Article
Chemistry, Multidisciplinary
Yangzhi Zhu, Rohollah Nasiri, Elham Davoodi, Shiming Zhang, Sourav Saha, Matthew Linn, Lu Jiang, Reihaneh Haghniaz, Martin C. Hartel, Vadim Jucaud, Mehmet R. Dokmeci, Anna Herland, Ehsan Toyserkani, Ali Khademhosseini
Summary: The study investigates the use of contact lenses with microchannels to enhance tear flow from the pre-lens tear film to the post-lens ocular surface. The results demonstrate that the tear transport can be enhanced by an artificial eyelid motion in a pressure range similar to human eyelid pressure. This research shows the feasibility of developing microfluidic contact lenses to prevent or minimize contact lens-induced dry eye and discomfort.
Article
Chemistry, Multidisciplinary
Ying Ye, Yuancai Ge, Qingwen Zhang, Meiling Yuan, Yu Cai, Kang Li, Yang Li, Ruifeng Xie, Changshun Xu, Danfeng Jiang, Jia Qu, Xiaohu Liu, Yi Wang
Summary: Contact lens sensors have become a popular wearable device for monitoring health. However, they often require complex electronics and can only detect one analyte. A new optical-based dual-functional smart contact lens sensor has been introduced to monitor intraocular pressure (IOP) and detect matrix metalloproteinase-9 (MMP-9). This provides a convenient and noninvasive sensing platform for monitoring health and diagnostic biomarkers in human tears.
Article
Engineering, Electrical & Electronic
Loic Massin, Fabrice Seguin, Vincent Nourrit, Emmanuel Daniel, Jean-Louis de Bougrenet de la Tocnaye, Cyril Lahuec
Summary: This paper introduces a new approach for gaze tracking using a smart contact lens without a camera, which calculates the gaze direction by computing the barycenter from photocurrents. Experimental results show that the proposed system is 2.5 times more accurate than current camera-based eye-trackers.
IEEE SENSORS JOURNAL
(2021)
Article
Engineering, Electrical & Electronic
Ching Hymn Christopher Lee, I. K. Karunaratne, Yifan Wei, Zidong Chen, Iok Tong Chong, Yangfan Yang, Minbin Yu, D. C. C. Lam
Summary: The study demonstrated that continuous intraocular pressure profiles from chipless contact lens sensor can reduce noise, but may still be affected by noise from tears and eyelids in in vivo experiments. The newly designed dual-compliance, dual-element CLS effectively reduces the sensing noise of intraocular pressure.
SENSORS AND ACTUATORS A-PHYSICAL
(2021)
Article
Chemistry, Multidisciplinary
Yousef Alqurashi, Mohamed Elsherif, Rosalia Moreddu, Magdalena Cieslak, Hemeth Dhaliwal, Khamis Essa, Haider Butt
Summary: Glaucoma is a leading cause of irreversible blindness, and intraocular pressure (IOP) is the most important biomarker for its diagnosis and monitoring. Current IOP monitoring techniques are invasive and inconvenient, while laser-processed contact lenses offer a potential solution for continuous and non-invasive monitoring of IOP variations.
APPLIED SCIENCES-BASEL
(2022)
Article
Chemistry, Multidisciplinary
Zongkang Li, Jeonghun Yun, Xiaoya Li, Moobum Kim, Jia Li, Donghoon Lee, Angyin Wu, Seok Woo Lee
Summary: Recent advancements in wearable devices have made noninvasive healthcare monitoring possible. This study introduces a power-free smart contact lens that can detect glucose levels through color changes of multiple electrochromic electrodes, eliminating the need for external wireless systems. The device demonstrates high accuracy and reproducibility, making it a potential tool for daily health monitoring without additional power supply or devices.
ADVANCED FUNCTIONAL MATERIALS
(2023)
Article
Engineering, Electrical & Electronic
Miao Yuan, Zhiduo Liu, Xiaoting Wu, Haoyang Gou, Yugui Zhang, Xin Ning, Weijun Li, Zhaohui Yao, Yijun Wang, Weihua Pei, Hongda Chen
Summary: Intraocular pressure (IOP) is a key indicator for glaucoma, and real-time monitoring with microfluidic contact lens sensors offers flexibility, straightforward reading, and low cost. A high-sensitivity microfluidic contact lens sensor based on bilateral wall structure and dyed fish oil as the liquid indicator is developed, showing a sensitivity of 660 mu m/mmHg and a linear regression coefficient of 0.999 in the operating range of 10-30 mmHg. The sensor demonstrates stable response to IOP changes and synchronization with pressure in multiple cycles at a pressure change rate of 3 mmHg/s. With its high sensitivity, linearity, and flexibility, the sensor holds great potential for clinical application of IOP monitoring.
