期刊
ANTIBIOTICS-BASEL
卷 11, 期 10, 页码 -出版社
MDPI
DOI: 10.3390/antibiotics11101406
关键词
multidrug-resistant Acinetobacter baumannii; phage therapy
资金
- Shanghai Agriculture Applied Technology Development Program, China [T20200104]
- National Key Research and Development Program of China [2018YFE0192600]
- Thousand Talents Program for high-end Innovation in Qinghai
- Scottish Government (RESAS)
Acinetobacter baumannii is a multidrug-resistant and invasive pathogen associated with nosocomial infections and poultry production. Phage therapy has gained importance as a potential treatment for multidrug-resistant Acinetobacter baumannii, but further research is needed.
Acinetobacter baumannii is a multidrug-resistant and invasive pathogen associated with the etiopathology of both an increasing number of nosocomial infections and is of relevance to poultry production systems. Multidrug-resistant Acinetobacter baumannii has been reported in connection to severe challenges to clinical treatment, mostly due to an increased rate of resistance to carbapenems. Amid the possible strategies aiming to reduce the insurgence of antimicrobial resistance, phage therapy has gained particular importance for the treatment of bacterial infections. This review summarizes the different phage-therapy approaches currently in use for multiple-drug resistant Acinetobacter baumannii, including single phage therapy, phage cocktails, phage-antibiotic combination therapy, phage-derived enzymes active on Acinetobacter baumannii and some novel technologies based on phage interventions. Although phage therapy represents a potential treatment solution for multidrug-resistant Acinetobacter baumannii, further research is needed to unravel some unanswered questions, especially in regard to its in vivo applications, before possible routine clinical use.
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