Article
Gastroenterology & Hepatology
Irina Midenfjord, Adam Borg, Hans Tornblom, Magnus Simren
Summary: This study found that psychological alterations are common in patients with irritable bowel syndrome (IBS) and there is often overlap among various psychological factors. Five psychological factors (physical fatigue, GI-specific anxiety, perceived stress, pain catastrophizing, and trait anxiety) were significantly associated with the severity of GI symptoms. An increasing number of these psychological alterations also led to a gradual increase in the overall severity of GI symptoms.
AMERICAN JOURNAL OF GASTROENTEROLOGY
(2021)
Article
Multidisciplinary Sciences
Agata Furgala, Katarzyna Ciesielczyk, Magdalena Przybylska-Felus, Konrad Jablonski, Krzysztof Gil, Malgorzata Zwolinska-Wcislo
Summary: This study aimed to assess the postprandial response, including gut peptide secretion and gastric myoelectric activity, in patients with constipation-predominant irritable bowel syndrome (IBS-C). The results showed that IBS-C patients had significantly elevated preprandial levels of gastrin and insulin, while VIP and ghrelin levels were decreased. Moreover, the gastric motility was impaired in IBS-C patients. These findings suggest that disturbances in the postprandial concentration of gut peptides may contribute to abnormal gastric function and intestinal motility, leading to exacerbation of clinical symptoms in IBS patients.
SCIENTIFIC REPORTS
(2023)
Article
Medicine, General & Internal
Juan J. Sebastian Domingo
Summary: Irritable bowel syndrome is a common functional bowel disorder with significant impact on patients' daily lives and society's economy. It is characterized by abdominal pain, bloating, and altered bowel movements, and its etiology and pathophysiological mechanism are still unknown.
Article
Psychiatry
Chloe Melchior, Katarina Wilpart, Irina Midenfjord, Ines A. Trindade, Hans Tornblom, Jan F. Tack, Magnus Simren, Lukas Van Oudenhove
Summary: The study found that abuse is associated with increased GI and extraintestinal symptom severity in IBS, and these associations are mediated by levels of GI-specific anxiety, depressive symptoms, and rectal sensitivity.
PSYCHOSOMATIC MEDICINE
(2022)
Article
Microbiology
Jonathan P. Jacobs, Arpana Gupta, Ravi R. Bhatt, Jacob Brawer, Kan Gao, Kirsten Tillisch, Venu Lagishetty, Rebecca Firth, Gregory D. Gudleski, Benjamin M. Ellingson, Jennifer S. Labus, Bruce D. Naliboff, Jeffrey M. Lackner, Emeran A. Mayer
Summary: This study found that pre-treatment intestinal microbiota and serotonin levels can predict the response to CBT in IBS patients. Responders to CBT showed changes in brain connectivity and microbiome post-treatment, indicating potential top-down effects of the brain on the microbiome during CBT.
Article
Gastroenterology & Hepatology
David J. Kearney, Kendra J. Kamp, Meghan Storms, Tracy L. Simpson
Summary: This study described the prevalence of irritable bowel syndrome (IBS) and other gastrointestinal symptoms in veterans with posttraumatic stress disorder (PTSD) and found a relationship between PTSD severity and gastrointestinal symptoms.
JOURNAL OF CLINICAL GASTROENTEROLOGY
(2022)
Article
Gastroenterology & Hepatology
Brigida Barberio, Lesley A. Houghton, Yan Yiannakou, Edoardo Savarino, Christopher J. Black, Alexander C. Ford
Summary: The study found that among individuals self-identifying as having IBS, the diagnosis and subtype of IBS were less stable, and starting new treatments did not affect symptom stability.
AMERICAN JOURNAL OF GASTROENTEROLOGY
(2021)
Review
Medicine, General & Internal
Michael Camilleri
Summary: This narrative review summarizes the epidemiology, pathophysiology, diagnosis, management, and prognosis of irritable bowel syndrome (IBS), which has a high prevalence in the United States, especially among women and young people. The diagnosis is traditionally based on the positive identification of symptoms related to various syndromes, while treatment methods should be customized based on specific symptoms.
