Article
Cell Biology
Kevin Bassand, Laurent Metzinger, Meriem Naim, Nesrine Mouhoubi, Oualid Haddad, Vincent Assoun, Naima Zaidi, Odile Sainte-Catherine, Amena Butt, Erwan Guyot, Olivier Oudar, Christelle Laguillier-Morizot, Angela Sutton, Nathalie Charnaux, Valerie Metzinger-Le Meuth, Hanna Hlawaty
Summary: The study revealed the significant role of miR-126 in CXCL12-induced angiogenesis, with inhibition of miR-126-3p affecting cell angiogenesis and migration capabilities. Furthermore, SPRED-1, a target of miR-126-3p, plays a crucial role in the process of angiogenesis.
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Yu-Jen Chen, Chia-Tien Hsu, Shang-Feng Tsai, Cheng-Hsu Chen
Summary: Chronic allograft dysfunction (CAD) is a major condition affecting long-term kidney graft survival. In this study, the correlation between plasma miR-21 and the severity of CAD was investigated. RNA sequencing was performed and differentially expressed miRNAs in CAD were identified. MiR-21-5p, miR-20a-5p, and miR-101-3p were found to be associated with the TGF-beta pathway and CAD. These findings may lead to the development of early prediction miRNA biomarkers and therapeutic tools for CAD in the field of kidney transplantation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Chairmandurai Aravindraja, Syam Jeepipalli, Krishna Mukesh Vekariya, Ruben Botello-Escalante, Edward K. L. Chan, Lakshmyya Kesavalu
Summary: This study aimed to investigate the global miRNA expression kinetics during the progression of periodontitis in mice infected with T. denticola. The results showed that T. denticola infection led to bacterial colonization and increased alveolar bone resorption. A total of 70 miRNAs with differential expression were identified, and miR-486, miR-126-3p, and miR-126-5p were found to be potential invasive biomarkers of T. denticola in periodontal disease.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Michele Manganelli, Ilaria Grossi, Manuela Ferracin, Paola Guerriero, Massimo Negrini, Michele Ghidini, Chiara Senti, Margherita Ratti, Claudio Pizzo, Rodolfo Passalacqua, Sarah Molfino, Gianluca Baiocchi, Nazario Portolani, Eleonora Marchina, Giuseppina De Petro, Alessandro Salvi
Summary: The study investigated the longitudinal levels of cell-free long ncRNA GAS5 and microRNAs miR-126-3p and miR-23b-3p in patients with hepatocellular carcinoma (HCC) undergoing sorafenib treatment. The results highlighted the significant downregulation of miR-23b-3p in untreated HCC patients and its diagnostic relevance.
Article
Cell Biology
Antonella Bordin, Maila Chirivi, Francesca Pagano, Marika Milan, Marco Iuliano, Eleonora Scaccia, Orazio Fortunato, Giorgio Mangino, Xhulio Dhori, Elisabetta De Marinis, Alessandra D'Amico, Selenia Miglietta, Vittorio Picchio, Roberto Rizzi, Giovanna Romeo, Fabio Pulcinelli, Isotta Chimenti, Giacomo Frati, Elena De Falco
Summary: Platelet lysate (PL) contains a subset of small vesicles with angiogenic effects, enriched with miR-126. These extracellular vesicles (EVs) play a key role in promoting angiogenic tubular structures in endothelial cells, representing a potential target for developing a product solely made of EVs for biological manipulation.
CELL PROLIFERATION
(2022)
Review
Endocrinology & Metabolism
Yixiao Ma, Hua Liu, Yong Wang, Junjie Xuan, Xing Gao, Huixian Ding, Chunlian Ma, Yanfang Chen, Yi Yang
Summary: This article reviews the roles of miR-126 and its downstream proteins as exercise mechanisms and proposes that miR-126 can be used as an exercise indicator for cardiovascular prescriptions and as a preventive or therapeutic target for cardiovascular complications in T2DM.
DIABETOLOGY & METABOLIC SYNDROME
(2022)
Article
Oncology
Chiara Verdelli, Irene Forno, Annamaria Morotti, Riccardo Maggiore, Gilberto Mari, Leonardo Vicentini, Stefano Ferrero, Elisabetta Kuhn, Valentina Vaira, Sabrina Corbetta
Summary: Tumors of the parathyroid glands display a distinct miRNA profile from normal glands, with miR-126-3p downregulated in parathyroid adenomas. Localization of miR-126-3p to endothelial cells and tumor-associated myofibroblasts suggests its role in promoting neoangiogenesis through VEGFA overexpression.
