Rational Design, Synthesis and Biological Evaluation of Novel Pyrazoline-Based Antiproliferative Agents in MCF-7 Cancer Cells

A novel series of benzothiazepine derivatives as tubulin polymerization inhibitors with anti-tumor potency

(2021) Bin Wang et al.   BIOORGANIC CHEMISTRY

Pyrazoline analogs as potential anticancer agents and their apoptosis, molecular docking, MD simulation, DNA binding and antioxidant studies

(2021) Manish Rana et al.   BIOORGANIC CHEMISTRY

Effect of the dichloro-substitution on antiproliferative activity of phthalimide-thiazole derivatives. Rational design, synthesis, elastase, caspase 3/7, and EGFR tyrosine kinase activity and molecular modeling study

(2021) Beata Donarska et al.   BIOORGANIC CHEMISTRY

Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries

(2021) Hyuna Sung et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Design, Synthesis, Anticancer Activity, and Solid Lipid Nanoparticle Formulation of Indole- and Benzimidazole-Based Compounds as Pro-Apoptotic Agents Targeting Bcl-2 Protein

(2021) Manar I. Nagy et al.   Pharmaceuticals

From Celecoxib to a Novel Class of Phosphodiesterase 5 Inhibitors: Trisubstituted Pyrazolines as Novel Phosphodiesterase 5 Inhibitors with Extremely High Potency and Phosphodiesterase Isozyme Selectivity

(2021) Mohammad Abdel-Halim et al.   JOURNAL OF MEDICINAL CHEMISTRY

Antiproliferative activity of thiazole and oxazole derivatives: A systematic review of in vitro and in vivo studies

(2021) Nancy Y. Guerrero-Pepinosa et al.   BIOMEDICINE & PHARMACOTHERAPY

Design, synthesis, and biological evaluation of new pyrimidine-5-carbonitrile derivatives bearing 1,3-thiazole moiety as novel anti-inflammatory EGFR inhibitors with cardiac safety profile

(2021) Salah A. Abdel-Aziz et al.   BIOORGANIC CHEMISTRY

Synthesis of new substituted pyridine derivatives as potent anti-liver cancer agents through apoptosis induction: In vitro, in vivo, and in silico integrated approaches

(2021) Ahmed T.A. Boraei et al.   BIOORGANIC CHEMISTRY

AutoDock Vina 1.2.0: New Docking Methods, Expanded Force Field, and Python Bindings

(2021) Jerome Eberhardt et al.   Journal of Chemical Information and Modeling

Quinoline‐based thiazolidinone derivatives as potent cytotoxic and apoptosis‐inducing agents through EGFR inhibition

(2021) Mohamed S. Nafie et al.   Chemical Biology & Drug Design

Synthesis and biological evaluation of new derivatives of thieno-thiazole and dihydrothiazolo-thiazole scaffolds integrated with a pyrazoline nucleus as anticancer and multi-targeting kinase inhibitors

(2021) Ismail M. M. Othman et al.   RSC Advances

Discovery of New Apoptosis-Inducing Agents for Breast Cancer Based on Ethyl 2-Amino-4,5,6,7-Tetra Hydrobenzo[b]Thiophene-3-Carboxylate: Synthesis, In Vitro, and In Vivo Activity Evaluation

(2020) Emad M. Gad et al.   MOLECULES

Triaryl dicationic DNA minor-groove binders with antioxidant activity display cytotoxicity and induce apoptosis in breast cancer

(2020) Mohamed S. Nafie et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Synthesis and biological evaluation of pyrazoline and pyrrolidine‐2,5‐dione hybrids as potential antitumor agents.

(2020) Kalpana Tilekar et al.   ChemMedChem

Pyrazoline Hybrids as Promising Anticancer Agents: An Up-to-Date Overview

(2020) Dimitris Matiadis et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Synthesis, characterization of some pyrazine derivatives as anti-cancer agents: In vitro and in Silico approaches

(2020) Eman S. Tantawy et al.   JOURNAL OF MOLECULAR STRUCTURE

Antimicrobial and antiproliferative activities of novel synthesized 6‐(quinolin‐2‐ylthio) pyridine derivatives with molecular docking study as multi‐targeted JAK2/STAT3 inhibitors

(2020) Mohamed S. Nafie et al.   Chemical Biology & Drug Design

Pharmacophore hybridization approach to discover novel pyrazoline-based hydantoin analogs with anti-tumor efficacy

(2020) Neha Upadhyay et al.   BIOORGANIC CHEMISTRY

Design, Synthesis, Characterization and In Silico Molecular Docking Studies and In Vivo Anti-inflammatory Activity of Pyrazoline Clubbed Thiazolinone Derivatives

(2020) Deepak Kumar Singh et al.   LETTERS IN ORGANIC CHEMISTRY

Transition From Heart Disease to Cancer as the Leading Cause of Death in the United States

(2019) Stephen Sidney et al.   ANNALS OF INTERNAL MEDICINE

Synthesis and biological evaluation of novel xanthine derivatives as potential apoptotic antitumor agents

