Astrocyte calcium dysfunction causes early network hyperactivity in Alzheimer’s disease

The amyloid hypothesis in Alzheimer disease: new insights from new therapeutics

(2022) Eric Karran et al.   NATURE REVIEWS DRUG DISCOVERY

Different posterior hippocampus and default mode network modulation in young APOE ε4 carriers: a functional connectome-informed phenotype longitudinal study

(2021) Li Juan Zheng et al.   MOLECULAR NEUROBIOLOGY

Astrocytes in Alzheimer’s Disease: Pathological Significance and Molecular Pathways

(2021) Pranav Preman et al.   Cells

Baseline cognition is the best predictor of 4-year cognitive change in cognitively intact older adults

(2021) Jolien M. Schaeverbeke et al.   Alzheimers Research & Therapy

Changes in the language system as amyloid-β accumulates

(2021) Mariska Reinartz et al.   BRAIN

Side-by-side comparison of the effects of Gq- and Gi-DREADD-mediated astrocyte modulation on intracellular calcium dynamics and synaptic plasticity in the hippocampal CA1

(2021) Yana Van Den Herrewegen et al.   Molecular Brain

Astrocyte‐neuronal network interplay is disrupted in Alzheimer's disease mice

(2021) Justin Lines et al.   GLIA

Resting-state brain connectivity in healthy young and middle-aged adults at risk of progressive Alzheimer’s disease

(2021) Ludmila Kucikova et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Identification of region-specific astrocyte subtypes at single cell resolution

(2020) Mykhailo Y. Batiuk et al.   Nature Communications

Transcriptomic profiling of microglia and astrocytes throughout aging

(2020) Jie Pan et al.   Journal of Neuroinflammation

Disease-associated astrocytes in Alzheimer’s disease and aging

(2020) Naomi Habib et al.   NATURE NEUROSCIENCE

Astrocytes modulate sensory-evoked neuronal network activity

(2020) Justin Lines et al.   Nature Communications

Reproducibility of graph measures at the subject level using resting‐state fMRI

(2020) Qian Ran et al.   Brain and Behavior

A Role for Astroglial Calcium in Mammalian Sleep and Sleep Regulation

(2020) Ashley M. Ingiosi et al.   CURRENT BIOLOGY

Regional, Layer, and Cell-Type-Specific Connectivity of the Mouse Default Mode Network

(2020) Jennifer D. Whitesell et al.   NEURON

Comparison of ELISA- and SIMOA-based quantification of plasma Aβ ratios for early detection of cerebral amyloidosis

(2020) Steffi De Meyer et al.   Alzheimers Research & Therapy

Aberrant Calcium Signals in Reactive Astrocytes: A Key Process in Neurological Disorders

(2019) Eiji Shigetomi et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Gi/o protein-coupled receptors inhibit neurons but activate astrocytes and stimulate gliotransmission

(2019) Caitlin A. Durkee et al.   GLIA

The role of astroglia in Alzheimer's disease: pathophysiology and clinical implications

(2019) Amaia M Arranz et al.   LANCET NEUROLOGY

The Emerging Nature of Astrocyte Diversity

(2019) Baljit S. Khakh et al.   Annual Review of Neuroscience

PTZ-induced seizures in mice require a revised Racine scale

(2019) Jan Van Erum et al.   EPILEPSY & BEHAVIOR

Comparison between transgenic and AAV-PHP.eB-mediated expression of GCaMP6s using in vivo wide-field functional imaging of brain activity

(2019) Nicholas J. Michelson et al.   Neurophotonics

Circadian regulation of astrocyte function: implications for Alzheimer’s disease

(2019) Celia A. McKee et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

The neuropathological diagnosis of Alzheimer’s disease

(2019) Michael A. DeTure et al.   Molecular Neurodegeneration

A vicious cycle of β amyloid–dependent neuronal hyperactivation

(2019) Benedikt Zott et al.   SCIENCE

The Hyperactivity–Impulsivity–Irritiability–Disinhibition–Aggression–Agitation Domain in Alzheimer’s Disease: Current Management and Future Directions