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
(2021)
Article
Gastroenterology & Hepatology
Eric D. Shah, Lin Chang, Jessica K. Salwen-Deremer, Peter R. Gibson, Laurie Keefer, Jane G. Muir, Shanti Eswaran, William D. Chey
Summary: From the perspective of insurers, it is cost-effective to implement routine and algorithmic prescription drug coverage restrictions that require patients to first fail low-cost behavioral, dietary, and off-label treatments. These findings suggest the importance of addressing insurance coverage and drug pricing to provide optimal care for patients with IBS.
AMERICAN JOURNAL OF GASTROENTEROLOGY
(2021)
Article
Gastroenterology & Hepatology
Syed Ahsan Rizvi, Chukwuemeka Oriala, Jessina Thomas, Shuan Li, Yamen Smadi
Summary: This study compared the number of mast cells (MCs) in children with and without irritable bowel syndrome (IBS) and established histopathological reference values in pediatrics.
JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION
(2022)
Article
Gastroenterology & Hepatology
James K. Ruffle, Linda Tinkler, Christopher Emmett, Alexander C. Ford, Parashkev Nachev, Qasim Aziz, Adam D. Farmer, Yan Yiannakou
Summary: Machine learning analysis of a large prospective cohort of patients with chronic constipation revealed that irritable bowel syndrome with constipation (IBS-C) and functional constipation (FC) only differ significantly in the presence of abdominal pain, suggesting that they may not be distinct syndromes but rather a single syndrome varying along a single clinical dimension. This has implications for patient recruitment into clinical trials, future disease classifications, and management guidelines.
AMERICAN JOURNAL OF GASTROENTEROLOGY
(2021)
Article
Neurosciences
Bojing Liu, Arvid Sjolander, Nancy L. Pedersen, Jonas F. Ludvigsson, Honglei Chen, Fang Fang, Karin Wirdefeldt
Summary: The study found an increased risk of PD diagnosis after IBS, particularly 5 years and more than 10 years after diagnosis. However, there was no statistically significant association between IBS and PD risk in the twin cohort analysis.
NPJ PARKINSONS DISEASE
(2021)
Article
Biochemistry & Molecular Biology
Ravi R. Bhatt, Arpana Gupta, Jennifer S. Labus, Cathy Liu, Priten P. Vora, Jean Stains, Bruce D. Naliboff, Emeran A. Mayer
Summary: The study found that using baseline multimodal neuroimaging and clinical features can accurately predict clinical improvement in patients with irritable bowel syndrome at 3 and 12 months, providing guidance for personalized treatment, especially therapies targeted at changing attentional systems.
MOLECULAR PSYCHIATRY
(2022)
Review
Gastroenterology & Hepatology
Imran Aziz, Magnus Simren
Summary: Irritable bowel syndrome (IBS) is a common functional bowel disorder characterized by symptoms of recurrent abdominal pain and changes in bowel habits. Diagnosis is made by identifying characteristic symptoms and excluding organic gastrointestinal diseases.
LANCET GASTROENTEROLOGY & HEPATOLOGY
(2021)
Review
Nutrition & Dietetics
Giuseppe Chiarioni, Stefan Lucian Popa, Abdulrahman Ismaiel, Cristina Pop, Dinu Iuliu Dumitrascu, Vlad Dumitru Brata, Traian Adrian Duse, Victor Incze, Teodora Surdea-Blaga, Jose Antonio Uranga
Summary: This systematic review evaluates the efficacy and safety of herbal remedies in the management of IBS-C. The included studies demonstrate some evidence of the beneficial effects of herbal remedies on IBS-C symptoms. However, the heterogeneity of the interventions and outcome measures limits the ability to perform a meta-analysis.
Review
Food Science & Technology
Lakshmi A. Dave, Suzanne M. Hodgkinson, Nicole C. Roy, Nick W. Smith, Warren C. McNabb
Summary: Clear nutrition metrics are necessary for advancing sustainable diets. Current assessment methods mainly focus on food composition, nutrient requirements, and dietary intake. However, most studies fail to consider the bioavailability of nutrients in mixed human diets, leading to misleading conclusions regarding the environmental impact of animal-source foods compared to plant-source foods.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2023)
Article
Gastroenterology & Hepatology
Carrie L. Falling, Simon Stebbings, G. David Baxter, Corey A. Siegel, Richard B. Gearry, Ramakrishnan Mani
Summary: This study aimed to investigate pain processing pathways in patients with inflammatory bowel disease (IBD) using somatosensory testing and assess associations with multiple patient factors. The results showed that the absence of a stoma and female sex were associated with greater pressure sensitivity in remote body regions, suggesting widespread hyperalgesia. In addition, worse abdominal pain severity and biologic therapy use were associated with decreased pain inhibition, while biologic therapy use was also associated with increased pain facilitation. These findings suggest altered pain processing and central sensitization mechanisms in patients with IBD.
EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY
(2022)
Article
Nutrition & Dietetics
Miranda C. E. Lomer, Bridgette Wilson, Catherine L. Wall
Summary: This study developed guidelines for the nutritional assessment and dietary management of inflammatory bowel disease (IBD) using a Delphi consensus method. The guidelines aim to improve equality of care for patients with IBD.
JOURNAL OF HUMAN NUTRITION AND DIETETICS
(2023)
Article
Gastroenterology & Hepatology
Thomas C. Mules, Akhilesh Swaminathan, Esther Hirschfeld, Grace M. Borichevsky, Chris M. Frampton, Andrew S. Day, Richard B. Gearry
Summary: This study investigated the association between disease activity and sexual dysfunction in patients with inflammatory bowel disease. The results showed that objective measures of disease activity were not associated with sexual dysfunction, but psychological symptoms played a role.
INFLAMMATORY BOWEL DISEASES
(2023)
Article
Gastroenterology & Hepatology
Sally Mortlock, Anton Lord, Grant Montgomery, Martha Zakrzewski, Lisa A. Simms, Krupa Krishnaprasad, Katherine Hanigan, James D. Doecke, Alissa Walsh, Ian C. Lawrance, Peter A. Bampton, Jane M. Andrews, Gillian Mahy, Susan J. Connor, Miles P. Sparrow, Sally Bell, Timothy H. Florin, Jakob Begun, Richard B. Gearry, Graham L. Radford-Smith
Summary: This study identified genetic loci associated with medically refractory ulcerative colitis (UC) through a genome wide association analysis. The findings suggest different genetic risk factors for medically refractory UC compared to non-medically refractory UC. Further research may uncover additional loci related to disease severity.
JOURNAL OF CROHNS & COLITIS
(2023)
Article
Nutrition & Dietetics
Catherine L. Wall, Bridgette Wilson, Miranda C. E. Lomer
Summary: This study aimed to develop and validate an IBD-specific nutrition self-screening tool (IBD-NST) that identifies patients at nutrition risk. The final validated IBD-NST includes body mass index (BMI), weight loss and IBD-specific nutrition-focussed questions which were acceptable to patients.
FRONTIERS IN NUTRITION
(2023)
Article
Nutrition & Dietetics
Alice MacIntosh, Phoebe E. Heenan, Morag Wright-McNaughton, Chris Frampton, Paula Skidmore, Catherine L. Wall, Jane Muir, Nicholas Joseph Talley, Nicole Clemence Roy, Richard B. Gearry
Summary: This study investigated the relationship between habitual FODMAP intake and post-prandial bowel symptoms in adults with IBS, FD, or FC, as well as in healthy adults. The results showed that IBS participants experienced more post-prandial bowel symptoms compared to participants with other functional bowel disorders or controls. Different symptoms were associated with different types of FODMAP intake.
FRONTIERS IN NUTRITION
(2023)
Article
Chemistry, Applied
Natalie G. Ahlborn, Carlos A. Montoya, Suzanne M. Hodgkinson, Anant Dave, Aiqian Ye, Linda M. Samuelsson, Nicole C. Roy, Warren C. McNabb
Summary: This study investigates the impact of heat treatment and homogenization on gastric curd formation and gastric emptying of milk proteins and lipids. The results show that both heat treatment and homogenization influence the in vivo gastric curd structure formed from bovine milk, and the extent of processing affects the gastric emptying rates of dry matter, proteins, and lipids.
