan-Xiao Ji, Peng Zhang, Zhi-Gang She, Xiao-Jing Zhang, Shaoze Chen, Jingjing Cai, Hongliang Li
Summary: The study found a close correlation between Trim16 expression and hypertrophy-related heart failure in both humans and mice. Trim16 deficiency exacerbated cardiomyocyte enlargement, while Trim16 overexpression attenuated cardiac hypertrophy and remodeling. Mechanistically, Prdx1 is an essential target of Trim16 in cardiac hypertrophy, and the Trim16-Prdx1 axis represents a promising therapeutic strategy for hypertrophy-related heart failure.
CIRCULATION RESEARCH
(2022)
Review
Peripheral Vascular Disease
Maria Ercu, Stephan Walter, Enno Klussmann
Summary: Hypertension with brachydactyly (HTNB) is a rare autosomal dominant form of hypertension characterized by a significant rise in blood pressure. HTNB is caused by gain-of-function mutations in the PDE3A gene, resulting in hyperactive mutant enzymes. Despite decades of hypertension, HTNB is not associated with cardiac damage commonly seen in other hypertensive conditions. The cardioprotective effect of HTNB involves local changes in cAMP signaling and inhibition of Ca2+ reuptake. Understanding the molecular mechanisms underlying HTNB could lead to improved strategies for treating essential hypertension and preventing hypertension-induced cardiac damage.
Article
Cardiac & Cardiovascular Systems
Andreas Romaine, Arne Olav Melleby, Jahedul Alam, Viola Helene Lobert, Ning Lu, Francesca E. Lockwood, Almira Hasic, Ida G. Lunde, Ivar Sjaastad, Harald Stenmark, Kate M. Herum, Donald Gullberg, Geir Christensen
Summary: Pathological myocardial hypertrophy in response to increased left ventricular afterload is a critical factor in the development of heart failure. This study identifies integrin a11 as a key mediator of pathological myocardial hypertrophy and demonstrates that syndecan-4 compensates for the lack of a11. Mice lacking both a11 and syndecan-4 show reduced myocardial hypertrophy, indicating the importance of their interplay in stress sensing in cardiac cells.
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
(2022)
Article
Chemistry, Medicinal
G. Ian Gallicano, Jiayu Fu, Samiksha Mahapatra, Michael V. R. Sharma, Conor Dillon, Claire Deng, Maliha Zahid
Summary: Research has shown that miRNA106a can target genes that cause hypertrophy and heart failure, reversing the disease. By using a cardiac targeting peptide reversibly linked to miRNA106a, delivery specific to cardiomyocytes has been demonstrated.
Article
Cell Biology
Sai Aung Phyo, Keita Uchida, Christina Yingxian Chen, Matthew A. Caporizzo, Kenneth Bedi, Joanna Griffin, Kenneth Margulies, Benjamin L. Prosser
Summary: This study investigates the transcriptional, autoregulatory, and post-translational mechanisms that contribute to microtubule network remodeling in different stages of heart disease using heart failure patient samples and murine models. The study reveals the operability of autoregulation across tubulin isoforms in the heart and the rapid induction of microtubule detyrosination after hypertrophic stimulus. It provides insights into the rapid rewriting of the tubulin code and the tunable autoregulation of tubulin during pathological progression.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Jing Zhao, Xiaoli Jiang, Jinhua Liu, Ping Ye, Lang Jiang, Manhua Chen, Jiahong Xia
Summary: The study found that DUSP26 inhibits cardiac hypertrophy and protects the heart from pressure overload-induced hypertrophy by modulating the transforming growth factor-beta activated kinase 1-p38/c-Jun N-terminal kinase signaling pathway. Therefore, DUSP26 may serve as a therapeutic target for the treatment of cardiac hypertrophy and heart failure.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2021)
Article
Cell Biology
Thomas Neill, Christopher Xie, Renato V. Iozzo
Summary: This study demonstrates that Decorin triggers mitochondrial depolarization in several types of cells, including breast carcinoma, HeLa, and endothelial cells. The bioactivity of Decorin is mediated by the MET receptor and its tyrosine kinase, as well as two mitochondrial proteins, mitostatin and mitofusin 2.
