Article
Neurosciences
Cortney M. Howard, Shivangi Jain, Angela D. Cook, Lauren E. Packard, Hollie A. Mullin, Nan-kuei Chen, Chunlei Liu, Allen W. Song, David J. Madden
Summary: Brain iron dyshomeostasis can disrupt cellular functions and aging-related iron accumulation may contribute to deficient neurotransmission and cell death. Studies suggest that brain iron levels may impact cognitive function and serve as an early indicator of neurodegenerative disease.
HUMAN BRAIN MAPPING
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Hyeong Woo Kim, Subin Lee, Jin Ho Yang, Yeonsil Moon, Jongho Lee, Won-Jin Moon
Summary: Cortical iron deposition, measured using quantitative susceptibility mapping (QSM), is found to be higher in patients with Alzheimer's disease and mild cognitive impairment compared to individuals with normal cognition. Iron deposition in the cingulate and insular cortices may serve as early imaging markers of cognitive impairment-related neurodegeneration.
KOREAN JOURNAL OF RADIOLOGY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Gregory Kuchcinski, Lucas Patin, Renaud Lopes, Melanie Leroy, Xavier Delbeuck, Adeline Rollin-Sillaire, Thibaud Lebouvier, Yi Wang, Pascal Spincemaille, Thomas Tourdias, Lotfi Hacein-Bey, David Devos, Florence Pasquier, Xavier Leclerc, Jean-Pierre Pruvo, Sebastien Verclytte
Summary: This study aimed to investigate the brain iron distribution patterns in subtypes of early-onset Alzheimer's disease (EOAD) using quantitative susceptibility mapping (QSM). The results showed that EOAD patients had higher QSM values in deep gray nuclei and limbic structures compared to controls. Among EOAD subtypes, HpSp(MRI) had the highest QSM values in deep gray nuclei, while LPMRI had the highest QSM values in limbic structures. Iron overload in deep gray nuclei could help identify patients with atypical presentation of Alzheimer's disease.
EUROPEAN RADIOLOGY
(2023)
Article
Neurosciences
Parsa Ravanfar, Samantha M. Loi, Warda T. Syeda, Tamsyn E. Van Rheenen, Ashley I. Bush, Patricia Desmond, Vanessa L. Cropley, Darius J. R. Lane, Carlos M. Opazo, Bradford A. Moffat, Dennis Velakoulis, Christos Pantelis
Summary: Iron has been increasingly implicated in the pathology of neurodegenerative diseases. The development of QSM technique allows for more comprehensive investigation of iron distribution in the brain. Existing studies have shown increased magnetic susceptibility in brain regions associated with different neurodegenerative disorders, indicating potential for QSM as a promising tool in investigating neurodegeneration.
FRONTIERS IN NEUROSCIENCE
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Chun Ki Franklin Au, Jill Abrigo, Chunlei Liu, Wanting Liu, Jack Lee, Lisa Wing Chi Au, Queenie Chan, Sirong Chen, Eric Yim Lung Leung, Chi Lai Ho, Ho Ko, Vincent Chung Tong Mok, Weitian Chen
Summary: AD is associated with higher magnetic susceptibility in the fimbria compared with controls. QSM values showed significant differences between the control and early AD groups, and could be used for differentiation, with a model incorporating clinical and radiologic data correctly classifying up to 76% of subjects.
JOURNAL OF MAGNETIC RESONANCE IMAGING
(2021)
Article
Clinical Neurology
Fengmei Fan, Junchao Huang, Shuping Tan, Zhiren Wang, Yanli Li, Song Chen, Hui Li, Stephanie Hare, Xiaoming Du, Fude Yang, Baopeng Tian, Peter Kochunov, Yunlong Tan, L. Elliot Hong
Summary: Treatment resistance in schizophrenia is associated with reduced cortical thickness in specific brain regions. These regions include the right caudal middle frontal gyrus, superior frontal cortex, fusiform gyrus, pars opercularis of the inferior frontal cortex, and supramarginal cortex. The reductions in cortical thickness in these regions are significantly correlated with cognitive deficits. Moreover, cortical abnormalities in the right caudal middle frontal gyrus, superior frontal cortex, and pars opercularis of the inferior frontal cortex mediate the effects of cognitive deficits on treatment resistance.
PSYCHIATRY AND CLINICAL NEUROSCIENCES
(2023)
Article
Multidisciplinary Sciences
Rui Li, Xiaoyan Miao, Buxin Han, Juan Li
Summary: Hearing impairment is a significant modifiable risk factor for cognitive decline and dementia. This study examines the association between central hearing ability in real-world conditions and cognitive aging. The findings suggest that higher hearing thresholds are linked to lower performance in memory, executive function, working memory, reading, and vocabulary comprehension. Furthermore, cortical thickness in the left parahippocampal cortex acts as a partial mediator in the relationship between central hearing and cognitive performance.
ANNALS OF THE NEW YORK ACADEMY OF SCIENCES
(2023)
Article
Neuroimaging
Neha Atulkumar Singh, Arvin Arani, Jonathan Graff-Radford, Matthew L. Senjem, Peter R. Martin, Mary M. Machulda, Christopher G. Schwarz, Yunhong Shu, Petrice M. Cogswell, David S. Knopman, Ronald C. Petersen, Val J. Lowe, Clifford R. Jack Jr, Keith A. Josephs, Jennifer L. Whitwell
Summary: This study used QSM to detect iron distribution in the brain and found differences in iron deposition patterns between typical AD and atypical AD (such as LPA and PCA). The results demonstrate the potential of QSM in studying iron deposition in these patients.