SENSORS AND ACTUATORS A-PHYSICAL
(2023)
Article
Chemistry, Applied
Dandan Liu, Yipeng Zang, Ziwei Hu, Chenrui Yu, Zhenxing Han, Mengmeng Wang, Maodong Xu, Xiaofeng Zhao, Wenjin Yue, Guangjun Nie
Summary: KH-570@HEMA hydrogel was synthesized to balance vision correction and drug sustained release in drug-loaded soft contact lens. The hydrogel composition was optimized using conditional maximum method, achieving high transmittance, oxygen permeability and wettability. Molecular imprinting technique improved the loading capacity and release time, potentially solving the issue of drug-loaded SCLs.
REACTIVE & FUNCTIONAL POLYMERS
(2023)
Article
Materials Science, Multidisciplinary
Xiaoxia Lin, Haitao Zhang, Yuqing Qin, Xiaohong Hu
Summary: The study introduced AZO into hydrogel to provide a control unit and solve the issues of uncontrollable recovery and light fatigue. Two kinds of crosslinkable AZO molecules were synthesized, resulting in AZO copolymerized hydrogel and AZO crosslinked hydrogel for potential use in contact lenses. Drug release behavior was evaluated, showing that AZO addition and hydrogel type would affect drug release.
FRONTIERS IN MATERIALS
(2021)
Article
Nanoscience & Nanotechnology
Yanyan Fan, Hailing Tu, Hongbin Zhao, Feng Wei, Yi Yang, Tianling Ren
Summary: This paper presents a piezo-resistive principle pressure sensor for continuous and non-invasive monitoring of intraocular pressure (IOP) in glaucoma treatment. The sensor, designed based on the Wheatstone bridge circuit and fabricated using hybrid nanomaterials of graphene and carbon nanotubes, demonstrated high sensitivity and stability in tests on a PDMS eyeball model.
Article
Optics
Parviz Zolfaghari, Arda D. Yalcinkaya, Onur Ferhanoglu
Summary: We have developed a non-contact and non-invasive gadget in the form of wearable glasses for monitoring intraocular pressure. The gadget includes a laser source, miniaturized lenses and mirrors, a mask for structured illumination of the cornea, and a miniaturized camera. The pressure level is determined by observing the radius of curvature of the grid pattern on the cornea. Experimental results show a pressure measurement resolution of 2.4 mmHg within a range of 0-55 mmHg. This device has the potential to be used for personalized real-time intraocular pressure monitoring during the daytime.
OPTICS COMMUNICATIONS
(2023)
Article
Chemistry, Multidisciplinary
Hayoung Song, Haein Shin, Hunkyu Seo, Wonjung Park, Byung Jun Joo, Jeongho Kim, Jeonghyun Kim, Hong Kyun Kim, Jayoung Kim, Jang-Ung Park
Summary: Researchers have developed a wireless and soft smart contact lens that can quantitatively record cholesterol levels in tear fluids in real-time for monitoring patients with hyperlipidemia. This lens incorporates an electrochemical biosensor, stretchable antenna, and integrated circuits for wireless communication, allowing it to be operated remotely using a smartphone without obstructing the wearer's vision. Animal models and human tests have demonstrated the feasibility of this smart contact lens for diagnosing cholesterol-related diseases, as well as its good biocompatibility, wearability, and reliability as a non-invasive healthcare device.
Article
Chemistry, Analytical
Mengyu Deng, Guangjie Song, Ke Zhong, Zhanchen Wang, Xi Xia, Yanqing Tian
Summary: This study developed smart and transparent contact lenses for real-time, continuous, non-invasive monitoring of glucose levels in tears, which is essential for diabetic patients' health. The smart contact lenses detect glucose using a fluorescent probe and reference dye, with the fluorescence images collected by a smartphone and transformed into RGB signals for glucose quantification. Animal experiments confirmed the biosafety of the lenses and the potential for painless glucose monitoring.
SENSORS AND ACTUATORS B-CHEMICAL
(2022)
Article
Engineering, Biomedical
Hye Hyeon Han, Su-Kyung Kim, Seong-Jong Kim, Inhoo Choi, Jee Won Mok, Choun-Ki Joo, Sangbaie Shin, Sei Kwang Hahn
Summary: Hyaluronate-modified Au@Pt bimetallic electrodes were developed for long-term glucose monitoring with smart contact lens. The electrodes exhibited high accuracy and stability, showing promising CGM performance in animal experiments.
