Article
Infectious Diseases
Emilie Charpentier, Ludovic Doudet, Ingrid Allart-Simon, Marius Colin, Sophie C. Gangloff, Stephane Gerard, Fany Reffuveille
Summary: The combination of non-antimicrobial molecules with antibiotics can significantly reduce bacterial biofilm formation, potentially offering a solution to combat antibiotic resistance emergence.
Article
Chemistry, Multidisciplinary
Shuai Zhang, Xiao Teng, Xinjin Liang, Geoffrey Michael Gadd, Colin Peter McCoy, Yuhang Dong, Yimeng Wang, Qi Zhao
Summary: Silicone-oil-infused silver-releasing catheters have shown promise in reducing biofilm formation by uropathogens. However, in the presence of fibrinogen, the oil-infused surfaces undergo conformational changes and promote the adsorption of fibrinogen, compromising the antibiofilm activity and facilitating bacterial colonization. This study suggests that the use of silicone oil-infused silver-releasing urinary catheters may not be a feasible strategy to combat infections and associated complications arising from severe inflammation.
Article
Chemistry, Multidisciplinary
Xiaodie Yuan, Xia Zhao, Yuan Lin, Zhaohui Su
Summary: This study synthesized PDA nanoparticles of various sizes and introduced different surface groups to investigate their penetration and accumulation abilities in biofilms. The PDA nanoparticles of approximately 60 nm size showed higher penetration and accumulation abilities, and the positively charged amine groups were more effective in enhancing the interactions with the biofilm compared to carboxyl or methoxy groups. The PDA60 nanoparticles with amine surface groups also exhibited good photothermal properties.
Article
Microbiology
Sarika Suresh, Joylin Saldanha, Ashwini Bhaskar Shetty, Ramya Premanath, D. S. Akhila, Juliet Roshini Mohan Raj
Summary: This study compared the ability of isolated bacteriophages to remove biofilms formed by Pseudomonas aeruginosa. It was found that bacteriophages were more effective in removing biofilms formed by environmental isolates compared to biofilms from diabetic and non-diabetic wounds. Additionally, clinical isolates were more susceptible to phage infection in planktonic form.
Article
Biochemistry & Molecular Biology
Giovanni Di Bonaventura, Veronica Lupetti, Simone De Fabritiis, Alessandra Piccirilli, Annamaria Porreca, Marta Di Nicola, Arianna Pompilio
Summary: This study evaluated the antibacterial and antivirulence activities of eight FDA-approved non-antibiotic drugs and their effects on biofilm formation. Ciclopirox and actinomycin D showed the best antibacterial activity and were most effective against preformed biofilms.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Microbiology
Giovanni Di Bonaventura, Veronica Lupetti, Fabio Verginelli, Sara Giancristofaro, Rosemary Barbieri, Giovanni Gherardi, Arianna Pompilio
Summary: This study evaluated the antibacterial, antibiofilm, and antivirulence activities of apramycin compared to tobramycin against P. aeruginosa in cystic fibrosis patients. Apramycin showed better efficacy than tobramycin, without cytotoxicity to bronchial epithelial CF cells.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Food Science & Technology
Md Ashrafudoulla, Md Furkanur Rahaman Mizan, Si Hong Park, Sang-Do Ha
Summary: This study demonstrated that carvacrol has significant inhibitory effects on biofilms of Pseudomonas aeruginosa and Listeria monocytogenes, showing reductions in biofilm formation on both MBECTM biofilm device and polypropylene surface. Visual observations using advanced microscopy confirmed the results, suggesting the potential use of carvacrol as a natural compound to prevent contaminations of food contact surfaces by these bacteria.
LWT-FOOD SCIENCE AND TECHNOLOGY
(2021)
Article
Microbiology
Sara Masihzadeh, Mansour Amin, Zahra Farshadzadeh
Summary: This study investigated the antibiofilm activity of the WLBU2 peptide against Pseudomonas aeruginosa isolates. Results showed that WLBU2 exhibited strong inhibitory and eradication potency against MDR and carbapenem-resistant strains of P. aeruginosa, both in vitro and in vivo.