FOOD HYDROCOLLOIDS
(2023)
Article
Biochemistry & Molecular Biology
Shanalee C. James, Karl Fraser, Janine Cooney, Catrin S. Guenther, Wayne Young, Richard B. Gearry, Phoebe E. Heenan, Tania Trower, Jacqueline I. Keenan, Nicholas J. Talley, Warren C. McNabb, Nicole C. Roy
Summary: This study aimed to compare the circulating concentrations of amino acids and neurotransmitters between healthy participants and those with functional gastrointestinal disorders (FGIDs). The results showed significant differences in branched-chain amino acids, ornithine, and alpha-aminobutyric acid between healthy controls and FGID groups. No other significant differences were observed for the neurotransmitters or any other amino acids analyzed.
Article
Microbiology
Tracey Bear, Nicole Roy, Julie Dalziel, Chrissie Butts, Jane Coad, Wayne Young, Shanthi G. Parkar, Duncan Hedderley, Hannah Dinnan, Sheridan Martell, Susanne Middlemiss-Kraak, Pramod Gopal
Summary: The relationship between microbiota profile and stress exposure is still unclear. A rat model of unpredictable chronic mild stress (UCMS) was used to investigate this relationship. Female Sprague Dawley rats showed atypical behaviors following UCMS, but no depressive-like behaviors were observed. The relative abundance of taxa from the Clostridiales order and Desulfovibrionaceae family correlated with anxiety-like behaviors and plasma cytokine concentrations, suggesting the brain-to-gut influence of mild anxiety with a microbiota profile that may involve inflammatory pathways.
Article
Food Science & Technology
Juliana A. S. Leite, Carlos A. Montoya, Evelyne Maes, Charles Hefer, Raul A. P. A. Cruz, Nicole C. Roy, Warren C. Mcnabb
Summary: This study investigated how heat treatments affect protein hydrolysis in the milk of ruminants and found that the effects vary depending on the species and heat treatment applied. Self-digestion increased the potential antithrombin peptides in bovine milk. These findings suggest the potential application of enhancing bioactive peptides in the industry.
Review
Gastroenterology & Hepatology
Alexander T. Elford, Rupert W. Leong, Emma P. Halmos, Manal Morgan, Kate Kilpatrick, Peter J. Lewindon, Richard B. Gearry, Britt Christensen
Summary: Australasia, including Australia, New Zealand, and Papua New Guinea, has a high prevalence of inflammatory bowel disease (IBD), and the practice of IBD medicine varies within this region. This review discusses barriers to IBD care across Australasia from the perspective of local healthcare professionals, including access to multidisciplinary teams, nutritional therapies, mental health disorders associated with IBD, medication availability, endoscopy access, rural barriers to care, Indigenous IBD care, and pediatric issues. The aim is to identify areas for improvement in IBD care and address research needs in Australasia.
THERAPEUTIC ADVANCES IN GASTROENTEROLOGY
(2023)
Article
Chemistry, Applied
Juliana A. S. Leite, Carlos A. Montoya, Simon M. Loveday, Jane A. Mullaney, Trevor S. Loo, Warren C. McNabb, Nicole C. Roy
Summary: This study examined the impact of heating and drying on milk protease activities in cow, sheep, and goat milk, compared to raw milk. The results showed that plasmin activity decreased in goat and sheep milk, while cathepsin D activity increased in spray-dried cow milk after heating. In vitro digestion with pancreatin increased both plasmin and cathepsin D activities. Milk proteases were found to contribute to protein hydrolysis in the stomach and small intestine.
Article
Pediatrics
Stephanie Christine Brown, Catherine L. Wall, Richard B. Gearry, Andrew S. Day
Summary: Crohn's disease (CD) is a chronic, incurable and relapsing disease that affects the gastrointestinal tract. Exclusive enteral nutrition (EEN) is the first-line therapy for CD, but little is known about the patient experience of EEN. This study aimed to assess children's experiences of EEN and understand their mindset. The findings show that limited formula flavors and the need for support are important challenges for children on EEN. Psychological support strategies should be developed to ensure successful implementation of EEN in children.
PEDIATRIC GASTROENTEROLOGY HEPATOLOGY & NUTRITION
(2023)
Correction
Gastroenterology & Hepatology
Thomas C. Mules, Akhilesh Swaminathan, Esther Hirschfeld, Grace M. Borichevsky, Chris M. Frampton, Andrew S. Day, Richard B. Gearry
INFLAMMATORY BOWEL DISEASES
(2023)
