Maturation of circulating Ly6ChiCCR2+ monocytes by mannan-MOG induces antigen-specific tolerance and reverses autoimmune encephalomyelitis

An adjuvant strategy enabled by modulation of the physical properties of microbial ligands expands antigen immunogenicity

(2022) Francesco Borriello et al.   CELL

IFNγ and GM-CSF control complementary differentiation programs in the monocyte-to-phagocyte transition during neuroinflammation

(2022) Ana Amorim et al.   NATURE IMMUNOLOGY

The pathology of central nervous system inflammatory demyelinating disease accompanying myelin oligodendrocyte glycoprotein autoantibody

(2020) Romana Höftberger et al.   ACTA NEUROPATHOLOGICA

Cxcl10+ monocytes define a pathogenic subset in the central nervous system during autoimmune neuroinflammation

(2020) Amir Giladi et al.   NATURE IMMUNOLOGY

The Role of Basement Membrane Laminins in Vascular Function

(2020) Rupert Hallmann et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Interferon-γ/Interleukin-27 Axis Induces Programmed Death Ligand 1 Expression in Monocyte-Derived Dendritic Cells and Restores Immune Tolerance in Central Nervous System Autoimmunity

(2020) Giacomo Casella et al.   Frontiers in Immunology

Mannan-MOG35-55 Reverses Experimental Autoimmune Encephalomyelitis, Inducing a Peripheral Type 2 Myeloid Response, Reducing CNS Inflammation, and Preserving Axons in Spinal Cord Lesions

(2020) Anastasia Dagkonaki et al.   Frontiers in Immunology

Frontline Science: Induction of experimental autoimmune encephalomyelitis mobilizes Th17-promoting myeloid derived suppressor cells to the lung

(2019) Justin D. Glenn et al.   JOURNAL OF LEUKOCYTE BIOLOGY

PD-L1 expression on nonclassical monocytes reveals their origin and immunoregulatory function

(2019) Mariaelvy Bianchini et al.   Science Immunology

Diversity, Mechanisms, and Significance of Macrophage Plasticity

(2019) Massimo Locati et al.   Annual Review of Pathology-Mechanisms of Disease

Myeloid cell plasticity in the evolution of central nervous system autoimmunity

(2018) David A. Giles et al.   ANNALS OF NEUROLOGY

High-Dimensional Single-Cell Mapping of Central Nervous System Immune Cells Reveals Distinct Myeloid Subsets in Health, Aging, and Disease

(2018) Dunja Mrdjen et al.   IMMUNITY

Phenotypic and functional alterations of myeloid-derived suppressor cells during the disease course of multiple sclerosis

(2018) Ellen Iacobaeus et al.   IMMUNOLOGY AND CELL BIOLOGY

Dendritic Cell PD-L1 Limits Autoimmunity and Follicular T Cell Differentiation and Function

(2018) Peter T. Sage et al.   JOURNAL OF IMMUNOLOGY

Gemcitabine directly inhibits effector CD4 T cell activation and prevents experimental autoimmune encephalomyelitis

(2018) Justin D. Glenn et al.   JOURNAL OF NEUROIMMUNOLOGY

Mononuclear phagocytes locally specify and adapt their phenotype in a multiple sclerosis model

(2018) Giuseppe Locatelli et al.   NATURE NEUROSCIENCE

Myeloid-derived suppressor cells control B cell accumulation in the central nervous system during autoimmunity

(2018) Benjamin Knier et al.   NATURE IMMUNOLOGY

An antigen-encapsulating nanoparticle platform for TH1/17 immune tolerance therapy

(2017) Derrick P. McCarthy et al.   Nanomedicine-Nanotechnology Biology and Medicine

The search for the target antigens of multiple sclerosis, part 1: autoreactive CD4+ T lymphocytes as pathogenic effectors and therapeutic targets

(2016) Reinhard Hohlfeld et al.   LANCET NEUROLOGY

Conjugation of a peptide to mannan and its confirmation by tricine sodium dodecyl sulfate–polyacrylamide gel electrophoresis

