期刊
JOURNAL OF MICROENCAPSULATION
卷 33, 期 3, 页码 239-248出版社
TAYLOR & FRANCIS LTD
DOI: 10.3109/02652048.2016.1156173
关键词
clove essential oil; amphiphilic micelle; PEG; PCL; controlled release; biodegradable polymer
资金
- Thammasat University [07/2556]
In this study, a micellar delivery system with an amphiphilic diblock copolymer of poly (ethylene glycol) and poly (-caprolactone) was synthesised and used to incorporate hydrophobic clove essential oil (CEO). To determine an optimal delivery system, the effects of the copolymer's hydrophobic block length and the CEO-loading content on the encapsulation of CEO were investigated. Percentages of entrapment efficiency (%EE), CEO loading (%CEO), and in vitro release profiles were determined. The size, size distribution, zeta potential, and morphology of the obtained micelles were determined by DLS, FE-SEM, and TEM. The %EE, %CEO, and in vitro release profiles of CEO incorporated in micelles were analysed by HPLC. The study revealed a sustained release profile of CEO from CEO-loaded micelles. The results indicate the successful formulation of CEO-loaded PEG-b-PCL micelle nanoparticles. It is suggested that this micelle system has considerably potential applications in the sustained release of CEO in intravascular drug delivery.
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