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Atsushi Sanbe, Yui Inomata, Naoko Matsushita, Yohei Sawa, Chizuru Hino, Hinano Yamazaki, Kei Takanohashi, Natsuko Takahashi, Rieko Higashio, Hideki Tsumura, Toshinori Aoyagi, Masamichi Hirose
Summary: This study investigated the functional role of HDAC6 in cardiac disease progression using transgenic mouse models. The findings indicate that HDAC6 activity can regulate levels of acetylated tubulin and cortactin, which play critical roles in cardiac diseases such as pressure-overload hypertrophy.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2022)
Article
Peripheral Vascular Disease
Ferda Demir, Kyoji Urayama, Anais Audebrand, Ayca Toprak-Semiz, Marja Steenman, Hitoshi Kurose, Canan G. Nebigil
Summary: This study reveals that pressure overload-mediated PKR2 signaling in cardiomyocytes contributes to cardiac hypertrophy through autocrine signaling, and vascular rarefaction via cardiac cytokine-mediated cardiomyocyte-endothelial cell communications. Our results may contribute to the development of potential therapeutic targets for heart failure.
Article
Cardiac & Cardiovascular Systems
Maximilian Kreibich, Matthias Siepe, Tim Berger, Friedhelm Beyersdorf, Martin Soschynski, Christopher L. Schlett, Martin Czerny, Bartosz Rylski
Summary: This study aimed to evaluate the long-term incidence and outcome of aortic interventions for medically managed uncomplicated thoracic aortic dissections. Among the patients discharged home with uncomplicated aortic dissections, 33% of them required aortic interventions. A descending thoracic aortic diameter exceeding 45 mm was a predictive factor for aortic intervention. The risk for aortic intervention after 1 and 3 years was 27% and 36%, respectively.
JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY
(2023)
Article
Cardiac & Cardiovascular Systems
Jan-Steffen Pooth, Sam J. Brixius, Christian Scherer, Patric Diel, Yechi Liu, Itumeleng C. Taunyane, Domagoj Damjanovic, Martin Wolkewitz, Joerg Haberstroh, Christoph Benk, Georg Trummer, Friedhelm Beyersdorf
Summary: The choice of plasma expander in the CARL priming solution plays a significant role in the success of CARL therapy, but it does not seem to have a clear impact on the seven-day survival rate and neurological deficit scoring.
Article
Cardiac & Cardiovascular Systems
Clarence Pingpoh, Maximillian Kreibich, Tim Berger, Martin Thoma, Friedhelm Beyersdorf, Thomas Comberg, Albi Fagu, Matthias Siepe, Martin Czerny
Summary: This study retrospectively evaluated the in-hospital and overall outcome of patients who underwent mitral valve replacement (MVR) after a failed MitraClip procedure. The study found that the need for MVR after failed MitraClip repair is low and the results are acceptable. However, the options for reconstruction are often limited and MVR is frequently required.
THORACIC AND CARDIOVASCULAR SURGEON
(2023)
Editorial Material
Cell Biology
Eric Delpire, Thomas J. Hawke, Mythreye Karthikeyan, Wei Kong, Alexander Nystroem, Shizuka Uchida, Liliana Schaefer
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
(2023)
Review
Cardiac & Cardiovascular Systems
Bartosz Rylski, Oliver Schilling, Martin Czerny
Summary: Remarkable progress has been made in aortic medicine in recent decades, leading to significant changes in the understanding and treatment of thoracic aortic dissection. This state-of-the-art review article explores the mechanisms of acute aortic dissection, the impact of its entry location and dissection extension on clinical presentation and treatment decisions, and presents the latest evidence on novel treatment methods and discussions on dissection classification. Future aspects of treating acute aortic dissection are also discussed.