ENDOCRINE-RELATED CANCER
(2021)
Article
Nanoscience & Nanotechnology
Shasha Duan, Chao Wang, Xiangli Xu, Xiaoshan Zhang, Gaofeng Su, You Li, Shuai Fu, Ping Sun, Jiawei Tian
Summary: In this study, we investigated the effect of exosomes extracted from the peripheral serum of patients with acute myocardial infarction (AMI) on angiogenesis and identified the downstream pathways. Our findings suggest that these exosomes promote angiogenesis through the miR-126-3p/TSC1/mTORC1/ HIF-1 alpha signaling pathway.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Nina P. Jordan, Samuel J. Tingle, Victoria G. Shuttleworth, Katie Cooke, Rachael E. Redgrave, Esha Singh, Emily K. Glover, Hafiza B. Ahmad Tajuddin, John A. Kirby, Helen M. Arthur, Chris Ward, Neil S. Sheerin, Simi Ali
Summary: The down-regulation of miR-126-3p is associated with EndMT, with its over-expression preventing the process and maintaining endothelial characteristics while repressing fibronectin expression. Lineage tracing in cardiac and kidney fibrosis models revealed that a significant subpopulation of endothelial-derived cells undergo EndMT and express mesenchymal markers. MiR-126-3p expression is restricted to endothelial cells and down-regulated in fibrotic kidney and heart tissue, making it a potential target for miRNA-based therapeutics in fibrotic organs.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Medicine, Research & Experimental
Peng Zeng, Jie Yang, Lipei Liu, Xiaoxiao Yang, Zhi Yao, Chuanrui Ma, Haibo Zhu, Jiamin Su, Qian Zhao, Ke Feng, Shu Yang, Yan Zhu, Xiaoju Li, Wenguang Wang, Yajun Duan, Jihong Han, Yuanli Chen
Summary: The study showed a positive correlation between calcification in human aortic valves and ERK1/2 activity. Inhibition of ERK1/2 reduced atherosclerosis and calcification in animal models, as well as calcification in SMCs and arterial rings. The reduction of calcification was due to decreased expression of ALP, BMP2, and RUNX2, and activation of DKK1 and LRP6 expression, thereby inactivating Wnt signaling pathways in SMCs.
Article
Immunology
Gemma Arderiu, Esther Pena, Anna Civit-Urgell, Lina Badimon
Summary: Hypoxic endothelial cells release extracellular microvesicles that induce monocyte homing and angiogenesis. The microvesicles contain noncoding RNAs, including miR-126, which can modulate cellular signaling pathways. Activated endothelial cells secrete microvesicles carrying miR-126, which regulate monocyte reprogramming of angiogenic genes.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Medicine, Research & Experimental
Jizi Zhou, Ying Zhao, Ping An, Huanqiang Zhao, Xiaotian Li, Yu Xiong
Summary: This study reveals that circRNA hsa_circ_0002348 is significantly increased in preeclampsia placentas and correlates with the severity of clinical manifestations. It functions as an endogenous sponge for miR-126-3p to upregulate BAK1 expression, thereby regulating trophoblast proliferation and apoptosis. Hsa_circ_0002348 may serve as a potential therapeutic target for preeclampsia.
JOURNAL OF TRANSLATIONAL MEDICINE
(2023)
Article
Health Care Sciences & Services
Milan Hromadka, Zuzana Motovska, Ota Hlinomaz, Petr Kala, Frantisek Tousek, Jiri Jarkovsky, Marketa Beranova, Pavel Jansky, Michal Svoboda, Iveta Krepelkova, Richard Rokyta, Petr Widimsky, Michal Karpisek
Summary: This study indicated that miR-223-3p and miR-126-3p are promising independent predictors of thrombotic events post-AMI, with miR-223-3p levels significantly associated with ischemic endpoints and the miR-126-3p to miR-223-3p ratio being related to risk reduction.
JOURNAL OF PERSONALIZED MEDICINE
(2021)
Article
Medicine, General & Internal
Olga Martinez-Arroyo, Ana Ortega, Ana Flores-Chova, Belen Sanchez-Garcia, Ana B. Garcia-Garcia, Felipe J. Chaves, Juan C. Martin-Escudero, Maria Jose Forner, Josep Redon, Raquel Cortes
Summary: Elevated plasma microRNA levels, particularly miR-126-3p, are associated with albuminuria in hypertensive patients, and may serve as prognostic markers for cardiovascular events. Further studies are needed to assess the potential role of miR-126-3p in evaluating endothelial dysfunction.
