Article
Neurosciences
Yuting Yang, Huijie Li, Chaonan Yang, Xiaodong Kong, Xiaohui Wu, Min Gong, Ying Li
Summary: This study revealed that the pathological mechanism of cell death in cerebral ischemia-reperfusion injury is complicated. RIPK1 plays an important role in necroptosis, apoptosis, and autophagy. The dominance of necroptosis in neuronal death is observed within 24 hours after ischemia/reperfusion injury, while apoptosis becomes the predominant feature after 24 hours of reperfusion. Additionally, this study found that TBK1 acts as a suppressor in regulating the kinase activity of RIPK1, providing a potential approach for mediating the kinase activity of RIPK1 in clinical settings.
Article
Critical Care Medicine
Man Guo, Jiarui Xu, Shuan Zhao, Daoqi Shen, Wuhua Jiang, Lin Zhang, Xiaoqiang Ding, Xialian Xu
Summary: This study investigated the role of SDC-1 shedding in ischemia/reperfusion-induced acute kidney injury (AKI) and found that inhibiting SDC-1 shedding can protect against renal injury by restoring cell polarity and reducing apoptosis in tubular epithelial cells.
Article
Orthopedics
Chen Yu, Xiaoxu Wang, Jian Qin
Summary: Necrostatin-1 (Nec-1) can reduce peripheral nerve lesions and protect Schwann cells and axons by inhibiting necroptosis. It also reduces inflammation and oxidative stress by inhibiting RIP1.
JOURNAL OF ORTHOPAEDIC SURGERY AND RESEARCH
(2023)
Review
Biotechnology & Applied Microbiology
Ying Fu, Wenjun Dang, Xiaocong He, Feng Xu, Haishui Huang
Summary: This paper systematically recaps the molecular cascades of cellular injuries induced by cryopreservation, providing a molecular basis to reduce cryoinjuries in future biopreservation methods.
BIOENGINEERING-BASEL
(2022)
Article
Biochemistry & Molecular Biology
Theodoros Eleftheriadis, Georgios Pissas, Spyridon Golfinopoulos, Maria Efthymiadi, Vassilios Liakopoulos, Ioannis Stefanidis
Summary: Inhibition of malate dehydrogenase-2 (MDH-2) protects renal cells from death or senescence caused by ischemia-reperfusion injury. MDH-2 inhibition reduces oxidative stress and inflammation, and maintains cell proliferation capacity.
Review
Medicine, General & Internal
Chao Li, Wei Wang, Shuai-shuai Xie, Wen-xian Ma, Qian-wen Fan, Ying Chen, Yuan He, Jia-nan Wang, Qin Yang, Hai-di Li, Juan Jin, Ming-ming Liu, Xiao-ming Meng, Jia-gen Wen
Summary: Sepsis-induced acute kidney injury (AKI) is a severe complication that involves multiple types of cells such as macrophages, ECs, and TECs, with programmed cell death playing a significant role. Mitochondrial dysfunction and oxidative stress are traditionally considered as the main triggers, while recent research highlights the involvement of autophagy, mitochondria quality control, and epigenetic modification in the process of programmed cell death.
FRONTIERS IN MEDICINE
(2021)
Article
Multidisciplinary Sciences
Man Guo, Daoqi Shen, Yiqi Su, Jiarui Xu, Shuan Zhao, Weidong Zhang, Yaqiong Wang, Wuhua Jiang, Jialin Wang, Xuemei Geng, Xiaoqiang Ding, Xialian Xu
Summary: Adherens junctions between tubular epithelial cells are disrupted in renal ischemia/reperfusion injury, and shedding of SDC-1 may play a key role in this process. Inhibiting SDC-1 shedding can alleviate the destruction of cell adherens junctions.
Article
Biochemistry & Molecular Biology
Lin Li, Lei Lin, Shaoqing Lei, Si Shi, Chun Chen, Zhongyuan Xia
Summary: The study found that maslinic acid (MA) can inhibit cell death caused by myocardial ischemia-reperfusion injury (MIRI) by promoting autophagic flux. MA can improve tissue damage caused by MIRI, reduce lactate dehydrogenase and creatine kinase-myocardial band levels in serum.
DNA AND CELL BIOLOGY
(2022)
Article
Urology & Nephrology
Keisuke Sako, Kengo Furuichi, Shohei Makiishi, Yuta Yamamura, Toshiya Okumura, Hong Thu Le, Shinji Kitajima, Tadashi Toyama, Akinori Hara, Yasunori Iwata, Norihiko Sakai, Miho Shimizu, Fumio Niimura, Taiji Matsusaka, Shuichi Kaneko, Takashi Wada
Summary: Paired box 2 (Pax2) is an essential transcription factor for kidney development and is reactivated during recovery from kidney injury. This study reveals that Pax2 reactivation plays a role in the regulation of cell proliferation in proximal tubular epithelial cells (PTECs). Knockout of Pax2 leads to increased interstitial fibrosis, decreased cell proliferation, and increased apoptotic cells.
