Article
Neurosciences
Michael Hecker, Brit Fitzner, Kathrin Jaeger, Jan Buehring, Margit Schwartz, Alexander Hartmann, Michael Walter, Uwe Klaus Zettl
Summary: This study found that telomere length in MS patients is associated with disease progression and patient type. The RRMS group had significantly shorter relative LTL, and shorter telomeres at baseline were associated with a higher conversion rate to SPMS in RRMS patients. The LTL decrease over time was similar in RRMS and PPMS patients.
MOLECULAR NEUROBIOLOGY
(2021)
Article
Cell Biology
Abraham Aviv
Summary: Approximately 25 trillion erythrocytes circulate in the bloodstream of an adult human, outnumbering leukocytes by a factor of about 1000. The turnover rate of erythrocytes accounts for approximately 76% of the turnover rate of all circulating blood cells. Therefore, erythropoiesis is the main factor causing telomere shortening in hematopoietic cells, which has significant implications for understanding the relationship between telomere length dynamics, health, and lifespan in modern humans.
Article
Public, Environmental & Occupational Health
Xiangdong Wang, Pei Xiao, Rui Wang, Chao Luo, Zeyao Zhang, Shali Yu, Qiyun Wu, Ye Li, Yali Zhang, Hongbing Zhang, Xinyuan Zhao
Summary: This study examined the link between urinary metal levels and cognitive performance in individuals aged 60 and above in the United States. The results showed that higher levels of barium, cobalt, cesium, manganese, and thallium in urine were associated with a lower prevalence of impaired cognitive performance. However, higher cadmium levels were related to cognitive impairment.
FRONTIERS IN PUBLIC HEALTH
(2022)
Article
Medicine, General & Internal
Dries S. Martens, Charlotte Van der Stukken, Catherine Derom, Evert Thiery, Esm Ee M. Bijnens, Tim S. Nawrot
Summary: The study found that there is a correlation between telomere length at birth and later in life in both children and adults. The ranking of telomere length tends to be stable over time, indicating the importance of understanding the initial setting of newborn telomere length and its significance for later life. Additionally, longer maternal telomere length is associated with lower telomere attrition in the next generation.
Article
Nutrition & Dietetics
Lingzhi Chen, Nitin Shivappa, Xiuxun Dong, Jingjing Ming, Qianqian Zhao, Huichao Xu, Pingping Liang, Min Cheng, Jie Liu, Peng Sun, Bo Ban
Summary: A higher appendicular skeletal muscle index (ASMI) is associated with longer telomeres in adult Americans. The association varies based on age and muscle mass status.
CLINICAL NUTRITION
(2021)
Article
Cell Biology
Aenne S. von Falkenhausen, Rebecca Freudling, Melanie Waldenberger, Christian Gieger, Annette Peters, Martina Mueller-Nurasyid, Stefan Kaeaeb, Moritz F. Sinner
Summary: This study aimed to investigate the association between ECG measures and telomere length, as well as their relationship with cardiac pathologies. The results showed that while ECG measures were influenced by age, they were not associated with shortened telomere length as a marker of biological aging.
Article
Environmental Sciences
Daheng Yang, Xiaoqin Chen, Weidong Cao, Cheng Xu, Lin Chang, Guangfeng Long
Summary: Although the association between single PAHs exposure and telomere length has been studied, the relationship between mixed PAHs exposure and telomere length in the general population is still uncertain. This study analyzed 8 PAHs and their correlation with telomere length, finding that mixed PAHs exposure was negatively associated with telomere length. Specifically, 2-napthol and 2-fluorene concentrations showed a significant negative correlation with telomere length. These findings indicate that PAHs may have a negative impact on telomere length in the general population.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Article
Endocrinology & Metabolism
Yiling Zhang, Ziye Xu, Yiling Yang, Shanshan Cao, Sali Lyu, Weiwei Duan
Summary: This study found that weight changes during adulthood are associated with leukocyte telomere length, suggesting that weight gain may promote aging among adults. The results showed that stable obesity, weight gain from non-obesity to obesity, and transitions from normal weight to overweight were all linked to shorter telomere length, with variations across sex and race/ethnicity.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Environmental Sciences
Zhen-Hua Li, Jiong Li, Yi-Cheng Mao, Jia-Wen Zhao, Hui-Yu Hu, Sun Zhang, Zhe-Ye Liu, Xue-Jie Liu, Kai Huang, Cheng-Yang Hu, Xiu-Jun Zhang
Summary: The study found a positive association between exposure to urinary lead, molybdenum, and strontium and periodontitis, while urinary cobalt, manganese, tin, and strontium were negatively associated with periodontitis. Overall, there was a positive association between urinary heavy metals and periodontitis.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Article
Environmental Sciences
Mingyang Wu, Lulin Wang, Lulu Song, Bingqing Liu, Yunyun Liu, Jianing Bi, Qing Liu, Kai Chen, Yuanyuan Li, Wei Xia, Shunqing Xu, Zhongqiang Cao, Aifen Zhou, Yaohua Tian, Youjie Wang
Summary: This study of 746 mother-newborn pairs in Wuhan, China found that prenatal thallium exposure was associated with shortened neonatal telomere length, particularly when thallium exposure levels in maternal urine samples collected during hospital delivery were increased. However, there was no significant association between neonatal telomere length and thallium exposure levels in urine samples collected during the three trimesters of pregnancy.
