Article
Transplantation
Pierre Delanaye, Emmanuelle Vidal-Petiot, Jonas Bjork, Natalie Ebert, Bjorn O. Eriksen, Laurence Dubourg, Anders Grubb, Magnus Hansson, Karin Littmann, Christophe Mariat, Toralf Melsom, Elke Schaeffner, Per-Ola Sundin, Arend Bokenkamp, Ulla B. Berg, Kajsa Asling-Monemi, Anna Akesson, Anders Larsson, Etienne Cavalier, R. Neil Dalton, Marie Courbebaisse, Lionel Couzi, Francois Gaillard, Cyril Garrouste, Lola Jacquemont, Nassim Kamar, Christophe Legendre, Lionel Rostaing, Thomas Stehle, Jean-Philippe Haymann, Luciano da Silva Selistre, Jorge P. Strogoff-de-Matos, Justine B. Bukabau, Ernest K. Sumaili, Eric Yayo, Dagui Monnet, Ulf Nyman, Hans Pottel, Martin Flamant
Summary: This study compared and validated the performance of the new Chronic Kidney Disease Epidemiology Collaboration equation (CKD-EPIAS) with the European Kidney Function Consortium (EKFC) and Lund-Malmo Revised (LMREV) equations in European and African cohorts. The results showed that the EKFC equation had the best performance in both European and African populations, while CKD-EPIAS had suboptimal performance.
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2023)
Review
Medicine, General & Internal
Linnea Malmgren, Carl Oberg, Emil den Bakker, Felicia Leion, Joanna Siodmiak, Anna Akesson, Veronica Lindstrom, Erik Herou, Alain Dardashti, Liana Xhakollari, Gabriel Grubb, Helena Strevens, Magnus Abrahamson, Johanna Helmersson-Karlqvist, Martin Magnusson, Jonas Bjork, Ulf Nyman, Johan Arnlov, Peter Ridefelt, Torbjorn Akerfeldt, Magnus Hansson, Anna Sjostrom, Johan Martensson, Yoshihisa Itoh, David Grubb, Olav Tenstad, Lars-Olov Hansson, Isleifur Olafsson, Araceli Jarquin Campos, Martin Risch, Lorenz Risch, Anders Larsson, Gunnar Nordin, Hans Pottel, Anders Christensson, Henrik Bjursten, Arend Bokenkamp, Anders Grubb
Summary: Estimation of kidney function is commonly done using endogenous GFR-markers creatinine or cystatin C. The recommendation in 2010 to use both markers in parallel led to the identification of selective glomerular hypofiltration syndromes, which are associated with increased mortality and morbidity. These syndromes, characterized by a selective reduction in the glomerular filtration of certain molecules, such as cystatin C, have proteomic changes that promote the development of atherosclerosis and may require new treatment modalities.
JOURNAL OF INTERNAL MEDICINE
(2023)
Article
Chemistry, Medicinal
Taisuke Tawaraishi, Atsuko Ochida, Yuichiro Akao, Sachiko Itono, Masahiro Kamaura, Thamina Akther, Mitsuyuki Shimada, Stacie Canan, Sanjoy Chowdhury, Yafeng Cao, Kevin Condroski, Ola Engkvist, Amanda Francisco, Sunil Ghosh, Rina Kaki, John M. Kelly, Chiaki Kimura, Thierry Kogej, Kazuya Nagaoka, Akira Naito, Garry Pairaudeau, Constantin Radu, Ieuan Roberts, David Shum, Nao-aki Watanabe, Huanxu Xie, Shuji Yonezawa, Osamu Yoshida, Ryu Yoshida, Charles Mowbray, Benjamin Perry
Summary: Probing multiple proprietary pharmaceutical libraries in parallel through virtual screening led to the rapid expansion of structure-activity relationship (SAR) around hit compounds with moderate efficacy against Trypanosoma cruzi. The SAR was further developed through a potency-improving scaffold hop and design guided by phenotypic virtual screening, resulting in the identification of two promising hit compounds 54 and 85. Compound 85 showed a significant reduction in parasitemia in an in vivo model, confirming its potential as an anti-trypanosome treatment.