KIDNEY INTERNATIONAL
(2022)
Article
Medicine, Research & Experimental
Tzu-Lin Lee, Tsai-Chun Lai, Shu-Rung Lin, Shu-Wha Lin, Yu-Chen Chen, Chi-Ming Pu, I-Ta Lee, Jaw-Shiun Tsai, Chiang-Wen Lee, Yuh-Lien Chen
Summary: The study demonstrates that ADSC-CM significantly reduces injury and fibrosis in I/R-treated hearts and H/R-treated cardiomyocytes, while decreasing expression of related proteins and promoting cell survival through the miR-221/222/p38/NF-kappa B pathway.
Article
Cell Biology
Shigang Qiao, Lei Hong, Yongming Zhu, Jun Zha, An Wang, Jia Qiu, Wei Li, Chen Wang, Jianzhong An, Huiling Zhang
Summary: Receptor-interacting protein kinase 1 and 3 play important roles in myocardial fibrosis and diabetic cardiomyopathy by activating the RIPK1/RIPK3 pathway and impairing the autophagic process.
CELL DEATH & DISEASE
(2022)
Article
Cardiac & Cardiovascular Systems
Liang Wang, Xuebai Lv, Jue Tian, Xiaoliang Wang, Ye Wu, Hui Rong Liu
Summary: The study found that Nec-1 may reduce myocardial cell death and maintain myocardial architectural integrity, thus inhibiting the reactive fibrosis process in rats during myocardial ischemia/late reperfusion. Administration of Nec-1 at the onset of reperfusion significantly reduced the release of creatine kinase and downregulated autophagy within 24 hours after reperfusion, with a significantly positive correlation between them.
CARDIOVASCULAR THERAPEUTICS
(2021)
Article
Chemistry, Medicinal
Kunyu Shi, Jifa Zhang, Enda Zhou, Jiaxing Wang, Yuxi Wang
Summary: This article summarizes the recent research progress in RIP1 small-molecule inhibitor development based on different binding modalities, and discusses prospective strategies for designing additional RIP1 therapeutic agents.
JOURNAL OF MEDICINAL CHEMISTRY
(2022)
Article
Immunology
Qiao Xu, Junjie Guo, Xiangen Li, Yang Wang, Dan Wang, Kan Xiao, Huiling Zhu, Xiuying Wang, Chien-An Andy Hu, Guolong Zhang, Yulan Liu
Summary: Necroptosis, a newly recognized form of programmed cell death with features of both necrosis and apoptosis, was found to occur in the liver during sepsis, contributing to septic hepatic injury. Inhibition of necroptosis led to reduced hepatic inflammation and damage in a piglet model of LPS-induced sepsis.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Cell Biology
HuiYa Li, DanQing Hu, Guilin Chen, DeDong Zheng, ShuMei Li, YunLing Lin, HuaShan Hong, Yukun Luo, YiLang Ke, Yu Huang, LingZhen Wu, TingXiang Lan, WenYing Wang, Jun Fang
Summary: The dual treatment with Adropin can enhance the therapeutic potential of MSCs to repair myocardium through a paracrine mechanism via pro-survival pathways.
CELL DEATH & DISEASE
(2021)
Article
Cardiac & Cardiovascular Systems
Fuxiang Liang, Bing Song, Ruisheng Liu, Liu Yang, Hanbo Tang, Yuanming Li
INTERACTIVE CARDIOVASCULAR AND THORACIC SURGERY
(2016)
Review
Rheumatology
Xingming Zhang, Fuxiang Liang, Xiaoxue Yin, Juan Xiao, Peiyu Shi, Dang Wei, Liang Yao, Qi Wang, Yaolong Chen
CLINICAL RHEUMATOLOGY
(2014)
Article
Health Care Sciences & Services
Lun Li, Jinhui Tian, Hongliang Tian, David Moher, Fuxiang Liang, Tongxiao Jiang, Liang Yao, Kehu Yang
JOURNAL OF CLINICAL EPIDEMIOLOGY
(2014)
Letter
Cardiac & Cardiovascular Systems
Fuxiang Liang, Bing Song, Qi Wang, Xiaoqin Wang, Liang Yao
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2020)
Review
Medicine, General & Internal
F. Liang, S. Liu, G. Liu, H. Liu, Q. Wang, B. Song, L. Yao
Summary: Remote ischaemic preconditioning (RIPC) has no clear benefits or harms in people undergoing major vascular surgery.
COCHRANE DATABASE OF SYSTEMATIC REVIEWS
(2023)
Letter
Medicine, General & Internal
Fuxiang Liang, Xiaoqin Wang, Qi Wang, Peijing Yan, Liang Yao