Article
Biotechnology & Applied Microbiology
Lianghui Zhao, Hongwei Wang, Chengcheng Feng, Fangying Song, Xianli Du
Summary: The study successfully prepared starch hydrogel/contact lens composites loaded with EGCG, which effectively reduced bacterial adhesion, exhibited good biocompatibility and degradability. These composites can sustainably release EGCG for at least 14 days, providing a potential intervention strategy for preventing ocular microbial infections.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2021)
Article
Multidisciplinary Sciences
Yifeng Xiong, Yushu Wang, Runze Zhu, Haotian Xu, Chenhui Wu, Jinhui Chen, Yang Ma, Yuan Liu, Ye Chen, Kenji Watanabe, Takashi Taniguchi, Mengzhu Shi, Xianhui Chen, Yanqing Lu, Peng Zhan, Yufeng Hao, Fei Xu
Summary: In this paper, a fiber-integrated polarimeter based on six-layer van der Waals materials is designed and fabricated for real-time, in-line analysis of light polarization in optical networks. The device structure is ultracompact and free from external optical and mechanical modules, which may inspire the development of miniaturized optical and optoelectronic systems.
Article
Optics
Yu Lei, Zi-xuan Ding, Jun-xian Luo, Ying-qing Ma, Ye Chen, Zhuo Chen, Fei Xu
Summary: This study investigates a method for obtaining high-precision cross-sections of various fibers using a femtosecond laser, providing a reference for cutting optical fibers of different structures.
OPTICS COMMUNICATIONS
(2022)
Article
Optics
Junxian Luo, Kanghu Zhou, Yingqing Ma, Yu Lei, Hanwen Liu, Hongwei Tong, Richard Xiao, Yuwen Wang, Ye Chen, Zhuo Chen, Fei Xu
Summary: This article introduces an epoxy-free bonding method using femtosecond laser welding borosilicate glass and optical fibers. Experimental results demonstrate the low-loss and polarization-independent fiber-to-fiber coupling reliability of this method.
Article
Optics
Yu Lei, Yifeng Xiong, Fei Xu, Zhuo Hen
Summary: This study demonstrates the design potential of optical fiber devices by integrating metasurfaces on the side surface of microfibers. The controllable phase shift and focusing effects are achieved by adjusting the positions of the dielectric rings and the polarization of the guided waves.
Article
Engineering, Electrical & Electronic
Hanqi Zhang, Hengtian Zhu, Qi Wu, Ye Chen, Rong Wang, Fei Xu, Ke Xiong
Summary: In this study, a microfiber Bragg grating (MFBG) bonded using tapered cantilever was designed and investigated using experimental, theoretical, and numerical methods. The tapered structure amplified the ultrasonic signal and eliminated the influences of static strain and evanescent field using the cantilever. Compared to the cantilevered fiber Bragg grating, the sensitivity of the sensor showed an upward trend with decreasing diameter, with 331% and 108% sensitivity increments observed for MFBGs with 20 and 40 μm diameters, respectively. The improvement was particularly apparent at high frequencies of the ultrasonic signal.
JOURNAL OF LIGHTWAVE TECHNOLOGY
(2023)
Article
Engineering, Electrical & Electronic
Yifeng Xiong, Zixuan Ding, Fei Xu
Summary: The integration of silica optical fibers with optoelectronic materials and electrical structures enables the development of miniaturized and multifunctional all-fiber optoelectronic systems. The flat endface of an optical fiber tip provides a platform for optoelectronic integration through micro- and nano-fabrication techniques. The rapid development of fiber-compatible fabrication technologies and the wide range of applications for active fiber tips, including photodetection, modulation, lasing, sensing, and light-emitting, are discussed in this paper. Challenges and opportunities for future development in this field are also addressed.
JOURNAL OF LIGHTWAVE TECHNOLOGY
(2023)
Article
Optics
Run-ze Zhu, Hao-gong Feng, Yi-feng Xiong, Liu-wei Zhan, Fei Xu
Summary: We have demonstrated all-fiber reflective single-pixel imaging with a long working distance and large field of view. By using wavelength-dependent multimode fiber speckle to illuminate the object, the system is made compact and stable. With collimated MMF speckle patterns and an optical fiber receiving device, we achieved reflective optical fiber single-pixel imaging with a working distance of over 5 mm and a field of view of about 9 mm2. By employing compressed sensing, object images can be reconstructed with a sampling rate of about 4%. This work provides a method and reference for practical applications of optical fiber endoscopic imaging with requirements for a long working distance and large field of view.