(2019) Mohamed Hisham et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Thiazole-containing compounds as therapeutic targets for cancer therapy

(2019) Prabodh Chander Sharma et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Heterocyclic compounds: 2-Pyrazolines are biological active as well as fluorescence agents, an Overview

(2018) Pramod Singh Negi et al.   Anti-Cancer Agents in Medicinal Chemistry

Anticancer Potential of Thiazole Derivatives: A Retrospective Review

(2018) Shweta Jain et al.   MINI-REVIEWS IN MEDICINAL CHEMISTRY

A comprehensive review of protein kinase inhibitors for cancer therapy

(2018) Radhamani Kannaiyan et al.   Expert Review of Anticancer Therapy

New azole derivatives showing antimicrobial effects and their mechanism of antifungal activity by molecular modeling studies

(2017) İnci Selin Doğan et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Synthesis, anticancer evaluation and pharmacokinetic study of novel 10- O -phenyl ethers of dihydroartemisinin

(2017) Shenglin Luan et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Unveiling a versatile heterocycle: pyrazoline – a review

(2017) Beena Varghese et al.   RSC Advances

A Biparatopic HER2-Targeting Antibody-Drug Conjugate Induces Tumor Regression in Primary Models Refractory to or Ineligible for HER2-Targeted Therapy

(2016) John Y. Li et al.   CANCER CELL

Synthesis and cytotoxic activities of some pyrazoline derivatives bearing phenyl pyridazine core as new apoptosis inducers

(2016) Riham F. George et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Classification of small molecule protein kinase inhibitors based upon the structures of their drug-enzyme complexes

(2016) Robert Roskoski   PHARMACOLOGICAL RESEARCH

Molecular architecture of the ErbB2 extracellular domain homodimer

(2015) Shi Hu et al.   Oncotarget

Rational approaches, design strategies, structure activity relationship and mechanistic insights for anticancer hybrids

(2014) Kunal Nepali et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Novel inhibitors of breast cancer relevant kinases Brk and HER2

(2014) Kazem Ahmed Mahmoud et al.   MedChemComm

Architecture and Membrane Interactions of the EGF Receptor

(2013) Anton Arkhipov et al.   CELL

DNA-Damaging Agents in Cancer Chemotherapy: Serendipity and Chemical Biology

(2013) Kahlin Cheung-Ong et al.   CHEMISTRY & BIOLOGY

Synthesis of some dihydropyrimidine-based compounds bearing pyrazoline moiety and evaluation of their antiproliferative activity

(2013) Fadi M. Awadallah et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

4,5-Dihydro-1H-pyrazole: an indispensable scaffold

(2013) Jimi Marin Alex et al.   JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY

The ErbB/HER family of protein-tyrosine kinases and cancer

(2013) Robert Roskoski   PHARMACOLOGICAL RESEARCH

Design, synthesis and biological evaluation of pyrazolyl-thiazolinone derivatives as potential EGFR and HER-2 kinase inhibitors

(2012) Ke-Ming Qiu et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Synthesis and biological evaluation of novel coumarin–pyrazoline hybrids endowed with phenylsulfonyl moiety as antitumor agents

(2012) Kamilia M. Amin et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Recent advances in the therapeutic applications of pyrazolines

(2012) Mohamed R Shaaban et al.   EXPERT OPINION ON THERAPEUTIC PATENTS

Design and Synthesis of Novel Human Epidermal Growth Factor Receptor 2 (HER2)/Epidermal Growth Factor Receptor (EGFR) Dual Inhibitors Bearing a Pyrrolo[3,2-d]pyrimidine Scaffold

(2011) Tomoyasu Ishikawa et al.   JOURNAL OF MEDICINAL CHEMISTRY

Synthesis, characterization, antiamoebic activity and cytotoxicity of novel series of pyrazoline derivatives bearing quinoline tail

(2010) Faisal Hayat et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

The role of HER2 in cancer therapy and targeted drug delivery

(2010) Wanyi Tai et al.   JOURNAL OF CONTROLLED RELEASE

Promise and challenges in drug discovery and development of hybrid anticancer drugs

(2009) Lalji K Gediya et al.   Expert Opinion on Drug Discovery

AutoDock Vina: Improving the speed and accuracy of docking with a new scoring function, efficient optimization, and multithreading

(2009) Oleg Trott et al.   JOURNAL OF COMPUTATIONAL CHEMISTRY

4-Pyridylanilinothiazoles That Selectively Target von Hippel−Lindau Deficient Renal Cell Carcinoma Cells by Inducing Autophagic Cell Death

(2009) Michael P. Hay et al.   JOURNAL OF MEDICINAL CHEMISTRY

A History of Cancer Chemotherapy

(2008) Vincent T. DeVita et al.   CANCER RESEARCH

Synthesis and antimicrobial evaluation of 1-(benzofuran-2-yl)-4-nitro-3-arylbutan-1-ones and 3-(benzofuran-2-yl)-4,5-dihydro-5-aryl-1-[4-(aryl)-1,3-thiazol-2-yl]-1H-pyrazoles

(2008) Bakr F. Abdel-Wahab et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY