Article
Pharmacology & Pharmacy
Ditixa T. Desai, Furqan A. Maulvi, Ankita R. Desai, Manish R. Shukla, Bhargavi Desai, Avinash D. Khadela, Kiran H. Shetty, Dinesh O. Shah, Mark D. P. Willcox
Summary: In this study, drug-eluting contact lenses containing graphene oxide were developed to overcome the challenges associated with low drug uptake, altered swelling and optical properties. The incorporation of graphene oxide improved water holding capacity, optical properties, drug uptake and release kinetics. Furthermore, the safety and efficacy of the graphene oxide-contact lenses were demonstrated in ocular irritation, histopathological and in vivo drug release studies.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2022)
Article
Nanoscience & Nanotechnology
Chun-Feng Lai, Fu-Jia Shiau
Summary: This study presents and investigates pH-triggered drug-eluting contact lenses (DCLs) combined with large-pore mesoporous silica nanoparticles (LPMSNs). LPMSN-laden DCLs can prolong the residence time of glaucoma drugs in an artificial lacrimal fluid (ALF) environment at pH 7.4 compared to reference DCLs. The LPMSN-laden DCLs do not require drug preloading and are compatible with current contact lens manufacturing processes. LPMSN-laden DCLs soaked at pH 6.5 exhibit better drug loading capabilities than reference DCLs due to specific adsorption.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Biophysics
Furqan A. Maulvi, Parth D. Soni, Pooja J. Patel, Ankita R. Desai, Ditixa T. Desai, Manish R. Shukla, Shailesh A. Shah, Dinesh O. Shah, Mark D. P. Willcox
Summary: The research used graphene oxide (GO) to control the release of bimatoprost from contact lenses in order to improve drug uptake, lens swelling, and transmittance. Although GO did not enhance bimatoprost uptake, it improved the in vitro release profile of the drug.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2021)
Article
Chemistry, Multidisciplinary
Zhao Wang, Xinhua Li, Xiaojuan Zhang, Ruilong Sheng, Qing Lin, Wenli Song, Lingyun Hao
Summary: Therapeutic ophthalmic contact lenses with prolonged drug release and improved bioavailability were successfully developed using drug-loaded nanogels. These contact lenses can sustainably deliver drugs and exhibit good biocompatibility compared to traditional eye drops or ointment formulations, making them a promising alternative for long-term oculopathy treatment.
Article
Chemistry, Multidisciplinary
Chun-Feng Lai, Fu-Jia Shiau
Summary: In this research, hydrogel contact lenses (CLs) were designed to deliver hyaluronic acid (HA) for treating dry eye syndrome. Large-pore mesoporous silica nanoparticles (LPMSNs) were used to achieve extended release of HA. The LPMSN-amine CLs demonstrated slower and superior release of HA compared to LPMSN-siloxane and standard CLs, making them a promising solution for dry eye management.
Review
Pharmacology & Pharmacy
Furqan A. Maulvi, Ditixa T. Desai, Kiran H. Shetty, Dinesh O. Shah, Mark D. P. Willcox
Summary: The delivery of drugs to ocular tissues can be challenging, and drug-laden contact lenses are being explored as a possible solution. However, there are several issues that need to be addressed before clinical application and commercialization, such as changes in contact lens properties during manufacture.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2021)
Article
Chemistry, Physical
Jae Min Jung, Yu Lip Jung, Seong Han Kim, Doo Sung Lee, Thavasyappan Thambi
Summary: Recently, injectable stimuli-sensitive hydrogels have been utilized as drug delivery carriers for the release of different anti-cancer drugs. However, the large pore size of microporous hydrogels leads to the premature release of small molecular anticancer drugs, limiting their application in cancer therapy. To overcome this limitation, reinforcing fillers such as mesoporous silica nanoparticles (MSNs) have been introduced, which not only load diverse types of anticancer drugs but also prevent premature drug release by strengthening the hydrogel networks. In this study, camptothecin (CPT), a hydrophobic anticancer drug, was loaded into MSNs and then incorporated into physiological stimuli-sensitive poly(ethylene glycol)-poly(b-aminoester urethane) (PAEU) hydrogels. The results showed that MSN-imbibed PAEU hydrogels exhibited sustained release of CPT, demonstrating their potential as a drug delivery depot for prolonged release of anticancer drugs.
