Article
Cell Biology
Shuang Liu, Ruonan Shao, Xiaoyun Bu, Yujie Xu, Ming Shi
Summary: This study identified pyroptosis-related genes as predictors for prognosis of HCC patients and targeting pyroptosis as a potential therapeutic alternative in HCC.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Jiezhang Tang, Xuechen Wu, Bo Cheng, Yajie Lu
Summary: Elevated polyamine levels in oral squamous cell carcinoma (OSCC) have been found to be associated with tumor development and prognosis. In this study, a prognostic model based on six biomarkers was developed and validated in OSCC patients. The high-risk group showed a poorer prognosis and increased susceptibility to chemotherapy drugs. The risk scores were also correlated with immune cell infiltration and tumor mutational burden. The findings provide insights for identifying new treatment targets in OSCC.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Shuqiao Zhang, Xinyu Li, Xiang Zhang, Shijun Zhang, Chunzhi Tang, Weihong Kuang
Summary: A novel pyroptosis-related genes signature was identified to predict the prognosis of HCC patients, showing good performance in survival analysis and association with immune response mechanisms.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2022)
Article
Oncology
Guoxu Fang, Qinghua Zhang, Jianhui Fan, Haitao Li, Zongren Ding, Jun Fu, Yijun Wu, Yongyi Zeng, Jingfeng Liu
Summary: This study developed a prognostic model based on pyroptosis-related genes (PRGs) expression for hepatocellular carcinoma (HCC) patients. The model showed the ability to predict prognosis, immune cell infiltration, and chemotherapeutic sensitivity in HCC patients.
Article
Oncology
Muyuan Liu, Litian Tong, Bin Liang, Xuhong Song, Lingzhu Xie, Hanwei Peng, Dongyang Huang
Summary: Our study successfully established a novel 15-mRNA prognostic model for predicting overall survival of non-distant metastatic OTSCC. The prediction ability of this 15-gene signature was independent of other clinicopathological factors and demonstrated excellent prediction accuracy. Additionally, an external validation using the GEO dataset confirmed the good prediction ability of the 15-gene model. The prognostic nomogram integrating the 15-gene signature and clinicopathological factors has the potential to be developed as a prognostic tool.
FRONTIERS IN ONCOLOGY
(2021)
Article
Immunology
Zhengguang Wang, Lei Cao, Sitong Zhou, Jin Lyu, Yang Gao, Ronghua Yang
Summary: This study investigates the role of pyroptosis-related long non-coding RNAs (lncRNAs) in predicting the diagnosis and prognosis of gastric adenocarcinoma. The study establishes a lncRNA signature associated with pyroptosis as a prognostic tool and evaluates their immune value. The findings suggest that these lncRNAs can effectively guide the prognosis and immune microenvironment in gastric adenocarcinoma patients.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Oncology
Chao Zhu, Liqun Gu, Mianfeng Yao, Jiang Li, Changyun Fang
Summary: A risk signature was constructed using differentially expressed immune-related genes in patients with OSCC, showing a negative correlation with immune cell infiltration rate and expression of related molecules. Functional enrichment analysis was conducted to identify multiple immune-related processes, metabolic pathways, and cancer-related pathways. These findings can predict overall survival and contribute to personalized management.
FRONTIERS IN ONCOLOGY
(2021)
Article
Genetics & Heredity
Kangjie Zhou, Nan Hu, Yidong Hong, Xueyu Wu, Jingzhou Zhang, Huan Lai, Yang Zhang, Fenglei Wu
Summary: This study established an immune-related gene signature to predict the clinical prognosis and tumor immunity of stomach adenocarcinomas (STAD) using expression and clinical data from the TCGA database. The infiltration abundance of activated memory CD4 T cells and CD8 T cells had a significant effect on the overall survival of STAD patients. Three signature genes (PEG10, DKK1, and RGS1) were identified to establish a prognostic model, which showed independent prognostic value. This study provides insights into the immune landscape of STAD and offers a potential prognostic tool for STAD patients.
