Inhibition of the pseudokinase MLKL alters extracellular vesicle release and reduces tumor growth in glioblastoma

A single–cell type transcriptomics map of human tissues

(2021) Max Karlsson et al.   Science Advances

Proteomic analysis of necroptotic extracellular vesicles

(2021) Inbar Shlomovitz et al.   Cell Death & Disease

The von Willebrand factor stamps plasmatic extracellular vesicles from glioblastoma patients

(2021) Quentin Sabbagh et al.   Scientific Reports

Gliomas Interact with Non-glioma Brain Cells via Extracellular Vesicles

(2020) Xiaofei Gao et al.   Cell Reports

2-Methoxy-6-acetyl-7-methyljuglone (MAM) induced programmed necrosis in glioblastoma by targeting NAD(P)H: Quinone oxidoreductase 1 (NQO1)

(2020) Jie Yu et al.   FREE RADICAL BIOLOGY AND MEDICINE

RIPK3 is a novel prognostic marker for lower grade glioma and further enriches IDH mutational status subgrouping

(2020) Guilherme Afonso Vergara et al.   JOURNAL OF NEURO-ONCOLOGY

A necroptotic-independent function of MLKL in regulating endothelial cell adhesion molecule expression

(2020) Jialin Dai et al.   Cell Death & Disease

Vesiclemia: counting on extracellular vesicles for glioblastoma patients

(2020) Quentin Sabbagh et al.   ONCOGENE

Exosomes from Nischarin-Expressing Cells Reduce Breast Cancer Cell Motility and tumor growth

(2019) Mazvita Maziveyi et al.   CANCER RESEARCH

Exosomal transfer of miR-1238 contributes to temozolomide-resistance in glioblastoma

(2019) Jianxing Yin et al.   EBioMedicine

Emodin induced necroptosis in the glioma cell line U251 via the TNF-α/RIP1/RIP3 pathway

(2019) Jiabin Zhou et al.   INVESTIGATIONAL NEW DRUGS

Exosomal transfer of long non-coding RNA SBF2-AS1 enhances chemoresistance to temozolomide in glioblastoma

(2019) Zhuoran Zhang et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Glioblastoma stem cells: lessons from the tumor hierarchy in a lethal cancer

(2019) Ryan C. Gimple et al.   GENES & DEVELOPMENT

MLKL contributes to shikonin-induced glioma cell necroptosis via promotion of chromatinolysis

(2019) Ye Ding et al.   CANCER LETTERS

Pannexin‐1 limits the production of proinflammatory cytokines during necroptosis

(2019) Tiphaine Douanne et al.   EMBO REPORTS

Paracaspase MALT1 regulates glioma cell survival by controlling endo‐lysosome homeostasis

(2019) Kathryn A Jacobs et al.   EMBO JOURNAL

Epigenetic Regulation of RIP3 Suppresses Necroptosis and Increases Resistance to Chemotherapy in NonSmall Cell Lung Cancer

(2019) Qiong Wang et al.   Translational Oncology

Temozolomide affects Extracellular Vesicles Released by Glioblastoma Cells

(2018) Gwennan André-Grégoire et al.   BIOCHIMIE

Down-regulation of RIP3 potentiates cisplatin chemoresistance by triggering HSP90-ERK pathway mediated DNA repair in esophageal squamous cell carcinoma

(2018) Yulin Sun et al.   CANCER LETTERS

Role of extracellular vesicles in glioma progression

(2018) Claudia Quezada et al.   MOLECULAR ASPECTS OF MEDICINE

Shedding light on the cell biology of extracellular vesicles

(2018) Guillaume van Niel et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Exosomal transfer of miR-151a enhances chemosensitivity to temozolomide in drug-resistant glioblastoma

(2018) Ailiang Zeng et al.   CANCER LETTERS

Acute and rapid degradation of endogenous proteins by Trim-Away

(2018) Dean Clift et al.   Nature Protocols

Clinical Significance of Extracellular Vesicles in Plasma from Glioblastoma Patients

(2018) Daniela Osti et al.   CLINICAL CANCER RESEARCH

Mixed Lineage Kinase Domain-like Protein MLKL Breaks Down Myelin following Nerve Injury

(2018) Zhengxin Ying et al.   MOLECULAR CELL

MLKL, the Protein that Mediates Necroptosis, Also Regulates Endosomal Trafficking and Extracellular Vesicle Generation

(2017) Seongmin Yoon et al.   IMMUNITY

EV-TRACK: transparent reporting and centralizing knowledge in extracellular vesicle research

(2017) Jan Van Deun et al.   NATURE METHODS

Divergent evolution of temozolomide resistance in glioblastoma stem cells is reflected in extracellular vesicles and coupled with radiosensitization

(2017) Delphine Garnier et al.   NEURO-ONCOLOGY

Phosphatidylserine externalization, “necroptotic bodies” release, and phagocytosis during necroptosis