JOURNAL OF COLLOID AND INTERFACE SCIENCE
(2023)
Article
Engineering, Biomedical
Liu Qu, Nileshkumar Dubey, Juliana S. Ribeiro, Ester A. F. Bordini, Jessica A. Ferreira, Jinping Xu, Rogerio M. Castilho, Marco C. Bottino
Summary: The study engineered metformin-loaded mesoporous silica nanospheres laden gelatin methacryloyl photocrosslinkable hydrogels, which demonstrated potential osteogenic effects on stem cells. Through testing mechanical properties, drug release, cytocompatibility, and osteogenic differentiation, the hydrogels showed promise for bone regeneration applications.
JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS
(2021)
Article
Engineering, Biomedical
Dongkai Zhu, Yangping Liu, Jeremy L. Gilbert
Summary: Adhesion properties of silicone hydrogel contact lenses are crucial for their performance and comfort in the eye. This study developed a new testing method to study adhesive interactions of different silicone contact lenses under dehydrating conditions, highlighting the importance of hydration state on adhesion.
ACTA BIOMATERIALIA
(2021)
Article
Engineering, Biomedical
Qiong Li, Cheng Ma, Yingpeng Ma, Yiping Ma, Yan Mao, Zelan Meng
Summary: The study investigated the effect of gold nanoparticles (GNPs) on bimatoprost loading/uptake and release kinetics from contact lenses. The presence of GNPs significantly improved drug uptake and sustained release of bimatoprost, without affecting the critical properties of the lenses for therapeutic application.
JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION
(2021)
Article
Pharmacology & Pharmacy
He Xiaojie, Jiang Fagang, Jing Jun, Wang Chunfang, Li Chengquan, Wang Xinghua
Summary: A novel bimatoprost-loaded silica shell nanoparticles-laden soft contact lens was developed in this study to achieve sustained drug delivery without altering the optophysical properties of the contact lens. Compared to traditional methods, the silica shell-coated nanoparticles-laden soft contact lenses demonstrated significant improvements in swelling, transmittance, oxygen permeability, and lysozyme adherence. In animal models, the silica shell nanoparticles showed high bimatoprost concentration for an extended period of time, indicating its potential as a safe and effective drug delivery system.
Review
Biotechnology & Applied Microbiology
Roghayyeh Baghban, Mohammad Reza Talebnejad, Aidin Meshksar, Mojtaba Heydari, Mohammad Reza Khalili
Summary: Contact lenses have emerged as a promising formulation for ocular drug delivery, increasing drug bioavailability and reducing unwanted side effects. They are particularly suitable for treating chronic eye conditions.
JOURNAL OF NANOBIOTECHNOLOGY
(2023)
Article
Chemistry, Analytical
Mengyu Deng, Guangjie Song, Ke Zhong, Zhanchen Wang, Xi Xia, Yanqing Tian
Summary: This study developed smart and transparent contact lenses for real-time, continuous, non-invasive monitoring of glucose levels in tears, which is essential for diabetic patients' health. The smart contact lenses detect glucose using a fluorescent probe and reference dye, with the fluorescence images collected by a smartphone and transformed into RGB signals for glucose quantification. Animal experiments confirmed the biosafety of the lenses and the potential for painless glucose monitoring.
SENSORS AND ACTUATORS B-CHEMICAL
(2022)
Article
Engineering, Biomedical
Yunli Xu, Hongyi Li
Summary: In this study, a novel drug-loaded contact lens was developed for the treatment of glaucoma. The contact lens, which contained brimonidine-loaded silica nanoparticles, demonstrated controlled drug release without altering the optophysical properties of the lens. The experimental results showed that the contact lens had good biocompatibility and effective drug release.
JOURNAL OF BIOMATERIALS APPLICATIONS
(2022)
Article
Ophthalmology
Joanna Stachura, Patryk Mlyniuk, Waldemar Bloch, Alfonso Jimenez-Villar, Ireneusz Grulkowski, Bartlomiej J. Kaluzny
Summary: This study found that continuous wear of silicon hydrogel soft contact lenses can lead to changes in the geometry of the anterior surface of the cornea, particularly in hyperopic patients. The variations in epithelial thickness affect the higher order aberrations of the cornea.
