Deciphering assumptions about stepped wedge designs: the case of Ebola vaccine research

Ethical Rationale for the Ebola “Ring Vaccination” Trial Design

(2016) Annette Rid et al.   AMERICAN JOURNAL OF PUBLIC HEALTH

Sample size calculations for stepped wedge and cluster randomised trials: a unified approach

(2016) Karla Hemming et al.   JOURNAL OF CLINICAL EPIDEMIOLOGY

The need to balance merits and limitations from different disciplines when considering the stepped wedge cluster randomized trial design

(2015) Esther de Hoop et al.   BMC Medical Research Methodology

Ebola vaccine trials back on track

(2015) Dara Mohammadi   LANCET

Morality in a time of Ebola

(2015) Arthur L Caplan   LANCET

Efficacy and effectiveness of an rVSV-vectored vaccine expressing Ebola surface glycoprotein: interim results from the Guinea ring vaccination cluster-randomised trial

(2015) Ana Maria Henao-Restrepo et al.   LANCET

Statistical power and validity of Ebola vaccine trials in Sierra Leone: a simulation study of trial design and analysis

(2015) Steven E Bellan et al.   LANCET INFECTIOUS DISEASES

Evaluating Ebola vaccine trials: insights from simulation

(2015) Juliet R C Pulliam et al.   LANCET INFECTIOUS DISEASES

Emergency Ebola response: a new approach to the rapid design and development of vaccines against emerging diseases

(2015) Claire M Tully et al.   LANCET INFECTIOUS DISEASES

Stepped-wedge trial design to evaluate Ebola treatments

(2015) Jolanta Piszczek et al.   LANCET INFECTIOUS DISEASES

Logistic, ethical, and political dimensions of stepped wedge trials: critical review and case studies

(2015) Audrey Prost et al.   Trials

Designing a stepped wedge trial: three main designs, carry-over effects and randomisation approaches

(2015) Andrew J. Copas et al.   Trials

Analysis and reporting of stepped wedge randomised controlled trials: synthesis and critical appraisal of published studies, 2010 to 2014

(2015) Calum Davey et al.   Trials

Sample size calculation for a stepped wedge trial

(2015) Gianluca Baio et al.   Trials

Stepped wedge randomised controlled trials: systematic review of studies published between 2010 and 2014

(2015) Emma Beard et al.   Trials

The stepped wedge cluster randomised trial: rationale, design, analysis, and reporting

(2015) K. Hemming et al.   BMJ-British Medical Journal

Uptake and Population-Level Impact of Expedited Partner Therapy (EPT) on Chlamydia trachomatis and Neisseria gonorrhoeae: The Washington State Community-Level Randomized Trial of EPT

(2015) Matthew R. Golden et al.   PLOS MEDICINE

The stepped wedge cluster randomised trial: rationale, design, analysis, and reporting

(2015) K. Hemming et al.   BMJ-British Medical Journal

Efficacy and effectiveness of infant vaccination against chronic hepatitis B in the Gambia Hepatitis Intervention Study (1986–90) and in the nationwide immunisation program

(2014) Thomas J Peto et al.   BMC INFECTIOUS DISEASES

Evaluating Novel Therapies During the Ebola Epidemic

(2014) Steven Joffe   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Ethical considerations of experimental interventions in the Ebola outbreak

(2014) Annette Rid et al.   LANCET

Randomised controlled trials for Ebola: practical and ethical issues

(2014) Clement Adebamowo et al.   LANCET

Evaluating Ebola Therapies — The Case for RCTs

(2014) Edward Cox et al.   NEW ENGLAND JOURNAL OF MEDICINE

Ebola Vaccine — An Urgent International Priority

(2014) Rupa Kanapathipillai et al.   NEW ENGLAND JOURNAL OF MEDICINE

Finite-sample corrected generalized estimating equation of population average treatment effects in stepped wedge cluster randomized trials

(2014) JoAnna M Scott et al.   STATISTICAL METHODS IN MEDICAL RESEARCH

Stepped-wedge cluster randomised controlled trials: a generic framework including parallel and multiple-level designs

(2014) Karla Hemming et al.   STATISTICS IN MEDICINE

Ebola virus vaccine trials: the ethical mandate for a therapeutic safety net

(2014) S. E. Bellan et al.   BMJ-British Medical Journal

Response to Open Peer Commentaries on “Ethics of Clinical Science in a Public Health Emergency: Drug Discovery at the Bedside”

(2013) Sarah J. L. Edwards   AMERICAN JOURNAL OF BIOETHICS

Ethics of Clinical Science in a Public Health Emergency: Drug Discovery at the Bedside

(2013) Sarah J. L. Edwards   AMERICAN JOURNAL OF BIOETHICS

Issues in the Use of Stepped Wedge Cluster and Alternative Designs in the Case of Pandemics

(2013) Ingeborg van der Tweel et al.   AMERICAN JOURNAL OF BIOETHICS

Stepped wedge designs could reduce the required sample size in cluster randomized trials

(2013) Willem Woertman et al.   JOURNAL OF CLINICAL EPIDEMIOLOGY

The Ottawa Statement on the ethical design and conduct of cluster randomised trials: precis for researchers and research ethics committees

(2013) M. Taljaard et al.   BMJ-British Medical Journal

Extended Follow-up Confirms Early Vaccine-Enhanced Risk of HIV Acquisition and Demonstrates Waning Effect Over Time Among Participants in a Randomized Trial of Recombinant Adenovirus HIV Vaccine (Step Study)

(2012) A. Duerr et al.   JOURNAL OF INFECTIOUS DISEASES

The Ottawa Statement on the Ethical Design and Conduct of Cluster Randomized Trials

(2012) Charles Weijer et al.   PLOS MEDICINE

Systematic review of stepped wedge cluster randomized trials shows that design is particularly used to evaluate interventions during routine implementation

(2011) Noreen D. Mdege et al.   JOURNAL OF CLINICAL EPIDEMIOLOGY

Design of a phase III multicenter trial to evaluate the efficacy of the RTS,S/AS01 malaria vaccine in children across diverse transmission settings in Africa

(2011) Amanda Leach et al.   MALARIA JOURNAL

The analysis of cross-over trials with baseline measurements

(2010) Chris Metcalfe   STATISTICS IN MEDICINE

Efficacy assessment of a cell-mediated immunity HIV-1 vaccine (the Step Study): a double-blind, randomised, placebo-controlled, test-of-concept trial

(2008) Susan P Buchbinder et al.   LANCET