(2019) Rachel M. Keszycki et al.   Frontiers in Pharmacology

Alzheimer's disease and sleep disturbances: a review

(2019) Conrado Regis Borges et al.   ARQUIVOS DE NEURO-PSIQUIATRIA

In vivo widefield calcium imaging of the mouse cortex for analysis of network connectivity in health and brain disease

(2019) Julia V. Cramer et al.   NEUROIMAGE

Astrocytic Activation Generates De Novo Neuronal Potentiation and Memory Enhancement

(2018) Adar Adamsky et al.   CELL

P2Y1 receptor blockade normalizes network dysfunction and cognition in an Alzheimer’s disease model

(2018) Nicole Reichenbach et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Alzheimer's Disease and Sleep–Wake Disturbances: Amyloid, Astrocytes, and Animal Models

(2018) William M. Vanderheyden et al.   JOURNAL OF NEUROSCIENCE

Neuroaging through the Lens of the Resting State Networks

(2018) Filippo Cieri et al.   Biomed Research International

Region- and Age-Specific Changes in Glutamate Transport in the AβPP23 Mouse Model for Alzheimer's Disease

(2018) Anneleen Schallier et al.   JOURNAL OF ALZHEIMERS DISEASE

Silent hippocampal seizures and spikes identified by foramen ovale electrodes in Alzheimer's disease

(2017) Alice D Lam et al.   NATURE MEDICINE

On the path to 2025: understanding the Alzheimer’s disease continuum

(2017) Paul S. Aisen et al.   Alzheimers Research & Therapy

Subtle behavioral changes and increased prefrontal-hippocampal network synchronicity in APPNL−G−F mice before prominent plaque deposition

(2017) Amira Latif-Hernandez et al.   BEHAVIOURAL BRAIN RESEARCH

Early pathologic amyloid induces hypersynchrony of BOLD resting-state networks in transgenic mice and provides an early therapeutic window before amyloid plaque deposition

(2016) Disha Shah et al.   Alzheimers & Dementia

Anterior cingulate cortex inactivation impairs rodent visual selective attention and prospective memory.

(2016) Jangjin Kim et al.   BEHAVIORAL NEUROSCIENCE

The Cellular Phase of Alzheimer’s Disease

(2016) Bart De Strooper et al.   CELL

Resting-state functional MRI and [18F]-FDG PET demonstrate differences in neuronal activity between commonly used mouse strains

(2016) Disha Shah et al.   NEUROIMAGE

DREADDs for Neuroscientists

(2016) Bryan L. Roth   NEURON

Astrogliosis: An integral player in the pathogenesis of Alzheimer's disease

(2016) Lana M. Osborn et al.   PROGRESS IN NEUROBIOLOGY

The Centiloid Project: Standardizing quantitative amyloid plaque estimation by PET

(2015) William E. Klunk et al.   Alzheimers & Dementia

Neuronal hyperactivity - A key defect in Alzheimer's disease?

(2015) Marc Aurel Busche et al.   BIOESSAYS

Resting-state synchrony between the retrosplenial cortex and anterior medial cortical structures relates to memory complaints in subjective cognitive impairment

(2015) Fumihiko Yasuno et al.   NEUROBIOLOGY OF AGING

Chemogenetic Inactivation of Dorsal Anterior Cingulate Cortex Neurons Disrupts Attentional Behavior in Mouse

(2015) Hiroyuki Koike et al.   NEUROPSYCHOPHARMACOLOGY

Astrocyte Calcium Signaling: From Observations to Functions and the Challenges Therein

(2015) Baljit S. Khakh et al.   Cold Spring Harbor Perspectives in Biology

Anterior Cingulate Cortex: Unique Role in Cognition and Emotion

(2014) Francis L. Stevens et al.   JOURNAL OF NEUROPSYCHIATRY AND CLINICAL NEUROSCIENCES