Article
Clinical Neurology
Dan He, Peilin Meng, Chun'e Li, Yumeng Jia, Yan Wen, Chuyu Pan, Zhen Zhang, Jingxi Zhang, Huijie Zhang, Yujing Chen, Yijing Zhao, Xiaoyue Qin, Qingqing Cai, Wenming Wei, Sirong Shi, Xiaoge Chu, Na Zhang, Feng Zhang
Summary: This study aimed to investigate the association and causal relationship between sleep and telomere length (TL). Using genome-wide association study (GWAS) datasets and mendelian randomization (MR) analysis, the study found no evidence for causal association between insomnia and TL in individuals of European ancestry, but identified a candidate gene associated with both insomnia and TL.
Review
Food Science & Technology
Bartu Eren Gunesliol, Esen Karaca, Duygu Agagunduz, Zeynep Alanur Acar
Summary: The aging of the population leads to a loss of ability to move independently, and the length of telomeres is associated with cell aging and death. Physical activity and nutrition can affect telomere length and slow down the aging process.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2023)
Article
Obstetrics & Gynecology
Gaojie Fan, Qing Liu, Jianing Bi, Xiya Qin, Qing Fang, Youjie Wang, Lulu Song
Summary: Early menarche, early menopause, short reproductive lifespan, early age at first birth, multiparity, and use of oral contraceptives (OCs) and hormone replacement therapy (HRT) were associated with shorter leukocyte telomere length (LTL).
HUMAN REPRODUCTION
(2023)
Article
Endocrinology & Metabolism
Xinyu Wang, Jingli Wen, Qiang Qu, Shujun Gu, Lixi Zhang, Yu Li, Xu Qi
Summary: This study investigates the association between weight range and telomere length, revealing a significant negative correlation. The findings also suggest that larger weight fluctuation may accelerate telomere shortening and aging.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Medicine, General & Internal
Sofia Pavanello, Manuela Campisi, Alberto Grassi, Giuseppe Mastrangelo, Elisabetta Durante, Arianna Veronesi, Maurizio Gallucci
Summary: Research on elderly individuals has shown that longer leukocyte telomere length (LTL) can predict a longer life and better health. The study found a positive relationship between LTL and survival, with factors like Short Physical Performance Battery (SPPB) scores and years of education affecting LTL elongation.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Environmental Sciences
Keran Wang, Jinyi Wu, Rui Wang, Yingying Yang, Renjie Chen, Jay E. Maddock, Yuanan Lu
SCIENCE OF THE TOTAL ENVIRONMENT
(2015)
Article
Environmental Sciences
Rui Wang, Yingying Yang, Renjie Chen, Haidong Kan, Jinyi Wu, Keran Wang, Jay E. Maddock, Yuanan Lu
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2015)
Article
Infectious Diseases
Jin-Yi Wu, Yi-Biao Zhou, Yue Chen, Song Liang, Lin-Han Li, Sheng-Bang Zheng, Shao-ping Zhu, Guang-Hui Ren, Xiu-Xia Song, Qing-Wu Jiang
PLOS NEGLECTED TROPICAL DISEASES
(2015)
Article
Parasitology
Jin-Yi Wu, Yi-Biao Zhou, Lin-Han Li, Sheng-Bang Zheng, Song Liang, Ashley Coatsworth, Guang-Hui Ren, Xiu-Xia Song, Zhong He, Bin Cai, Jia-Bian You, Qing-Wu Jiang
PARASITES & VECTORS
(2014)
Article
Medicine, General & Internal
Xin Zheng, Jia Shi, Jinyi Wu
Article
Public, Environmental & Occupational Health
Fang Xia, Qingwen Li, Xin Luo, Jinyi Wu
Summary: This study used a machine learning model to explore the association between depression and blood metal elements. The results showed that Cd, EtHg, and Hg were significantly associated with depression. An online application for depression prediction was developed.