Article
Chemistry, Multidisciplinary
Sakkarin Lethongkam, Supakit Paosen, Siwaporn Bilhman, Krittima Dumjun, Suttiwan Wunnoo, Suntree Choojit, Ratchaneewan Siri, Chalongrat Daengngam, Supayang P. Voravuthikunchai, Tanan Bejrananda
Summary: A Foley urinary catheter coated with synthesized silver nanoparticles was developed to inhibit microbial adhesion and biofilm formation, reducing the risk of catheter-associated urinary tract infections.
Article
Multidisciplinary Sciences
Haajira Beevi Habeeb Rahuman, Ranjithkumar Dhandapani, Velmurugan Palanivel, Sathiamoorthi Thangavelu, Ragul Paramasivam, Saravanan Muthupandian
Summary: The surface modification of urinary catheters with environmentally friendly synthesized phytomolecules-capped silver nanoparticles effectively prevents urinary tract infections and has potential antibiofilm activity. Further research shows that the synergistic effects of synthesized AgNPs enhance antibacterial and antibiofilm activities, indicating a promising new approach to control clinical pathogens.
Article
Chemistry, Medicinal
Maya Rima, Jeanne Trognon, Laure Latapie, Asma Chbani, Christine Roques, Fatima El Garah
Summary: This study evaluated the antibiofilm activity of extracts from three seaweeds and found that the extract from green Ulva lactuca showed promising antibiofilm activity and exhibited a synergistic effect with tobramycin. Preliminary chemical composition analysis also provided some insights into the active compounds.
Article
Chemistry, Applied
Felix LewisOscar, Chari Nithya, Sasikumar Vismaya, Manivel Arunkumar, Arivalagan Pugazhendhi, Phuong Nguyen-Tri, Sulaiman Ali Alharbi, Naiyf S. Alharbi, Nooruddin Thajuddin
Summary: The methanolic extract of Spirulina platensis was used for the green synthesis of AgNPs, which showed high inhibition of biofilm formation against Pseudomonas aeruginosa PA14. The AgNPs also exhibited potential in preventing biofilm formation on medical devices.
PROGRESS IN ORGANIC COATINGS
(2021)
Article
Biotechnology & Applied Microbiology
D. Lahiri, M. Nag, B. Dutta, S. Dey, D. Mukherjee, S. J. Joshi, R. R. Ray
Summary: Eugenol and linalool extracted from Ocimum tenuiflorum leaves are effective in eradicating biofilms produced by Pseudomonas aeruginosa, reducing exopolysaccharide content and impacting the synthesis of quorum sensing proteins and virulence factors. These compounds show potential as a safe and cost-effective alternative to conventional antibiotics, with minimal side effects and no risk of antibiotic resistance.
JOURNAL OF APPLIED MICROBIOLOGY
(2021)
Article
Food Science & Technology
Junyu Tao, Shilun Yan, Huaqian Wang, Liqing Zhao, Hui Zhu, Zhen Wen
Summary: TFP has inhibitory effects on P. aeruginosa planktonic cells and biofilms by damaging cell membrane integrity, inhibiting bacterial motility, reducing virulence factor production, and decreasing surface hydrophobicity. These results support the potential utilization of TFP as a novel natural bioactive preservative in food processing.
