期刊
TRENDS IN MOLECULAR MEDICINE
卷 28, 期 11, 页码 989-1005出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.molmed.2022.09.005
关键词
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资金
- German Research Foundation (DFG) [SCHN 1626/1-1]
- Boehringer-Ingelheim Fonds MD Fellowship
- Evangelisches Studienwerk Villigst
- Irma and Norman Braman Endowed Chair for GI Motility
- Suzi and Scott Lustgarten Center Endowment
- Children's Hospital of Philadelphia Frontier Program award
- Canadian Institute of Health Research [153264]
- NIH [R21 NS116574, R01 DK122798-01, R01 DK129691-01, R01 DK128282, R01-DK-129691]
- Children's Hospital of Philadelphia Institutional Development Funds
- NIH Director's New Innovator Award [DP2AG067492]
- Edward Mallinckrodt Jr Foundation
- Agilent Early Career Professor Award
- Thyssen Foundation
- IDSA Foundation
- Human Frontier Science Program (HFSP)
- Penn Diabetes Research Center [P30-DK-019525]
- Penn Center for Musculoskeletal Disorders [P30AR069619]
- Penn Institute on Aging
The enteric nervous system is an integrative sensory system with manifold immunoregulatory functions, interacting with various cell types in the bowel and forming connections with the central and peripheral nervous systems.
The enteric nervous system (ENS) forms a versatile sensory system along the gastrointestinal tract that interacts with most cell types in the bowel. Herein, we portray host-environment interactions at the intestinal mucosal surface through the lens of the enteric nervous system. We describe local cellular inter-actions as well as long-range circuits between the enteric, central, and peripheral nervous systems. Additionally, we discuss recently discovered mechanisms by which enteric neurons and glia respond to biotic and abiotic environmental changes and how they regulate intestinal immunity and inflammation. The enteric nervous system emerges as an integrative sensory system with manifold immunoregulatory functions under both homeostatic and pathophysiological conditions.
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