JOURNAL OF MEDICINAL CHEMISTRY
(2023)
Article
Medicine, General & Internal
H. Pottel, J. Bjork, A. D. Rule, N. Ebert, B. O. Eriksen, L. Dubourg, E. Vidal-Petiot, A. Grubb, M. Hansson, E. J. Lamb, K. Littmann, C. Mariat, T. Melsom, E. Schaeffner, P. -O. Sundin, A. Akesson, A. Larsson, E. Cavalier, J. B. Bukabau, E. K. Sumaili, E. Yayo, D. Monnet, M. Flamant, U. Nyman, P. Delanaye
Summary: The study developed a cystatin C-based equation (EKFC eGFRcys) to estimate glomerular filtration rate (GFR). This equation had similar accuracy to a creatinine-based equation (EKFC eGFRcr) and outperformed other commonly used equations. Furthermore, taking the arithmetic mean of EKFC eGFRcr and EKFC eGFRcys further improved the accuracy of GFR estimation.
NEW ENGLAND JOURNAL OF MEDICINE
(2023)
Review
Pediatrics
Hans Pottel, Oyindamola C. Adebayo, Agathe B. Nkoy, Pierre Delanaye
Summary: Glomerular hyperfiltration (GHF) is an increase in single-nephron glomerular filtration rate (GFR), which can occur in both physiological and pathological states. The threshold for GHF is currently undefined, but a consensus pediatric threshold for GHF can reliably be set at 135 mL/min/1.73m² for children over 2 years old. Diagnosing GHF using SCr-based estimated GFR is unreliable in individuals with reduced muscle mass, and alternative methods such as cystatin C-based eGFR or measured GFR should be used for confirmation.
PEDIATRIC NEPHROLOGY
(2023)
Article
Orthopedics
Guy Putzeys, Thomas Dekeyser, Patrick Garre, Tim Chesser, Hans Pottel
Summary: This study aimed to investigate the impact of posterior ring involvement on the outcomes of conservatively treated acute low energy pubic rami fractures, as well as the usefulness of early CT in predicting treatment failure. The study found that posterior ring involvement had some impact on treatment failure, but the value of early CT in predicting conservative treatment failure was limited.
BMC MUSCULOSKELETAL DISORDERS
(2023)
Article
Pediatrics
Pieter Schellekens, Marcelien Verjans, Peter Janssens, Angelique Dachy, Stephanie De Rechter, Luc Breysem, Karel Allegaert, Bert Bammens, Rudi Vennekens, Pieter Vermeersch, Hans Pottel, Djalila Mekahli
Summary: This study examined a cohort of 68 genotyped ADPKD patients and compared several commonly used equations for estimating eGFR. The CKiD and CKiDU25 equations showed age or sex differences, while the FAS equations were independent of age and sex. Therefore, having reliable methods to calculate eGFR is crucial for clinical follow-up and trials.
PEDIATRIC NEPHROLOGY
(2023)
Review
Urology & Nephrology
Fateme Nateghi Haredasht, Laban Vanhoutte, Celine Vens, Hans Pottel, Liesbeth Viaene, Wouter De Corte
Summary: This study found that there are few validated risk prediction models for predicting poor renal outcomes after experiencing acute kidney injury (AKI), most of which are based on simple statistical or machine learning models. Although some of these models have been externally validated, none of them are currently available for use or evaluation in a clinical setting.
Article
Multidisciplinary Sciences
Fateme Nateghi Haredasht, Liesbeth Viaene, Hans Pottel, Wouter De Corte, Celine Vens
Summary: Acute Kidney Injury (AKI) is a sudden kidney failure seen in critically ill patients. Machine learning models were developed to predict outcomes following AKI stage 3 events, including the progression to chronic kidney disease (CKD) and mortality. The models showed better performance than baseline models, indicating their potential in assisting clinical decisions for critically ill patients with severe AKI.
SCIENTIFIC REPORTS
(2023)
Article
Medical Laboratory Technology
Ulf Nyman, Jonas Bjork, Pierre Delanaye, Alexandre Lahens, Hans Pottel, Emmanuelle Vidal-Petiot, Martin Flamant
Summary: GFR estimating equations can be re-expressed to include rescaled creatinine (sCr/Q) and used across populations with different creatinine generation if population-specific average creatinine concentrations (Q-values) for healthy persons are established.
