期刊
SCIENCE ADVANCES
卷 8, 期 37, 页码 -出版社
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/sciadv.abq0897
关键词
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资金
- Ministry of Science and ICT (MSIT)
- Ministry of Trade, Industry and Energy (MOTIE) of Korea [2021M3D1A204991411]
- Bio & Medical Technology Development Program [2018M3A9F1021649]
- Korea Initiative for fostering University of Research and Innovation (KIURI) Program [2020M3H1A1077207]
- Technology Innovation Program [20010366, 20013621]
- Samsung Research Funding and Incubation Center of Samsung Electronics [SRFC-TC2003-03]
- Institute for Basic Science [IBS-R026-D1]
- Wearable Platform Materials Technology Center ERC Program [2022R1A5A6000846]
- National Research Foundation of Korea [2020M3H1A1077207] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
This study presents an unconventional single-device platform that allows for in situ diagnosis and therapeutic electrical stimulation of the heart to prevent cardiac arrhythmia. The platform can monitor cardiac activities even in wet conditions and control heart motions without interfering with recording signals.
The in situ diagnosis of cardiac activities with simultaneous therapeutic electrical stimulation of the heart is key to preventing cardiac arrhythmia. Here, we present an unconventional single-device platform that enables in situ monitoring even in a wet condition and control of beating heart motions without interferences to the recording signal. This platform consists of the active- matrix array of pressure-sensitive transistors for detecting cardiac beatings, biocompatible, low-impedance electrodes for cardiac stimulations, and an alginate-based hydrogel adhesive for attaching this platform conformally to the epicardium. In contrast to conventional electrophysiological sensing using electrodes, the pressure-sensitive transistors measured mechanophysiological characteristics by monitoring the spatiotemporal distributions of cardiac pressures during heart beating motions. In vivo tests show mechanophysiological readings having good correlation with electrocardiography and negligible interference with the electrical artifacts caused during cardiac stimulations. This platform can therapeutically synchronize the rhythm of abnormal heartbeats through efficient pacing of cardiac arrhythmia.
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