KLF4 recruits SWI/SNF to increase chromatin accessibility and reprogram the endothelial enhancer landscape under laminar shear stress

Remodeling of active endothelial enhancers is associated with aberrant gene-regulatory networks in pulmonary arterial hypertension

(2020) Armando Reyes-Palomares et al.   Nature Communications

Atheroprotective Flow Upregulates ITPR3 (Inositol 1,4,5-Trisphosphate Receptor 3) in Vascular Endothelium via KLF4 (Krüppel-Like Factor 4)-Mediated Histone Modifications

(2019) Ming He et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

KLF4 is involved in the organization and regulation of pluripotency-associated three-dimensional enhancer networks

(2019) Dafne Campigli Di Giammartino et al.   NATURE CELL BIOLOGY

A key role for the novel coronary artery disease gene JCAD in atherosclerosis via shear stress mechanotransduction

(2019) Gillian Douglas et al.   CARDIOVASCULAR RESEARCH

Activity-by-contact model of enhancer–promoter regulation from thousands of CRISPR perturbations

(2019) Charles P. Fulco et al.   NATURE GENETICS

Identification of significant chromatin contacts from HiChIP data by FitHiChIP

(2019) Sourya Bhattacharyya et al.   Nature Communications

An enhanced CRISPR repressor for targeted mammalian gene regulation

(2018) Nan Cher Yeo et al.   NATURE METHODS

Angiogenic patterning by STEEL, an endothelial-enriched long noncoding RNA

(2018) H. S. Jeffrey Man et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Enhancer-associated long non-coding RNA LEENE regulates endothelial nitric oxide synthase and endothelial function

(2018) Yifei Miao et al.   Nature Communications

Enhancer redundancy provides phenotypic robustness in mammalian development

(2018) Marco Osterwalder et al.   NATURE

Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits

(2018) Evangelos Evangelou et al.   NATURE GENETICS

Enhancer connectome in primary human cells identifies target genes of disease-associated DNA elements

(2017) Maxwell R Mumbach et al.   NATURE GENETICS

The SWI/SNF chromatin remodelling complex is required for maintenance of lineage specific enhancers

(2017) Burak H. Alver et al.   Nature Communications

Shear-induced Notch-Cx37-p27 axis arrests endothelial cell cycle to enable arterial specification

(2017) Jennifer S. Fang et al.   Nature Communications

An efficient targeted nuclease strategy for high-resolution mapping of DNA binding sites

(2017) Peter J Skene et al.   eLife

Perturb-Seq: Dissecting Molecular Circuits with Scalable Single-Cell RNA Profiling of Pooled Genetic Screens

(2016) Atray Dixit et al.   CELL

HiChIP: efficient and sensitive analysis of protein-directed genome architecture

(2016) Maxwell R Mumbach et al.   NATURE METHODS

Deep transcriptomic profiling reveals the similarity between endothelial cells cultured under static and oscillatory shear stress conditions

(2016) Congzhen Qiao et al.   PHYSIOLOGICAL GENOMICS

The decrease in histone methyltransferase EZH2 in response to fluid shear stress alters endothelial gene expression and promotes quiescence

(2015) Monika Maleszewska et al.   ANGIOGENESIS

Arterial endothelial methylome: differential DNA methylation in athero-susceptible disturbed flow regions in vivo

(2015) Yi-Zhou Jiang et al.   BMC GENOMICS

Endothelial-to-mesenchymal transition contributes to fibro-proliferative vascular disease and is modulated by fluid shear stress

(2015) Jan-Renier A.J. Moonen et al.   CARDIOVASCULAR RESEARCH

Pioneer Transcription Factors Target Partial DNA Motifs on Nucleosomes to Initiate Reprogramming

(2015) Abdenour Soufi et al.   CELL

Role of Flow-Sensitive microRNAs in Endothelial Dysfunction and Atherosclerosis

(2014) Sandeep Kumar et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

A 3D Map of the Human Genome at Kilobase Resolution Reveals Principles of Chromatin Looping

(2014) Suhas S.P. Rao et al.   CELL

Epigenetic Mechanism in Regulation of Endothelial Function by Disturbed Flow: Induction of DNA Hypermethylation by DNMT1

(2014) Jing Zhou et al.   Cellular and Molecular Bioengineering

Pioneer transcription factors in cell reprogramming

(2014) Makiko Iwafuchi-Doi et al.   GENES & DEVELOPMENT

Flow-dependent epigenetic DNA methylation regulates endothelial gene expression and atherosclerosis

(2014) Jessilyn Dunn et al.   JOURNAL OF CLINICAL INVESTIGATION

The atherosusceptible endothelium: endothelial phenotypes in complex haemodynamic shear stress regions in vivo

