Spreading of P301S Aggregated Tau Investigated in Organotypic Mouse Brain Slice Cultures

Spreading of Aggregated α-Synuclein in Sagittal Organotypic Mouse Brain Slices

(2022) Buket Uçar et al.   Biomolecules

Tau assemblies do not behave like independently acting prion-like particles in mouse neural tissue

(2021) Lauren V. C. Miller et al.   Acta Neuropathologica Communications

Development of P301S tau seeded organotypic hippocampal slice cultures to study potential therapeutics

(2021) James M. McCarthy et al.   Scientific Reports

Spreading of Beta-Amyloid in Organotypic Mouse Brain Slices and Microglial Elimination and Effects on Cholinergic Neurons

(2021) Kurt Moelgg et al.   Biomolecules

Natural biomaterials in brain repair: A focus on collagen

(2021) Buket Ucar   NEUROCHEMISTRY INTERNATIONAL

LRP1 is a master regulator of tau uptake and spread

(2020) Jennifer N. Rauch et al.   NATURE

POSCAbilities: The Application of the Prion Organotypic Slice Culture Assay to Neurodegenerative Disease Research

(2020) Hailey Pineau et al.   Biomolecules

Comprehensive Review on Alzheimer’s Disease: Causes and Treatment

(2020) Zeinab Breijyeh et al.   MOLECULES

Therapeutic efficacy of glial cell-derived neurotrophic factor loaded collagen scaffolds in ex vivo organotypic brain slice Parkinson’s disease models

(2019) Buket Ucar et al.   BRAIN RESEARCH BULLETIN

Evidence of corticofugal tau spreading in patients with frontotemporal dementia

(2019) Eun-Joo Kim et al.   ACTA NEUROPATHOLOGICA

Mechanisms of secretion and spreading of pathological tau protein

(2019) Cecilia A. Brunello et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Autophagy-Mediated Secretory Pathway is Responsible for Both Normal and Pathological Tau in Neurons

(2019) Seokjo Kang et al.   JOURNAL OF ALZHEIMERS DISEASE

Cerebral amyloid angiopathy and Alzheimer disease — one peptide, two pathways

(2019) Steven M. Greenberg et al.   Nature Reviews Neurology

Tau Does Not Stabilize Axonal Microtubules but Rather Enables Them to Have Long Labile Domains

(2018) Liang Qiang et al.   CURRENT BIOLOGY

Nerve growth factor released from collagen scaffolds protects axotomized cholinergic neurons of the basal nucleus of Meynert in organotypic brain slices

(2018) Bettina M. Foidl et al.   JOURNAL OF NEUROSCIENCE METHODS

Long-Term Culture of Organotypic Hippocampal Slice from Old 3xTg-AD Mouse: An ex vivo Model of Alzheimer’s Disease

(2018) Sooah Jang et al.   Psychiatry Investigation

Unconventional Secretion Mediates the Trans-cellular Spreading of Tau

(2018) Taxiarchis Katsinelos et al.   Cell Reports

Differential Hyperphosphorylation of Tau-S199, -T231 and -S396 in Organotypic Brain Slices of Alzheimer Mice. A Model to Study Early Tau Hyperphosphorylation Using Okadaic Acid

(2018) Bettina M. Foidl et al.   Frontiers in Aging Neuroscience

The release and trans-synaptic transmission of Tau via exosomes

(2017) Yipeng Wang et al.   Molecular Neurodegeneration

What is the evidence that tau pathology spreads through prion-like propagation?

(2017) Amrit Mudher et al.   Acta Neuropathologica Communications

Astrogliopathy predominates the earliest stage of corticobasal degeneration pathology

(2016) Helen Ling et al.   BRAIN

Unique pathological tau conformers from Alzheimer’s brains transmit tau pathology in nontransgenic mice

(2016) Jing L. Guo et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Synaptophysin depletion and intraneuronal Aβ in organotypic hippocampal slice cultures from huAPP transgenic mice

(2016) Claire S. Harwell et al.   Molecular Neurodegeneration

Neuronal activity enhances tau propagation and tau pathology in vivo

(2016) Jessica W Wu et al.   NATURE NEUROSCIENCE

Tau Prion Strains Dictate Patterns of Cell Pathology, Progression Rate, and Regional Vulnerability In Vivo

(2016) Sarah K. Kaufman et al.   NEURON

Tunneling nanotubes: A possible highway in the spreading of tau and other prion-like proteins in neurodegenerative diseases