Single App knock-in mouse models of Alzheimer's disease

(2014) Takashi Saito et al.   NATURE NEUROSCIENCE

Removable cranial windows for long-term imaging in awake mice

(2014) Glenn J Goldey et al.   Nature Protocols

Optimization of anesthesia protocol for resting-state fMRI in mice based on differential effects of anesthetics on functional connectivity patterns

(2014) Joanes Grandjean et al.   NEUROIMAGE

Large-scale topology and the default mode network in the mouse connectome

(2014) James M. Stafford et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Metabotropic P2Y1 receptor signalling mediates astrocytic hyperactivity in vivo in an Alzheimer’s disease mouse model

(2014) Andrea Delekate et al.   Nature Communications

Remembering to attend: The anterior cingulate cortex and remote memory

(2013) Aldis P. Weible   BEHAVIOURAL BRAIN RESEARCH

The role of the posterior cingulate cortex in cognition and disease

(2013) Robert Leech et al.   BRAIN

α1-Adrenergic receptors mediate coordinated Ca2+ signaling of cortical astrocytes in awake, behaving mice

(2013) Fengfei Ding et al.   CELL CALCIUM

Astrocyte-Neuron Interaction at Tripartite Synapses

(2013) Alberto Pérez-Alvarez et al.   CURRENT DRUG TARGETS

Sleep and Alzheimer disease pathology—a bidirectional relationship

(2013) Yo-El S. Ju et al.   Nature Reviews Neurology

Seizures and Epileptiform Activity in the Early Stages of Alzheimer Disease

(2013) Keith A. Vossel et al.   JAMA Neurology

Polymorphism of brain derived neurotrophic factor influences β amyloid load in cognitively intact apolipoprotein E ε4 carriers

(2013) Katarzyna Adamczuk et al.   NeuroImage-Clinical

Glutamate transporter EAAT2: a new target for the treatment of neurodegenerative diseases

(2012) Chien-Liang Glenn Lin et al.   Future Medicinal Chemistry

Human dorsal anterior cingulate cortex neurons mediate ongoing behavioural adaptation

(2012) Sameer A. Sheth et al.   NATURE

Reduction of Hippocampal Hyperactivity Improves Cognition in Amnestic Mild Cognitive Impairment

(2012) Arnold Bakker et al.   NEURON

Critical role of soluble amyloid-  for early hippocampal hyperactivity in a mouse model of Alzheimer's disease

(2012) M. A. Busche et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Imaging the default mode network in aging and dementia

(2011) Anne Hafkemeijer et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Dementia and the Default Mode

(2011) Lori L. Beason-Held   Current Alzheimer Research

Neuroimaging markers for the prediction and early diagnosis of Alzheimer's disease dementia

(2011) Michael Ewers et al.   TRENDS IN NEUROSCIENCES

18F-flutemetamol amyloid imaging in Alzheimer disease and mild cognitive impairment: A phase 2 trial

(2010) Rik Vandenberghe et al.   ANNALS OF NEUROLOGY

Amyloid-β–induced neuronal dysfunction in Alzheimer's disease: from synapses toward neural networks

(2010) Jorge J Palop et al.   NATURE NEUROSCIENCE

Specific disruption of astrocytic Ca2+ signaling pathway in vivo by adeno-associated viral transduction

(2010) Y. Xie et al.   NEUROSCIENCE

Whole-Body Biodistribution and Radiation Dosimetry of 18F-GE067: A Radioligand for In Vivo Brain Amyloid Imaging

(2009) M. Koole et al.   JOURNAL OF NUCLEAR MEDICINE

Synchronous Hyperactivity and Intercellular Calcium Waves in Astrocytes in Alzheimer Mice

(2009) K. V. Kuchibhotla et al.   SCIENCE

Clusters of Hyperactive Neurons Near Amyloid Plaques in a Mouse Model of Alzheimer's Disease

(2008) M. A. Busche et al.   SCIENCE