FRONTIERS IN GENETICS
(2022)
Article
Oncology
Wei Zhou, Wenxiong Zhang
Summary: In this study, a novel pyroptosis-associated signature with independent value for the prognosis of lung squamous cell carcinoma (LUSC) patients was developed. The PRlncRNAs were found to be closely associated with the tumor immune microenvironment in LUSC and might offer new directions for immunotherapy.
Article
Cell Biology
Xiao-Wei Fu, Chun-Qing Song
Summary: The study revealed that the pyroptosis-related gene signature comprised of GSDME, GPX4, and SCAF11 can serve as an independent prognostic factor for HCC patients, providing further evidence for more clinical and functional studies.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Surgery
Yuqi Xin, Jieyuan Zhang, Qingkun Jiang, Jiaxuan Qiu
Summary: This study aimed to evaluate the association between pyroptosis-related lncRNAs and prognosis in patients with OSCC. By analyzing RNA-seq data and clinicopathological data, a risk prognostic model for OSCC was constructed, and 8 pyroptosis-related lncRNAs were identified. These lncRNAs showed high accuracy in predicting the prognosis of OSCC patients and affected immune responses in the microenvironment of OSCC.
FRONTIERS IN SURGERY
(2022)
Article
Oncology
Ze-Kun Liu, Ke-Fei Wu, Ren-Yu Zhang, Ling-Min Kong, Run-Ze Shang, Jian-Jun Lv, Can Li, Meng Lu, Yu-Le Yong, Cong Zhang, Nai-Shan Zheng, Yan-Hong Li, Zhi-Nan Chen, Huijie Bian, Ding Wei
Summary: In this study, a prognostic signature based on pyroptosis-related lncRNAs in hepatocellular carcinoma (HCC) was constructed, showing significant predictive value for HCC patient prognosis and potential clinical guidance for individualized immunotherapy.
FRONTIERS IN ONCOLOGY
(2022)
Article
Multidisciplinary Sciences
Jianxin Li, Ting Han, Xin Wang, Yinchun Wang, Xuan Chen, Wangsheng Chen, Qingqiang Yang
Summary: In this study, an immune-related lncRNA signature was developed to assess the prognosis of colorectal cancer patients. The signature divided patients into high- and low-risk groups and was associated with clinical outcome, tumor characteristics, immune cells, immune status, tumor mutation burden, and immunotherapy responsiveness. Overall, this immune-related lncRNA signature is a promising biomarker for predicting the prognosis and immune status of colorectal cancer patients.
SCIENTIFIC REPORTS
(2023)
Article
Oncology
Yanan Peng, Chang Liu, Mengting Li, Wenjie Li, Mengna Zhang, Xiang Jiang, Ying Chang, Lan Liu, Fan Wang, Qiu Zhao
Summary: This study identified immune-related genes as indicators for the prognosis of HCC patients, with a 7-IRGs signature established as a robust independent prognostic factor associated with clinical features and the immune cell infiltration in the tumor microenvironment (TME). Additionally, these IRGs were found to have great potential for indicating the immunotherapy response in HCC patients, suggesting their value as potential immunotherapeutic targets.
CANCER CELL INTERNATIONAL
(2021)
Article
Oncology
Yang Gao, Xin Zhang, Ying Li, Jingbo Gao, Shuting Liu, Hongbing Cai, Jingwei Zhang
Summary: This study constructed a PSscore risk model and found that low PSscore was associated with survival advantage, richer immune cell infiltration, more active immune-related pathways, and lower tumor purity in OSCC patients. In addition, high PSscore group patients had higher immune escape potential and were less sensitive to immunotherapy, while low PSscore group patients might be more sensitive to PD1 and CTLA4 + PD1 immunotherapy. BAK1 was identified as a potential target in OSCC and knockdown of BAK1 could significantly reduce OSCC cell proliferation.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2023)