(2015) Anthi Tapeinou et al.   ANALYTICAL BIOCHEMISTRY

Use of the 2-chlorotrityl chloride resin for microwave-assisted solid phase peptide synthesis

(2015) Matthaia Ieronymaki et al.   BIOPOLYMERS

Mannan-conjugated myelin peptides prime non-pathogenic Th1 and Th17 cells and ameliorate experimental autoimmune encephalomyelitis

(2015) Vivian Tseveleki et al.   EXPERIMENTAL NEUROLOGY

The Cytokine GM-CSF Drives the Inflammatory Signature of CCR2+ Monocytes and Licenses Autoimmunity

(2015) Andrew L. Croxford et al.   IMMUNITY

Neuroimmunotherapies Targeting T Cells: From Pathophysiology to Therapeutic Applications

(2015) Stefan Bittner et al.   Neurotherapeutics

Differential roles of microglia and monocytes in the inflamed central nervous system

(2014) Ryo Yamasaki et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The Adjuvanticity of a Mannosylated Antigen Reveals TLR4 Functionality Essential for Subset Specialization and Functional Maturation of Mouse Dendritic Cells

(2014) K.-C. Sheng et al.   JOURNAL OF IMMUNOLOGY

GM-CSF-Responsive Monocyte-Derived Dendritic Cells Are Pivotal in Th17 Pathogenesis

(2014) H.-J. Ko et al.   JOURNAL OF IMMUNOLOGY

Up to 15-year clinical follow-up of a pilot Phase III immunotherapy study in stage II breast cancer patients using oxidized mannan–MUC1

(2013) Stamatis Vassilaros et al.   Immunotherapy

Fate Mapping Reveals Origins and Dynamics of Monocytes and Tissue Macrophages under Homeostasis

(2012) Simon Yona et al.   IMMUNITY

Mouse CD11b + Gr-1 + Myeloid Cells Can Promote Th17 Cell Differentiation and Experimental Autoimmune Encephalomyelitis

(2012) Huanfa Yi et al.   JOURNAL OF IMMUNOLOGY

Myelin-oligodendrocyte glycoprotein antibodies in adults with a neuromyelitis optica phenotype

(2012) J. Kitley et al.   NEUROLOGY

Communication between pathogenic T cells and myeloid cells in neuroinflammatory disease

(2012) Laura Codarri et al.   TRENDS IN IMMUNOLOGY

Myeloid-Derived Suppressor Cells Limit the Inflammation by Promoting T Lymphocyte Apoptosis in the Spinal Cord of a Murine Model of Multiple Sclerosis

(2011) Verónica Moliné-Velázquez et al.   BRAIN PATHOLOGY

Plasticity of Ly-6Chi Myeloid Cells in T Cell Regulation

(2011) B. Zhu et al.   JOURNAL OF IMMUNOLOGY

Crucial Role of Granulocytic Myeloid-Derived Suppressor Cells in the Regulation of Central Nervous System Autoimmune Disease

(2011) M. Ioannou et al.   JOURNAL OF IMMUNOLOGY

Tolerance Induced by Apoptotic Antigen-Coupled Leukocytes Is Induced by PD-L1+ and IL-10-Producing Splenic Macrophages and Maintained by T Regulatory Cells

(2011) D. R. Getts et al.   JOURNAL OF IMMUNOLOGY

Infiltrating monocytes trigger EAE progression, but do not contribute to the resident microglia pool

(2011) Bahareh Ajami et al.   NATURE NEUROSCIENCE

The PD-1 pathway in tolerance and autoimmunity

(2010) Loise M. Francisco et al.   IMMUNOLOGICAL REVIEWS

Selective Chemokine Receptor Usage by Central Nervous System Myeloid Cells in CCR2-Red Fluorescent Protein Knock-In Mice

(2010) Noah Saederup et al.   PLoS One

Circulating Ly-6C+ myeloid precursors migrate to the CNS and play a pathogenic role during autoimmune demyelinating disease

(2009) I. L. King et al.   BLOOD

CCR2+Ly-6Chi monocytes are crucial for the effector phase of autoimmunity in the central nervous system

(2009) Alexander Mildner et al.   BRAIN