CLINICAL CHEMISTRY AND LABORATORY MEDICINE
(2023)
Article
Chemistry, Medicinal
Livio Racane, Lucija Pticek, Sanja Kostrun, Silvana Raic-Malic, Martin Craig Taylor, Michael Delves, Sam Alsford, Francisco Olmo, Amanda Fortes Francisco, John M. Kelly
Summary: We designed and synthesized a series of symmetric benzothiazole derivatives and evaluated their efficacy against Trypanosoma brucei and Plasmodium falciparum. One compound showed high selectivity and trypanocidal activity, curing mice infected with trypanosomiasis. It also exhibited activity against the malaria parasite.
JOURNAL OF MEDICINAL CHEMISTRY
(2023)
Article
Pediatrics
Hans Pottel, Ulf Nyman, Jonas Bjoerk, Ulla Berg, Arend Boekenkamp, Laurence Derain Dubourg, Sandrine Lemoine, Karolien Goffin, Anders Grubb, Magnus Hansson, Anders Larsson, Karin Littmann, Kajsa asling-Monemi, Khosrow Adeli, Etienne Cavalier, Pierre Delanaye
Summary: A new cystatin C based equation has been developed for measuring kidney function in both adults and children. The study compared the results of using a simple rescaling factor for cystatin C with a more complex polynomial method, and found that both methods produced similar results. Additionally, taking the average of the cystatin C based equation and the creatinine based equation resulted in more accurate measurements.
PEDIATRIC NEPHROLOGY
(2023)
Article
Multidisciplinary Sciences
Srinivasa P. S. Rao, Matthew K. Gould, Jonas Noeske, Manuel Saldivia, Rajiv S. Jumani, Pearly S. Ng, Olivier Rene, Yen-Liang Chen, Marcel Kaiser, Ryan Ritchie, Amanda Fortes Francisco, Nila Johnson, Debjani Patra, Harry Cheung, Colin Deniston, Andreas D. Schenk, Wilian A. Cortopassi, Remo S. Schmidt, Natalie Wiedemar, Bryanna Thomas, Rima Palkar, Nahdiyah A. Ghafar, Vanessa Manoharan, Catherine Luu, Jonathan E. Gable, Kah Fei Wan, Elmarie Myburgh, Jeremy C. Mottram, Whitney Barnes, John Walker, Charles Wartchow, Natasha Aziz, Colin Osborne, Juergen Wagner, Christopher Sarko, John M. Kelly, Ujjini H. Manjunatha, Pascal Maeser, Jan Jiricek, Suresh B. Lakshminarayana, Michael P. Barrett, Thierry T. Diagana
Summary: Millions of people in Latin America and sub-Saharan Africa are at risk of trypanosomatid infections. Researchers have identified a class of cyanotriazoles (CTs) that have potent trypanocidal activity and can potentially be used for the treatment of Chagas disease and human African trypanosomiasis. These CT compounds act by selectively and irreversibly inhibiting trypanosomal topoisomerase II and stabilizing DNA:enzyme cleavage complexes.
Article
Microbiology
Amanda Fortes Francisco, Giovane R. Sousa, Mhairi Vaughan, Harry Langston, Archie Khan, Shiromani Jayawardhana, Martin C. Taylor, Michael D. Lewis, John M. Kelly
Summary: This study demonstrates the potential of the C3H/HeN:JR host:parasite combination as an experimental model for Chronic Chagas cardiomyopathy (CCC). The model exhibited cardiac abnormalities and inflammation, and could be used for screening new compounds and drugs to prevent or alleviate CCC development.
Article
Surgery
M. D'Hondt, A. Devooght, E. Willems, D. Wicherts, C. De Meyere, I Parmentier, A. Provoost, H. Pottel, C. Verslype
Summary: This study evaluates the short-term outcomes and cost differences of robotic liver surgery (RLS) compared to laparoscopic liver surgery (LLS). The findings indicate that RLS has comparable short-term outcomes to LLS but with shorter operative time, lower intraoperative blood loss, and shorter hospital stay. The cost analysis also shows that RLS is more cost-effective compared to LLS.
JOURNAL OF ROBOTIC SURGERY
(2023)