EUROPEAN HEART JOURNAL
(2023)
Editorial Material
Cell Biology
Liliana Schaefer, Sandrine V. Pierre
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
(2023)
Review
Cell Biology
Sarah Miethe, Daniel P. Potaczek, Stanislawa Bazan-Socha, Melanie Bachl, Liliana Schaefer, Malgorzata Wygrecka, Holger Garn
Summary: Extracellular vesicles (EVs) have gained attention for their role in intercellular signaling, particularly in the connection between adipose tissue (AT) and the lung in diseases such as obesity-associated asthma and lung cancer-associated cachexia. Studies have shown both pathogenic and protective effects of EVs in these diseases, with AT-derived EVs playing a potential therapeutic role. Further research is needed to better understand the role of EVs in disease development and organ interconnectivity.
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
(2023)
Review
Cardiac & Cardiovascular Systems
Sabine Steffens, Katrin Schroeder, Martina Krueger, Christoph Maack, Katrin Streckfuss-Boemeke, Johannes Backs, Rolf Backofen, Bettina Baessler, Yvan Devaux, Ralf Gilsbach, Jordi Heijman, Jochen Knaus, Rafael Kramann, Dominik Linz, Allyson L. Lister, Henrike Maatz, Lars Maegdefessel, Manuel Mayr, Benjamin Meder, Sara Y. Nussbeck, Eva A. Rog-Zielinska, Marcel H. Schulz, Albert Sickmann, Goekhan Yigit, Peter Kohl
Summary: Sharing and documentation of cardiovascular research data are essential but challenges like lack of time, incentives, funding, standardization, and legal understanding exist. More tools, education, and training are needed for effective data sharing and an open science culture. Long-term effort is required for FAIR RDM.
CLINICAL RESEARCH IN CARDIOLOGY
(2023)
Article
Medicine, General & Internal
Barbara Zieger, Denise Schneider, Sam Joe Brixius, Christian Scherer, Armin Buchwald, Georg Trummer, Martin Czerny, Friedhelm Beyersdorf, Hans-Joerg Busch, Christoph Benk, Jan-Steffen Pooth
Summary: This study investigated the effects of pulsatile blood flow in an ex-vivo setting. After 6 hours of circulation, increased levels of interleukin 8 (IL-8) were observed in both non-pulsatile and pulsatile pump settings. Pulsatile pump flow resulted in significantly increased hemolysis after 6 hours of circulation. The study suggests that caution should be exercised when using prolonged durations of pulsatile pump flow in clinical practice.
FRONTIERS IN MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Rodrigo Sandoval Boburg, Stoyan Kondov, Mladen Karamitev, Christian Schlensak, Rafal Berger, Helene Haeberle, Walter Jost, Albi Fagu, Friedhelm Beyersdorf, Maximilian Kreibich, Martin Czerny, Matthias Siepe
Summary: This study analyzed outcomes in patients undergoing surgery for ventricular septal rupture (VSR) after myocardial infarction (MI) and the preoperative use of extracorporeal life support (ECLS). The results showed that ECLS could be an effective procedure as a bridge to surgery in patients with VSR and cardiogenic shock, but there was no statistical difference in in-hospital and long-term mortality compared to those without ECLS.
JOURNAL OF CARDIOVASCULAR DEVELOPMENT AND DISEASE
(2023)
Review
Cardiac & Cardiovascular Systems
Achim Lother, Peter Kohl
Summary: The heterocellular nature of the heart, including non-myocytes cells, has gained increasing attention in recent years. Single-cell sequencing technologies have enabled the identification of subtle differences and prompted a reexamination of cell identity. This article provides an overview of major cardiac cell types, their roles in homeostasis, and recent findings on non-canonical functions that may be relevant for cardiology.
BASIC RESEARCH IN CARDIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Andrzej Juraszek, Tim Berger, Maximilian Kreibich, Konstantinos Tsagakis, Thanos Sioris, Zeynep Berkarda, Bartosz Rylski, Matthias Siepe, Martin Czerny
Summary: The frozen elephant trunk technique is a good treatment option for patients with aneurysms of an aberrant left subclavian artery with Kommerell's diverticulum arising from right aortic arches. Secondary stent graft extension is a frequently needed component of the treatment concept. The most common variant of the aortic arch branching represents 'the bovine aortic arch' with the prevalence of 11-27% in the adult population.