(2016) Saida Abounit et al.   Prion

The Metamorphic Nature of the Tau Protein: Dynamic Flexibility Comes at a Cost

(2016) Jonathan J. Sabbagh et al.   Frontiers in Neuroscience

Tunneling nanotube (TNT)-mediated neuron-to neuron transfer of pathological Tau protein assemblies

(2016) Meryem Tardivel et al.   Acta Neuropathologica Communications

Templated misfolding of Tau by prion-like seeding along neuronal connections impairs neuronal network function and associated behavioral outcomes in Tau transgenic mice

(2015) Ilie-Cosmin Stancu et al.   ACTA NEUROPATHOLOGICA

Depletion of microglia and inhibition of exosome synthesis halt tau propagation

(2015) Hirohide Asai et al.   NATURE NEUROSCIENCE

Intracerebral injection of preformed synthetic tau fibrils initiates widespread tauopathy and neuronal loss in the brains of tau transgenic mice

(2015) Eve Peeraer et al.   NEUROBIOLOGY OF DISEASE

Organotypic brain slice cultures: A review

(2015) C. Humpel   NEUROSCIENCE

Synaptic Contacts Enhance Cell-to-Cell Tau Pathology Propagation

(2015) Sara Calafate et al.   Cell Reports

Organotypic vibrosections from whole brain adult Alzheimer mice (overexpressing amyloid-precursor-protein with the Swedish-Dutch-Iowa mutations) as a model to study clearance of beta-amyloid plaques

(2015) Christian Humpel   Frontiers in Aging Neuroscience

Alzheimer's disease

(2015) Colin L. Masters et al.   Nature Reviews Disease Primers

A novel in vivo model of tau propagation with rapid and progressive neurofibrillary tangle pathology: the pattern of spread is determined by connectivity, not proximity

(2014) Zeshan Ahmed et al.   ACTA NEUROPATHOLOGICA

Differential induction and spread of tau pathology in young PS19 tau transgenic mice following intracerebral injections of pathological tau from Alzheimer’s disease or corticobasal degeneration brains

(2014) Susana Boluda et al.   ACTA NEUROPATHOLOGICA

Ectosomes: A New Mechanism for Non-Exosomal Secretion of Tau Protein

(2014) Simon Dujardin et al.   PLoS One

Physiological release of endogenous tau is stimulated by neuronal activity

(2013) Amy M Pooler et al.   EMBO REPORTS

Synthetic Tau Fibrils Mediate Transmission of Neurofibrillary Tangles in a Transgenic Mouse Model of Alzheimer's-Like Tauopathy

(2013) M. Iba et al.   JOURNAL OF NEUROSCIENCE

Brain homogenates from human tauopathies induce tau inclusions in mouse brain

(2013) Florence Clavaguera et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Heparan sulfate proteoglycans mediate internalization and propagation of specific proteopathic seeds

(2013) B. B. Holmes et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Neuropathological Alterations in Alzheimer Disease

(2013) A. Serrano-Pozo et al.   Cold Spring Harbor Perspectives in Medicine

Organotypic Brain Slice Cultures of Adult Transgenic P301S Mice—A Model for Tauopathy Studies

(2012) Agneta Mewes et al.   PLoS One

Purified and synthetic Alzheimer's amyloid beta (A ) prions

(2012) J. Stohr et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Organotypic hippocampal slice culture from the adult mouse brain: A versatile tool for translational neuropsychopharmacology

(2012) Hyunjeong Kim et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

Pathological  -Synuclein Transmission Initiates Parkinson-like Neurodegeneration in Nontransgenic Mice

(2012) K. C. Luk et al.   SCIENCE

Alzheimer brain-derived tau oligomers propagate pathology from endogenous tau

(2012) Cristian A. Lasagna-Reeves et al.   Scientific Reports

Seeding of Normal Tau by Pathological Tau Conformers Drives Pathogenesis of Alzheimer-like Tangles

(2011) Jing L. Guo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Total and phosphorylated tau protein as biological markers of Alzheimer’s disease

(2009) Harald Hampel et al.   EXPERIMENTAL GERONTOLOGY

Propagation of Tau Misfolding from the Outside to the Inside of a Cell

(2009) Bess Frost et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Transmission and spreading of tauopathy in transgenic mouse brain

(2009) Florence Clavaguera et al.   NATURE CELL BIOLOGY