OPTICS AND LASER TECHNOLOGY
(2023)
Article
Optics
Run-ze Zhu, Hao-gong Feng, Fei Xu
Summary: Multimode optical fiber (MMF) imaging is an emerging technology that allows for multispectral and polarimetric imaging. By controlling the wavelength and polarization, different channels can be constructed. With neural network training, image reconstruction and channel classification can be achieved with high accuracy and similarity.
OPTICS AND LASERS IN ENGINEERING
(2023)
Article
Optics
Mengmeng Chen, Runze Zhu, Junxian Luo, Ali Masoudi, Ye Chen, Gilberto Brambilla, Fei Xu
Summary: Distributed vibration sensors (DVSs) are widely used in industrial production. This study demonstrates that the strain dynamic range of DVSs can be improved by analyzing the harmonic numbers in the vibration response spectrum, enabling quantitative measurement of vibration amplitude with a strain resolution of 0.78 mu epsilon for each additional harmonic.
OPTICS AND LASER TECHNOLOGY
(2023)
Article
Engineering, Electrical & Electronic
Junxian Luo, Hanwen Liu, Huan Xing, Runze Zhu, Zhuo Chen, Fei Xu
Summary: In recent years, dexterous robotic hands have become indispensable in intelligent equipment. The use of bionic neurons that provide finger motion perception improves joint control accuracy. By utilizing series- and parallel-integrated inner cladding fiber Bragg gratings (ICFBG) as bionic neurons, the proposed fiber-optic neurons (FON) can achieve multi-joint bending perception in a robotic finger. The FONs are insensitive to temperature and axial strain and can potentially be utilized in robotic gesture recognition and control systems.
JOURNAL OF LIGHTWAVE TECHNOLOGY
(2023)
Editorial Material
Engineering, Electrical & Electronic
Gaozhi (George) Xiao, Tuan Guo, Fei Xu, Francesco Chiavaioli
JOURNAL OF LIGHTWAVE TECHNOLOGY
(2023)
Article
Optics
Zixuan Ding, Guorui Wang, Yifeng Xiong, Ye Chen, Fei Xu
Summary: An all-fiber dual-comb laser with a high repetition rate and repetition rate difference was demonstrated in this study. The laser generates asynchronous combs based on the high birefringence of the fiber and achieves a larger repetition rate difference compared to previous work. This laser exhibits good stability and coherence, which has the potential to enhance the acquisition rate and accuracy of dual-comb measurement systems.
Article
Nanoscience & Nanotechnology
Runze Zhu, Junxian Luo, Xinxin Zhou, Haogong Feng, Fei Xu
Summary: Multimode fiber (MMF) imaging is a new field of fiber imaging technology that has emerged in the last few decades. However, its sensitivity to dynamic perturbance limits its practical applications. In this study, an anti-perturbation scheme for MMF imaging based on active measurement of the fiber configuration is proposed. Experimental results show that the introduction of fiber configuration parameters can improve the quality of anti-perturbation imaging. Additionally, speckle prediction using the configuration parameters and a trained neural network is realized.
Article
Optics
Shu Xin, Lu Yingshen, Zhang Zifa, Kang Jiaxing, Yuan Xiang, Hong Feng, Xu Run, Ma Zhongquan, Xu Fei
Summary: In this study, high-quality CsPbIBr2 thick films were successfully prepared by pneumatic spraying via an interfacial seed layer modification strategy under an atmospheric environment with RH below 90%. The introduction of interfacial seed layers improved the crystallinity, interfacial contact, and structural stability of the CsPbIBr2 thick films. The photodiode-type CsPbIBr2 photodetectors showed low dark current, high performance photodetection parameters, and resistance to water and oxygen.
ACTA OPTICA SINICA
(2023)
Proceedings Paper
Engineering, Electrical & Electronic
Ling Hao, Zhenlan Dou, Fei Xu, Lei Chen, Qun Chen, Yong Min, Chunyan Zhang
Summary: The increasing proportion of renewable energy poses challenges to power grid in ensuring power supply. A large-scale ice-storage-based district cooling system and run-of-river hydropower can effectively reduce electricity load during peak periods. This paper establishes an integrated electricity and heat dispatch model considering ice storage systems and run-of-river hydropower, and analyzes the power supply ensuring effects of the combined systems under different operation strategies. Furthermore, multi-agent economic analyses are conducted to evaluate investments in ice storage equipment by cooling users, power grid, or third-party.
2023 5TH ASIA ENERGY AND ELECTRICAL ENGINEERING SYMPOSIUM, AEEES
(2023)