INTERDISCIPLINARY CARDIOVASCULAR AND THORACIC SURGERY
(2023)
Article
Medicine, General & Internal
Domagoj Damjanovic, Jan-Steffen Pooth, Yechi Liu, Fabienne Frensch, Martin Wolkewitz, Joerg Haberstroh, Soroush Doostkam, Heidi Ramona Cristina Schmitz, Katharina Foerster, Itumeleng Taunyane, Tabea Neubert, Christian Scherer, Patric Diel, Christoph Benk, Friedhelm Beyersdorf, Georg Trummer
Summary: Head elevation after cardiac arrest can improve survival and neurological recovery. Head positioning is an independent factor in neurologically favorable survival. Head elevation did not result in significant differences in neurohistopathology, but transient neurological deficits were observed in clinical follow-up, potentially related to functions localized in the posterior perfusion area.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Charlotte Mutter, Julia Benk, Tim Berger, Stoyan Kondov, Salome Chikvatia, Frank Humburger, Martin Roesslein, Felix Ulbrich, Martin Czerny, Bartosz Rylski, Maximilian Kreibich
Summary: This study analysed the risks and benefits of cerebrospinal fluid drainage (CSFD) placement in patients undergoing thoracic endovascular aortic repair. The results showed that preoperative CSFD can potentially help prevent permanent spinal cord ischaemia (SCI), but the decision to perform preoperative CSFD should be based on a comprehensive assessment of other patient factors.
INTERDISCIPLINARY CARDIOVASCULAR AND THORACIC SURGERY
(2023)
Article
Cardiac & Cardiovascular Systems
Andrew B. Harvey, Renelyn A. Woltes, Raymond N. Deepe, Hannah G. Tarolli, Jenna R. Drummond, Allison Trouten, Auva Zandi, Jeremy L. Barth, Rupak Mukherjee, Martin J. Romeo, Silvia G. Vaena, Ge Tao, Robin Muise-Helmericks, Paula S. Ramos, Russell A. Norris, Andy Wessels
Summary: This study highlights the importance of SOX9 in the regulation of epicardial cell invasion and emphasizes the role of EPDCs in regulating atrioventricular valve development and homeostasis. It also reports a novel expression profile of Cd109, a gene with previously unknown relevance in heart development.
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
(2024)
Review
Cardiac & Cardiovascular Systems
MariaSanta C. Mangione, Jinhua Wen, Dian J. Cao
Summary: mTOR, a mechanistic target of rapamycin, is an evolutionarily conserved pathway that plays a fundamental role in nutrient sensing, growth, metabolism, lifespan, and aging. Recent studies have highlighted the regulatory role of mTOR in innate immune responses and its involvement in the pathogenesis of cardiovascular diseases, especially in acute inflammation and atherosclerotic cardiovascular disease. This review also discusses mTOR's role in trained immunity, immune senescence, and clonal hematopoiesis, as well as its architecture and regulatory complexes.
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
(2024)
Article
Cardiac & Cardiovascular Systems
Junlin Li, Yajun Gong, Yiren Wang, Huihui Huang, Huan Du, Lianying Cheng, Cui Ma, Yongxiang Cai, Hukui Han, Jianhong Tao, Gang Li, Panke Cheng
Summary: Myocardial ischemia-reperfusion injury is closely related to the final infarct size in acute myocardial infarction. Regulatory T cells play an important role in the inflammatory response after AMI, but different subtypes of Tregs have different effects on the injury.
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
(2024)
Article
Cardiac & Cardiovascular Systems
Yuxin Chu, Yutao Hua, Lihao He, Jin He, Yunxi Chen, Jing Yang, Ismail Mahmoud, Fanfang Zeng, Xiaochang Zeng, Gloria A. Benavides, Victor M. Darley-Usmar, Martin E. Young, Scott W. Ballinger, Sumanth D. Prabhu, Cheng Zhang, Min Xie
Summary: This study demonstrates that administering beta-hydroxybutyrate (beta-OHB) at the time of reperfusion can reduce infarct size and preserve cardiac function by activating autophagy and preserving mitochondrial homeostasis, potentially through mTOR inhibition.
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
(2024)