LWT-FOOD SCIENCE AND TECHNOLOGY
(2022)
Article
Pharmacology & Pharmacy
Mariana Martins Drumond, Ana Paula Tapia-Costa, Elisabeth Neumann, alvaro Cantini Nunes, Jorge Wanderson Barbosa, Diego E. Kassuha, Pamela Mancha-Agresti
Summary: This study aimed to investigate the effect of cell-free spent medium (CFSM) from four lactic acid bacteria on Pseudomonas aeruginosa. The results showed that the CFSM had antibacterial and antibiofilm activity against the pathogenic strains. The findings suggest that the CFSM derived from different Lactobacilli could be a potential adjuvant therapy for hospital infections caused by Pseudomonas aeruginosa.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Microbiology
Taylor D. Lenzmeier, Nithya S. Mudaliar, Joshua A. Stanbro, Chase Watters, Aatiya Ahmad, Mark P. Simons, Gary Ventolini, John C. Zak, Jane A. Colmer-Hamood, Abdul N. Hamood
JOURNAL OF MEDICAL MICROBIOLOGY
(2019)
Article
Endocrinology & Metabolism
Moamen M. Elmassry, Nithya S. Mudaliar, Jane A. Colmer-Hamood, Michael J. San Francisco, John A. Griswold, Sharmila Dissanaike, Abdul N. Hamood
Article
Multidisciplinary Sciences
Kellsie L. Beasley, Shane A. Cristy, Moamen M. Elmassry, Nyaradzo Dzvova, Jane A. Colmer-Hamood, Abdul N. Hamood
Article
Biochemistry & Molecular Biology
Moamen M. Elmassry, Karishma Bisht, Jane A. Colmer-Hamood, Catherine A. Wakeman, Michael J. San Francisco, Abdul N. Hamood
Summary: The utilization of malonate significantly impacts P. aeruginosa pathogenesis by influencing quorum sensing systems, the production of virulence factors, biofilm formation, and antibiotic resistance.
MOLECULAR MICROBIOLOGY
(2021)
Article
Dermatology
Kayla Bounds, Jane A. Colmer-Hamood, Matthew Myntti, Randall M. Jeter, Abdul N. Hamood
Summary: The study found that the novel biofilm-dispersing wound gel (BDWG) does not interfere with the wound healing process and may actually benefit healing by reducing inflammation and promoting the transition to the proliferative stage of wound healing by day 3.
INTERNATIONAL WOUND JOURNAL
(2022)
Article
Biochemistry & Molecular Biology
Chwan-Li Shen, Moamen M. Elmassry, Katherine Grue, Hayli E. Joiner, A. Unique Jacobo, Abdul Hamood, Eunhee Chung
Summary: Natural bioactive compounds, such as geranylgeraniol and green tea polyphenols, were found to alleviate muscle atrophy and modify gut microbiome composition in mice fed a high-fat diet. The combination of geranylgeraniol and green tea polyphenols resulted in decreased body and fat mass, increased skeletal muscle mass, and changes in gut microbiota composition.
Review
Infectious Diseases
Abdulaziz Alqahtani, Jonathan Kopel, Abdul Hamood
Summary: Pseudomonas aeruginosa is a bacteria that can develop resistance to multiple antibiotics, making conventional antibiotic treatments difficult. There is an increasing interest in developing novel treatments against antibiotic-resistant strains, such as the use of pyocins, antimicrobial peptides secreted by P. aeruginosa.
Review
Infectious Diseases
Jonathan Kopel, Julianna McDonald, Abdul Hamood
Summary: With the global increase in antibiotic use, there has been a rise in antibiotic-resistant bacteria, prompting research into novel antibiotics. Utilizing plants with their long history of medicinal use as potential alternatives to common antibiotic treatments has shown promise in combating antibiotic-resistant strains.
Review
Microbiology
Moamen M. M. Elmassry, Jane A. A. Colmer-Hamood, Jonathan Kopel, Michael J. San J. Francisco, Abdul N. N. Hamood
Summary: Pseudomonas aeruginosa is a Gram-negative opportunistic pathogen that causes high morbidity and mortality in CF and immunocompromised patients, and eradicating the bacteria is difficult due to its antibiotic resistance mechanisms and virulence factors. It is considered as one of the urgently needed targets for the development of novel antibiotics by the WHO.