FRONTIERS IN PUBLIC HEALTH
(2022)
Article
Public, Environmental & Occupational Health
Fang Xia, Qingwen Li, Xin Luo, Jinyi Wu
Summary: This research investigates the association between heavy metals and osteoarthritis (OA) by analyzing a wide range of variables and using machine learning algorithms for prediction. The findings suggest that lead (Pb) and cadmium (Cd) promote the prevalence of OA, while manganese (Mn) may act as a protective factor. The XGBoost model proves to be the most effective for OA prediction.
FRONTIERS IN PUBLIC HEALTH
(2022)
Article
Endocrinology & Metabolism
Pei Xiao, Pu Liang, Panjun Gao, Jinyi Wu
Summary: Higher appendicular skeletal muscle mass is associated with a lower risk of MAFLD, while higher trunk skeletal muscle mass is associated with an increased risk of significant fibrosis in females.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Public, Environmental & Occupational Health
Kai Wang, Fang Xia, Qingwen Li, Xin Luo, Jinyi Wu
Summary: This study aims to explore the association between weekend warrior activity and other physical activity patterns with VAI in US adults. The results show that weekend warriors can lower VAI compared to inactive adults, and there is no significant difference in reducing VAI between weekend warriors and regularly active adults. This study provides compelling evidence of the beneficial effect of weekend warrior activity on visceral obesity.
JMIR PUBLIC HEALTH AND SURVEILLANCE
(2023)
Article
Cardiac & Cardiovascular Systems
Yue Zhang, Changjian Lin, Ming Liu, Wei Zhang, Xiaoyun Xun, Jinyi Wu, Xiaopan Li, Zheng Luo
Summary: This study fills the gap by evaluating the burden and trend of cardiovascular disease (CVD) in people younger than 20 years in China, the Western Pacific Region, and the world from 1990 to 2019. The results show a decline in the incidence, mortality, and prevalence of CVD among people under 20, indicating the need for more effective preventive policies and interventions.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Article
Nutrition & Dietetics
Jinyi Wu, Kai Wang, Fengxi Tao, Qingwen Li, Xin Luo, Fang Xia
Summary: This study aimed to investigate the relationship between metal exposure and latent tuberculosis infection (LTBI) among US adults and adolescents. The study found a positive association between total mercury and LTBI among adults, and a positive association between blood manganese and LTBI among adolescents.
FRONTIERS IN NUTRITION
(2023)
Article
Nutrition & Dietetics
Yue Zhang, Zheng Luo, Juan Yi, Junjie Zhu, Yun Qiu, Xiaoyun Xu, Wanying Xie, Jinyi Wu, Huihui Lv, Changhua Mou, Wei Zhang, Xiaopan Li
Summary: This study aimed to compare the burden and trends of stroke attributed to dietary risk factors in the Belt and Road (B & R) countries from 1990 to 2019. Geographical differences were found in mortality and DALYs of diet-attributable stroke among member countries. Most member states showed a decline in age-standardized rates of diet-induced stroke mortality and DALYs from 1990 to 2019, with Estonia having the fastest decline. There was a substantial downward trend in stroke burden due to dietary risk factors in the final decade for most member states.
FRONTIERS IN NUTRITION
(2023)
Article
Nutrition & Dietetics
Kai Wang, Minggang Deng, Jinyi Wu, Lingli Luo, Rui Chen, Fang Liu, Jiaqi Nie, Fengxi Tao, Qingwen Li, Xin Luo, Fang Xia
Summary: This study explores the association between the oxidative balance score (OBS) and the percentages of total abdominal fat mass (TAFM) and visceral adipose tissue mass (VATM) in young and middle-aged US adults. The findings suggest that higher OBS is correlated with lower risks of abdominal obesity and visceral fat accumulation.
FRONTIERS IN NUTRITION
(2023)