NEUROIMAGE-CLINICAL
(2022)
Article
Neuroimaging
Jan-Patrick Stellmann, Nadine Wanke, Adil Maarouf, Susanne Gellissen, Christoph Heesen, Bertrand Audoin, Stefan M. Gold, Wafaa Zaaraoui, Jana Poettgen
Summary: The study investigated the association between cognitive impairment and regional cortical thickness in MS patients using a comprehensive neuropsychological assessment. Results showed specific cortical regions in the left hemisphere associated with different cognitive tasks, while the right hemisphere showed strong associations in the sulcus interparietalis. The findings suggest a pathophysiological dependency rather than a physiological one in MS patients compared to healthy controls.
NEUROIMAGE-CLINICAL
(2021)
Article
Geriatrics & Gerontology
William D. Hopkins, Xiang Li, Neil Roberts, Michele M. Mulholland, Chet C. Sherwood, Melissa K. Edler, Mary Ann Raghanti, Steven J. Schapiro
Summary: Humans and chimpanzees share genetic and cognitive similarities, but little is known about age-related changes in cognitive and motor functions in chimpanzees. In this study, we examined the effects of age on cognition and cortical thickness in chimpanzees. We found that chimpanzees exhibit thinning of the cortex with age and variations in cortical thickness are associated with cognitive functions. Additionally, sex differences in cortical thickness were observed in certain brain regions.
NEUROBIOLOGY OF AGING
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Ziji Qin, Wenjun Wu, Dingxi Liu, Chuansheng Zheng, Jiamin Kang, Hongyan Zhou, Xueni Meng, E. Mark Haacke, Lixia Wang
Summary: This study measured brain susceptibility using QSM and found that brain iron deposition is significantly higher in HTN patients. Cognitive impairment is correlated with regional brain iron deposition.
JOURNAL OF MAGNETIC RESONANCE IMAGING
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Julia V. Velikina, Ruiyang Zhao, Collin J. Buelo, Alexey A. Samsonov, Scott B. Reeder, Diego Hernando
Summary: To improve repeatability and reproducibility in quantitative susceptibility mapping (QSM) of the liver, an optimized regularized reconstruction algorithm for abdominal QSM was developed. The algorithm incorporates estimates of data reliability and anatomical priors, resulting in higher quality susceptibility maps. Evaluations show that the proposed method outperforms the standard method in terms of linear correlation, test-retest repeatability, and reproducibility across different acquisition protocols.
MAGNETIC RESONANCE IN MEDICINE
(2023)
Article
Behavioral Sciences
Wen-Rui Gao, Xiao-Hong Hu, Kai-Yue Yu, Hong-Yan Cai, Zhao-Jun Wang, Lei Wang, Mei-Na Wu
Summary: Cognitive dysfunction is a main clinical manifestation of Alzheimer's disease (AD). Previous research has found a correlation between elevated orexin level and the progression of AD. Orexin-A treatment has been shown to increase amyloid beta protein (A beta) deposition and worsen spatial memory impairment in mice. Dual orexin receptor (OXR) antagonist has been found to affect A beta level and cognitive dysfunction in AD, but the effects of OX1R or OX2R alone have not been reported. This study investigates the role of OX1R in AD cognitive dysfunction and its possible mechanism.
BEHAVIOURAL BRAIN RESEARCH
(2023)
Article
Geriatrics & Gerontology
Mabel Seto, Logan Dumitrescu, Emily R. Mahoney, Annah M. Sclafani, Philip L. De Jager, Vilas Menon, Mary E. I. Koran, Rena A. Robinson, Douglas M. Ruderfer, Nancy J. Cox, Nicholas T. Seyfried, Angela L. Jefferson, Julie A. Schneider, David A. Bennett, Vladislav A. Petyuk, Timothy J. Hohman
Summary: This study expands on previous work and investigates the role of the vascular endothelial growth factor (VEGF) signaling family in cognitive decline and Alzheimer's disease (AD). Using various molecular techniques, the study reveals that higher expression of VEGFB and FLT1 is associated with worse cognitive outcomes. Additionally, the study highlights the involvement of microglia, oligodendrocytes, and endothelial cells in these associations, and the potential cognitive benefits of FLT4 and NRP2 expression. Overall, this study provides important insights into the biomarker and therapeutic potential of VEGF family members in AD.
NEUROBIOLOGY OF AGING
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Aaryani Tipirneni-Sajja, Ralf B. Loeffler, Jane S. Hankins, Cara Morin, Claudia M. Hillenbrand
Summary: This study demonstrated the feasibility of using ARMA-QSM to simultaneously estimate susceptibility-based wet HIC, R2*-based dry HIC, and FFs. The results showed strong correlations between ARMA R2* and susceptibility values with iron concentrations in phantoms, and high correlation with clinical HIC values in patients. ARMA-QSM has the potential to provide a confounder-free assessment of hepatic iron overload.
JOURNAL OF MAGNETIC RESONANCE IMAGING
(2021)