(2017) Sefi Zargarian et al.   PLOS BIOLOGY

Secreted Glioblastoma Nanovesicles Contain Intracellular Signaling Proteins and Active Ras Incorporated in a Farnesylation-dependent Manner

(2016) Natalie Luhtala et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Qki deficiency maintains stemness of glioma stem cells in suboptimal environment by downregulating endolysosomal degradation

(2016) Takashi Shingu et al.   NATURE GENETICS

GlioVis data portal for visualization and analysis of brain tumor expression datasets

(2016) Robert L. Bowman et al.   NEURO-ONCOLOGY

Spitting out the demons: Extracellular vesicles in glioblastoma

(2016) Gwennan André-Grégoire et al.   Cell Adhesion & Migration

Methylation-dependent loss of RIP3 expression in cancer represses programmed necrosis in response to chemotherapeutics

(2015) Gi-Bang Koo et al.   CELL RESEARCH

Glioblastoma-derived extracellular vesicles modify the phenotype of monocytic cells

(2015) Jeroen de Vrij et al.   INTERNATIONAL JOURNAL OF CANCER

Photodynamic therapy using talaporfin sodium induces concentration-dependent programmed necroptosis in human glioblastoma T98G cells

(2015) Yuichi Miki et al.   LASERS IN MEDICAL SCIENCE

Serum exosomes and cytokines promote a T-helper cell type 2 environment in the peripheral blood of glioblastoma patients

(2015) Larry A. Harshyne et al.   NEURO-ONCOLOGY

Extracellular vesicle-transported Semaphorin3A promotes vascular permeability in glioblastoma

(2015) L Treps et al.   ONCOGENE

Differential roles of RIPK1 and RIPK3 in TNF-induced necroptosis and chemotherapeutic agent-induced cell death

(2015) K Moriwaki et al.   Cell Death & Disease

Extracellular Vesicles Modulate the Glioblastoma Microenvironment via a Tumor Suppression Signaling Network Directed by miR-1

(2013) A. Bronisz et al.   CANCER RESEARCH

Mlkl knockout mice demonstrate the indispensable role of Mlkl in necroptosis

(2013) Jianfeng Wu et al.   CELL RESEARCH

Rac and Rab GTPases dual effector Nischarin regulates vesicle maturation to facilitate survival of intracellular bacteria

(2013) Coenraad Kuijl et al.   EMBO JOURNAL

The Pseudokinase MLKL Mediates Necroptosis via a Molecular Switch Mechanism

(2013) James M. Murphy et al.   IMMUNITY

Plasma membrane translocation of trimerized MLKL protein is required for TNF-induced necroptosis

(2013) Zhenyu Cai et al.   NATURE CELL BIOLOGY

Shikonin Kills Glioma Cells through Necroptosis Mediated by RIP-1

(2013) Chuanjiang Huang et al.   PLoS One

Rab27a Supports Exosome-Dependent and -Independent Mechanisms That Modify the Tumor Microenvironment and Can Promote Tumor Progression

(2012) A. Bobrie et al.   CANCER RESEARCH

Mixed Lineage Kinase Domain-like Protein Mediates Necrosis Signaling Downstream of RIP3 Kinase

(2012) Liming Sun et al.   CELL

A restricted cell population propagates glioblastoma growth after chemotherapy

(2012) Jian Chen et al.   NATURE

Inhibition of Glioma Cell Lysosome Exocytosis Inhibits Glioma Invasion

(2012) Yu Liu et al.   PLoS One

Mixed lineage kinase domain-like is a key receptor interacting protein 3 downstream component of TNF-induced necrosis

(2012) J. Zhao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Integrated Genomic Analysis Identifies Clinically Relevant Subtypes of Glioblastoma Characterized by Abnormalities in PDGFRA, IDH1, EGFR, and NF1

(2010) Roel G.W. Verhaak et al.   CANCER CELL

ELDA: Extreme limiting dilution analysis for comparing depleted and enriched populations in stem cell and other assays

(2009) Yifang Hu et al.   JOURNAL OF IMMUNOLOGICAL METHODS

Rab27a and Rab27b control different steps of the exosome secretion pathway

(2009) Matias Ostrowski et al.   NATURE CELL BIOLOGY

IDH1andIDH2Mutations in Gliomas

(2009) Hai Yan et al.   NEW ENGLAND JOURNAL OF MEDICINE

Quantitation of Human Seroresponsiveness to Merkel Cell Polyomavirus

(2009) Diana V. Pastrana et al.   PLoS Pathogens

Intercellular transfer of the oncogenic receptor EGFRvIII by microvesicles derived from tumour cells

(2008) Khalid Al-Nedawi et al.   NATURE CELL BIOLOGY

Glioblastoma microvesicles transport RNA and proteins that promote tumour growth and provide diagnostic biomarkers

(2008) Johan Skog et al.   NATURE CELL BIOLOGY