Article
Chemistry, Inorganic & Nuclear
C. S. Shivananda
Summary: Colloidal silver nanoparticles were synthesized using aqueous silk fibroin under white light and at ambient temperature. The nanoparticles exhibited a characteristic surface plasmon resonance band in the UV-Vis spectrum and were spherical with smooth surfaces, with sizes ranging from 35 to 40 nm. X-ray diffraction analysis confirmed the presence of silver nanocrystals with an FCC crystal structure. These biogenic silver nanoparticles showed significant antibacterial activity against human bacterial pathogens and also exhibited excellent anti-cancer activity at low dosage.
INORGANIC CHEMISTRY COMMUNICATIONS
(2023)
Article
Microbiology
Ida Romano, Giuseppe Vitiello, Noemi Gallucci, Rocco Di Girolamo, Andrea Cattaneo, Annarita Poli, Paola Di Donato
Summary: The study demonstrates that extremophilic microorganisms can be valuable producers of biologically active nanoparticles, but further experiments are needed to improve synthesis protocols and downstream processes.
Article
Agricultural Engineering
Jiansong Chen, Liangliang An, Jin Ho Bae, Ji Won Heo, Song Yi Han, Yong Sik Kim
Summary: In this study, aminated lignin-silver complex was prepared as an effective antibacterial agent using kraft lignin. The complex showed antibacterial activity against various bacteria, making it a potential green alternative to silver nanoparticles.
INDUSTRIAL CROPS AND PRODUCTS
(2021)
Article
Environmental Sciences
Paresh Prabhu, Medha Rao, Gokulakrishnan Murugesan, Manoj Kumar Narasimhan, Thivaharan Varadavenkatesan, Ramesh Vinayagam, Nguyen Thuy Lan Chi, Arivalagan Pugazhendhi, Raja Selvaraj
Summary: This study successfully prepared hematite nanoparticles (HNPs) with superparamagnetic properties and anticancer potential using fruit extract of Spondias pinnata available in Western-coastal India. The method is cheap, effective, and eco-friendly, making it promising for various biomedical applications.
ENVIRONMENTAL RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Amal A. Althubiti, Samar A. Alsudir, Ahmed J. Alfahad, Abdullah A. Alshehri, Abrar A. Bakr, Ali A. Alamer, Rasheed H. Alrasheed, Essam A. Tawfik, Paschalis Alexandridis
Summary: In this study, green silver nanoparticles (green-AgNPs) were synthesized using Jacobaea maritima aqueous leaf extract, which serves as a simple and environmentally-friendly method. The synthesized AgNPs exhibited controlled size and shape, and demonstrated significant antimicrobial and anticancer activities. This green synthesis of AgNPs has potential clinical applications, but further in vivo studies are required to evaluate their safety and efficacy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Chemistry, Multidisciplinary
Guibin Lin, Chenhui Zhao, Wenqiang Liao, Jianmin Yang, Yunquan Zheng
Summary: Rubropunctatin-functionalized silver nanoparticles (R-AgNPs) were successfully synthesized using rubropunctatin as the reducing and blocking agent. R-AgNPs exhibited excellent stability and strong antibacterial activity, with the mechanism of antibacterial action being the destruction of bacterial cell membrane. The cytotoxicity of R-AgNPs was lower than that of commercial silver nanoparticles.
Article
Chemistry, Applied
A. Wasilewska, U. Klekotka, M. Zambrzycka, G. Zambrowski, I. Swiecicka, B. Kalska-Szostko
Summary: Understanding the properties of silver nanoparticles is crucial for developing new antimicrobial agents. In this study, silver nanoparticles were synthesized using natural reducing agents from plant extracts, and their antimicrobial properties were evaluated against various microorganisms. The results showed that the nanoparticles obtained from different extracts exhibited specific characteristics and varied antimicrobial activities.
Article
Chemistry, Inorganic & Nuclear
Fouzia Mashkoor, Mohd Shoeb, Mohd Ahmar Rauf, Sumairah Kareem, Sayed Mohammed Adnan, Rushda Mashkoor, Sang-Soo Baek, Changyoon Jeong
Summary: This research evaluates the effectiveness of a nanocomposite composed of egg albumen-mediated hematite nanoparticles (α-Fe2O3) and reduced graphene oxide decorated with α-Fe2O3 (RGO-α-Fe2O3 NCs) in removing dyes and heavy metals. The nanocomposite shows remarkable adsorbing properties and exhibits anticancer and antimicrobial activities. It is also a potent antimicrobial agent against pathogenic bacteria and a promising anticancer agent against human lung cancer cells. The powerful antibacterial and anticancer properties of RGO-α-Fe2O3 NCs are attributed to the combined effects of Fe2+ ions and graphene sheets.