EUROPEAN JOURNAL OF INTERNAL MEDICINE
(2023)
Article
Pharmacology & Pharmacy
Stephanie He, Davindra Singh, Hossein Yusefi, Brandon Helfield
Summary: This study investigates the feasibility of delivering the angiogenesis-promoting miR-126 using ultrasound-stimulated microbubbles. The results show that by stimulating miR-126-decorated microbubbles, the intracellular levels of miR-126 can be increased while decreasing the expression of its target genes. This delivery method has the potential to stimulate therapeutic angiogenesis while minimizing endothelial damage.
Article
Multidisciplinary Sciences
Xing-Hui Li, Wen-Long Xue, Ming-Jie Wang, Yu Zhou, Cai-Cai Zhang, Chen Sun, Lei Zhu, Kun Liang, Ying Chen, Bei-Bei Tao, Bo Tan, Bo Yu, Yi-Chun Zhu
SCIENTIFIC REPORTS
(2017)
Article
Pharmacology & Pharmacy
Beibei Tao, Rui Wang, Chen Sun, Yichun Zhu
FRONTIERS IN PHARMACOLOGY
(2017)
Article
Cell Biology
Ya-dan Bai, Yu-rong Yang, Xue-pan Mu, Ge Lin, You-ping Wang, Sheng Jin, Ying Chen, Ming-jie Wang, Yi-chun Zhu
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
(2018)
Article
Cardiac & Cardiovascular Systems
Rui Song, Yurong Yang, Han Lei, Guangxue Wang, Yong Huang, Wenlong Xue, Yinfang Wang, Lingling Yao, Yichun Zhu
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
(2018)
Article
Cell Biology
Wen-long Xue, Rui-qin Chen, Qing-qing Zhang, Xing-hui Li, Lei Cao, Meng-yao Li, Ye Li, Ge Lin, Ying Chen, Ming-jie Wang, Yi-chun Zhu
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
(2020)
Article
Pharmacology & Pharmacy
Ke Ning, Ming-Jie Wang, Ge Lin, Yi-Lin Zhang, Meng-Yao Li, Bao-Feng Yang, Ying Chen, Yong Huang, Zhi-Ming Li, Yi-Jun Huang, Lei Zhu, Kun Liang, Bo Yu, Yi-Zhun Zhu, Yi-Chun Zhu
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS
(2020)
Article
Cell Biology
Yong Huang, Ke Ning, Wen-Wen Li, Ge Lin, Cui-Lan Hou, Ming-Jie Wang, Yi-Chun Zhu
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
(2020)
Article
Cardiac & Cardiovascular Systems
Ye Li, Kui-Fang Xie, Ya-Hong Chang, Cheng Wang, Ying Chen, Ming-Jie Wang, Yi-Chun Zhu
Summary: SPRC shows beneficial effects on diabetic cardiomyopathy in db/db diabetic mice by improving myocardial hypertrophy, fibrosis, cardiac dysfunction, glucose tolerance, and activating insulin receptor signaling pathway.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Yu Zhou, Xing-Hui Li, Wen-Long Xue, Sheng Jin, Meng-Yao Li, Cai-Cai Zhang, Bo Yu, Lei Zhu, Kun Liang, Ying Chen, Bei-Bei Tao, Yi-Zhun Zhu, Ming-Jie Wang, Yi-Chun Zhu
Summary: This study aimed to investigate the feedback mechanisms that control the biosynthesis of miRNAs essential for miRNA feedback networks in cells. By regulating miR-192 biosynthesis, H2S promotes angiogenesis in vitro and in mice.
ANTIOXIDANTS & REDOX SIGNALING
(2022)
Article
Clinical Neurology
Limin Yin, Jianhui Zhou, Tianyou Li, Xinghua Wang, Wenlong Xue, Jie Zhang, Lingxi Lin, Ning Wang, Xinyi Kang, Yu Zhou, Hong Liu, Yang Li
Summary: A novel regulator, the DAT-CDK9-TFEB signaling axis, has been identified to play a crucial role in lysosome biogenesis. The study sheds light on the mechanisms of protein quality control under pathophysiological conditions.
ALZHEIMERS & DEMENTIA
(2023)
Article
Biochemistry & Molecular Biology
Tianyou Li, Limin Yin, Xinyi Kang, Wenlong Xue, Ning Wang, Jie Zhang, Ping Yuan, Lingxi Lin, Yang Li
Summary: This study reveals the essential roles of TFEB acetylation in TFEB nuclear translocation and lysosome biogenesis. The pan-inhibitor of HDACs, TSA, promotes TFEB nuclear translocation and enhances the expression of lysosomal and autophagic genes. These findings suggest that TFEB acetylation is a novel mechanism of TFEB activation and can alleviate the pathogenesis of Alzheimer's disease.
JOURNAL OF BIOLOGICAL CHEMISTRY
(2022)