OPHTHALMIC AND PHYSIOLOGICAL OPTICS
(2021)
Article
Pharmacology & Pharmacy
Akshay R. Koli, Ketan M. Ranch, Hetal P. Patel, Rajesh K. Parikh, Dinesh O. Shah, Furqan A. Maulvi
Summary: Felodipine, a calcium channel blocker with low oral bioavailability, was studied using microemulsion to improve drug permeability in the intestine. Research showed that a stable microemulsion can significantly enhance the oral bioavailability of Felodipine through improved drug stability and permeability.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2021)
Article
Pharmacology & Pharmacy
Ketan M. Ranch, Furqan A. Maulvi, Akshay R. Koli, Ditixa T. Desai, Rajesh K. Parikh, Dinesh O. Shah
Summary: The study successfully developed tailored doxycycline hyclate laden in situ gel for periodontitis treatment, which achieved sustained drug release above MIC, easy administration, and localization in the periodontal cavity. Optimization was conducted using Box-Behnken design with minimal polymers to meet the required characteristics for effective drug delivery.
Article
Pharmacology & Pharmacy
Hetal P. Patel, Priyanka S. Chaudhari, Priyanshi A. Gandhi, Bhargavi Desai, Ditixa T. Desai, Praful P. Dedhiya, Bhavin A. Vyas, Furqan A. Maulvi
Summary: Clozapine nanosuspension prepared for intranasal delivery showed improved drug permeability and increased therapeutic concentration in brain tissue compared to conventional oral clozapine suspension, suggesting its potential for successful nose-to-brain drug delivery.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2021)
Article
Pharmacology & Pharmacy
Hetal P. Patel, Priyanshi A. Gandhi, Priyanka S. Chaudhari, Bhargavi V. Desai, Ditixa T. Desai, Praful P. Dedhiya, Furqan A. Maulvi, Bhavin A. Vyas
Summary: Tailored clozapine-loaded nanostructured lipid carriers (NLCs) designed in this study significantly improved the therapeutic concentration of clozapine in brain tissue, bypassed hepatic first-pass metabolism, and overcame the blood-brain barrier, showing a 6.15-fold increase in relative bioavailability, potentially benefiting schizophrenia treatment.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2021)
Article
Biophysics
Furqan A. Maulvi, Parth D. Soni, Pooja J. Patel, Ankita R. Desai, Ditixa T. Desai, Manish R. Shukla, Shailesh A. Shah, Dinesh O. Shah, Mark D. P. Willcox
Summary: The research used graphene oxide (GO) to control the release of bimatoprost from contact lenses in order to improve drug uptake, lens swelling, and transmittance. Although GO did not enhance bimatoprost uptake, it improved the in vitro release profile of the drug.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2021)
Review
Pharmacology & Pharmacy
Furqan A. Maulvi, Ditixa T. Desai, Kiran H. Shetty, Dinesh O. Shah, Mark D. P. Willcox
Summary: The delivery of drugs to ocular tissues can be challenging, and drug-laden contact lenses are being explored as a possible solution. However, there are several issues that need to be addressed before clinical application and commercialization, such as changes in contact lens properties during manufacture.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2021)
Article
Pharmacology & Pharmacy
Ditixa T. Desai, Furqan A. Maulvi, Ankita R. Desai, Manish R. Shukla, Bhargavi Desai, Avinash D. Khadela, Kiran H. Shetty, Dinesh O. Shah, Mark D. P. Willcox
Summary: In this study, drug-eluting contact lenses containing graphene oxide were developed to overcome the challenges associated with low drug uptake, altered swelling and optical properties. The incorporation of graphene oxide improved water holding capacity, optical properties, drug uptake and release kinetics. Furthermore, the safety and efficacy of the graphene oxide-contact lenses were demonstrated in ocular irritation, histopathological and in vivo drug release studies.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2022)
Article
Pharmacology & Pharmacy
Furqan A. Maulvi, Prince A. Kanani, Harshani J. Jadav, Bhargavi Desai, Ditixa T. Desai, Hetal P. Patel, Kiran H. Shetty, Dinesh O. Shah, Mark D. P. Willcox
Summary: This study successfully improved the swelling and transmittance properties of contact lenses by incorporating graphene oxide (GO) during the fabrication process. Additionally, it achieved controlled release of timolol, a hydrophobic drug, through the use of GO-laden contact lenses.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2022)
Article
Pharmacology & Pharmacy
Kailas K. Moravkar, Devanshi S. Shah, Anuja G. Magar, Bhushan A. Bhairav, Sudarshan D. Korde, Ketan M. Ranch, Shailesh S. Chalikwar
Summary: This study evaluated and compared the flow properties of different lubricants during dosage form preparation. Traditional and advanced techniques were used to evaluate the flow properties of raw materials and granules. The addition of lubricants improved the flow behavior.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2022)
Review
Chemistry, Multidisciplinary
Chandrasekhar Garapati, Sai HS. Boddu, Shery Jacob, Ketan M. Ranch, Chirag Patel, R. Jayachandra Babu, Amit K. Tiwari, Haya Yasin
Summary: Resistance to antimicrobial drugs is a growing healthcare problem. Photodynamic therapy, using photosensitizers activated by light, shows effectiveness against microbial cells. Nanocarrier systems can enhance the internalization of photosensitizers into microbial cells, improving therapeutic efficiency. This review highlights the principles of photodynamic therapy and emphasizes the use of nanosystems for antimicrobial photodynamic therapy.