INORGANIC CHEMISTRY COMMUNICATIONS
(2023)
Article
Biochemistry & Molecular Biology
Muhammad Yahya Tahir, Awais Ahmad, Asma A. Alothman, Mohammed Sheikh Saleh Mushab, Shafaqat Ali
Summary: The green synthesis method was used to fabricate Ag-NPs, which showed efficient photocatalytic degradation of methylene blue (MB) dye and potent anticancer property. The study highlighted the significance of as-synthesized green Ag-NPs over other physically/chemically prepared Ag-NPs.
BIOINORGANIC CHEMISTRY AND APPLICATIONS
(2022)
Article
Polymer Science
Aya Elbrolesy, Y. Abdou, F. A. Elhussiny, Reda Morsy
Summary: This study aimed to synthesize multifunctional zinc oxide nanoparticles (ZnO NPs) using Solanum Lycopersicum (SL) fruit juice as antibacterial/cancer/UV sunscreens. The synthesized ZnO NPs showed good optical properties, cytotoxicity against human lung fibroblast and hepatocellular carcinoma cell lines, antibacterial activity against Escherichia coli and Staphylococcus aureus, antioxidant activity, and in vitro sun protection factor (SPF). The SL fruit juice acted as a solvent, reducing agent, and stabilizer in the synthesis of ZnO NPs sunscreen with antibacterial and anti-carcinogenic properties.
JOURNAL OF INORGANIC AND ORGANOMETALLIC POLYMERS AND MATERIALS
(2023)
Article
Engineering, Biomedical
Veer Shah, David Medina-Cruz, Ada Vernet-Crua, Linh B. Truong, Eduardo Sotelo, Ebrahim Mostafavi, Maria Ujue Gonzalez, Jose Miguel Garcia-Martin, Jorge L. Cholula-Diaz, Thomas J. Webster
Summary: The conventional physicochemical approaches for producing nanoparticles for biomedical applications have limitations in terms of biocompatibility, requiring additional functionalization. In contrast, green nanotechnology and environmentally friendly nanomaterial synthesis using natural sources have gained attention. This study synthesized selenium and tellurium nanoparticles using extracts from jalapeno and habanero peppers and evaluated their antimicrobial and anticancer properties. The nanoparticles showed different antimicrobial profiles, with tellurium nanoparticles exhibiting a significant antibacterial effect. The nanoparticles also demonstrated cytocompatibility and dose-dependent anticancer effects, with tellurium nanoparticles being biocompatible but having a powerful anti-cancer effect.
JOURNAL OF FUNCTIONAL BIOMATERIALS
(2023)
Article
Chemistry, Physical
Nasrin Rahmatian, Shahryar Abbasi, Mohammad Tavakkoli Yaraki, Naser Abbasi
Summary: Green synthesis of silver nanoparticles using Echinophora platyloba plant extract was successfully achieved in this study, demonstrating the environmentally friendly synthesis of nanomaterials with excellent antibacterial and catalytic properties. The size of the nanoparticles could be controlled by adjusting synthesis parameters, with pH being a critical factor. The as-synthesized silver nanoparticles showed potential applications in dye degradation and antibacterial activity.
JOURNAL OF MOLECULAR LIQUIDS
(2023)
Article
Chemistry, Applied
Rui Zhang, Jiyuan Yu, Xiaoyu Guo, Weidong Li, Yunhan Xing, Yurong Wang
Summary: Silver nanoparticles (AgNPs) were rapidly synthesized with the assistance of Monascus pigments under simulated sunlight. Various analytical tools were used to characterize the prepared AgNPs, confirming their stability and potential antibacterial, antioxidant, and extraordinary catalytic activity. The biosynthesized AgNPs have shown significant antibacterial activity, antioxidant capacity, and the ability to catalyze the degradation of various dyes, indicating their potential applications in biomedical, food packaging, pathogen mitigation, and industrial wastewater management.
APPLIED ORGANOMETALLIC CHEMISTRY
(2021)
Article
Chemistry, Inorganic & Nuclear
Hamed Barabadi, Faraz Mojab, Hossein Vahidi, Boshra Marashi, Niloufar Talank, Omid Hosseini, Muthupandian Saravanan
Summary: This study aimed to fabricate Zataria multiflora-derived silver nanoparticles (AgNPs) and compare their antibacterial and biofilm inhibitory activities against Staphylococcus aureus ATCC 25923 with commercial AgNPs. The plant-mediated fabricated AgNPs (P-AgNPs) exhibited significant antibacterial activity and biofilm inhibition at lower concentrations, showing stronger effects compared to commercial AgNPs.