(2013) Peter F. Davies et al.   CARDIOVASCULAR RESEARCH

Transposition of native chromatin for fast and sensitive epigenomic profiling of open chromatin, DNA-binding proteins and nucleosome position

(2013) Jason D Buenrostro et al.   NATURE METHODS

Site-Specific MicroRNA-92a Regulation of Krüppel-Like Factors 4 and 2 in Atherosusceptible Endothelium

(2012) Yun Fang et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Foxa2 and H2A.Z Mediate Nucleosome Depletion during Embryonic Stem Cell Differentiation

(2012) Zhaoyu Li et al.   CELL

Facilitators and Impediments of the Pluripotency Reprogramming Factors' Initial Engagement with the Genome

(2012) Abdenour Soufi et al.   CELL

Cooperative Binding of KLF4, pELK-1, and HDAC2 to a G/C Repressor Element in the SM22α Promoter Mediates Transcriptional Silencing During SMC Phenotypic Switching In Vivo

(2012) Morgan Salmon et al.   CIRCULATION RESEARCH

Endothelial Nitric Oxide Synthase Polymorphism rs3918226 Associated With Hypertension Does Not Affect Plasma Nitrite Levels in Healthy Subjects

(2012) Marcelo R. Luizon et al.   HYPERTENSION

Laminar Flow Activation of ERK5 Protein in Vascular Endothelium Leads to Atheroprotective Effect via NF-E2-related Factor 2 (Nrf2) Activation

(2012) Miso Kim et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Molecular pathogenesis of pulmonary arterial hypertension

(2012) Marlene Rabinovitch   JOURNAL OF CLINICAL INVESTIGATION

Role of histone deacetylases in transcription factor regulation and cell cycle modulation in endothelial cells in response to disturbed flow

(2012) D.-Y. Lee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Systematic Localization of Common Disease-Associated Variation in Regulatory DNA

(2012) M. T. Maurano et al.   SCIENCE

Wall Shear Stress is Decreased in the Pulmonary Arteries of Patients with Pulmonary Arterial Hypertension: An Image-Based, Computational Fluid Dynamics Study

(2012) Beverly T. Tang et al.   Pulmonary Circulation

Flow-Dependent Regulation of Krüppel-Like Factor 2 Is Mediated by MicroRNA-92a

(2011) Wei Wu et al.   CIRCULATION

Genomewide Association Study Using a High-Density Single Nucleotide Polymorphism Array and Case-Control Design Identifies a Novel Essential Hypertension Susceptibility Locus in the Promoter Region of Endothelial NO Synthase

(2011) Erika Salvi et al.   HYPERTENSION

Molecular characterization of myosin phosphatase in endothelium

(2011) Kyung-mi Kim et al.   JOURNAL OF CELLULAR PHYSIOLOGY

A genome-wide association study in Europeans and South Asians identifies five new loci for coronary artery disease

(2011) John F Peden et al.   NATURE GENETICS

Genome-wide association study identifies a new locus for coronary artery disease on chromosome 10p11.23

(2010) J. Erdmann et al.   EUROPEAN HEART JOURNAL

Erk5 Activation Elicits a Vasoprotective Endothelial Phenotype via Induction of Krüppel-like Factor 4 (KLF4)

(2010) Nils Ohnesorge et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Lentiviral Functional Proteomics Approach Identifies Chromatin Remodeling Complexes Important for the Induction of Pluripotency

(2010) Anthony B. Mak et al.   MOLECULAR & CELLULAR PROTEOMICS

Shear stress, SIRT1, and vascular homeostasis

(2010) Z. Chen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Defining the regulation of KLF4 expression and its downstream transcriptional targets in vascular endothelial cells

(2009) Guadalupe Villarreal et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Histone Deacetylase 3 Is Critical in Endothelial Survival and Atherosclerosis Development in Response to Disturbed Flow

(2009) Anna Zampetaki et al.   CIRCULATION

Comprehensive Mapping of Long-Range Interactions Reveals Folding Principles of the Human Genome

(2009) E. Lieberman-Aiden et al.   SCIENCE

Combinatorial Regulation of Endothelial Gene Expression by Ets and Forkhead Transcription Factors

(2008) Sarah De Val et al.   CELL

Activation of p300 Histone Acetyltransferase Activity Is an Early Endothelial Response to Laminar Shear Stress and Is Essential for Stimulation of Endothelial Nitric-oxide Synthase mRNA Transcription

(2008) Wei Chen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mechanotransduction in vascular physiology and atherogenesis

(2008) Cornelia Hahn et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

SWI/SNF-Brg1 Regulates Self-Renewal and Occupies Core Pluripotency-Related Genes in Embryonic Stem Cells

(2008) Benjamin L. Kidder et al.   STEM CELLS