ARABIAN JOURNAL OF CHEMISTRY
(2023)
Review
Pharmacology & Pharmacy
Chirag Patel, Sonal Pande, Vrunda Sagathia, Ketan Ranch, Jayesh Beladiya, Sai H. S. Boddu, Shery Jacob, Moawia M. Al-Tabakha, Nageeb Hassan, Moyad Shahwan
Summary: Retinal neurodegeneration is an early event in the pathogenesis of ocular diseases, and there is currently no definitive treatment to prevent vision loss caused by photoreceptor degeneration. Neuroprotective approaches are being developed to maintain neuronal shape/function and prevent vision loss. Recent advancements in nanotechnology-based drug delivery systems show promise in treating ocular neurodegenerative diseases.
Review
Chemistry, Multidisciplinary
Palak K. Parikh, Nisha H. Parikh, B. Mahalakshmi, Ketan M. Ranch, Sai H. S. Boddu, R. Jayachandra Babu, Amit K. Tiwari
Summary: Given the continuous emergence of hepatitis and the associated consequences, developing effective antiviral strategies has become a major public health concern. Current antiviral strategies for hepatitis, especially for HBV and HCV, include small molecule modulators, peptides, nucleic acid polymers, siRNA, antisense oligonucleotides, monoclonal antibodies, and vaccines. Small molecule antiviral agents targeting HBV and HCV have advanced into different phases of clinical investigation, mainly targeting complex molecular interactions between virus and host cells involved in viral replication.
ARABIAN JOURNAL OF CHEMISTRY
(2023)
Review
Chemistry, Multidisciplinary
Sai H. S. Boddu, Devarshi Acharya, Vivek Hala, Harshil Jani, Sonal Pande, Chirag Patel, Moyad Shahwan, Renukuntla Jwala, Ketan M. Ranch
Summary: Advancements in protein engineering, biotechnology, and structural biochemistry have increased the utilization of proteins and peptides in the treatment of ocular diseases. However, the delivery of large molecules to the eye is challenging due to their properties. Various strategies such as glycoengineering, PEGylation, Fc-fusion, chitosan nanoparticles, and liposomes have improved the efficacy, safety, and stability of protein and peptide delivery.
Article
Chemistry, Medicinal
Chirag Patel, Lalita Shahgond, Sanjeev Acharya, Sai HS. Boddu, Ketan Ranch
Summary: The study evaluated the protective effect of probiotics and ascorbic acid combination therapy on BDL-induced chronic HE in rats. The combination therapy was found to reduce ammonia and oxidative stress, improve behavioral parameters, and attenuate hepatic inflammation/fibrosis in cirrhotic rats.
RESEARCH IN PHARMACEUTICAL SCIENCES
(2022)
Article
Engineering, Biomedical
Sai H. S. Boddu, Prakash Bhagav, Pradeep K. Karla, Shery Jacob, Mansi D. Adatiya, Tejas M. Dhameliya, Ketan M. Ranch, Amit K. Tiwari
Summary: Poly(amino acid)s play a critical role in drug delivery systems, providing sustained and controlled release of both hydrophobic and hydrophilic drugs. Their distinct features like biocompatibility and slow degradability make them effective in reducing drug-related side effects and enhancing anti-tumor efficacy.
JOURNAL OF FUNCTIONAL BIOMATERIALS
(2021)