INORGANIC CHEMISTRY COMMUNICATIONS
(2021)
Article
Environmental Sciences
M. Mani, R. Harikrishnan, P. Purushothaman, S. Pavithra, P. Rajkumar, S. Kumaresan, Dunia A. Al Farraj, Mohamed Soliman Elshikh, Balamuralikrishnan Balasubramanian, K. Kaviyarasu
Summary: In this study, nanostructured silver particles (NS-AgPs) were successfully synthesized using bio active agents present in Cleome gynandra leaf extracts via green synthesis. Various analytical techniques such as UV-vis, FTIR, SEM, TEM, DLS, and antibacterial studies were utilized to confirm the existence, size, stability, and antibacterial activity of NS-AgPs.
ENVIRONMENTAL RESEARCH
(2021)
Review
Biochemistry & Molecular Biology
Robert Czarnomysy, Dominika Radomska, Olga Klaudia Szewczyk, Piotr Roszczenko, Krzysztof Bielawski
Summary: New, safer, and more effective agents are needed for cancer treatment. Cytostatics with transition metals are attracting renewed interest from scientists, who are exploring combination therapy and molecular modifications to enhance effectiveness and selectivity. Recent drug findings with palladium and platinum atoms are being organized.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Olga Klaudia Szewczyk, Piotr Roszczenko, Robert Czarnomysy, Anna Bielawska, Krzysztof Bielawski
Summary: Nanotechnology shows great potential in advanced cancer therapies, allowing for simultaneous drug administration and immune system engagement. Nanoparticles can locate metastases and deliver medications, effectively reducing tumors with minimal toxicity to healthy tissue.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Piotr Roszczenko, Serhii Holota, Olga Klaudia Szewczyk, Rostyslav Dudchak, Krzysztof Bielawski, Anna Bielawska, Roman Lesyk
Summary: Oncological diseases have become epidemic, especially in industrialized countries. Researchers in medicinal chemistry have conducted complex studies to develop novel effective anticancer drugs. This review summarizes the data on new 4-thiazolidinone-bearing hybrid molecules with potential anticancer activity and highlights the application of molecular hybridization methodologies and strategies in the design of small molecules as anticancer agents.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Iryna Ivasechko, Ihor Yushyn, Piotr Roszczenko, Julia Senkiv, Nataliya Finiuk, Danylo Lesyk, Serhii Holota, Robert Czarnomysy, Olga Klyuchivska, Dmytro Khyluk, Nataliya Kashchak, Andrzej Gzella, Krzysztof Bielawski, Anna Bielawska, Rostyslav Stoika, Roman Lesyk
Summary: Novel pyridine-thiazole hybrid molecules showed high antiproliferative activity against various cancer cell lines, suggesting their potential as anticancer agents. The selective cytotoxicity of these compounds prompted further investigation into their mechanisms of action, which may be related to inducing genetic instability in tumor cells.
Article
Chemistry, Medicinal
Iryna Ivasechko, Andrii Lozynskyi, Julia Senkiv, Piotr Roszczenko, Yuliia Kozak, Nataliya Finiuk, Olga Klyuchivska, Nataliya Kashchak, Nazar Manko, Zvenyslava Maslyak, Danylo Lesyk, Andriy Karkhut, Svyatoslav Polovkovych, Robert Czarnomysy, Olga Szewczyk, Andriy Kozytskiy, Olexandr Karpenko, Dmytro Khyluk, Andrzej Gzella, Krzysztof Bielawski, Anna Bielawska, Petr Dzubak, Sona Gurska, Marian Hajduch, Rostyslav Stoika, Roman Lesyk
Summary: A series of 11-substituted 9-hydroxy-3,5,10,11-tetrahydro-2H-benzo[6,7]thiochromeno[2,3-d][1,3]thiazole-2,5,10-triones were synthesized and their structures were confirmed through spectral data and X-ray diffraction analysis. These compounds showed potential anticancer activity, particularly compound 3.10 which exhibited a cytotoxic effect similar to doxorubicin but was less toxic to normal cells. In vivo testing on mice showed that compound 3.10 had no acute toxic effects on their blood parameters, indicating its potential as a bio-tolerant anticancer drug.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2023)
Review
Cell Biology
Olga Klaudia Szewczyk-Roszczenko, Piotr Roszczenko, Anna Shmakova, Nataliya Finiuk, Serhii Holota, Roman Lesyk, Anna Bielawska, Yegor Vassetzky, Krzysztof Bielawski
Summary: Endocytosis is a major cellular communication process that can be hijacked by pathogens and involved in oncogenic transformation. This review explores different approaches to inhibit endocytosis, discusses chemical inhibitors, and explores potential clinical applications.